GREMLIN Database
PPIA - Peptidyl-prolyl cis-trans isomerase A
UniProt: P0AFL3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10757
Length: 190 (153)
Sequences: 9520 (5293)
Seq/√Len: 427.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_R160_D3.3851.00
34_T39_N3.0811.00
41_E154_K2.8251.00
110_G156_M2.7881.00
131_V163_S2.6161.00
66_N185_S2.5091.00
108_T151_K2.5021.00
107_N113_A2.3631.00
32_L39_N2.0861.00
113_A128_F2.0401.00
68_T81_G2.0241.00
33_L40_I1.8941.00
33_L42_L1.8681.00
40_I159_A1.8531.00
42_L112_I1.8311.00
33_L186_A1.8071.00
54_Q58_D1.8061.00
69_T180_P1.7401.00
43_E151_K1.7341.00
34_T185_S1.7321.00
34_T184_L1.6901.00
43_E153_V1.6831.00
37_A161_K1.6741.00
34_T187_K1.6651.00
108_T111_T1.6461.00
165_V181_V1.6441.00
36_S184_L1.6331.00
58_D62_S1.6231.00
32_L187_K1.6181.00
51_V98_K1.6081.00
40_I152_V1.5961.00
44_L53_V1.5761.00
30_H41_E1.5621.00
166_P178_S1.5281.00
29_P57_V1.5101.00
97_I123_A1.5031.00
30_H153_V1.4901.00
46_K53_V1.4791.00
75_P163_S1.4531.00
29_P46_K1.4511.00
130_N134_N1.4291.00
28_D43_E1.4191.00
60_V186_A1.4181.00
45_D48_K1.3691.00
79_I131_V1.3621.00
75_P164_Q1.3501.00
48_K105_L1.3481.00
74_I78_M1.3311.00
62_S94_N1.3161.00
111_T151_K1.3071.00
111_T130_N1.3061.00
168_H178_S1.3001.00
36_S182_V1.2851.00
45_D151_K1.2831.00
73_V162_I1.2791.00
28_D46_K1.2701.00
63_G66_N1.2701.00
32_L41_E1.2391.00
48_K104_G1.2241.00
167_T175_N1.2101.00
75_P167_T1.2101.00
162_I181_V1.2091.00
107_N138_D1.1971.00
79_I162_I1.1891.00
70_F81_G1.1821.00
183_I186_A1.1681.00
160_D163_S1.1641.00
58_D94_N1.1341.00
152_V156_M1.1271.00
106_R138_D1.1261.00
33_L183_I1.1181.00
52_S149_F1.1091.00
52_S114_M1.0901.00
168_H174_Q1.0831.00
31_V56_F1.0511.00
111_T148_V1.0431.00
69_T182_V1.0371.00
169_D174_Q1.0311.00
98_K121_D1.0281.00
42_L129_I1.0241.00
110_G160_D1.0221.00
74_I175_N1.0201.00
51_V54_Q1.0171.00
57_V188_V1.0001.00
129_I159_A0.9931.00
108_T133_D0.9881.00
116_R119_D0.9861.00
76_G132_A0.9801.00
35_T40_I0.9751.00
37_A165_V0.9741.00
101_A144_F0.9741.00
97_I100_E0.9641.00
49_A53_V0.9581.00
72_R80_Q0.9571.00
156_M159_A0.9411.00
152_V159_A0.9321.00
88_M91_K0.9301.00
85_T88_M0.9291.00
113_A138_D0.9201.00
31_V57_V0.9141.00
68_T83_G0.9081.00
119_D122_S0.9021.00
106_R135_A0.8981.00
107_N128_F0.8971.00
166_P175_N0.8891.00
113_A148_V0.8841.00
40_I129_I0.8781.00
116_R122_S0.8751.00
69_T87_Q0.8731.00
99_N116_R0.8641.00
52_S147_A0.8611.00
54_Q57_V0.8421.00
41_E153_V0.8411.00
168_H176_V0.8281.00
69_T176_V0.8181.00
59_Y62_S0.8151.00
165_V179_K0.8091.00
112_I149_F0.8061.00
64_F125_S0.8051.00
99_N123_A0.8021.00
30_H43_E0.8001.00
109_R132_A0.7951.00
39_N187_K0.7951.00
156_M160_D0.7931.00
64_F84_F0.7841.00
37_A179_K0.7821.00
31_V186_A0.7821.00
107_N130_N0.7781.00
31_V60_V0.7771.00
80_Q126_Q0.7721.00
131_V159_A0.7691.00
53_V57_V0.7641.00
49_A147_A0.7571.00
135_A138_D0.7571.00
109_R156_M0.7521.00
84_F87_Q0.7521.00
78_M131_V0.7471.00
84_F90_Q0.7471.00
35_T70_F0.7451.00
73_V79_I0.7401.00
121_D144_F0.7391.00
116_R123_A0.7381.00
35_T158_V0.7291.00
96_P118_A0.7291.00
56_F149_F0.7191.00
71_H126_Q0.7131.00
51_V97_I0.7041.00
129_I152_V0.7031.00
116_R146_Y0.7021.00
57_V61_N0.7001.00
42_L152_V0.6931.00
73_V181_V0.6891.00
158_V161_K0.6871.00
96_P124_T0.6821.00
69_T86_E0.6811.00
85_T89_Q0.6801.00
88_M92_K0.6681.00
75_P131_V0.6661.00
73_V131_V0.6651.00
37_A158_V0.6631.00
67_N182_V0.6550.99
167_T177_P0.6540.99
101_A104_G0.6520.99
66_N186_A0.6410.99
63_G90_Q0.6410.99
28_D45_D0.6390.99
114_M123_A0.6330.99
78_M136_F0.6300.99
67_N184_L0.6280.99
49_A101_A0.6240.99
85_T90_Q0.6240.99
52_S97_I0.6210.99
61_N188_V0.6150.99
89_Q125_S0.6120.99
155_G158_V0.6120.99
41_E155_G0.6110.99
43_E46_K0.6070.99
76_G163_S0.5980.99
109_R131_V0.5960.99
28_D47_Q0.5940.99
38_G158_V0.5930.99
84_F124_T0.5930.99
105_L148_V0.5920.99
72_R115_A0.5910.99
99_N121_D0.5870.99
59_Y64_F0.5860.99
175_N178_S0.5760.99
79_I129_I0.5670.98
167_T178_S0.5660.98
154_K157_D0.5650.98
157_D161_K0.5610.98
80_Q115_A0.5590.98
102_D144_F0.5580.98
58_D61_N0.5580.98
35_T38_G0.5570.98
63_G185_S0.5520.98
49_A102_D0.5510.98
106_R144_F0.5490.98
64_F90_Q0.5490.98
109_R133_D0.5490.98
48_K102_D0.5470.98
153_V157_D0.5460.98
108_T138_D0.5400.98
115_A126_Q0.5330.98
29_P188_V0.5320.98
161_K164_Q0.5310.98
169_D175_N0.5310.98
88_M93_P0.5290.98
132_A136_F0.5290.98
37_A181_V0.5260.98
45_D111_T0.5230.97
95_P124_T0.5230.97
73_V177_P0.5200.97
68_T84_F0.5180.97
55_N95_P0.5180.97
27_G43_E0.5180.97
93_P124_T0.5180.97
176_V180_P0.5170.97
118_A122_S0.5160.97
27_G46_K0.5160.97
81_G112_I0.5150.97
77_F80_Q0.5130.97
68_T85_T0.5090.97
112_I150_G0.5080.97
39_N158_V0.5060.97
157_D160_D0.5050.97
40_I156_M0.5050.97
35_T184_L0.5040.97
66_N187_K0.5030.97
108_T130_N0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v9tA 1 0.8474 100 0.169 Contact Map
2x7kA 1 0.8474 100 0.173 Contact Map
2k7nA 1 0.8579 100 0.177 Contact Map
2oseA 3 0.8684 100 0.179 Contact Map
3s6mA 1 0.8158 100 0.181 Contact Map
2b71A 1 0.8737 100 0.187 Contact Map
1mzwA 1 0.8211 100 0.187 Contact Map
1lopA 1 0.8211 100 0.189 Contact Map
3bo7A 3 0.8053 100 0.192 Contact Map
2poeA 1 0.8105 100 0.192 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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