GREMLIN Database
PSPA - Phage shock protein A
UniProt: P0AFM6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10776
Length: 222 (216)
Sequences: 1645 (1072)
Seq/√Len: 73.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_L84_E5.6821.00
76_E216_K4.3471.00
68_E101_I3.3891.00
58_T62_E2.9181.00
61_I105_E2.9031.00
105_E109_T2.8891.00
65_S105_E2.8451.00
142_R179_E2.8321.00
72_Q76_E2.8091.00
88_R207_S2.7041.00
31_L35_E2.6821.00
150_R181_E2.5781.00
208_E211_A2.5131.00
94_K209_Q2.4331.00
2_G5_S2.4311.00
135_R172_E2.3881.00
147_N151_D2.2951.00
61_I101_I2.2521.00
71_W74_K2.2151.00
30_R136_Q2.1151.00
84_E214_K2.1071.00
70_E74_K2.0821.00
54_K112_D2.0721.00
76_E213_L1.9721.00
76_E80_L1.9711.00
61_I65_S1.9671.00
44_R126_E1.9561.00
211_A215_A1.9471.00
65_S101_I1.9271.00
109_T113_D1.9181.00
37_E133_R1.8781.00
6_R23_E1.8621.00
212_Q216_K1.8531.00
8_A12_N1.8521.00
207_S211_A1.8361.00
98_T102_K1.8171.00
131_E135_R1.7921.00
102_K105_E1.7641.00
72_Q212_Q1.7521.00
72_Q216_K1.7201.00
68_E98_T1.7151.00
31_L34_Q1.7111.00
212_Q215_A1.7021.00
146_A182_A1.6811.00
47_S118_M1.6451.00
75_A213_L1.6441.00
14_N27_K1.6250.99
207_S217_M1.6040.99
69_V73_E1.5470.99
209_Q212_Q1.5460.99
113_D117_R1.5340.99
177_Q181_E1.4890.99
65_S69_V1.4790.99
79_L217_M1.4700.99
70_E73_E1.4300.99
83_R196_Q1.4200.99
197_F200_L1.4100.99
198_A201_K1.4050.98
61_I108_V1.4020.98
30_R140_M1.3930.98
197_F201_K1.3520.98
54_K115_L1.3460.98
20_E23_E1.3400.98
95_Q205_A1.3390.98
54_K58_T1.3380.98
195_D198_A1.3070.98
86_L200_L1.3010.97
88_R206_I1.2760.97
56_Q60_R1.2680.97
193_L196_Q1.2640.97
102_K106_H1.2570.97
94_K98_T1.2520.97
79_L213_L1.2500.97
33_I129_L1.2220.96
20_E34_Q1.2200.96
47_S122_I1.2200.96
99_D102_K1.2190.96
35_E38_D1.2140.96
80_L217_M1.2100.96
22_A27_K1.2070.96
192_S195_D1.2010.96
112_D116_A1.1920.96
76_E217_M1.1600.95
66_A70_E1.1490.95
79_L214_K1.1330.94
12_N35_E1.0990.93
121_E124_E1.0850.93
139_L175_I1.0710.93
68_E94_K1.0710.93
13_A17_A1.0700.93
143_H147_N1.0690.92
62_E65_S1.0590.92
58_T108_V1.0510.92
127_N131_E1.0450.92
85_D196_Q1.0420.92
150_R154_R1.0320.91
77_L81_K1.0300.91
194_D197_F1.0300.91
128_K131_E1.0090.90
15_I18_L1.0040.90
208_E212_Q0.9910.89
164_A168_F0.9880.89
17_A27_K0.9870.89
73_E76_E0.9870.89
62_E66_A0.9850.89
71_W93_E0.9640.88
111_V115_L0.9600.88
170_S173_R0.9540.87
28_L31_L0.9440.87
125_L132_T0.9440.87
92_I96_K0.9400.87
64_A97_L0.9390.87
191_K196_Q0.9390.87
54_K108_V0.9380.87
35_E39_T0.9320.86
173_R177_Q0.9320.86
75_A91_L0.9300.86
140_M144_Q0.9210.86
84_E177_Q0.9120.85
26_Q144_Q0.8770.83
10_I29_V0.8740.82
93_E96_K0.8720.82
24_D27_K0.8720.82
17_A21_K0.8710.82
13_A28_L0.8700.82
11_V18_L0.8680.82
29_V168_F0.8640.82
150_R182_A0.8610.81
72_Q94_K0.8590.81
40_L129_L0.8550.81
64_A100_L0.8500.81
39_T43_V0.8400.80
16_N34_Q0.8370.80
9_D12_N0.8330.79
19_L23_E0.8190.78
123_G127_N0.8190.78
15_I22_A0.8120.78
13_A21_K0.8100.77
91_L94_K0.8050.77
195_D199_E0.8000.76
106_H211_A0.7990.76
99_D205_A0.7980.76
71_W90_A0.7870.75
18_L22_A0.7860.75
60_R63_Q0.7860.75
9_D167_R0.7810.75
101_I203_D0.7810.75
213_L216_K0.7800.75
193_L197_F0.7780.74
29_V136_Q0.7760.74
67_R97_L0.7750.74
74_K77_L0.7740.74
116_A120_K0.7740.74
52_A193_L0.7650.73
196_Q200_L0.7650.73
79_L207_S0.7630.73
184_S188_G0.7620.73
38_D42_E0.7610.73
129_L167_R0.7570.72
151_D154_R0.7540.72
71_W197_F0.7530.72
6_R25_P0.7520.72
61_I109_T0.7480.72
89_A92_I0.7450.71
111_V114_T0.7430.71
63_Q69_V0.7430.71
9_D136_Q0.7400.71
26_Q128_K0.7330.70
47_S50_A0.7330.70
3_I15_I0.7310.70
26_Q30_R0.7310.70
32_M71_W0.7280.69
84_E88_R0.7240.69
9_D28_L0.7230.69
109_T112_D0.7210.69
168_F172_E0.7180.68
77_L80_L0.7160.68
106_H109_T0.7140.68
110_L114_T0.7130.68
9_D14_N0.7100.68
168_F178_M0.7050.67
49_R67_R0.7030.67
90_A197_F0.7030.67
30_R138_A0.7020.67
195_D208_E0.6960.66
51_L119_K0.6940.66
12_N31_L0.6920.66
46_T144_Q0.6900.65
154_R173_R0.6890.65
48_A56_Q0.6870.65
37_E129_L0.6860.65
26_Q132_T0.6820.64
86_L196_Q0.6790.64
9_D19_L0.6770.64
72_Q79_L0.6740.64
29_V36_M0.6730.63
157_D160_K0.6730.63
107_E111_V0.6700.63
40_L56_Q0.6700.63
108_V112_D0.6650.62
39_T186_S0.6640.62
153_R156_L0.6640.62
66_A203_D0.6620.62
86_L193_L0.6590.62
193_L199_E0.6560.61
130_S134_A0.6560.61
72_Q98_T0.6520.61
210_L214_K0.6510.61
91_L95_Q0.6490.61
63_Q116_A0.6470.60
213_L217_M0.6430.60
64_A104_L0.6430.60
63_Q66_A0.6430.60
118_M148_S0.6420.60
95_Q209_Q0.6400.60
199_E203_D0.6390.59
29_V171_F0.6370.59
89_A196_Q0.6370.59
64_A101_I0.6360.59
68_E103_S0.6340.59
75_A184_S0.6330.59
33_I37_E0.6330.59
83_R86_L0.6320.59
74_K144_Q0.6320.59
104_L107_E0.6290.58
141_L148_S0.6280.58
40_L48_A0.6280.58
6_R13_A0.6260.58
55_K58_T0.6250.58
36_M132_T0.6250.58
92_I206_I0.6200.57
114_T117_R0.6190.57
87_A91_L0.6180.57
74_K90_A0.6140.56
76_E212_Q0.6090.56
58_T112_D0.6080.56
72_Q92_I0.6070.56
59_R180_A0.6050.55
84_E87_A0.6040.55
124_E127_N0.6040.55
57_L61_I0.6010.55
16_N149_S0.6000.55
20_E28_L0.5980.54
106_H110_L0.5980.54
40_L43_V0.5960.54
9_D35_E0.5920.54
40_L126_E0.5920.54
78_A128_K0.5900.53
51_L115_L0.5900.53
55_K183_E0.5890.53
77_L186_S0.5880.53
15_I99_D0.5820.52
88_R91_L0.5810.52
95_Q206_I0.5800.52
25_P90_A0.5790.52
99_D103_S0.5790.52
56_Q63_Q0.5720.51
19_L22_A0.5720.51
192_S196_Q0.5690.51
47_S51_L0.5680.51
114_T121_E0.5680.51
90_A128_K0.5650.50
69_V106_H0.5650.50
173_R176_D0.5640.50
28_L175_I0.5620.50
137_Q146_A0.5610.50
39_T153_R0.5610.50
14_N22_A0.5600.50
50_A167_R0.5590.50
178_M181_E0.5590.50
182_A185_H0.5590.50
65_S109_T0.5580.50
174_R177_Q0.5560.49
169_E173_R0.5520.49
152_V171_F0.5510.49
77_L201_K0.5510.49
60_R170_S0.5510.49
40_L44_R0.5500.49
9_D129_L0.5470.48
98_T101_I0.5460.48
47_S148_S0.5450.48
32_M171_F0.5450.48
23_E28_L0.5440.48
191_K199_E0.5430.48
142_R146_A0.5430.48
95_Q203_D0.5400.47
205_A208_E0.5400.47
133_R173_R0.5390.47
194_D198_A0.5380.47
196_Q199_E0.5370.47
108_V116_A0.5360.47
91_L125_L0.5360.47
82_E216_K0.5340.47
12_N19_L0.5320.46
14_N17_A0.5310.46
50_A145_A0.5280.46
66_A127_N0.5280.46
18_L21_K0.5270.46
11_V15_I0.5260.46
98_T190_Q0.5250.45
143_H171_F0.5240.45
101_I105_E0.5230.45
6_R19_L0.5220.45
33_I136_Q0.5210.45
44_R178_M0.5200.45
33_I133_R0.5180.45
2_G108_V0.5180.45
86_L90_A0.5180.45
112_D130_S0.5150.44
119_K122_I0.5120.44
167_R171_F0.5110.44
99_D158_S0.5110.44
36_M48_A0.5090.43
11_V150_R0.5090.43
61_I97_L0.5070.43
51_L182_A0.5070.43
26_Q71_W0.5050.43
63_Q139_L0.5020.43
50_A111_V0.5020.43
36_M129_L0.5020.43
154_R185_H0.5010.43
89_A93_E0.5010.43
84_E91_L0.5000.42
86_L197_F0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i84S 2 0.4369 92.5 0.887 Contact Map
2gd5A 2 0.7072 88.1 0.898 Contact Map
3frtA 1 0.6396 87.6 0.898 Contact Map
3ghgA 2 0.6982 86.9 0.899 Contact Map
4abmA 2 0.3559 81.5 0.906 Contact Map
3ojaB 1 0.5946 80.6 0.907 Contact Map
1deqA 1 0.7387 74.5 0.912 Contact Map
1c1gA 2 0.9459 71.7 0.914 Contact Map
4iloA 3 0.7207 71.5 0.914 Contact Map
3mq9A 4 0.5541 66 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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