GREMLIN Database
PITA - Low-affinity inorganic phosphate transporter 1
UniProt: P0AFJ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12230
Length: 499 (466)
Sequences: 360 (170)
Seq/√Len: 7.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_K154_S5.7371.00
177_L181_W5.0580.99
118_A484_A4.8340.99
267_I371_L4.7270.99
48_M60_F4.6210.99
178_R461_D4.3800.98
164_I168_V3.7160.96
348_S372_K3.1600.90
74_Y381_Y3.0760.88
161_V165_V2.9820.87
56_M219_I2.9660.86
227_A438_S2.9400.86
417_G427_Q2.9130.85
129_I348_S2.5630.77
88_M103_A2.5610.77
354_V428_M2.5270.76
71_S441_G2.5220.76
156_F224_S2.4810.74
190_I197_R2.4690.74
165_V224_S2.4620.74
220_G431_A2.3760.71
133_L141_T2.3090.69
137_L489_G2.3040.68
74_Y473_I2.2290.66
87_N496_L2.2120.65
297_G311_T2.1240.62
484_A488_S2.1230.62
113_Y116_L2.1050.61
106_I116_L2.0940.61
82_T379_I2.0330.58
123_T449_V2.0250.58
134_T486_L2.0150.57
399_M403_R2.0130.57
50_S496_L2.0030.57
217_S427_Q1.9720.56
155_I412_K1.9600.55
118_A136_A1.9390.54
136_A496_L1.9350.54
149_I453_S1.9240.54
77_V428_M1.9130.53
151_K242_I1.8990.53
60_F63_L1.8940.53
157_G161_V1.8900.52
102_L392_L1.8830.52
105_I458_M1.8690.52
422_Q458_M1.8680.52
110_G116_L1.8580.51
75_A156_F1.8310.50
88_M242_I1.8200.50
327_E403_R1.8190.50
134_T493_W1.8140.49
368_L435_G1.8110.49
167_L459_V1.7920.48
327_E498_F1.7880.48
106_I483_A1.7850.48
198_E201_D1.7820.48
139_T496_L1.7810.48
442_M453_S1.7450.47
220_G224_S1.7340.46
88_M356_K1.6960.45
438_S449_V1.6910.44
149_I152_V1.6830.44
215_I311_T1.6720.44
60_F381_Y1.6690.44
434_I481_L1.6670.43
86_L90_S1.6610.43
416_K468_K1.6600.43
24_L90_S1.6550.43
154_S347_V1.6510.43
133_L442_M1.6500.43
294_P301_P1.6470.43
48_M424_M1.6390.42
23_V433_S1.6340.42
223_F453_S1.6290.42
59_V425_S1.6220.42
57_A152_V1.6150.41
303_E472_S1.6120.41
242_I276_Q1.6090.41
59_V62_F1.6000.41
382_A387_I1.5940.41
89_G124_L1.5810.40
106_I202_G1.5770.40
18_L359_G1.5370.38
42_V223_F1.5260.38
85_L234_I1.5250.38
368_L421_A1.5220.38
425_S472_S1.5160.38
172_G310_N1.5110.37
63_L492_Y1.5040.37
68_G382_A1.4960.37
118_A488_S1.4950.37
138_M412_K1.4910.37
361_S365_Q1.4890.36
374_D495_S1.4870.36
165_V441_G1.4830.36
184_T197_R1.4820.36
425_S428_M1.4690.36
88_M93_G1.4600.35
133_L136_A1.4540.35
202_G205_K1.4530.35
110_G114_F1.4500.35
326_V344_M1.4430.35
436_L440_T1.4320.34
336_Q492_Y1.4280.34
115_G423_G1.4270.34
55_V138_M1.4240.34
210_T453_S1.4130.34
395_G465_L1.4090.34
19_A47_A1.4050.33
92_H242_I1.4030.33
103_A470_V1.4020.33
74_Y349_D1.3960.33
133_L139_T1.3960.33
305_H361_S1.3930.33
406_A460_V1.3880.33
371_L392_L1.3880.33
29_I427_Q1.3860.33
216_L484_A1.3850.33
56_M218_A1.3840.33
350_T493_W1.3830.33
47_A322_L1.3660.32
103_A263_T1.3630.32
70_L382_A1.3620.32
91_S171_G1.3590.32
220_G457_T1.3490.31
156_F164_I1.3440.31
388_M484_A1.3410.31
49_R253_M1.3400.31
271_E320_G1.3290.31
59_V67_L1.3280.31
18_L201_D1.3190.30
60_F412_K1.3170.30
83_D463_G1.3140.30
337_R370_K1.3060.30
69_G382_A1.3020.30
463_G478_V1.3020.30
20_L390_V1.2920.29
273_Y367_L1.2900.29
252_N400_I1.2790.29
220_G422_Q1.2750.29
60_F136_A1.2670.29
22_F263_T1.2490.28
24_L393_A1.2480.28
218_A427_Q1.2360.28
171_G326_V1.2350.28
479_F485_V1.2320.27
328_S350_T1.2300.27
143_V295_E1.2230.27
245_A442_M1.2220.27
361_S364_D1.2130.27
124_L152_V1.2110.27
265_D269_N1.2090.27
256_T334_L1.2060.27
165_V169_F1.2060.27
277_H364_D1.2040.27
106_I484_A1.2010.26
200_K205_K1.1970.26
136_A142_S1.1960.26
486_L489_G1.1940.26
133_L496_L1.1940.26
378_T473_I1.1940.26
114_F283_Q1.1920.26
146_A409_I1.1870.26
250_V424_M1.1850.26
77_V215_I1.1840.26
242_I270_V1.1790.26
161_V361_S1.1750.26
203_K354_V1.1710.26
402_W420_Y1.1690.25
292_P340_M1.1630.25
105_I422_Q1.1620.25
198_E416_K1.1580.25
334_L486_L1.1560.25
253_M256_T1.1520.25
133_L198_E1.1470.25
106_I205_K1.1450.25
172_G176_L1.1430.25
174_I384_V1.1430.25
103_A484_A1.1420.25
174_I460_V1.1400.25
157_G473_I1.1370.24
352_D484_A1.1330.24
364_D367_L1.1290.24
103_A390_V1.1260.24
271_E275_E1.1240.24
22_F495_S1.1230.24
244_V459_V1.1190.24
97_V118_A1.1160.24
55_V168_V1.1140.24
152_V158_S1.1130.24
147_L379_I1.1120.24
20_L135_N1.1120.24
69_G177_L1.1080.24
421_A425_S1.1080.24
69_G387_I1.1040.23
69_G270_V1.1040.23
472_S479_F1.0970.23
89_G338_S1.0940.23
217_S417_G1.0810.23
70_L438_S1.0800.23
338_S492_Y1.0720.23
77_V488_S1.0710.23
94_L249_F1.0710.23
278_P340_M1.0700.23
47_A493_W1.0680.22
218_A417_G1.0660.22
263_T344_M1.0650.22
255_A337_R1.0640.22
350_T467_R1.0640.22
127_A396_I1.0610.22
66_L388_M1.0600.22
34_D37_N1.0600.22
233_G241_L1.0590.22
470_V474_L1.0590.22
209_W212_I1.0570.22
375_M379_I1.0530.22
303_E478_V1.0490.22
223_F449_V1.0470.22
47_A87_N1.0470.22
242_I247_A1.0460.22
301_P313_N1.0400.22
201_D204_K1.0390.22
97_V123_T1.0350.22
208_F473_I1.0300.21
147_L386_I1.0290.21
47_A78_H1.0270.21
340_M358_P1.0270.21
339_Q484_A1.0240.21
314_A344_M1.0230.21
114_F479_F1.0230.21
274_F277_H1.0220.21
190_I433_S1.0220.21
244_V442_M1.0160.21
245_A311_T1.0130.21
263_T326_V1.0130.21
425_S474_L1.0130.21
272_A276_Q1.0090.21
374_D473_I1.0090.21
243_G399_M1.0050.21
151_K467_R1.0050.21
91_S137_L1.0030.21
155_I266_A1.0030.21
70_L387_I0.9970.21
208_F479_F0.9930.20
442_M489_G0.9860.20
340_M371_L0.9780.20
124_L209_W0.9770.20
328_S432_V0.9750.20
92_H179_R0.9730.20
100_M430_A0.9730.20
242_I343_I0.9680.20
438_S441_G0.9680.20
245_A449_V0.9680.20
278_P317_R0.9680.20
381_Y473_I0.9680.20
164_I310_N0.9670.20
150_P198_E0.9660.20
87_N322_L0.9660.20
76_I215_I0.9650.20
85_L344_M0.9650.20
94_L234_I0.9620.20
198_E215_I0.9600.20
155_I353_K0.9590.20
118_A306_C0.9570.19
123_T438_S0.9570.19
297_G400_I0.9550.19
209_W451_S0.9520.19
97_V399_M0.9510.19
386_I460_V0.9490.19
177_L421_A0.9460.19
129_I317_R0.9440.19
317_R428_M0.9430.19
75_A304_F0.9400.19
88_M98_F0.9400.19
318_L379_I0.9390.19
138_M493_W0.9350.19
415_K472_S0.9330.19
299_T302_A0.9330.19
340_M485_V0.9290.19
282_K388_M0.9250.19
298_A436_L0.9230.19
75_A247_A0.9210.19
468_K486_L0.9170.18
75_A240_V0.9150.18
136_A141_T0.9130.18
148_N337_R0.9130.18
165_V475_M0.9130.18
68_G387_I0.9120.18
49_R483_A0.9120.18
164_I362_A0.9100.18
60_F354_V0.9090.18
440_T484_A0.9060.18
245_A274_F0.9050.18
154_S474_L0.9010.18
295_E299_T0.9010.18
180_Y425_S0.9000.18
113_Y399_M0.8990.18
270_V273_Y0.8990.18
118_A123_T0.8980.18
369_K425_S0.8970.18
336_Q370_K0.8940.18
123_T227_A0.8940.18
155_I161_V0.8930.18
69_G264_R0.8900.18
60_F254_N0.8890.18
172_G300_Q0.8880.18
142_S355_V0.8880.18
14_L161_V0.8870.18
135_N390_V0.8860.18
136_A353_K0.8850.18
354_V360_V0.8830.18
247_A263_T0.8810.18
256_T475_M0.8790.18
205_K405_V0.8760.17
161_V492_Y0.8750.17
75_A349_D0.8740.17
63_L103_A0.8700.17
176_L478_V0.8700.17
77_V355_V0.8690.17
50_S395_G0.8690.17
95_A415_K0.8680.17
265_D310_N0.8640.17
217_S418_M0.8640.17
17_L136_A0.8600.17
116_L165_V0.8550.17
247_A320_G0.8550.17
116_L358_P0.8520.17
40_A115_G0.8510.17
345_L387_I0.8490.17
164_I176_L0.8490.17
178_R425_S0.8480.17
179_R277_H0.8470.17
88_M430_A0.8460.17
315_L322_L0.8450.17
177_L425_S0.8450.17
234_I427_Q0.8430.17
160_I354_V0.8420.17
91_S486_L0.8410.17
86_L136_A0.8390.17
142_S198_E0.8370.17
28_A386_I0.8360.17
234_I382_A0.8360.17
69_G483_A0.8340.17
57_A453_S0.8340.17
177_L208_F0.8320.16
223_F474_L0.8290.16
145_D495_S0.8270.16
77_V298_A0.8270.16
30_N33_H0.8270.16
16_L40_A0.8270.16
28_A167_L0.8260.16
342_R436_L0.8260.16
260_I292_P0.8240.16
329_Y492_Y0.8230.16
326_V329_Y0.8200.16
140_G282_K0.8200.16
56_M427_Q0.8200.16
442_M460_V0.8190.16
60_F496_L0.8190.16
108_N446_T0.8180.16
16_L42_V0.8150.16
242_I245_A0.8150.16
89_G234_I0.8140.16
51_Q91_S0.8110.16
136_A254_N0.8100.16
131_I455_A0.8100.16
353_K470_V0.8100.16
169_F172_G0.8090.16
269_N367_L0.8090.16
137_L365_Q0.8080.16
327_E377_S0.8070.16
267_I367_L0.8070.16
227_A449_V0.8070.16
179_R360_V0.8070.16
70_L210_T0.8060.16
310_N489_G0.8040.16
305_H355_V0.8030.16
190_I343_I0.8010.16
184_T215_I0.8010.16
165_V484_A0.8010.16
138_M318_L0.8010.16
424_M453_S0.8010.16
99_S259_E0.8000.16
177_L260_I0.8000.16
49_R60_F0.7990.16
172_G197_R0.7990.16
48_M274_F0.7990.16
259_E498_F0.7990.16
178_R271_E0.7990.16
29_I234_I0.7970.16
18_L116_L0.7970.16
298_A318_L0.7950.16
26_Y50_S0.7940.16
88_M92_H0.7920.16
244_V396_I0.7920.16
276_Q310_N0.7920.16
152_V479_F0.7920.16
296_A359_G0.7900.16
68_G381_Y0.7870.15
21_A431_A0.7870.15
312_I333_S0.7870.15
220_G454_V0.7850.15
490_G494_L0.7840.15
141_T496_L0.7810.15
116_L479_F0.7780.15
319_K492_Y0.7770.15
133_L467_R0.7740.15
21_A470_V0.7730.15
260_I439_Y0.7730.15
145_D342_R0.7720.15
17_L484_A0.7640.15
20_L396_I0.7640.15
48_M67_L0.7620.15
69_G151_K0.7610.15
157_G364_D0.7610.15
295_E298_A0.7580.15
70_L234_I0.7530.15
56_M217_S0.7530.15
198_E486_L0.7530.15
198_E472_S0.7470.15
215_I404_R0.7450.15
235_G446_T0.7440.15
294_P297_G0.7400.15
233_G402_W0.7400.15
146_A386_I0.7390.15
253_M261_T0.7370.14
327_E439_Y0.7360.14
49_R103_A0.7360.14
197_R347_V0.7360.14
343_I429_T0.7350.14
21_A215_I0.7350.14
274_F349_D0.7330.14
366_R418_M0.7320.14
133_L484_A0.7310.14
127_A461_D0.7300.14
225_H235_G0.7280.14
321_M334_L0.7240.14
247_A270_V0.7240.14
180_Y442_M0.7210.14
133_L462_G0.7200.14
275_E324_T0.7190.14
106_I183_G0.7180.14
47_A149_I0.7150.14
205_K248_G0.7130.14
52_L329_Y0.7120.14
139_T331_K0.7120.14
40_A423_G0.7110.14
368_L451_S0.7040.14
307_H363_D0.7040.14
89_G174_I0.7040.14
264_R267_I0.7020.14
214_L419_T0.7020.14
214_L341_R0.7000.14
476_A481_L0.7000.14
224_S441_G0.7000.14
350_T354_V0.6990.14
313_N319_K0.6970.14
118_A462_G0.6970.14
129_I459_V0.6950.14
17_L388_M0.6940.14
85_L144_V0.6930.14
458_M463_G0.6920.14
47_A181_W0.6910.14
271_E368_L0.6910.14
326_V403_R0.6900.14
180_Y184_T0.6890.14
158_S340_M0.6880.14
178_R335_D0.6870.13
177_L272_A0.6840.13
349_D364_D0.6830.13
87_N244_V0.6830.13
129_I479_F0.6820.13
209_W458_M0.6810.13
283_Q428_M0.6790.13
247_A339_Q0.6770.13
45_T111_T0.6770.13
217_S274_F0.6760.13
152_V168_V0.6760.13
173_L178_R0.6760.13
58_A79_M0.6750.13
102_L492_Y0.6740.13
50_S471_T0.6720.13
133_L264_R0.6700.13
261_T380_E0.6700.13
97_V304_F0.6700.13
319_K375_M0.6680.13
171_G497_Q0.6650.13
138_M475_M0.6650.13
242_I311_T0.6640.13
372_K400_I0.6630.13
362_A373_S0.6580.13
162_S422_Q0.6580.13
326_V366_R0.6560.13
55_V403_R0.6560.13
485_V492_Y0.6540.13
158_S367_L0.6540.13
78_H244_V0.6530.13
269_N468_K0.6530.13
86_L314_A0.6530.13
43_I230_G0.6520.13
202_G440_T0.6510.13
259_E276_Q0.6470.13
49_R352_D0.6470.13
217_S346_C0.6460.13
210_T351_I0.6460.13
295_E302_A0.6430.13
264_R333_S0.6410.13
198_E370_K0.6410.13
322_L496_L0.6400.13
422_Q457_T0.6390.13
265_D403_R0.6390.13
77_V350_T0.6370.13
358_P494_L0.6360.13
433_S438_S0.6340.13
147_L199_K0.6340.13
165_V364_D0.6330.12
156_F449_V0.6310.12
95_A221_V0.6310.12
93_G481_L0.6300.12
435_G439_Y0.6290.12
154_S484_A0.6280.12
345_L396_I0.6280.12
68_G234_I0.6270.12
477_W480_T0.6260.12
113_Y123_T0.6250.12
209_W422_Q0.6230.12
18_L245_A0.6220.12
69_G234_I0.6210.12
479_F483_A0.6200.12
314_A400_I0.6200.12
431_A459_V0.6190.12
255_A418_M0.6180.12
94_L140_G0.6170.12
356_K498_F0.6140.12
495_S498_F0.6140.12
253_M380_E0.6120.12
354_V362_A0.6120.12
74_Y372_K0.6110.12
279_A478_V0.6100.12
48_M439_Y0.6090.12
136_A151_K0.6080.12
177_L416_K0.6050.12
202_G478_V0.6050.12
94_L427_Q0.6040.12
165_V362_A0.6030.12
93_G393_A0.6030.12
218_A346_C0.6020.12
113_Y157_G0.6020.12
142_S416_K0.6010.12
139_T473_I0.5990.12
177_L365_Q0.5980.12
402_W469_T0.5970.12
329_Y333_S0.5940.12
183_G416_K0.5940.12
103_A336_Q0.5930.12
54_V406_A0.5910.12
352_D462_G0.5910.12
326_V333_S0.5910.12
38_A481_L0.5900.12
46_R94_L0.5870.12
91_S106_I0.5860.12
430_A476_A0.5860.12
133_L244_V0.5840.12
158_S162_S0.5840.12
116_L353_K0.5830.12
165_V317_R0.5830.12
61_N166_G0.5830.12
113_Y244_V0.5820.12
82_T243_G0.5810.12
337_R374_D0.5810.12
30_N166_G0.5800.12
165_V367_L0.5790.12
294_P298_A0.5790.12
279_A311_T0.5780.12
21_A198_E0.5780.12
168_V489_G0.5770.12
457_T468_K0.5760.12
23_V234_I0.5750.11
250_V352_D0.5750.11
224_S406_A0.5750.11
46_R116_L0.5740.11
212_I368_L0.5730.11
255_A339_Q0.5720.11
344_M416_K0.5710.11
462_G498_F0.5710.11
293_A490_G0.5710.11
59_V253_M0.5710.11
240_V495_S0.5700.11
59_V352_D0.5700.11
428_M483_A0.5700.11
136_A242_I0.5690.11
68_G345_L0.5680.11
174_I498_F0.5680.11
141_T486_L0.5680.11
18_L102_L0.5680.11
369_K372_K0.5660.11
32_F112_W0.5660.11
257_G328_S0.5660.11
20_L237_V0.5640.11
169_F242_I0.5640.11
87_N181_W0.5610.11
26_Y29_I0.5600.11
386_I461_D0.5600.11
142_S392_L0.5590.11
74_Y418_M0.5590.11
348_S351_I0.5580.11
131_I147_L0.5570.11
203_K366_R0.5560.11
108_N112_W0.5560.11
124_L473_I0.5540.11
166_G398_T0.5540.11
155_I417_G0.5540.11
277_H334_L0.5530.11
337_R380_E0.5520.11
255_A358_P0.5510.11
199_K205_K0.5510.11
388_M494_L0.5510.11
94_L438_S0.5510.11
300_Q331_K0.5480.11
198_E244_V0.5480.11
224_S461_D0.5460.11
208_F435_G0.5460.11
77_V311_T0.5450.11
97_V261_T0.5450.11
261_T389_A0.5430.11
149_I156_F0.5420.11
68_G380_E0.5410.11
18_L267_I0.5400.11
84_L402_W0.5400.11
352_D454_V0.5390.11
416_K488_S0.5370.11
83_D462_G0.5360.11
328_S362_A0.5350.11
184_T275_E0.5350.11
138_M497_Q0.5350.11
129_I133_L0.5350.11
113_Y133_L0.5340.11
370_K389_A0.5340.11
184_T198_E0.5340.11
81_P414_G0.5330.11
59_V184_T0.5330.11
227_A386_I0.5330.11
247_A462_G0.5310.11
320_G352_D0.5310.11
110_G153_L0.5310.11
241_L402_W0.5310.11
204_K347_V0.5300.11
328_S333_S0.5290.11
436_L449_V0.5280.11
241_L420_Y0.5280.11
165_V216_L0.5280.11
349_D380_E0.5280.11
100_M103_A0.5280.11
345_L382_A0.5270.11
50_S99_S0.5270.11
328_S495_S0.5260.11
17_L339_Q0.5250.11
33_H112_W0.5250.11
96_M434_I0.5250.11
84_L420_Y0.5230.11
125_I425_S0.5230.11
245_A378_T0.5220.11
26_Y149_I0.5220.11
153_L272_A0.5220.11
242_I320_G0.5190.11
151_K353_K0.5190.11
108_N235_G0.5170.11
248_G329_Y0.5170.11
27_E32_F0.5150.11
214_L485_V0.5140.11
365_Q369_K0.5130.11
106_I374_D0.5130.11
51_Q87_N0.5130.11
116_L154_S0.5120.10
156_F313_N0.5120.10
74_Y438_S0.5120.10
136_A262_R0.5110.10
298_A421_A0.5110.10
226_G446_T0.5100.10
199_K409_I0.5100.10
471_T483_A0.5090.10
19_A368_L0.5090.10
35_T39_V0.5080.10
74_Y449_V0.5080.10
328_S486_L0.5080.10
231_Q482_P0.5080.10
60_F67_L0.5070.10
245_A263_T0.5060.10
467_R496_L0.5060.10
181_W432_V0.5040.10
190_I416_K0.5040.10
116_L349_D0.5030.10
17_L158_S0.5030.10
63_L488_S0.5030.10
111_T121_S0.5030.10
220_G388_M0.5010.10
100_M395_G0.5000.10
36_A79_M0.5000.10
178_R375_M0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jlnA 1 0.3547 68.2 0.979 Contact Map
2xq2A 2 0.4469 46.9 0.982 Contact Map
3qe7A 2 0.3387 36 0.983 Contact Map
4m5bA 1 0.2305 26.5 0.984 Contact Map
4xk8I 1 0.0581 14 0.986 Contact Map
1jb0I 1 0.0762 11.9 0.986 Contact Map
3zbhA 2 0.1944 10.1 0.987 Contact Map
4i0xB 1 0.1703 10 0.987 Contact Map
2ls4A 1 0.0461 9.4 0.987 Contact Map
2wscI 1 0.0601 9.4 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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