GREMLIN Database
POTC - Spermidine/putrescine transport system permease protein PotC
UniProt: P0AFK6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10751
Length: 264 (247)
Sequences: 73447 (47290)
Seq/√Len: 3009.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_T175_K3.8831.00
61_Q65_T3.3151.00
163_K172_I3.1901.00
148_Y152_K2.9911.00
59_A217_K2.6361.00
58_Q61_Q2.6051.00
150_R184_A2.5981.00
168_S171_T2.5591.00
162_A172_I2.5411.00
69_F132_L2.5151.00
73_F136_I2.4851.00
87_R159_L2.4681.00
159_L177_I2.4491.00
212_E220_S2.4461.00
29_S47_Y2.4141.00
169_E172_I2.3961.00
48_S52_N2.3931.00
57_L61_Q2.3701.00
170_F174_R2.3001.00
226_V229_E2.2891.00
45_K48_S2.2521.00
71_A189_W2.2201.00
147_V185_V2.1601.00
90_F93_K2.1431.00
45_K49_L2.0551.00
167_A171_T2.0521.00
171_T174_R1.9881.00
86_Y152_K1.9391.00
97_S148_Y1.8821.00
158_M180_L1.8781.00
143_V188_G1.8771.00
162_A167_A1.8691.00
151_L181_A1.8621.00
27_V31_N1.8601.00
79_S173_L1.8291.00
79_S181_A1.8181.00
23_I27_V1.8111.00
159_L172_I1.7921.00
246_I250_L1.7781.00
58_Q62_H1.7451.00
163_K169_E1.7431.00
75_T189_W1.7391.00
159_L163_K1.6841.00
217_K221_M1.6511.00
65_T69_F1.6421.00
78_G143_V1.6301.00
49_L229_E1.6221.00
67_A193_F1.6221.00
70_S196_S1.6071.00
81_T144_V1.5891.00
79_S147_V1.5481.00
156_V159_L1.5221.00
85_L144_V1.5051.00
20_I24_I1.4851.00
76_L80_L1.4821.00
143_V192_S1.4801.00
26_I235_T1.4741.00
8_G12_T1.4731.00
49_L52_N1.4571.00
92_G95_F1.4471.00
89_R93_K1.4191.00
55_S58_Q1.4141.00
66_M213_I1.3971.00
86_Y148_Y1.3861.00
200_V204_S1.3791.00
82_A147_V1.3511.00
44_T48_S1.3471.00
212_E217_K1.3371.00
24_I28_N1.3281.00
156_V160_E1.3221.00
151_L177_I1.3191.00
187_A191_L1.3181.00
74_A192_S1.3161.00
178_L185_V1.3131.00
128_F211_Y1.2971.00
43_T46_W1.2911.00
147_V188_G1.2891.00
157_R160_E1.2821.00
162_A176_I1.2551.00
79_S185_V1.2511.00
95_F98_G1.2451.00
62_H65_T1.2401.00
83_V151_L1.2321.00
87_R156_V1.2301.00
221_M224_V1.2281.00
72_T76_L1.2261.00
200_V219_Y1.2241.00
207_T211_Y1.2181.00
154_F180_L1.1891.00
221_M226_V1.1751.00
220_S223_K1.1721.00
134_S206_V1.1691.00
168_S172_I1.1651.00
86_Y151_L1.1581.00
75_T185_V1.1441.00
202_V206_V1.1391.00
69_F72_T1.1361.00
140_L144_V1.1241.00
119_F130_S1.1221.00
250_L253_R1.1151.00
132_L136_I1.1081.00
12_T16_A1.1071.00
95_F99_M1.1021.00
35_F41_G1.1011.00
63_S214_L1.0991.00
182_M186_A1.0961.00
73_F132_L1.0931.00
124_I129_W1.0761.00
25_L235_T1.0741.00
32_S35_F1.0731.00
69_F73_F1.0681.00
203_S213_I1.0641.00
131_L203_S1.0581.00
117_V121_L1.0551.00
247_A251_I1.0491.00
83_V173_L1.0411.00
159_L169_E1.0381.00
38_N41_G1.0361.00
217_K233_L1.0321.00
199_D202_V1.0301.00
51_M57_L1.0281.00
24_I27_V1.0211.00
70_S135_H1.0181.00
212_E216_L1.0131.00
172_I175_K1.0131.00
80_L84_A0.9961.00
167_A172_I0.9911.00
93_K152_K0.9901.00
180_L183_P0.9881.00
60_A214_L0.9881.00
213_I216_L0.9871.00
147_V184_A0.9811.00
126_L129_W0.9801.00
36_G40_Q0.9771.00
70_S74_A0.9761.00
64_L68_V0.9681.00
146_T188_G0.9681.00
122_L125_Q0.9561.00
78_G144_V0.9371.00
49_L53_N0.9371.00
217_K220_S0.9311.00
83_V169_E0.9291.00
82_A86_Y0.9241.00
36_G39_W0.9191.00
72_T189_W0.9191.00
247_A250_L0.9171.00
70_S132_L0.9031.00
221_M229_E0.8991.00
167_A175_K0.8961.00
65_T68_V0.8921.00
221_M233_L0.8901.00
65_T128_F0.8881.00
7_R11_M0.8871.00
47_Y235_T0.8851.00
108_D138_F0.8821.00
222_V230_V0.8761.00
56_L233_L0.8741.00
116_L120_M0.8731.00
199_D203_S0.8731.00
172_I177_I0.8721.00
68_V72_T0.8681.00
208_G211_Y0.8651.00
134_S202_V0.8581.00
147_V181_A0.8551.00
182_M185_V0.8551.00
91_R94_P0.8531.00
150_R181_A0.8531.00
204_S216_L0.8501.00
15_Y19_Y0.8471.00
181_A184_A0.8461.00
115_L206_V0.8451.00
101_F145_V0.8441.00
82_A151_L0.8441.00
216_L220_S0.8421.00
74_A78_G0.8371.00
94_P97_S0.8321.00
28_N32_S0.8311.00
115_L134_S0.8301.00
174_R178_L0.8281.00
28_N31_N0.8261.00
84_A90_F0.8261.00
61_Q64_L0.8261.00
120_M125_Q0.8241.00
135_H196_S0.8231.00
60_A64_L0.8191.00
192_S196_S0.8131.00
85_L97_S0.8101.00
81_T140_L0.8081.00
143_V147_V0.8051.00
71_A193_F0.8041.00
73_F76_L0.8001.00
31_N35_F0.8001.00
46_W228_P0.7861.00
173_L178_L0.7851.00
85_L148_Y0.7831.00
74_A143_V0.7801.00
248_S251_I0.7801.00
243_V247_A0.7721.00
78_G147_V0.7701.00
242_L246_I0.7701.00
82_A144_V0.7681.00
29_S33_S0.7671.00
241_S245_V0.7661.00
74_A139_C0.7661.00
69_F136_I0.7651.00
139_C192_S0.7651.00
50_L236_I0.7641.00
66_M135_H0.7631.00
28_N231_N0.7621.00
169_E173_L0.7521.00
158_M176_I0.7491.00
30_F42_F0.7451.00
46_W49_L0.7441.00
111_M137_T0.7331.00
32_S41_G0.7311.00
77_I140_L0.7261.00
218_I233_L0.7261.00
85_L96_V0.7241.00
21_P25_L0.7241.00
112_A201_V0.7211.00
53_N57_L0.7211.00
42_F45_K0.7171.00
48_S51_M0.7161.00
173_L177_I0.7131.00
74_A196_S0.7081.00
77_I136_I0.7071.00
108_D201_V0.7071.00
67_A71_A0.7071.00
185_V188_G0.7031.00
131_L135_H0.7021.00
59_A62_H0.6971.00
57_L60_A0.6941.00
161_A165_L0.6921.00
177_I180_L0.6901.00
130_S134_S0.6881.00
43_T47_Y0.6871.00
156_V163_K0.6861.00
229_E233_L0.6851.00
161_A164_D0.6811.00
35_F40_Q0.6781.00
44_T47_Y0.6781.00
66_M131_L0.6771.00
75_T147_V0.6771.00
214_L237_L0.6751.00
54_D58_Q0.6731.00
20_I23_I0.6721.00
124_I127_G0.6691.00
14_I18_L0.6661.00
184_A188_G0.6621.00
112_A205_F0.6611.00
139_C195_L0.6611.00
227_S231_N0.6571.00
59_A214_L0.6571.00
31_N39_W0.6551.00
25_L234_A0.6541.00
25_L231_N0.6541.00
66_M132_L0.6541.00
84_A88_Y0.6521.00
182_M251_I0.6521.00
101_F104_M0.6511.00
91_R95_F0.6461.00
41_G45_K0.6441.00
154_F181_A0.6431.00
122_L126_L0.6411.00
17_Y21_P0.6411.00
16_A20_I0.6361.00
21_P28_N0.6361.00
199_D213_I0.6351.00
97_S145_V0.6341.00
15_Y18_L0.6301.00
81_T100_L0.6291.00
63_S197_M0.6281.00
89_R94_P0.6271.00
32_S40_Q0.6271.00
90_F94_P0.6261.00
30_F43_T0.6221.00
49_L226_V0.6221.00
100_L141_P0.6211.00
115_L118_L0.6211.00
90_F96_V0.6171.00
28_N33_S0.6161.00
63_S215_P0.6151.00
54_D57_L0.6151.00
215_P237_L0.6141.00
201_V204_S0.6141.00
207_T212_E0.6131.00
117_V120_M0.6131.00
33_S39_W0.6111.00
9_G12_T0.6101.00
209_P212_E0.6061.00
10_F14_I0.6041.00
185_V189_W0.6031.00
83_V177_I0.6031.00
66_M70_S0.5961.00
147_V151_L0.5941.00
109_I205_F0.5901.00
231_N235_T0.5891.00
94_P98_G0.5881.00
186_A189_W0.5871.00
50_L233_L0.5861.00
174_R177_I0.5861.00
55_S212_E0.5841.00
189_W192_S0.5831.00
82_A148_Y0.5811.00
172_I176_I0.5811.00
55_S217_K0.5811.00
195_L198_D0.5761.00
131_L207_T0.5761.00
71_A75_T0.5751.00
75_T79_S0.5751.00
21_P26_I0.5751.00
74_A136_I0.5711.00
19_Y23_I0.5701.00
92_G96_V0.5701.00
67_A197_M0.5701.00
11_M15_Y0.5701.00
227_S230_V0.5691.00
122_L129_W0.5631.00
70_S136_I0.5621.00
41_G44_T0.5581.00
58_Q65_T0.5571.00
97_S152_K0.5561.00
47_Y232_A0.5561.00
237_L241_S0.5501.00
135_H199_D0.5501.00
216_L219_Y0.5491.00
77_I80_L0.5491.00
62_H211_Y0.5481.00
146_T184_A0.5431.00
196_S199_D0.5431.00
93_K97_S0.5421.00
67_A196_S0.5401.00
160_E163_K0.5371.00
135_H138_F0.5361.00
37_I40_Q0.5361.00
104_M141_P0.5351.00
87_R177_I0.5351.00
234_A237_L0.5351.00
188_G192_S0.5351.00
203_S207_T0.5331.00
126_L208_G0.5321.00
76_L79_S0.5321.00
66_M128_F0.5301.00
228_P231_N0.5301.00
138_F202_V0.5291.00
8_G11_M0.5291.00
50_L229_E0.5281.00
29_S235_T0.5271.00
71_A196_S0.5271.00
112_A116_L0.5251.00
81_T84_A0.5241.00
98_G102_V0.5241.00
83_V87_R0.5241.00
108_D112_A0.5221.00
245_V249_Q0.5201.00
29_S232_A0.5181.00
246_I249_Q0.5181.00
177_I181_A0.5181.00
88_Y169_E0.5161.00
201_V205_F0.5131.00
219_Y223_K0.5111.00
194_T198_D0.5061.00
122_L127_G0.5051.00
104_M142_F0.5041.00
99_M103_V0.5041.00
25_L29_S0.5031.00
72_T75_T0.5021.00
97_S144_V0.5021.00
203_S216_L0.5001.00
168_S174_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.9129 100 0.238 Contact Map
3d31C 2 0.8977 100 0.278 Contact Map
4tquM 1 0.9356 100 0.278 Contact Map
3rlfG 1 0.9848 100 0.321 Contact Map
4tquN 1 0.947 100 0.321 Contact Map
3rlfF 1 0.9167 100 0.333 Contact Map
4ymuD 2 0.8106 100 0.412 Contact Map
3tuiA 2 0.7841 99.9 0.463 Contact Map
2xq2A 2 0.7614 34.6 0.927 Contact Map
2a65A 2 0.8447 11.8 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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