GREMLIN Database
GTPC1 - Putative GTP cyclohydrolase 1 type 2
UniProt: P0AFP6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13305
Length: 247 (236)
Sequences: 3741 (2799)
Seq/√Len: 182.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
213_A218_T3.5371.00
50_D85_T3.3371.00
169_A187_V2.8581.00
132_E167_R2.6671.00
137_V145_W2.5561.00
132_E166_Q2.5431.00
41_G62_V2.4531.00
142_L189_A2.4401.00
145_W149_R2.4181.00
138_P141_E2.2221.00
19_I25_N2.2181.00
86_L93_L2.1441.00
36_Q58_D2.0951.00
39_V57_A2.0631.00
53_V89_N2.0561.00
227_S231_N2.0421.00
112_L150_L2.0231.00
55_L239_T2.0091.00
192_T210_F1.9961.00
6_L59_A1.9761.00
136_P164_V1.9471.00
119_T134_T1.9301.00
40_T227_S1.9111.00
46_Q81_N1.8971.00
37_K237_D1.8881.00
165_V189_A1.8781.00
51_E55_L1.8751.00
120_V132_E1.8741.00
37_K58_D1.8561.00
11_N16_S1.8021.00
13_K229_W1.7881.00
41_G48_L1.7871.00
19_I102_A1.7771.00
53_V85_T1.7741.00
3_N92_N1.7291.00
9_L229_W1.7231.00
194_E212_A1.7231.00
37_K239_T1.6741.00
50_D54_R1.6731.00
9_L234_T1.6601.00
189_A211_Y1.6421.00
41_G60_V1.6181.00
115_L224_R1.6181.00
136_P166_Q1.6071.00
146_I191_I1.5971.00
86_L91_I1.5911.00
49_L60_V1.5851.00
7_E94_Y1.5801.00
49_L86_L1.5671.00
84_K88_A1.5641.00
110_A129_P1.5441.00
140_L162_P1.5411.00
46_Q85_T1.5101.00
171_C178_F1.5101.00
49_L85_T1.4951.00
44_A62_V1.4921.00
109_N172_T1.4531.00
192_T195_V1.4281.00
12_E233_N1.4081.00
3_N35_V1.4061.00
39_V60_V1.4051.00
62_V95_G1.3981.00
193_G214_G1.3851.00
195_V210_F1.3781.00
111_Q225_A1.3751.00
146_I211_Y1.3681.00
139_G209_H1.3601.00
3_N59_A1.3571.00
124_I128_V1.3521.00
39_V55_L1.3521.00
124_I185_F1.3411.00
130_W187_V1.3411.00
106_L110_A1.3321.00
37_K56_G1.3311.00
6_L35_V1.3201.00
67_F71_E1.3191.00
142_L191_I1.3171.00
182_A187_V1.3151.00
46_Q50_D1.2831.00
140_L144_S1.2781.00
177_S198_Q1.2691.00
5_E8_Q1.2511.00
84_K87_L1.2501.00
11_N94_Y1.2481.00
114_A225_A1.2311.00
33_E90_D1.2221.00
114_A121_M1.2121.00
100_L222_G1.2041.00
125_E181_S1.1891.00
40_T61_I1.1881.00
139_G211_Y1.1841.00
44_A60_V1.1801.00
4_T32_K1.1791.00
137_V141_E1.1781.00
160_T163_E1.1761.00
183_A206_Q1.1761.00
113_A170_W1.1731.00
139_G157_C1.1711.00
7_E11_N1.1701.00
166_Q188_D1.1681.00
156_W212_A1.1621.00
196_S199_T1.1541.00
111_Q114_A1.1531.00
37_K55_L1.1501.00
108_N172_T1.1451.00
13_K106_L1.1451.00
24_P72_S1.1411.00
189_A209_H1.1381.00
39_V51_E1.1341.00
75_I83_L1.1311.00
139_G189_A1.1291.00
176_Q196_S1.1211.00
45_S201_H1.1011.00
161_G164_V1.1001.00
122_G167_R1.0891.00
40_T223_I1.0811.00
228_E232_E1.0811.00
10_I61_I1.0801.00
117_G145_W1.0731.00
59_A92_N1.0691.00
40_T230_L1.0651.00
25_N99_P1.0581.00
180_D184_R1.0571.00
49_L82_R1.0431.00
179_I208_L1.0391.00
118_I131_G1.0381.00
80_R87_L1.0321.00
59_A94_Y1.0311.00
15_N18_A1.0120.99
180_D202_S1.0090.99
29_V86_L1.0020.99
163_E209_H1.0010.99
161_G209_H0.9990.99
174_G196_S0.9910.99
122_G185_F0.9860.99
100_L226_L0.9830.99
40_T238_V0.9730.99
181_S184_R0.9680.99
147_E153_K0.9650.99
10_I96_W0.9640.99
33_E58_D0.9560.99
46_Q205_E0.9460.99
133_L168_V0.9440.99
144_S148_A0.9440.99
142_L168_V0.9380.99
102_A127_L0.9340.99
225_A228_E0.9290.99
117_G134_T0.9260.99
197_E216_H0.9230.99
51_E54_R0.9210.99
191_I211_Y0.9200.99
43_T197_E0.9130.99
9_L233_N0.9060.99
20_S102_A0.9040.99
135_M141_E0.9030.99
167_R186_G0.8970.99
50_D53_V0.8960.99
118_I142_L0.8900.99
197_E201_H0.8900.99
182_A186_G0.8880.99
111_Q115_L0.8870.99
130_W185_F0.8860.99
6_L38_I0.8850.99
80_R84_K0.8820.99
121_M132_E0.8790.98
181_S185_F0.8720.98
171_C190_F0.8680.98
116_L146_I0.8660.98
113_A131_G0.8600.98
118_I121_M0.8590.98
77_G80_R0.8590.98
9_L12_E0.8570.98
14_L100_L0.8560.98
176_Q199_T0.8540.98
141_E144_S0.8510.98
229_W233_N0.8500.98
142_L146_I0.8480.98
195_V200_I0.8480.98
81_N85_T0.8460.98
27_L92_N0.8450.98
113_A121_M0.8420.98
48_L60_V0.8410.98
108_N222_G0.8400.98
171_C175_G0.8330.98
180_D206_Q0.8300.98
228_E231_N0.8290.98
145_W148_A0.8250.98
33_E92_N0.8110.97
36_Q56_G0.8100.97
47_A204_R0.8060.97
108_N111_Q0.8030.97
216_H220_R0.8020.97
80_R83_L0.8020.97
197_E214_G0.7980.97
9_L13_K0.7980.97
143_A157_C0.7920.97
14_L103_H0.7900.97
142_L211_Y0.7870.97
116_L191_I0.7820.97
200_I210_F0.7730.97
110_A114_A0.7710.97
137_V142_L0.7670.96
16_S94_Y0.7640.96
10_I94_Y0.7620.96
28_Q95_G0.7620.96
123_E126_P0.7610.96
140_L161_G0.7600.96
45_S48_L0.7570.96
117_G149_R0.7530.96
44_A49_L0.7480.96
165_V211_Y0.7430.96
100_L225_A0.7360.95
10_I226_L0.7360.95
38_I59_A0.7340.95
31_G92_N0.7330.95
39_V91_I0.7300.95
115_L119_T0.7290.95
163_E188_D0.7260.95
138_P164_V0.7260.95
143_A211_Y0.7260.95
7_E16_S0.7170.95
137_V189_A0.7150.95
3_N33_E0.7150.95
115_L149_R0.7120.95
7_E59_A0.7100.95
235_D238_V0.7070.94
167_R187_V0.7070.94
108_N221_G0.7060.94
18_A102_A0.7010.94
122_G132_E0.7000.94
8_Q12_E0.6970.94
96_W99_P0.6960.94
130_W167_R0.6960.94
133_L136_P0.6920.94
29_V83_L0.6840.93
85_T89_N0.6830.93
53_V91_I0.6830.93
66_Y79_K0.6820.93
48_L51_E0.6820.93
3_N94_Y0.6810.93
119_T132_E0.6770.93
202_S206_Q0.6730.93
133_L137_V0.6690.93
150_L218_T0.6690.93
111_Q222_G0.6670.93
213_A217_A0.6640.92
106_L229_W0.6600.92
20_S178_F0.6600.92
31_G88_A0.6580.92
61_I226_L0.6520.92
183_A208_L0.6500.92
103_H110_A0.6500.92
46_Q82_R0.6460.91
199_T202_S0.6450.91
111_Q221_G0.6420.91
4_T8_Q0.6410.91
113_A118_I0.6400.91
195_V212_A0.6380.91
27_L30_E0.6340.91
157_C211_Y0.6320.90
224_R227_S0.6280.90
158_G200_I0.6240.90
24_P28_Q0.6230.90
30_E80_R0.6220.90
22_Y65_G0.6220.90
115_L221_G0.6220.90
139_G143_A0.6180.89
53_V56_G0.6180.89
139_G162_P0.6170.89
138_P143_A0.6160.89
78_M206_Q0.6150.89
133_L142_L0.6150.89
157_C161_G0.6120.89
25_N28_Q0.6120.89
65_G95_G0.6110.89
131_G182_A0.6090.89
30_E92_N0.6070.89
122_G130_W0.6030.88
179_I183_A0.6020.88
142_L188_D0.6010.88
147_E152_R0.5980.88
23_A200_I0.5940.87
23_A198_Q0.5920.87
10_I13_K0.5890.87
16_S25_N0.5890.87
179_I206_Q0.5880.87
10_I14_L0.5820.86
170_W191_I0.5810.86
11_N17_A0.5790.86
35_V59_A0.5780.86
50_D81_N0.5770.86
22_Y25_N0.5730.86
220_R223_I0.5720.85
190_F203_A0.5710.85
175_G190_F0.5650.85
22_Y174_G0.5630.85
182_A185_F0.5620.84
44_A82_R0.5600.84
200_I204_R0.5560.84
79_K82_R0.5550.84
150_L213_A0.5550.84
215_H219_E0.5540.84
35_V92_N0.5540.84
71_E83_L0.5520.83
179_I203_A0.5440.82
194_E200_I0.5430.82
222_G226_L0.5420.82
64_H101_D0.5410.82
177_S196_S0.5400.82
167_R188_D0.5360.82
139_G163_E0.5360.82
125_E190_F0.5350.81
197_E217_A0.5350.81
129_P170_W0.5340.81
85_T88_A0.5330.81
100_L108_N0.5320.81
13_K226_L0.5320.81
75_I84_K0.5310.81
80_R88_A0.5310.81
44_A93_L0.5300.81
81_N84_K0.5280.81
152_R155_L0.5280.81
112_L170_W0.5250.80
31_G90_D0.5250.80
193_G213_A0.5250.80
52_A60_V0.5250.80
163_E166_Q0.5220.80
37_K57_A0.5220.80
66_Y93_L0.5220.80
109_N129_P0.5210.80
201_H204_R0.5200.80
74_V80_R0.5190.79
123_E129_P0.5190.79
156_W214_G0.5180.79
74_V83_L0.5180.79
29_V93_L0.5180.79
24_P68_W0.5180.79
236_L239_T0.5170.79
124_I130_W0.5160.79
22_Y177_S0.5160.79
141_E145_W0.5130.79
103_H106_L0.5120.79
155_L213_A0.5090.78
120_V131_G0.5090.78
140_L160_T0.5070.78
143_A155_L0.5070.78
20_S127_L0.5070.78
107_G129_P0.5060.78
20_S125_E0.5060.78
28_Q66_Y0.5060.78
112_L172_T0.5050.78
192_T199_T0.5050.78
170_W190_F0.5030.77
124_I182_A0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nmoA 4 1 100 0.067 Contact Map
2gx8A 5 0.9919 100 0.077 Contact Map
2nydA 5 0.9919 100 0.084 Contact Map
2fywA 3 0.9879 100 0.099 Contact Map
2yybA 3 0.9757 100 0.107 Contact Map
3wsfA 3 0.9595 100 0.137 Contact Map
3rxyA 4 0.9231 100 0.234 Contact Map
4bubA 1 0.8664 81.3 0.938 Contact Map
1w0mA 3 0.7368 68.2 0.944 Contact Map
3f4wA 2 0.7409 52.7 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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