POTI - ECOLI - GREMLIN Contacts

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POTI - Putrescine transport system permease protein PotI

UniProt:	P0AFL1	Sequences: MNNLPVVRSPWRIVILLLGFTFLYAPMLMLVIYSFNSSKLVTVWAGWSTRWYGELLRDDAMMSAVGLSLTIAACAATAAAILGTIAAVVLVRFGRFRGSNGFAFMITAPLVMPDVITGLSLLLLFVALAHAIGWPADRGMLTIWLAHVTFCTAYVAVVISSRLRELDRSIEEAAMDLGATPLKVFFVITLPMIMPAIISGWLLAFTLSLDDLVIASFVSGPGATTLPMLVFSSVRMGVNPEINALATLILGAVGIVGFIAWYLMARAEKQRIRDIQRARRG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11632
Length:	281 (251)
Sequences:	70134 (45421)
Seq/√Len:	2867.0

ECOLI - POTI POTH UGPE POTC YCJP CYSW THIP MALG YCJO UGPA YNJC POTB YDCV PSTC YDCU PSTA CYST MODB SSUC MALF TAUC YEHY YEHW PHNE PROW METI YECS GLNP
BACSU - AMYC MDXG GANP GANQ AMYD YURN YESP ARAP MDXF ARAQ YESQ YQGI YTEP YURM YQGH LPLB YTCP LPLC SSUC YVGM YTLD OPUAB TCYB TCYL METP OPUCB YXEN OPUBD OPUCD OPUBB ARTQ
HALSA - Q9HML6 Q9HMT4 Q9HP01 Q9HP02 Q9HS11 Q9HHQ7 Q9HR05 Q9HHQ6 Q9HPK3 Q9HNI9 Q9HS12 Q9HML7
SULSO - Q97YY2 Q97YY3 Q97UY9 Q97ZT6 Q97UZ0 Q97UF3 Q97ZC1 Q97ZC2 Q97ZT7 Q97UF4 Q97VC0 Q97Z98

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
183_K	187_V	4.037	1.00
66_G	70_T	3.208	1.00
175_M	184_V	3.074	1.00
160_S	164_R	3.010	1.00
34_S	52_Y	2.749	1.00
64_A	229_L	2.608	1.00
63_S	66_G	2.599	1.00
92_R	171_E	2.560	1.00
174_A	184_V	2.547	1.00
180_T	183_K	2.536	1.00
74_C	144_W	2.511	1.00
171_E	189_T	2.508	1.00
78_A	148_V	2.484	1.00
162_R	196_A	2.478	1.00
50_R	53_G	2.361	1.00
224_T	232_S	2.339	1.00
53_G	57_R	2.331	1.00
62_M	66_G	2.328	1.00
76_A	201_W	2.307	1.00
181_P	184_V	2.295	1.00
182_L	186_F	2.238	1.00
159_I	197_I	2.237	1.00
50_R	54_E	2.180	1.00
96_F	99_S	2.164	1.00
179_A	183_K	2.063	1.00
183_K	186_F	2.032	1.00
84_T	185_F	2.005	1.00
91_V	164_R	1.942	1.00
155_V	200_G	1.912	1.00
170_I	192_M	1.875	1.00
163_L	193_I	1.873	1.00
174_A	179_A	1.855	1.00
28_L	32_I	1.833	1.00
70_T	140_M	1.811	1.00
84_T	193_I	1.807	1.00
32_I	36_N	1.798	1.00
103_A	160_S	1.793	1.00
80_A	201_W	1.767	1.00
63_S	67_L	1.755	1.00
175_M	181_P	1.751	1.00
72_A	205_F	1.734	1.00
171_E	184_V	1.712	1.00
258_F	262_Y	1.690	1.00
83_G	155_V	1.678	1.00
70_T	74_C	1.636	1.00
239_N	242_I	1.614	1.00
84_T	159_I	1.613	1.00
75_A	208_S	1.595	1.00
86_A	156_A	1.572	1.00
171_E	175_M	1.569	1.00
90_L	156_A	1.560	1.00
229_L	233_S	1.545	1.00
25_A	29_M	1.520	1.00
13_I	17_L	1.497	1.00
140_M	223_A	1.463	1.00
155_V	204_A	1.438	1.00
168_R	171_E	1.438	1.00
54_E	242_I	1.433	1.00
71_I	225_T	1.421	1.00
31_V	247_T	1.418	1.00
98_G	101_G	1.415	1.00
95_R	99_S	1.414	1.00
48_S	51_W	1.414	1.00
212_L	216_S	1.410	1.00
87_A	159_I	1.405	1.00
81_I	85_I	1.391	1.00
49_T	53_G	1.377	1.00
163_L	189_T	1.375	1.00
91_V	160_S	1.374	1.00
54_E	57_R	1.371	1.00
199_S	203_L	1.345	1.00
29_M	33_Y	1.337	1.00
79_A	204_A	1.335	1.00
190_L	197_I	1.333	1.00
60_A	63_S	1.309	1.00
159_I	200_G	1.283	1.00
212_L	231_F	1.277	1.00
168_R	172_E	1.267	1.00
92_R	168_R	1.265	1.00
174_A	188_I	1.239	1.00
84_T	197_I	1.231	1.00
138_R	141_L	1.228	1.00
214_I	218_V	1.222	1.00
146_A	218_V	1.212	1.00
169_S	172_E	1.208	1.00
88_V	163_L	1.199	1.00
224_T	229_L	1.184	1.00
180_T	184_V	1.175	1.00
74_C	77_T	1.167	1.00
125_F	142_T	1.163	1.00
101_G	104_F	1.162	1.00
17_L	21_T	1.149	1.00
77_T	81_I	1.131	1.00
40_L	46_G	1.130	1.00
68_S	226_L	1.129	1.00
67_L	70_T	1.127	1.00
166_L	192_M	1.126	1.00
80_A	197_I	1.115	1.00
152_T	156_A	1.113	1.00
194_M	198_I	1.105	1.00
30_L	247_T	1.100	1.00
143_I	215_A	1.092	1.00
101_G	105_M	1.076	1.00
233_S	239_N	1.069	1.00
233_S	237_G	1.064	1.00
159_I	196_A	1.062	1.00
219_S	223_A	1.054	1.00
8_R	12_R	1.054	1.00
93_F	96_F	1.052	1.00
171_E	181_P	1.048	1.00
91_V	163_L	1.046	1.00
144_W	148_V	1.035	1.00
74_C	78_A	1.032	1.00
259_I	263_L	1.032	1.00
158_V	200_G	1.027	1.00
78_A	144_W	1.025	1.00
29_M	32_I	1.023	1.00
123_L	127_A	1.019	1.00
56_L	62_M	1.016	1.00
52_Y	247_T	1.012	1.00
75_A	79_A	1.010	1.00
85_I	89_V	1.009	1.00
88_V	181_P	1.009	1.00
224_T	228_M	1.008	1.00
88_V	185_F	1.008	1.00
10_P	14_V	1.008	1.00
37_S	40_L	1.005	1.00
192_M	195_P	1.004	1.00
262_Y	265_A	0.999	1.00
215_A	225_T	0.990	1.00
75_A	147_H	0.989	1.00
184_V	187_V	0.988	1.00
179_A	184_V	0.986	1.00
69_L	73_A	0.980	1.00
211_D	214_I	0.975	1.00
10_P	13_I	0.975	1.00
225_T	228_M	0.972	1.00
65_V	226_L	0.971	1.00
137_D	140_M	0.968	1.00
99_S	164_R	0.964	1.00
211_D	215_A	0.958	1.00
139_G	223_A	0.954	1.00
12_R	16_L	0.947	1.00
140_M	144_W	0.941	1.00
33_Y	243_N	0.936	1.00
229_L	245_L	0.930	1.00
9_S	13_I	0.930	1.00
216_S	228_M	0.919	1.00
136_A	141_L	0.919	1.00
147_H	208_S	0.915	1.00
54_E	58_D	0.911	1.00
20_F	24_Y	0.907	1.00
87_A	91_V	0.903	1.00
162_R	193_I	0.902	1.00
73_A	77_T	0.900	1.00
121_L	218_V	0.895	1.00
141_L	145_L	0.891	1.00
77_T	201_W	0.890	1.00
137_D	141_L	0.886	1.00
70_T	73_A	0.882	1.00
97_R	100_N	0.881	1.00
70_T	141_L	0.880	1.00
194_M	197_I	0.867	1.00
121_L	146_A	0.864	1.00
185_F	190_L	0.860	1.00
186_F	190_L	0.857	1.00
78_A	81_I	0.857	1.00
36_N	40_L	0.856	1.00
100_N	103_A	0.851	1.00
83_G	156_A	0.851	1.00
33_Y	36_N	0.850	1.00
79_A	83_G	0.848	1.00
71_I	140_M	0.845	1.00
232_S	236_M	0.845	1.00
231_F	235_R	0.843	1.00
65_V	69_L	0.836	1.00
159_I	193_I	0.836	1.00
114_D	150_F	0.835	1.00
193_I	196_A	0.835	1.00
184_V	189_T	0.835	1.00
75_A	144_W	0.834	1.00
67_L	140_M	0.833	1.00
61_M	245_L	0.830	1.00
155_V	159_I	0.830	1.00
107_T	157_V	0.828	1.00
146_A	214_I	0.827	1.00
30_L	243_N	0.825	1.00
90_L	103_A	0.817	1.00
122_L	126_V	0.810	1.00
138_R	142_T	0.810	1.00
204_A	208_S	0.809	1.00
259_I	262_Y	0.805	1.00
87_A	163_L	0.804	1.00
89_V	96_F	0.796	1.00
260_A	263_L	0.795	1.00
87_A	156_A	0.793	1.00
74_C	148_V	0.793	1.00
54_E	239_N	0.789	1.00
179_A	187_V	0.789	1.00
233_S	245_L	0.789	1.00
55_L	248_L	0.787	1.00
35_F	47_W	0.786	1.00
255_I	259_I	0.781	1.00
71_I	147_H	0.780	1.00
118_G	213_V	0.778	1.00
66_G	69_L	0.776	1.00
138_R	221_P	0.769	1.00
33_Y	37_S	0.768	1.00
58_D	62_M	0.765	1.00
181_P	185_F	0.765	1.00
253_V	257_G	0.763	1.00
118_G	217_F	0.754	1.00
185_F	189_T	0.751	1.00
72_A	76_A	0.750	1.00
51_W	241_E	0.748	1.00
170_I	188_I	0.745	1.00
35_F	48_S	0.744	1.00
79_A	155_V	0.742	1.00
40_L	45_A	0.740	1.00
141_L	144_W	0.737	1.00
80_A	159_I	0.736	1.00
257_G	261_W	0.735	1.00
229_L	232_S	0.734	1.00
25_A	28_L	0.733	1.00
79_A	151_C	0.733	1.00
139_G	142_T	0.732	1.00
51_W	54_E	0.730	1.00
166_L	193_I	0.724	1.00
230_V	245_L	0.724	1.00
47_W	50_R	0.723	1.00
90_L	160_S	0.723	1.00
243_N	247_T	0.722	1.00
14_V	17_L	0.722	1.00
83_G	159_I	0.721	1.00
226_L	249_I	0.717	1.00
90_L	102_F	0.714	1.00
126_V	137_D	0.714	1.00
168_R	175_M	0.713	1.00
68_S	227_P	0.706	1.00
107_T	110_L	0.705	1.00
76_A	205_F	0.704	1.00
159_I	163_L	0.702	1.00
211_D	225_T	0.700	1.00
64_A	67_L	0.700	1.00
194_M	263_L	0.695	1.00
34_S	38_S	0.691	1.00
37_S	46_G	0.684	1.00
37_S	45_A	0.683	1.00
228_M	232_S	0.683	1.00
62_M	65_V	0.682	1.00
143_I	219_S	0.682	1.00
89_V	93_F	0.680	1.00
219_S	224_T	0.679	1.00
19_G	23_L	0.679	1.00
71_I	143_I	0.678	1.00
11_W	15_I	0.677	1.00
11_W	14_V	0.676	1.00
48_S	52_Y	0.676	1.00
22_F	26_P	0.676	1.00
197_I	200_G	0.675	1.00
64_A	226_L	0.674	1.00
189_T	192_M	0.674	1.00
55_L	242_I	0.670	1.00
151_C	204_A	0.667	1.00
236_M	239_N	0.667	1.00
114_D	213_V	0.661	1.00
49_T	52_Y	0.661	1.00
117_T	149_T	0.659	1.00
53_G	56_L	0.657	1.00
142_T	146_A	0.656	1.00
123_L	126_V	0.653	1.00
59_D	63_S	0.653	1.00
86_A	152_T	0.652	1.00
76_A	80_A	0.650	1.00
136_A	139_G	0.647	1.00
173_A	177_L	0.646	1.00
26_P	30_L	0.646	1.00
95_R	100_N	0.643	1.00
30_L	246_A	0.642	1.00
173_A	176_D	0.641	1.00
39_K	42_T	0.641	1.00
86_A	106_I	0.637	1.00
151_C	207_L	0.635	1.00
68_S	209_L	0.634	1.00
197_I	201_W	0.633	1.00
96_F	102_F	0.631	1.00
71_I	144_W	0.630	1.00
20_F	23_L	0.630	1.00
79_A	208_S	0.629	1.00
196_A	200_G	0.624	1.00
98_G	102_F	0.624	1.00
82_L	148_V	0.620	1.00
110_L	153_A	0.608	1.00
215_A	228_M	0.608	1.00
46_G	50_R	0.607	1.00
52_Y	244_A	0.606	1.00
254_G	258_F	0.605	1.00
92_R	95_R	0.605	1.00
103_A	157_V	0.602	1.00
15_I	19_G	0.601	1.00
16_L	20_F	0.599	1.00
198_I	201_W	0.598	1.00
233_S	242_I	0.595	1.00
36_N	46_G	0.594	1.00
227_P	249_I	0.594	1.00
238_V	242_I	0.593	1.00
115_V	217_F	0.590	1.00
106_I	153_A	0.590	1.00
121_L	124_L	0.590	1.00
55_L	245_L	0.586	1.00
249_I	253_V	0.586	1.00
158_V	196_A	0.585	1.00
206_T	210_D	0.583	1.00
38_S	42_T	0.583	1.00
142_T	218_V	0.582	1.00
213_V	217_F	0.580	1.00
79_A	148_V	0.577	1.00
34_S	244_A	0.577	1.00
238_V	241_E	0.577	1.00
21_T	25_A	0.576	1.00
46_G	49_T	0.574	1.00
97_R	101_G	0.573	1.00
60_A	229_L	0.571	1.00
184_V	188_I	0.570	1.00
9_S	12_R	0.568	1.00
110_L	154_Y	0.565	1.00
87_A	160_S	0.565	1.00
45_A	48_S	0.564	1.00
80_A	84_T	0.562	1.00
59_D	62_M	0.562	1.00
213_V	216_S	0.562	1.00
180_T	186_F	0.561	1.00
71_I	75_A	0.560	1.00
82_L	152_T	0.559	1.00
143_I	147_H	0.557	1.00
100_N	104_F	0.553	1.00
147_H	215_A	0.553	1.00
122_L	137_D	0.553	1.00
129_A	136_A	0.552	1.00
147_H	211_D	0.551	1.00
76_A	208_S	0.546	1.00
33_Y	38_S	0.545	1.00
72_A	208_S	0.544	1.00
75_A	148_V	0.543	1.00
252_A	255_I	0.542	1.00
41_V	44_W	0.541	1.00
102_F	106_I	0.538	1.00
201_W	204_A	0.537	1.00
207_L	210_D	0.536	1.00
186_F	189_T	0.536	1.00
88_V	189_T	0.536	1.00
72_A	209_L	0.534	1.00
242_I	245_L	0.534	1.00
256_V	260_A	0.533	1.00
114_D	118_G	0.532	1.00
228_M	231_F	0.530	1.00
67_L	223_A	0.528	1.00
251_G	255_I	0.523	1.00
13_I	16_L	0.523	1.00
166_L	171_E	0.522	1.00
93_F	181_P	0.521	1.00
95_R	168_R	0.521	1.00
109_P	153_A	0.520	1.00
104_F	108_A	0.519	1.00
112_M	116_I	0.519	1.00
243_N	246_A	0.517	1.00
215_A	219_S	0.514	1.00
67_L	225_T	0.513	1.00
208_S	211_D	0.512	1.00
60_A	224_T	0.507	1.00
200_G	204_A	0.506	1.00
246_A	249_I	0.505	1.00
24_Y	28_L	0.503	1.00
76_A	81_I	0.502	1.00
86_A	89_V	0.501	1.00
31_V	35_F	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2onkC	2	0.8826	100	0.316	Contact Map
3d31C	2	0.8648	100	0.336	Contact Map
4tquM	1	0.9181	100	0.34	Contact Map
3rlfG	1	0.9502	100	0.349	Contact Map
4tquN	1	0.9075	100	0.368	Contact Map
3rlfF	1	0.9004	100	0.399	Contact Map
4ymuD	2	0.7651	100	0.477	Contact Map
3tuiA	2	0.7438	99.9	0.523	Contact Map
2a65A	2	0.8292	12.6	0.947	Contact Map
3rkoJ	1	0.5872	11.9	0.947	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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