GREMLIN Database
PMBA - Metalloprotease PmbA
UniProt: P0AFK0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10741
Length: 450 (423)
Sequences: 4579 (2979)
Seq/√Len: 144.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
320_K325_T4.1711.00
317_D320_K3.9811.00
369_T398_E3.9231.00
294_H315_R3.7311.00
371_L406_V3.6541.00
283_Q287_D3.5831.00
423_V443_P3.4551.00
243_K444_E3.4091.00
368_G399_N3.3701.00
423_V441_L3.2561.00
367_M397_V3.1861.00
359_S362_Q3.1461.00
133_S136_E3.0381.00
398_E403_Q3.0371.00
237_R404_Y2.9991.00
143_R220_E2.9961.00
279_S282_K2.9711.00
396_W404_Y2.8491.00
398_E404_Y2.7071.00
154_R197_E2.6091.00
369_T396_W2.5491.00
139_E143_R2.5321.00
42_K169_V2.4131.00
182_Y305_P2.3891.00
24_T86_P2.3391.00
363_M439_S2.3251.00
396_W403_Q2.2901.00
77_G96_A2.2881.00
428_D439_S2.2811.00
359_S427_N2.2601.00
196_E199_G2.2211.00
290_T317_D2.1941.00
225_D228_R2.1551.00
364_L397_V2.0781.00
292_E354_A2.0751.00
283_Q420_R2.0521.00
292_E315_R2.0011.00
146_Q150_Q1.9851.00
288_W425_V1.9851.00
28_L90_A1.9831.00
358_L362_Q1.9591.00
314_E340_K1.9331.00
155_I195_A1.9151.00
288_W321_D1.8861.00
287_D321_D1.8801.00
23_S27_E1.8601.00
290_T321_D1.8281.00
90_A94_Q1.8191.00
244_A447_I1.8191.00
304_T313_T1.8141.00
206_A225_D1.7961.00
171_V179_L1.7941.00
365_K401_E1.7891.00
224_A228_R1.7831.00
195_A231_L1.7671.00
363_M424_T1.7601.00
228_R232_S1.7461.00
151_A224_A1.7421.00
418_M442_L1.7221.00
285_L419_W1.7221.00
195_A230_T1.7211.00
283_Q323_I1.7141.00
247_I367_M1.7001.00
360_F439_S1.6921.00
329_L339_L1.6921.00
83_D88_A1.6911.00
180_Q306_F1.6821.00
94_Q98_D1.6741.00
366_E424_T1.6701.00
29_A36_A1.6301.00
22_V173_G1.6251.00
85_S88_A1.6241.00
36_A175_S1.6121.00
397_V403_Q1.6021.00
387_D414_N1.6011.00
355_G429_I1.5971.00
151_A227_A1.5871.00
137_A163_F1.5821.00
147_A223_G1.5671.00
367_M441_L1.5641.00
197_E235_S1.5621.00
421_N444_E1.5611.00
316_R344_H1.5541.00
75_R105_P1.5501.00
272_K277_L1.5411.00
70_V96_A1.5381.00
329_L333_S1.5301.00
72_H101_R1.5271.00
372_V397_V1.5241.00
139_E142_A1.5231.00
334_A340_K1.5161.00
147_A220_E1.5131.00
50_T55_V1.4911.00
417_D421_N1.4861.00
395_F402_I1.4811.00
366_E441_L1.4791.00
316_R326_Q1.4771.00
155_I231_L1.4771.00
195_A234_L1.4721.00
421_N443_P1.4721.00
245_P441_L1.4711.00
136_E139_E1.4621.00
414_N417_D1.4621.00
91_R94_Q1.4571.00
245_P443_P1.4431.00
304_T349_H1.4431.00
66_L81_S1.4411.00
197_E200_D1.4351.00
360_F364_L1.4341.00
169_V181_G1.4331.00
315_R352_R1.4321.00
42_K64_G1.4171.00
261_V351_W1.4121.00
247_I363_M1.4031.00
370_G397_V1.4011.00
358_L424_T1.3901.00
253_A440_V1.3811.00
148_A223_G1.3801.00
24_T27_E1.3771.00
135_D139_E1.3681.00
269_V327_W1.3561.00
318_I328_L1.3471.00
329_L337_L1.3461.00
249_A372_V1.3391.00
28_L31_G1.3341.00
87_Q91_R1.3341.00
285_L289_L1.3241.00
173_G179_L1.3201.00
156_T196_E1.3191.00
279_S416_K1.3121.00
142_A146_Q1.3061.00
247_I441_L1.3061.00
217_Q221_W1.2991.00
145_E149_L1.2941.00
137_A165_S1.2901.00
169_V183_C1.2881.00
52_Y157_N1.2861.00
292_E317_D1.2661.00
311_V341_S1.2651.00
281_G325_T1.2631.00
264_I318_I1.2621.00
358_L366_E1.2481.00
147_A224_A1.2421.00
37_E69_T1.2371.00
270_Y337_L1.2331.00
72_H100_A1.2311.00
212_A299_K1.2281.00
138_I142_A1.2221.00
212_A215_D1.2221.00
202_E407_S1.2171.00
23_S179_L1.2171.00
289_L425_V1.2141.00
321_D325_T1.2131.00
296_H313_T1.1891.00
361_E401_E1.1861.00
361_E365_K1.1821.00
371_L409_I1.1801.00
223_G227_A1.1791.00
141_A161_G1.1751.00
317_D321_D1.1701.00
360_F363_M1.1701.00
352_R436_Q1.1651.00
208_T222_V1.1641.00
315_R354_A1.1601.00
425_V440_V1.1581.00
155_I227_A1.1581.00
431_T436_Q1.1551.00
372_V402_I1.1531.00
37_E174_N1.1531.00
48_V55_V1.1501.00
53_G145_E1.1480.99
46_I137_A1.1480.99
317_D325_T1.1450.99
426_G439_S1.1430.99
79_A92_T1.1390.99
73_Q105_P1.1340.99
72_H97_L1.1330.99
163_F189_L1.1290.99
290_T354_A1.1280.99
364_L372_V1.1260.99
311_V343_G1.1120.99
221_W225_D1.1120.99
382_S387_D1.1030.99
290_T320_K1.1000.99
247_I397_V1.0970.99
148_A193_V1.0970.99
334_A341_S1.0970.99
193_V227_A1.0920.99
280_L339_L1.0870.99
28_L94_Q1.0840.99
311_V331_S1.0810.99
239_L244_A1.0760.99
245_P444_E1.0750.99
87_Q90_A1.0740.99
257_F353_I1.0740.99
26_L38_V1.0740.99
237_R396_W1.0740.99
247_I360_F1.0680.99
243_K446_K1.0670.99
154_R231_L1.0620.99
26_L36_A1.0600.99
167_Y183_C1.0600.99
266_G329_L1.0560.99
326_Q342_T1.0550.99
352_R429_I1.0500.99
204_D226_C1.0470.99
406_V409_I1.0440.99
360_F427_N1.0390.99
42_K62_S1.0350.99
196_E201_M1.0300.99
418_M445_M1.0300.99
363_M426_G1.0280.99
26_L175_S1.0220.99
195_A227_A1.0200.99
227_A231_L1.0190.99
215_D299_K1.0180.99
291_I319_I1.0180.99
417_D420_R1.0110.99
74_N105_P1.0070.99
291_I351_W0.9960.99
24_T28_L0.9960.99
143_R146_Q0.9960.99
46_I165_S0.9870.98
174_N178_M0.9860.98
360_F428_D0.9840.98
35_G176_H0.9820.98
88_A92_T0.9810.98
288_W358_L0.9800.98
65_A78_S0.9790.98
121_A124_L0.9770.98
220_E224_A0.9760.98
286_P425_V0.9750.98
329_L341_S0.9740.98
382_S385_T0.9720.98
50_T142_A0.9650.98
24_T90_A0.9650.98
367_M370_G0.9640.98
91_R95_A0.9640.98
29_A33_S0.9580.98
259_H263_A0.9530.98
295_P304_T0.9480.98
388_Y418_M0.9470.98
68_I92_T0.9420.98
275_F416_K0.9390.98
364_L367_M0.9380.98
114_K117_L0.9340.98
362_Q365_K0.9280.98
289_L422_I0.9230.98
244_A396_W0.9220.98
215_D218_T0.9210.98
29_A32_K0.9160.98
303_S350_N0.9140.97
316_R342_T0.9100.97
358_L427_N0.9080.97
213_M216_L0.9080.97
358_L363_M0.9080.97
253_A437_C0.9080.97
22_V38_V0.9030.97
424_T441_L0.9010.97
190_S205_Y0.9000.97
38_V66_L0.8940.97
295_P349_H0.8910.97
379_Q390_R0.8910.97
71_Y76_K0.8860.97
248_F373_V0.8830.97
81_S92_T0.8810.97
40_V66_L0.8790.97
25_A89_I0.8760.97
226_C230_T0.8740.97
360_F372_V0.8740.97
295_P313_T0.8730.97
289_L353_I0.8720.97
147_A150_Q0.8720.97
370_G402_I0.8700.97
44_T62_S0.8660.97
143_R147_A0.8650.96
272_K278_D0.8640.96
373_V411_I0.8630.96
118_A121_A0.8630.96
31_G94_Q0.8580.96
30_S175_S0.8530.96
285_L319_I0.8480.96
397_V402_I0.8420.96
22_V40_V0.8420.96
144_A189_L0.8420.96
171_V181_G0.8410.96
148_A226_C0.8380.96
33_S70_V0.8360.96
154_R234_L0.8300.96
81_S88_A0.8290.96
35_G172_F0.8280.95
41_S168_G0.8270.95
309_E331_S0.8250.95
376_L380_G0.8250.95
344_H349_H0.8240.95
55_V138_I0.8210.95
172_F180_Q0.8180.95
361_E364_L0.8180.95
364_L402_I0.8180.95
381_V390_R0.8160.95
260_L285_L0.8150.95
240_S369_T0.8150.95
242_M369_T0.8140.95
367_M423_V0.8140.95
148_A227_A0.8100.95
297_L300_G0.8060.95
97_L101_R0.8060.95
110_G335_R0.8010.95
33_S72_H0.8000.95
51_R56_E0.7990.95
295_P316_R0.7980.94
206_A222_V0.7980.94
221_W224_A0.7960.94
108_C111_V0.7930.94
93_V97_L0.7920.94
328_L348_I0.7920.94
259_H262_G0.7900.94
193_V230_T0.7890.94
257_F291_I0.7890.94
49_S57_N0.7880.94
401_E404_Y0.7840.94
297_L352_R0.7830.94
147_A151_A0.7760.94
395_F405_P0.7760.94
116_L340_K0.7750.94
112_A115_E0.7740.94
247_I372_V0.7720.93
237_R398_E0.7710.93
348_I351_W0.7700.93
44_T167_Y0.7700.93
363_M367_M0.7640.93
261_V419_W0.7610.93
364_L369_T0.7590.93
49_S162_S0.7580.93
252_V255_G0.7570.93
259_H390_R0.7560.93
35_G175_S0.7550.93
140_L213_M0.7530.93
139_E146_Q0.7520.93
245_P369_T0.7510.93
270_Y329_L0.7500.92
202_E233_R0.7480.92
236_P407_S0.7450.92
330_T333_S0.7430.92
176_H331_S0.7430.92
69_T309_E0.7420.92
270_Y333_S0.7410.92
29_A70_V0.7410.92
239_L371_L0.7410.92
329_L334_A0.7380.92
22_V26_L0.7380.92
115_E340_K0.7370.92
293_E316_R0.7370.92
64_G84_L0.7360.92
79_A96_A0.7350.92
140_L143_R0.7340.92
285_L422_I0.7330.92
260_L263_A0.7320.92
224_A227_A0.7280.91
244_A371_L0.7260.91
264_I324_L0.7220.91
246_V445_M0.7210.91
112_A116_L0.7200.91
238_K408_E0.7190.91
88_A91_R0.7150.91
352_R431_T0.7150.91
113_D176_H0.7130.90
170_K182_Y0.7120.90
231_L234_L0.7110.90
374_T395_F0.7090.90
388_Y413_G0.7080.90
151_A231_L0.7060.90
132_V136_E0.7050.90
429_I436_Q0.7010.90
127_F167_Y0.7000.90
47_S59_E0.6980.90
295_P303_S0.6970.89
283_Q321_D0.6950.89
120_D123_D0.6930.89
422_I440_V0.6930.89
258_G347_G0.6920.89
359_S426_G0.6920.89
45_G164_N0.6910.89
257_F289_L0.6900.89
252_V376_L0.6900.89
40_V64_G0.6880.89
225_D229_R0.6870.89
91_R98_D0.6860.89
52_Y149_L0.6840.89
244_A406_V0.6830.88
193_V226_C0.6820.88
248_F376_L0.6810.88
394_G406_V0.6800.88
147_A227_A0.6780.88
371_L396_W0.6770.88
206_A226_C0.6740.88
112_A311_V0.6740.88
381_V415_L0.6730.88
307_D343_G0.6730.88
77_G100_A0.6680.87
265_A268_S0.6680.87
165_S187_H0.6670.87
258_G348_I0.6650.87
48_V134_P0.6650.87
320_K323_I0.6640.87
214_S217_Q0.6640.87
269_V274_T0.6640.87
47_S162_S0.6620.87
313_T349_H0.6620.87
253_A353_I0.6610.87
286_P289_L0.6610.87
25_A31_G0.6610.87
364_L368_G0.6590.87
66_L89_I0.6550.86
294_H352_R0.6530.86
276_L324_L0.6520.86
136_E140_L0.6510.86
257_F440_V0.6500.86
31_G97_L0.6500.86
39_A170_K0.6490.86
376_L390_R0.6460.86
356_Q438_G0.6460.86
314_E326_Q0.6450.86
264_I319_I0.6440.85
321_D340_K0.6440.85
259_H348_I0.6430.85
397_V441_L0.6430.85
267_G271_R0.6420.85
37_E67_G0.6400.85
256_L376_L0.6400.85
363_M441_L0.6390.85
266_G337_L0.6390.85
132_V137_A0.6390.85
43_T166_H0.6380.85
378_G413_G0.6380.85
332_Y336_K0.6360.85
258_G262_G0.6360.85
77_G99_I0.6360.85
115_E118_A0.6360.85
331_S335_R0.6330.84
94_Q224_A0.6300.84
297_L303_S0.6280.84
128_H131_E0.6280.84
43_T168_G0.6280.84
127_F131_E0.6270.84
372_V439_S0.6260.84
380_G389_S0.6260.84
204_D230_T0.6250.84
33_S36_A0.6240.84
229_R249_A0.6220.83
23_S30_S0.6200.83
378_G389_S0.6190.83
265_A348_I0.6160.83
333_S337_L0.6160.83
208_T212_A0.6140.83
239_L242_M0.6140.83
213_M217_Q0.6090.82
365_K369_T0.6090.82
96_A100_A0.6080.82
357_G427_N0.6070.82
399_N403_Q0.6070.82
168_G184_S0.6050.82
421_N445_M0.6040.82
208_T217_Q0.6030.81
274_T327_W0.6000.81
356_Q427_N0.5980.81
252_V373_V0.5980.81
37_E78_S0.5980.81
278_D282_K0.5980.81
363_M402_I0.5970.81
110_G113_D0.5970.81
113_D117_L0.5960.81
263_A347_G0.5960.81
280_L327_W0.5950.81
209_I301_L0.5950.81
437_C440_V0.5950.81
245_P367_M0.5940.81
81_S89_I0.5940.81
66_L84_L0.5920.80
308_S346_G0.5900.80
334_A339_L0.5890.80
282_K323_I0.5890.80
369_T399_N0.5880.80
124_L128_H0.5870.80
285_L291_I0.5850.80
366_E399_N0.5850.80
132_V213_M0.5840.79
391_G408_E0.5840.79
231_L235_S0.5820.79
39_A168_G0.5810.79
380_G390_R0.5810.79
368_G403_Q0.5800.79
265_A379_Q0.5780.79
376_L379_Q0.5780.79
284_I420_R0.5780.79
28_L93_V0.5760.78
58_V142_A0.5750.78
255_G259_H0.5750.78
217_Q225_D0.5750.78
44_T169_V0.5740.78
159_E192_C0.5740.78
200_D235_S0.5740.78
392_A409_I0.5730.78
162_S190_S0.5720.78
50_T141_A0.5720.78
114_K178_M0.5710.78
137_A141_A0.5700.78
378_G410_T0.5700.78
266_G270_Y0.5700.78
232_S395_F0.5700.78
86_P90_A0.5690.78
52_Y158_T0.5680.78
255_G378_G0.5670.77
145_E161_G0.5670.77
377_M410_T0.5660.77
270_Y336_K0.5660.77
260_L419_W0.5660.77
99_I327_W0.5650.77
369_T403_Q0.5640.77
303_S349_H0.5640.77
426_G438_G0.5640.77
70_V93_V0.5640.77
262_G383_A0.5630.77
150_Q224_A0.5630.77
249_A374_T0.5620.77
416_K420_R0.5620.77
39_A78_S0.5610.77
148_A158_T0.5610.77
144_A191_S0.5600.77
296_H315_R0.5590.76
258_G263_A0.5580.76
133_S139_E0.5570.76
357_G424_T0.5560.76
280_L326_Q0.5550.76
389_S412_A0.5550.76
70_V100_A0.5540.76
114_K118_A0.5540.76
386_G414_N0.5530.76
100_A103_T0.5530.76
235_S405_P0.5520.75
275_F419_W0.5520.75
70_V77_G0.5520.75
242_M447_I0.5510.75
126_L129_P0.5510.75
263_A348_I0.5500.75
291_I353_I0.5490.75
33_S97_L0.5490.75
366_E423_V0.5490.75
148_A191_S0.5480.75
268_S383_A0.5480.75
237_R403_Q0.5470.75
143_R218_T0.5470.75
355_G427_N0.5470.75
318_I351_W0.5460.75
45_G166_H0.5460.75
107_P115_E0.5450.75
45_G63_D0.5430.74
55_V58_V0.5430.74
26_L29_A0.5420.74
65_A80_S0.5410.74
94_Q105_P0.5410.74
270_Y278_D0.5410.74
262_G347_G0.5410.74
66_L88_A0.5400.74
351_W437_C0.5400.74
353_I440_V0.5400.74
389_S410_T0.5390.74
228_R231_L0.5380.74
255_G390_R0.5380.74
321_D354_A0.5380.74
39_A65_A0.5370.74
158_T193_V0.5370.74
300_G303_S0.5360.73
265_A330_T0.5350.73
261_V348_I0.5350.73
235_S401_E0.5350.73
330_T345_A0.5350.73
329_L342_T0.5340.73
67_G78_S0.5320.73
259_H347_G0.5320.73
362_Q366_E0.5310.73
259_H381_V0.5310.73
223_G230_T0.5310.73
120_D181_G0.5310.73
31_G90_A0.5300.73
141_A163_F0.5290.72
271_R385_T0.5290.72
26_L173_G0.5280.72
121_A305_P0.5280.72
360_F367_M0.5270.72
255_G261_V0.5250.72
44_T60_F0.5240.72
392_A411_I0.5240.72
217_Q224_A0.5220.71
245_P368_G0.5220.71
111_V114_K0.5200.71
272_K279_S0.5200.71
365_K368_G0.5190.71
391_G410_T0.5180.71
292_E352_R0.5180.71
380_G410_T0.5160.71
367_M372_V0.5160.71
132_V196_E0.5150.70
127_F130_A0.5140.70
48_V137_A0.5130.70
29_A175_S0.5130.70
45_G61_N0.5130.70
155_I230_T0.5120.70
392_A414_N0.5120.70
291_I422_I0.5110.70
248_F253_A0.5110.70
153_K224_A0.5110.70
330_T341_S0.5100.70
254_T430_E0.5100.70
33_S100_A0.5090.70
47_S164_N0.5090.70
352_R355_G0.5070.69
69_T76_K0.5070.69
366_E397_V0.5070.69
374_T402_I0.5060.69
264_I328_L0.5060.69
25_A86_P0.5060.69
206_A229_R0.5050.69
280_L325_T0.5050.69
116_L123_D0.5040.69
247_I364_L0.5040.69
26_L30_S0.5040.69
328_L351_W0.5040.69
61_N282_K0.5030.69
69_T78_S0.5030.69
207_Y211_R0.5020.68
29_A97_L0.5020.68
286_P290_T0.5010.68
25_A28_L0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qtdA 2 0.98 100 0.08 Contact Map
3tv9A 2 0.9689 100 0.097 Contact Map
1vpbA 2 0.96 100 0.119 Contact Map
1vl4A 2 0.9378 100 0.137 Contact Map
3u1kA 3 0.2133 10.6 0.974 Contact Map
2zp1A 2 0.2467 8.9 0.974 Contact Map
2plgA 4 0.3133 6 0.976 Contact Map
1jg8A 4 0.2267 5.2 0.977 Contact Map
1v5sA 1 0.2556 5 0.977 Contact Map
1im3D 1 0.1244 4.9 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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