GREMLIN Database
POTI - Putrescine transport system permease protein PotI
UniProt: P0AFL1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11632
Length: 281 (251)
Sequences: 70134 (45421)
Seq/√Len: 2867.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_K187_V4.0371.00
66_G70_T3.2081.00
175_M184_V3.0741.00
160_S164_R3.0101.00
34_S52_Y2.7491.00
64_A229_L2.6081.00
63_S66_G2.5991.00
92_R171_E2.5601.00
174_A184_V2.5471.00
180_T183_K2.5361.00
74_C144_W2.5111.00
171_E189_T2.5081.00
78_A148_V2.4841.00
162_R196_A2.4781.00
50_R53_G2.3611.00
224_T232_S2.3391.00
53_G57_R2.3311.00
62_M66_G2.3281.00
76_A201_W2.3071.00
181_P184_V2.2951.00
182_L186_F2.2381.00
159_I197_I2.2371.00
50_R54_E2.1801.00
96_F99_S2.1641.00
179_A183_K2.0631.00
183_K186_F2.0321.00
84_T185_F2.0051.00
91_V164_R1.9421.00
155_V200_G1.9121.00
170_I192_M1.8751.00
163_L193_I1.8731.00
174_A179_A1.8551.00
28_L32_I1.8331.00
70_T140_M1.8111.00
84_T193_I1.8071.00
32_I36_N1.7981.00
103_A160_S1.7931.00
80_A201_W1.7671.00
63_S67_L1.7551.00
175_M181_P1.7511.00
72_A205_F1.7341.00
171_E184_V1.7121.00
258_F262_Y1.6901.00
83_G155_V1.6781.00
70_T74_C1.6361.00
239_N242_I1.6141.00
84_T159_I1.6131.00
75_A208_S1.5951.00
86_A156_A1.5721.00
171_E175_M1.5691.00
90_L156_A1.5601.00
229_L233_S1.5451.00
25_A29_M1.5201.00
13_I17_L1.4971.00
140_M223_A1.4631.00
155_V204_A1.4381.00
168_R171_E1.4381.00
54_E242_I1.4331.00
71_I225_T1.4211.00
31_V247_T1.4181.00
98_G101_G1.4151.00
95_R99_S1.4141.00
48_S51_W1.4141.00
212_L216_S1.4101.00
87_A159_I1.4051.00
81_I85_I1.3911.00
49_T53_G1.3771.00
163_L189_T1.3751.00
91_V160_S1.3741.00
54_E57_R1.3711.00
199_S203_L1.3451.00
29_M33_Y1.3371.00
79_A204_A1.3351.00
190_L197_I1.3331.00
60_A63_S1.3091.00
159_I200_G1.2831.00
212_L231_F1.2771.00
168_R172_E1.2671.00
92_R168_R1.2651.00
174_A188_I1.2391.00
84_T197_I1.2311.00
138_R141_L1.2281.00
214_I218_V1.2221.00
146_A218_V1.2121.00
169_S172_E1.2081.00
88_V163_L1.1991.00
224_T229_L1.1841.00
180_T184_V1.1751.00
74_C77_T1.1671.00
125_F142_T1.1631.00
101_G104_F1.1621.00
17_L21_T1.1491.00
77_T81_I1.1311.00
40_L46_G1.1301.00
68_S226_L1.1291.00
67_L70_T1.1271.00
166_L192_M1.1261.00
80_A197_I1.1151.00
152_T156_A1.1131.00
194_M198_I1.1051.00
30_L247_T1.1001.00
143_I215_A1.0921.00
101_G105_M1.0761.00
233_S239_N1.0691.00
233_S237_G1.0641.00
159_I196_A1.0621.00
219_S223_A1.0541.00
8_R12_R1.0541.00
93_F96_F1.0521.00
171_E181_P1.0481.00
91_V163_L1.0461.00
144_W148_V1.0351.00
74_C78_A1.0321.00
259_I263_L1.0321.00
158_V200_G1.0271.00
78_A144_W1.0251.00
29_M32_I1.0231.00
123_L127_A1.0191.00
56_L62_M1.0161.00
52_Y247_T1.0121.00
75_A79_A1.0101.00
85_I89_V1.0091.00
88_V181_P1.0091.00
224_T228_M1.0081.00
88_V185_F1.0081.00
10_P14_V1.0081.00
37_S40_L1.0051.00
192_M195_P1.0041.00
262_Y265_A0.9991.00
215_A225_T0.9901.00
75_A147_H0.9891.00
184_V187_V0.9881.00
179_A184_V0.9861.00
69_L73_A0.9801.00
211_D214_I0.9751.00
10_P13_I0.9751.00
225_T228_M0.9721.00
65_V226_L0.9711.00
137_D140_M0.9681.00
99_S164_R0.9641.00
211_D215_A0.9581.00
139_G223_A0.9541.00
12_R16_L0.9471.00
140_M144_W0.9411.00
33_Y243_N0.9361.00
229_L245_L0.9301.00
9_S13_I0.9301.00
216_S228_M0.9191.00
136_A141_L0.9191.00
147_H208_S0.9151.00
54_E58_D0.9111.00
20_F24_Y0.9071.00
87_A91_V0.9031.00
162_R193_I0.9021.00
73_A77_T0.9001.00
121_L218_V0.8951.00
141_L145_L0.8911.00
77_T201_W0.8901.00
137_D141_L0.8861.00
70_T73_A0.8821.00
97_R100_N0.8811.00
70_T141_L0.8801.00
194_M197_I0.8671.00
121_L146_A0.8641.00
185_F190_L0.8601.00
186_F190_L0.8571.00
78_A81_I0.8571.00
36_N40_L0.8561.00
100_N103_A0.8511.00
83_G156_A0.8511.00
33_Y36_N0.8501.00
79_A83_G0.8481.00
71_I140_M0.8451.00
232_S236_M0.8451.00
231_F235_R0.8431.00
65_V69_L0.8361.00
159_I193_I0.8361.00
114_D150_F0.8351.00
193_I196_A0.8351.00
184_V189_T0.8351.00
75_A144_W0.8341.00
67_L140_M0.8331.00
61_M245_L0.8301.00
155_V159_I0.8301.00
107_T157_V0.8281.00
146_A214_I0.8271.00
30_L243_N0.8251.00
90_L103_A0.8171.00
122_L126_V0.8101.00
138_R142_T0.8101.00
204_A208_S0.8091.00
259_I262_Y0.8051.00
87_A163_L0.8041.00
89_V96_F0.7961.00
260_A263_L0.7951.00
87_A156_A0.7931.00
74_C148_V0.7931.00
54_E239_N0.7891.00
179_A187_V0.7891.00
233_S245_L0.7891.00
55_L248_L0.7871.00
35_F47_W0.7861.00
255_I259_I0.7811.00
71_I147_H0.7801.00
118_G213_V0.7781.00
66_G69_L0.7761.00
138_R221_P0.7691.00
33_Y37_S0.7681.00
58_D62_M0.7651.00
181_P185_F0.7651.00
253_V257_G0.7631.00
118_G217_F0.7541.00
185_F189_T0.7511.00
72_A76_A0.7501.00
51_W241_E0.7481.00
170_I188_I0.7451.00
35_F48_S0.7441.00
79_A155_V0.7421.00
40_L45_A0.7401.00
141_L144_W0.7371.00
80_A159_I0.7361.00
257_G261_W0.7351.00
229_L232_S0.7341.00
25_A28_L0.7331.00
79_A151_C0.7331.00
139_G142_T0.7321.00
51_W54_E0.7301.00
166_L193_I0.7241.00
230_V245_L0.7241.00
47_W50_R0.7231.00
90_L160_S0.7231.00
243_N247_T0.7221.00
14_V17_L0.7221.00
83_G159_I0.7211.00
226_L249_I0.7171.00
90_L102_F0.7141.00
126_V137_D0.7141.00
168_R175_M0.7131.00
68_S227_P0.7061.00
107_T110_L0.7051.00
76_A205_F0.7041.00
159_I163_L0.7021.00
211_D225_T0.7001.00
64_A67_L0.7001.00
194_M263_L0.6951.00
34_S38_S0.6911.00
37_S46_G0.6841.00
37_S45_A0.6831.00
228_M232_S0.6831.00
62_M65_V0.6821.00
143_I219_S0.6821.00
89_V93_F0.6801.00
219_S224_T0.6791.00
19_G23_L0.6791.00
71_I143_I0.6781.00
11_W15_I0.6771.00
11_W14_V0.6761.00
48_S52_Y0.6761.00
22_F26_P0.6761.00
197_I200_G0.6751.00
64_A226_L0.6741.00
189_T192_M0.6741.00
55_L242_I0.6701.00
151_C204_A0.6671.00
236_M239_N0.6671.00
114_D213_V0.6611.00
49_T52_Y0.6611.00
117_T149_T0.6591.00
53_G56_L0.6571.00
142_T146_A0.6561.00
123_L126_V0.6531.00
59_D63_S0.6531.00
86_A152_T0.6521.00
76_A80_A0.6501.00
136_A139_G0.6471.00
173_A177_L0.6461.00
26_P30_L0.6461.00
95_R100_N0.6431.00
30_L246_A0.6421.00
173_A176_D0.6411.00
39_K42_T0.6411.00
86_A106_I0.6371.00
151_C207_L0.6351.00
68_S209_L0.6341.00
197_I201_W0.6331.00
96_F102_F0.6311.00
71_I144_W0.6301.00
20_F23_L0.6301.00
79_A208_S0.6291.00
196_A200_G0.6241.00
98_G102_F0.6241.00
82_L148_V0.6201.00
110_L153_A0.6081.00
215_A228_M0.6081.00
46_G50_R0.6071.00
52_Y244_A0.6061.00
254_G258_F0.6051.00
92_R95_R0.6051.00
103_A157_V0.6021.00
15_I19_G0.6011.00
16_L20_F0.5991.00
198_I201_W0.5981.00
233_S242_I0.5951.00
36_N46_G0.5941.00
227_P249_I0.5941.00
238_V242_I0.5931.00
115_V217_F0.5901.00
106_I153_A0.5901.00
121_L124_L0.5901.00
55_L245_L0.5861.00
249_I253_V0.5861.00
158_V196_A0.5851.00
206_T210_D0.5831.00
38_S42_T0.5831.00
142_T218_V0.5821.00
213_V217_F0.5801.00
79_A148_V0.5771.00
34_S244_A0.5771.00
238_V241_E0.5771.00
21_T25_A0.5761.00
46_G49_T0.5741.00
97_R101_G0.5731.00
60_A229_L0.5711.00
184_V188_I0.5701.00
9_S12_R0.5681.00
110_L154_Y0.5651.00
87_A160_S0.5651.00
45_A48_S0.5641.00
80_A84_T0.5621.00
59_D62_M0.5621.00
213_V216_S0.5621.00
180_T186_F0.5611.00
71_I75_A0.5601.00
82_L152_T0.5591.00
143_I147_H0.5571.00
100_N104_F0.5531.00
147_H215_A0.5531.00
122_L137_D0.5531.00
129_A136_A0.5521.00
147_H211_D0.5511.00
76_A208_S0.5461.00
33_Y38_S0.5451.00
72_A208_S0.5441.00
75_A148_V0.5431.00
252_A255_I0.5421.00
41_V44_W0.5411.00
102_F106_I0.5381.00
201_W204_A0.5371.00
207_L210_D0.5361.00
186_F189_T0.5361.00
88_V189_T0.5361.00
72_A209_L0.5341.00
242_I245_L0.5341.00
256_V260_A0.5331.00
114_D118_G0.5321.00
228_M231_F0.5301.00
67_L223_A0.5281.00
251_G255_I0.5231.00
13_I16_L0.5231.00
166_L171_E0.5221.00
93_F181_P0.5211.00
95_R168_R0.5211.00
109_P153_A0.5201.00
104_F108_A0.5191.00
112_M116_I0.5191.00
243_N246_A0.5171.00
215_A219_S0.5141.00
67_L225_T0.5131.00
208_S211_D0.5121.00
60_A224_T0.5071.00
200_G204_A0.5061.00
246_A249_I0.5051.00
24_Y28_L0.5031.00
76_A81_I0.5021.00
86_A89_V0.5011.00
31_V35_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.8826 100 0.316 Contact Map
3d31C 2 0.8648 100 0.336 Contact Map
4tquM 1 0.9181 100 0.34 Contact Map
3rlfG 1 0.9502 100 0.349 Contact Map
4tquN 1 0.9075 100 0.368 Contact Map
3rlfF 1 0.9004 100 0.399 Contact Map
4ymuD 2 0.7651 100 0.477 Contact Map
3tuiA 2 0.7438 99.9 0.523 Contact Map
2a65A 2 0.8292 12.6 0.947 Contact Map
3rkoJ 1 0.5872 11.9 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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