PARC - ECOLI - GREMLIN Contacts

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PARC - DNA topoisomerase 4 subunit A

UniProt:	P0AFI2	Sequences: MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVRMRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPLQEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSNQPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDLPQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10686
Length:	752 (675)
Sequences:	5214 (2596)
Seq/√Len:	99.9

ECOLI - PARC GYRA
BACSU - PARC GYRA
HALSA - Q9HR29

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
71_L	82_C	5.772	1.00
370_L	448_Q	5.546	1.00
186_R	473_G	4.502	1.00
197_D	462_K	4.385	1.00
190_Q	469_A	4.275	1.00
194_A	201_T	4.098	1.00
647_T	672_I	3.665	1.00
60_F	101_D	3.582	1.00
194_A	209_I	3.467	1.00
449_G	456_K	3.322	1.00
139_G	367_E	3.135	1.00
449_G	453_S	3.057	1.00
191_A	210_V	3.010	1.00
446_Q	456_K	2.988	1.00
245_W	316_F	2.984	1.00
109_P	295_T	2.966	1.00
195_L	347_L	2.949	1.00
195_L	201_T	2.858	1.00
367_E	371_K	2.822	1.00
599_D	629_H	2.818	1.00
388_E	406_R	2.812	1.00
391_E	395_N	2.767	1.00
144_V	155_K	2.711	1.00
193_I	466_Q	2.696	1.00
202_T	205_Q	2.663	1.00
66_T	123_S	2.647	1.00
446_Q	449_G	2.636	1.00
648_Q	679_A	2.572	1.00
648_Q	678_E	2.569	1.00
142_D	360_R	2.565	1.00
161_L	166_L	2.563	1.00
625_P	667_K	2.553	1.00
65_R	73_K	2.547	1.00
204_D	233_E	2.529	1.00
186_R	475_D	2.528	1.00
56_A	130_E	2.518	1.00
642_M	654_M	2.494	1.00
381_V	409_L	2.485	1.00
506_Q	530_S	2.476	1.00
359_R	363_N	2.470	1.00
206_L	343_L	2.462	1.00
203_L	342_N	2.401	1.00
467_A	471_A	2.391	1.00
246_K	255_S	2.388	1.00
415_E	419_E	2.379	1.00
189_A	465_L	2.373	1.00
639_A	657_V	2.327	1.00
244_V	479_P	2.322	1.00
196_I	458_N	2.319	1.00
245_W	252_V	2.315	1.00
186_R	190_Q	2.312	1.00
186_R	469_A	2.311	1.00
206_L	344_L	2.297	1.00
670_K	673_N	2.283	1.00
371_K	412_T	2.251	1.00
97_Y	474_D	2.242	1.00
194_A	198_Q	2.228	1.00
456_K	459_N	2.184	1.00
101_D	124_R	2.168	1.00
283_D	302_R	2.165	1.00
138_Q	365_R	2.155	1.00
250_G	308_M	2.153	1.00
131_L	472_Y	2.150	1.00
355_R	458_N	2.150	1.00
180_I	329_L	2.126	1.00
597_A	645_A	2.117	1.00
548_S	629_H	2.108	1.00
439_E	443_E	2.102	1.00
254_I	299_I	2.098	1.00
372_R	436_E	2.095	1.00
201_T	205_Q	2.086	1.00
443_E	447_L	2.083	1.00
204_D	229_R	2.080	1.00
448_Q	452_A	2.075	1.00
127_K	471_A	2.067	1.00
63_S	86_M	2.058	1.00
368_K	371_K	2.043	1.00
636_I	657_V	2.036	1.00
663_L	666_G	2.034	1.00
500_V	557_P	2.024	1.00
145_P	152_Q	2.023	1.00
376_L	433_I	2.022	1.00
166_L	188_V	2.020	1.00
188_V	210_V	1.994	1.00
198_Q	205_Q	1.987	1.00
645_A	671_I	1.987	1.00
362_L	447_L	1.976	1.00
400_K	415_E	1.963	1.00
45_I	85_A	1.950	1.00
537_G	541_Q	1.944	1.00
145_P	149_G	1.938	1.00
636_I	639_A	1.937	1.00
435_G	439_E	1.932	1.00
637_E	641_D	1.921	1.00
599_D	628_A	1.919	1.00
245_W	312_M	1.911	1.00
358_V	461_L	1.909	1.00
229_R	233_E	1.907	1.00
240_R	322_E	1.907	1.00
195_L	348_S	1.907	1.00
597_A	683_E	1.905	1.00
355_R	454_E	1.896	1.00
265_R	268_E	1.889	1.00
359_R	451_L	1.883	1.00
34_I	349_E	1.876	1.00
497_S	538_K	1.872	1.00
599_D	679_A	1.871	1.00
203_L	233_E	1.860	1.00
243_A	254_I	1.853	1.00
431_M	435_G	1.852	1.00
344_L	348_S	1.843	1.00
459_N	463_K	1.842	1.00
81_A	85_A	1.841	1.00
373_L	437_Q	1.832	1.00
392_I	402_A	1.832	1.00
342_N	345_E	1.810	1.00
450_I	460_L	1.808	1.00
193_I	462_K	1.805	1.00
339_A	345_E	1.804	1.00
201_T	209_I	1.803	1.00
672_I	680_A	1.790	1.00
334_L	341_K	1.790	1.00
549_T	579_G	1.767	1.00
349_E	352_V	1.761	1.00
457_M	460_L	1.735	1.00
257_L	297_L	1.735	1.00
603_G	671_I	1.727	1.00
363_N	367_E	1.724	1.00
80_S	84_E	1.718	1.00
453_S	456_K	1.707	1.00
61_K	65_R	1.694	1.00
438_S	442_K	1.691	1.00
65_R	69_D	1.682	1.00
142_D	155_K	1.679	1.00
180_I	346_I	1.662	1.00
205_Q	208_D	1.654	1.00
195_L	351_L	1.653	1.00
348_S	352_V	1.649	1.00
192_A	351_L	1.649	1.00
161_L	468_D	1.648	1.00
86_M	123_S	1.641	1.00
203_L	344_L	1.641	1.00
34_I	346_I	1.638	1.00
434_R	438_S	1.606	1.00
381_V	385_N	1.604	1.00
547_D	582_V	1.596	1.00
445_D	449_G	1.582	1.00
212_G	228_I	1.574	1.00
429_E	432_K	1.573	1.00
395_N	402_A	1.569	1.00
602_Y	670_K	1.565	1.00
595_L	643_L	1.558	1.00
240_R	324_S	1.529	1.00
170_T	179_D	1.524	1.00
225_R	482_E	1.522	1.00
365_R	447_L	1.509	1.00
595_L	603_G	1.504	1.00
131_L	134_S	1.501	1.00
642_M	656_P	1.492	1.00
446_Q	450_I	1.492	1.00
48_A	69_D	1.491	1.00
361_R	464_E	1.477	1.00
244_V	256_A	1.472	1.00
335_D	352_V	1.463	1.00
329_L	346_I	1.437	1.00
443_E	446_Q	1.437	1.00
389_V	403_L	1.430	1.00
226_A	230_K	1.420	1.00
65_R	151_L	1.420	1.00
230_K	233_E	1.419	1.00
89_M	95_Y	1.419	1.00
377_E	441_E	1.410	1.00
65_R	72_G	1.408	1.00
282_V	299_I	1.407	1.00
507_M	526_K	1.392	1.00
198_Q	201_T	1.391	1.00
192_A	347_L	1.391	1.00
320_D	323_K	1.386	0.99
498_E	539_S	1.381	0.99
334_L	349_E	1.376	0.99
87_V	115_F	1.367	0.99
380_L	437_Q	1.360	0.99
366_L	444_R	1.358	0.99
288_E	298_V	1.353	0.99
269_Q	272_A	1.350	0.99
359_R	457_M	1.346	0.99
538_K	541_Q	1.345	0.99
454_E	458_N	1.337	0.99
63_S	123_S	1.337	0.99
437_Q	441_E	1.336	0.99
345_E	348_S	1.322	0.99
401_P	405_S	1.317	0.99
474_D	477_R	1.317	0.99
418_L	423_R	1.316	0.99
133_L	157_L	1.316	0.99
65_R	118_M	1.313	0.99
595_L	660_L	1.312	0.99
593_K	662_Q	1.311	0.99
442_K	446_Q	1.309	0.99
69_D	73_K	1.297	0.99
445_D	448_Q	1.285	0.99
466_Q	470_Q	1.280	0.99
220_E	244_V	1.276	0.99
549_T	577_P	1.276	0.99
48_A	71_L	1.271	0.99
247_K	252_V	1.271	0.99
462_K	466_Q	1.270	0.99
179_D	326_R	1.267	0.99
645_A	680_A	1.267	0.99
270_I	285_L	1.267	0.99
290_D	293_N	1.258	0.99
506_Q	532_K	1.255	0.99
270_I	299_I	1.251	0.99
449_G	452_A	1.248	0.99
73_K	151_L	1.243	0.99
232_Y	327_I	1.241	0.99
392_I	406_R	1.241	0.99
388_E	391_E	1.239	0.99
96_R	474_D	1.238	0.99
266_V	297_L	1.234	0.99
267_L	297_L	1.229	0.99
554_A	614_R	1.229	0.99
377_E	437_Q	1.227	0.99
238_S	324_S	1.222	0.99
623_T	666_G	1.221	0.99
439_E	442_K	1.221	0.99
288_E	296_R	1.216	0.99
466_Q	469_A	1.215	0.99
597_A	680_A	1.212	0.99
596_M	630_V	1.205	0.99
350_W	354_R	1.205	0.99
355_R	457_M	1.199	0.99
232_Y	343_L	1.197	0.98
400_K	411_E	1.197	0.98
248_E	296_R	1.194	0.98
330_N	340_V	1.193	0.98
380_L	434_R	1.190	0.98
546_V	633_P	1.186	0.98
248_E	253_V	1.185	0.98
9_A	12_E	1.185	0.98
243_A	321_L	1.185	0.98
404_M	414_A	1.183	0.98
463_K	466_Q	1.175	0.98
195_L	344_L	1.174	0.98
47_Y	50_S	1.169	0.98
306_V	311_V	1.167	0.98
139_G	363_N	1.165	0.98
385_N	409_L	1.164	0.98
548_S	580_A	1.164	0.98
220_E	481_Q	1.163	0.98
203_L	207_L	1.159	0.98
194_A	205_Q	1.157	0.98
267_L	285_L	1.153	0.98
442_K	445_D	1.152	0.98
649_A	678_E	1.152	0.98
463_K	467_A	1.145	0.98
18_Y	28_D	1.145	0.98
594_L	633_P	1.144	0.98
375_I	416_A	1.144	0.98
352_V	355_R	1.141	0.98
27_M	332_I	1.138	0.98
59_K	124_R	1.135	0.98
203_L	206_L	1.127	0.98
647_T	678_E	1.124	0.98
225_R	228_I	1.116	0.98
241_M	323_K	1.114	0.98
450_I	456_K	1.113	0.98
245_W	254_I	1.113	0.98
286_R	300_V	1.112	0.98
376_L	440_L	1.112	0.98
11_H	15_E	1.109	0.98
374_H	410_T	1.103	0.97
548_S	581_T	1.101	0.97
380_L	433_I	1.099	0.97
363_N	370_L	1.097	0.97
52_L	69_D	1.097	0.97
430_E	434_R	1.092	0.97
189_A	469_A	1.090	0.97
251_A	300_V	1.089	0.97
593_K	605_V	1.088	0.97
100_V	123_S	1.087	0.97
71_L	147_F	1.083	0.97
605_V	662_Q	1.080	0.97
56_A	127_K	1.080	0.97
644_L	652_M	1.076	0.97
160_R	354_R	1.074	0.97
228_I	239_V	1.071	0.97
247_K	312_M	1.070	0.97
393_I	422_L	1.067	0.97
379_L	433_I	1.067	0.97
497_S	539_S	1.062	0.97
181_P	329_L	1.057	0.97
467_A	470_Q	1.054	0.97
16_N	20_N	1.053	0.97
231_I	327_I	1.048	0.97
544_V	552_S	1.045	0.96
61_K	150_T	1.045	0.96
301_P	306_V	1.044	0.96
139_G	360_R	1.044	0.96
220_E	241_M	1.043	0.96
137_G	365_R	1.042	0.96
219_A	243_A	1.039	0.96
132_L	159_A	1.038	0.96
597_A	671_I	1.038	0.96
386_I	394_R	1.037	0.96
358_V	464_E	1.036	0.96
161_L	189_A	1.035	0.96
595_L	636_I	1.033	0.96
331_M	346_I	1.030	0.96
602_Y	667_K	1.030	0.96
46_V	133_L	1.024	0.96
48_A	82_C	1.024	0.96
399_P	426_A	1.023	0.96
647_T	680_A	1.021	0.96
358_V	457_M	1.015	0.96
373_L	444_R	1.014	0.96
227_E	230_K	1.014	0.96
268_E	272_A	1.013	0.96
600_A	627_N	1.006	0.96
221_I	478_S	1.006	0.96
492_H	556_D	1.004	0.96
128_Y	163_N	1.001	0.95
301_P	311_V	0.999	0.95
54_L	66_T	0.998	0.95
239_V	327_I	0.998	0.95
99_L	132_L	0.998	0.95
70_V	82_C	0.998	0.95
364_Y	368_K	0.995	0.95
396_E	402_A	0.989	0.95
42_Q	94_S	0.986	0.95
373_L	441_E	0.983	0.95
254_I	321_L	0.983	0.95
34_I	341_K	0.983	0.95
606_C	610_D	0.981	0.95
241_M	478_S	0.978	0.95
190_Q	193_I	0.978	0.95
546_V	552_S	0.978	0.95
55_N	58_A	0.976	0.95
207_L	233_E	0.974	0.95
362_L	450_I	0.973	0.95
634_V	683_E	0.967	0.95
166_L	185_L	0.964	0.94
600_A	628_A	0.962	0.94
367_E	370_L	0.962	0.94
269_Q	320_D	0.962	0.94
404_M	411_E	0.962	0.94
537_G	557_P	0.961	0.94
402_A	405_S	0.960	0.94
596_M	633_P	0.956	0.94
225_R	229_R	0.954	0.94
385_N	388_E	0.954	0.94
455_R	459_N	0.949	0.94
438_S	441_E	0.949	0.94
607_T	610_D	0.946	0.94
456_K	460_L	0.945	0.94
551_R	577_P	0.944	0.94
455_R	463_K	0.942	0.94
383_F	430_E	0.940	0.94
607_T	662_Q	0.939	0.94
334_L	339_A	0.938	0.94
193_I	469_A	0.937	0.94
591_D	609_N	0.936	0.94
606_C	611_L	0.928	0.93
71_L	80_S	0.926	0.93
212_G	480_L	0.925	0.93
182_P	216_P	0.924	0.93
224_S	227_E	0.922	0.93
189_A	192_A	0.922	0.93
52_L	65_R	0.920	0.93
545_F	585_M	0.919	0.93
48_A	74_Y	0.912	0.93
290_D	295_T	0.911	0.93
192_A	465_L	0.911	0.93
637_E	640_S	0.906	0.92
596_M	621_L	0.905	0.92
525_Y	531_F	0.905	0.92
97_Y	128_Y	0.903	0.92
194_A	208_D	0.902	0.92
398_E	401_P	0.898	0.92
125_L	129_S	0.894	0.92
220_E	479_P	0.893	0.92
52_L	66_T	0.893	0.92
372_R	376_L	0.891	0.92
365_R	443_E	0.889	0.92
435_G	438_S	0.888	0.92
611_L	621_L	0.887	0.92
663_L	667_K	0.887	0.92
459_N	470_Q	0.886	0.92
69_D	147_F	0.886	0.92
411_E	415_E	0.884	0.91
416_A	420_L	0.882	0.91
581_T	629_H	0.882	0.91
242_R	322_E	0.882	0.91
198_Q	202_T	0.881	0.91
602_Y	625_P	0.880	0.91
238_S	326_R	0.877	0.91
261_V	266_V	0.876	0.91
347_L	351_L	0.875	0.91
502_I	557_P	0.874	0.91
210_V	343_L	0.871	0.91
549_T	580_A	0.871	0.91
387_D	394_R	0.870	0.91
164_I	331_M	0.870	0.91
13_F	17_A	0.868	0.91
641_D	687_A	0.867	0.91
52_L	147_F	0.866	0.91
226_A	229_R	0.863	0.90
221_I	241_M	0.863	0.90
592_Q	635_V	0.861	0.90
224_S	228_I	0.858	0.90
253_V	298_V	0.858	0.90
384_L	430_E	0.855	0.90
218_E	244_V	0.855	0.90
539_S	557_P	0.854	0.90
61_K	73_K	0.854	0.90
420_L	424_H	0.853	0.90
655_F	660_L	0.851	0.90
446_Q	453_S	0.851	0.90
446_Q	460_L	0.850	0.90
193_I	197_D	0.847	0.90
198_Q	209_I	0.844	0.89
59_K	150_T	0.842	0.89
197_D	466_Q	0.840	0.89
134_S	354_R	0.839	0.89
632_P	683_E	0.837	0.89
500_V	539_S	0.833	0.89
285_L	299_I	0.833	0.89
446_Q	463_K	0.832	0.89
57_S	130_E	0.831	0.89
366_L	448_Q	0.831	0.89
221_I	239_V	0.830	0.89
265_R	269_Q	0.829	0.89
164_I	346_I	0.827	0.88
186_R	470_Q	0.826	0.88
651_R	675_P	0.826	0.88
201_T	351_L	0.826	0.88
51_E	74_Y	0.824	0.88
110_D	263_G	0.822	0.88
99_L	163_N	0.821	0.88
468_D	472_Y	0.821	0.88
498_E	514_K	0.821	0.88
250_G	301_P	0.820	0.88
381_V	408_G	0.820	0.88
499_P	538_K	0.818	0.88
55_N	130_E	0.818	0.88
23_M	27_M	0.817	0.88
202_T	344_L	0.817	0.88
389_V	407_F	0.816	0.88
66_T	71_L	0.816	0.88
452_A	456_K	0.815	0.88
421_K	424_H	0.813	0.88
537_G	587_M	0.812	0.88
166_L	189_A	0.811	0.87
190_Q	466_Q	0.810	0.87
97_Y	475_D	0.808	0.87
608_F	635_V	0.808	0.87
47_Y	51_E	0.803	0.87
267_L	271_A	0.802	0.87
192_A	350_W	0.802	0.87
228_I	231_I	0.802	0.87
134_S	160_R	0.799	0.87
160_R	468_D	0.798	0.87
497_S	540_N	0.798	0.87
441_E	445_D	0.797	0.87
203_L	209_I	0.797	0.87
598_S	622_I	0.796	0.86
196_I	462_K	0.795	0.86
272_A	276_N	0.793	0.86
252_V	312_M	0.793	0.86
502_I	560_L	0.793	0.86
432_K	435_G	0.793	0.86
390_I	394_R	0.792	0.86
35_G	156_M	0.792	0.86
312_M	316_F	0.791	0.86
28_D	169_T	0.789	0.86
504_L	585_M	0.789	0.86
595_L	671_I	0.788	0.86
362_L	451_L	0.788	0.86
597_A	603_G	0.785	0.86
328_N	340_V	0.784	0.86
52_L	73_K	0.784	0.86
611_L	663_L	0.782	0.86
504_L	535_V	0.782	0.86
385_N	392_I	0.782	0.86
390_I	393_I	0.781	0.85
450_I	457_M	0.778	0.85
377_E	410_T	0.776	0.85
245_W	308_M	0.775	0.85
48_A	52_L	0.774	0.85
392_I	414_A	0.773	0.85
362_L	460_L	0.770	0.85
547_D	553_Y	0.769	0.85
356_D	363_N	0.768	0.84
449_G	454_E	0.768	0.84
185_L	468_D	0.768	0.84
211_Q	225_R	0.766	0.84
645_A	672_I	0.766	0.84
190_Q	473_G	0.766	0.84
630_V	633_P	0.764	0.84
207_L	344_L	0.763	0.84
570_L	582_V	0.762	0.84
147_F	150_T	0.762	0.84
388_E	407_F	0.760	0.84
383_F	433_I	0.759	0.84
135_E	138_Q	0.758	0.84
60_F	103_Q	0.756	0.84
97_Y	473_G	0.756	0.84
362_L	443_E	0.756	0.84
208_D	225_R	0.756	0.84
210_V	342_N	0.756	0.84
61_K	151_L	0.755	0.83
128_Y	185_L	0.753	0.83
160_R	467_A	0.753	0.83
636_I	641_D	0.752	0.83
243_A	257_L	0.752	0.83
139_G	371_K	0.751	0.83
598_S	628_A	0.751	0.83
126_S	129_S	0.750	0.83
360_R	363_N	0.749	0.83
615_N	619_K	0.748	0.83
24_Y	28_D	0.747	0.83
190_Q	470_Q	0.747	0.83
341_K	345_E	0.745	0.83
339_A	349_E	0.744	0.83
71_L	85_A	0.743	0.82
233_E	344_L	0.741	0.82
279_L	314_H	0.741	0.82
111_D	114_S	0.740	0.82
310_Q	493_D	0.740	0.82
504_L	533_A	0.739	0.82
188_V	191_A	0.739	0.82
594_L	608_F	0.735	0.82
192_A	461_L	0.735	0.82
190_Q	211_Q	0.733	0.82
389_V	393_I	0.733	0.82
195_L	199_P	0.733	0.82
388_E	392_I	0.732	0.82
449_G	459_N	0.732	0.82
647_T	651_R	0.732	0.82
191_A	206_L	0.731	0.81
66_T	72_G	0.730	0.81
111_D	262_S	0.729	0.81
600_A	679_A	0.727	0.81
67_V	118_M	0.726	0.81
576_L	582_V	0.725	0.81
57_S	124_R	0.725	0.81
535_V	585_M	0.724	0.81
209_I	344_L	0.724	0.81
128_Y	161_L	0.722	0.81
341_K	349_E	0.720	0.80
510_V	570_L	0.719	0.80
95_Y	98_P	0.719	0.80
146_N	150_T	0.719	0.80
392_I	407_F	0.716	0.80
262_S	266_V	0.716	0.80
378_G	409_L	0.714	0.80
239_V	324_S	0.713	0.80
72_G	151_L	0.713	0.80
547_D	580_A	0.712	0.80
69_D	72_G	0.711	0.80
387_D	393_I	0.709	0.79
513_A	517_D	0.708	0.79
389_V	409_L	0.708	0.79
185_L	189_A	0.708	0.79
373_L	377_E	0.708	0.79
204_D	207_L	0.704	0.79
197_D	455_R	0.704	0.79
109_P	257_L	0.704	0.79
418_L	424_H	0.703	0.79
189_A	468_D	0.702	0.79
446_Q	459_N	0.702	0.79
98_P	126_S	0.697	0.78
52_L	61_K	0.695	0.78
263_G	287_D	0.694	0.78
382_A	386_I	0.694	0.78
622_I	630_V	0.693	0.78
379_L	428_L	0.693	0.78
386_I	389_V	0.693	0.78
597_A	632_P	0.693	0.78
71_L	79_D	0.693	0.78
63_S	71_L	0.692	0.78
438_S	445_D	0.691	0.78
542_P	554_A	0.691	0.78
366_L	370_L	0.689	0.77
207_L	210_V	0.689	0.77
592_Q	637_E	0.688	0.77
431_M	434_R	0.688	0.77
33_F	156_M	0.686	0.77
449_G	457_M	0.686	0.77
84_E	88_L	0.684	0.77
54_L	71_L	0.683	0.77
53_G	58_A	0.683	0.77
247_K	308_M	0.681	0.77
392_I	423_R	0.681	0.77
545_F	574_L	0.681	0.77
54_L	61_K	0.681	0.77
135_E	140_T	0.681	0.77
593_K	639_A	0.680	0.77
464_E	467_A	0.680	0.77
385_N	389_V	0.679	0.76
264_A	267_L	0.678	0.76
25_V	174_V	0.678	0.76
65_R	150_T	0.678	0.76
640_S	656_P	0.677	0.76
48_A	70_V	0.677	0.76
382_A	389_V	0.677	0.76
512_S	562_S	0.677	0.76
358_V	361_R	0.677	0.76
20_N	27_M	0.675	0.76
646_I	682_G	0.675	0.76
535_V	543_V	0.675	0.76
502_I	535_V	0.674	0.76
207_L	229_R	0.673	0.76
553_Y	618_G	0.673	0.76
387_D	390_I	0.672	0.76
190_Q	209_I	0.672	0.76
369_V	443_E	0.671	0.76
405_S	408_G	0.671	0.76
65_R	147_F	0.671	0.76
67_V	79_D	0.670	0.76
201_T	348_S	0.670	0.76
391_E	394_R	0.670	0.76
469_A	473_G	0.667	0.75
583_D	596_M	0.667	0.75
245_W	255_S	0.666	0.75
19_L	147_F	0.665	0.75
379_L	382_A	0.665	0.75
146_N	151_L	0.664	0.75
545_F	570_L	0.663	0.75
605_V	657_V	0.662	0.75
28_D	332_I	0.661	0.75
509_W	569_P	0.661	0.75
205_Q	209_I	0.661	0.75
31_L	331_M	0.661	0.75
378_G	410_T	0.660	0.74
501_T	515_G	0.660	0.74
370_L	444_R	0.660	0.74
147_F	238_S	0.660	0.74
90_A	100_V	0.659	0.74
242_R	316_F	0.658	0.74
54_L	124_R	0.656	0.74
348_S	351_L	0.655	0.74
200_K	205_Q	0.655	0.74
241_M	325_Y	0.655	0.74
374_H	412_T	0.654	0.74
63_S	118_M	0.652	0.74
654_M	686_L	0.650	0.73
514_K	517_D	0.650	0.73
554_A	613_A	0.650	0.73
219_A	244_V	0.650	0.73
391_E	406_R	0.649	0.73
453_S	459_N	0.649	0.73
376_L	437_Q	0.648	0.73
278_K	318_T	0.648	0.73
641_D	657_V	0.648	0.73
549_T	629_H	0.648	0.73
496_P	540_N	0.647	0.73
208_D	475_D	0.646	0.73
215_Y	325_Y	0.645	0.73
554_A	612_V	0.645	0.73
469_A	475_D	0.643	0.73
531_F	534_A	0.643	0.73
113_K	263_G	0.643	0.73
118_M	151_L	0.642	0.72
247_K	301_P	0.642	0.72
203_L	343_L	0.641	0.72
397_D	431_M	0.641	0.72
243_A	316_F	0.640	0.72
379_L	420_L	0.640	0.72
591_D	607_T	0.640	0.72
415_E	423_R	0.640	0.72
184_N	473_G	0.639	0.72
90_A	102_G	0.639	0.72
263_G	293_N	0.637	0.72
460_L	463_K	0.637	0.72
89_M	94_S	0.637	0.72
248_E	254_I	0.637	0.72
227_E	231_I	0.636	0.72
131_L	468_D	0.636	0.72
501_T	536_K	0.636	0.72
383_F	426_A	0.635	0.72
500_V	512_S	0.635	0.72
61_K	69_D	0.635	0.72
620_A	623_T	0.634	0.71
674_I	678_E	0.634	0.71
51_E	69_D	0.634	0.71
421_K	426_A	0.633	0.71
170_T	325_Y	0.633	0.71
399_P	418_L	0.632	0.71
248_E	251_A	0.632	0.71
271_A	284_D	0.632	0.71
89_M	181_P	0.631	0.71
552_S	614_R	0.630	0.71
503_V	513_A	0.630	0.71
595_L	683_E	0.630	0.71
34_I	331_M	0.630	0.71
283_D	306_V	0.629	0.71
58_A	124_R	0.628	0.71
156_M	353_F	0.628	0.71
418_L	433_I	0.627	0.71
200_K	344_L	0.626	0.70
194_A	206_L	0.626	0.70
623_T	667_K	0.626	0.70
159_A	350_W	0.625	0.70
369_V	444_R	0.623	0.70
248_E	288_E	0.623	0.70
96_R	477_R	0.623	0.70
144_V	153_E	0.622	0.70
41_V	85_A	0.621	0.70
192_A	457_M	0.620	0.70
614_R	617_A	0.619	0.70
634_V	685_G	0.618	0.70
31_L	169_T	0.618	0.70
380_L	430_E	0.618	0.70
390_I	426_A	0.618	0.70
163_N	166_L	0.618	0.70
397_D	427_K	0.618	0.70
327_I	346_I	0.617	0.69
253_V	296_R	0.616	0.69
221_I	480_L	0.615	0.69
137_G	140_T	0.615	0.69
241_M	259_H	0.615	0.69
50_S	136_L	0.614	0.69
526_K	566_Q	0.614	0.69
57_S	103_Q	0.614	0.69
66_T	70_V	0.614	0.69
191_A	201_T	0.614	0.69
384_L	394_R	0.614	0.69
403_L	408_G	0.613	0.69
218_E	257_L	0.613	0.69
125_L	147_F	0.612	0.69
103_Q	568_E	0.612	0.69
427_K	430_E	0.612	0.69
379_L	416_A	0.611	0.69
97_Y	166_L	0.610	0.69
386_I	390_I	0.610	0.69
355_R	359_R	0.610	0.69
543_V	557_P	0.610	0.69
546_V	630_V	0.610	0.69
601_G	672_I	0.608	0.68
611_L	666_G	0.608	0.68
542_P	556_D	0.608	0.68
254_I	297_L	0.608	0.68
60_F	124_R	0.607	0.68
490_S	559_T	0.607	0.68
80_S	86_M	0.607	0.68
263_G	295_T	0.606	0.68
402_A	414_A	0.606	0.68
48_A	61_K	0.606	0.68
264_A	271_A	0.604	0.68
263_G	289_S	0.602	0.68
509_W	572_G	0.600	0.67
576_L	580_A	0.598	0.67
271_A	285_L	0.598	0.67
649_A	677_A	0.597	0.67
243_A	297_L	0.597	0.67
215_Y	239_V	0.597	0.67
197_D	470_Q	0.597	0.67
28_D	84_E	0.596	0.67
588_E	608_F	0.596	0.67
266_V	321_L	0.595	0.67
247_K	250_G	0.595	0.67
243_A	323_K	0.595	0.67
497_S	541_Q	0.595	0.67
219_A	241_M	0.595	0.67
353_F	357_T	0.595	0.67
369_V	447_L	0.593	0.66
195_L	205_Q	0.593	0.66
646_I	652_M	0.592	0.66
385_N	406_R	0.591	0.66
644_L	654_M	0.589	0.66
54_L	86_M	0.589	0.66
397_D	426_A	0.589	0.66
648_Q	681_R	0.588	0.66
423_R	426_A	0.588	0.66
593_K	607_T	0.586	0.65
381_V	407_F	0.586	0.65
50_S	133_L	0.585	0.65
436_E	440_L	0.585	0.65
335_D	339_A	0.585	0.65
270_I	319_T	0.585	0.65
207_L	211_Q	0.585	0.65
637_E	657_V	0.585	0.65
583_D	624_L	0.584	0.65
202_T	233_E	0.584	0.65
10_L	14_T	0.584	0.65
398_E	423_R	0.584	0.65
384_L	427_K	0.583	0.65
59_K	65_R	0.583	0.65
41_V	84_E	0.583	0.65
15_E	19_L	0.583	0.65
266_V	270_I	0.583	0.65
396_E	399_P	0.582	0.65
84_E	115_F	0.581	0.65
400_K	404_M	0.581	0.65
509_W	567_G	0.580	0.65
52_L	118_M	0.580	0.65
118_M	148_D	0.580	0.65
71_L	118_M	0.579	0.65
453_S	457_M	0.579	0.65
584_H	633_P	0.579	0.65
58_A	61_K	0.578	0.64
191_A	194_A	0.577	0.64
451_L	457_M	0.577	0.64
49_M	100_V	0.575	0.64
50_S	125_L	0.574	0.64
238_S	241_M	0.574	0.64
263_G	267_L	0.573	0.64
222_I	481_Q	0.573	0.64
204_D	208_D	0.573	0.64
546_V	621_L	0.573	0.64
128_Y	131_L	0.571	0.63
135_E	358_V	0.571	0.63
649_A	675_P	0.570	0.63
188_V	346_I	0.567	0.63
555_I	574_L	0.567	0.63
230_K	234_N	0.567	0.63
135_E	361_R	0.567	0.63
673_N	676_S	0.567	0.63
54_L	59_K	0.567	0.63
19_L	81_A	0.566	0.63
118_M	147_F	0.566	0.63
222_I	483_R	0.565	0.63
519_D	522_G	0.565	0.63
483_R	487_K	0.565	0.63
655_F	659_D	0.565	0.63
257_L	264_A	0.565	0.63
179_D	325_Y	0.564	0.63
541_Q	587_M	0.564	0.63
575_T	617_A	0.564	0.63
647_T	674_I	0.564	0.63
524_N	566_Q	0.563	0.62
598_S	630_V	0.562	0.62
81_A	93_F	0.561	0.62
42_Q	82_C	0.560	0.62
280_P	302_R	0.560	0.62
161_L	192_A	0.559	0.62
523_L	531_F	0.559	0.62
436_E	439_E	0.559	0.62
529_D	567_G	0.559	0.62
42_Q	84_E	0.559	0.62
376_L	436_E	0.559	0.62
505_S	529_D	0.558	0.62
186_R	474_D	0.558	0.62
507_M	528_G	0.558	0.62
459_N	462_K	0.558	0.62
349_E	353_F	0.557	0.62
271_A	274_M	0.556	0.61
166_L	186_R	0.556	0.61
365_R	446_Q	0.556	0.61
136_L	143_W	0.556	0.61
407_F	410_T	0.556	0.61
641_D	656_P	0.556	0.61
392_I	395_N	0.556	0.61
274_M	284_D	0.555	0.61
661_P	669_N	0.555	0.61
253_V	297_L	0.555	0.61
634_V	684_D	0.554	0.61
189_A	457_M	0.554	0.61
108_A	291_H	0.553	0.61
48_A	66_T	0.552	0.61
541_Q	589_S	0.552	0.61
594_L	635_V	0.551	0.61
419_E	423_R	0.551	0.61
643_L	657_V	0.551	0.61
495_L	558_I	0.551	0.61
110_D	287_D	0.551	0.61
277_K	280_P	0.550	0.61
205_Q	466_Q	0.550	0.61
18_Y	354_R	0.550	0.61
426_A	431_M	0.550	0.61
535_V	587_M	0.549	0.60
351_L	462_K	0.549	0.60
427_K	431_M	0.549	0.60
643_L	685_G	0.548	0.60
314_H	318_T	0.547	0.60
358_V	460_L	0.547	0.60
335_D	341_K	0.546	0.60
452_A	459_N	0.546	0.60
160_R	464_E	0.545	0.60
279_L	319_T	0.545	0.60
267_L	274_M	0.545	0.60
132_L	157_L	0.544	0.60
597_A	634_V	0.544	0.60
18_Y	328_N	0.544	0.60
498_E	512_S	0.543	0.60
268_E	271_A	0.543	0.60
449_G	455_R	0.542	0.59
400_K	418_L	0.542	0.59
196_I	351_L	0.542	0.59
632_P	645_A	0.542	0.59
636_I	640_S	0.540	0.59
94_S	268_E	0.539	0.59
191_A	347_L	0.539	0.59
383_F	429_E	0.538	0.59
180_I	347_L	0.538	0.59
387_D	391_E	0.538	0.59
586_L	594_L	0.538	0.59
16_N	22_S	0.538	0.59
286_R	296_R	0.537	0.59
52_L	55_N	0.537	0.59
228_I	232_Y	0.537	0.59
446_Q	452_A	0.537	0.59
631_M	634_V	0.536	0.59
38_L	132_L	0.536	0.59
548_S	583_D	0.536	0.59
359_R	454_E	0.536	0.59
60_F	114_S	0.536	0.59
285_L	297_L	0.536	0.59
271_A	275_R	0.536	0.59
420_L	427_K	0.536	0.59
190_Q	475_D	0.535	0.59
503_V	518_I	0.535	0.59
48_A	54_L	0.534	0.58
373_L	440_L	0.534	0.58
197_D	459_N	0.533	0.58
105_N	108_A	0.533	0.58
24_Y	27_M	0.533	0.58
52_L	123_S	0.532	0.58
22_S	66_T	0.531	0.58
631_M	680_A	0.531	0.58
489_M	494_M	0.531	0.58
73_K	150_T	0.531	0.58
10_L	20_N	0.530	0.58
205_Q	455_R	0.529	0.58
28_D	81_A	0.529	0.58
640_S	658_S	0.529	0.58
45_I	95_Y	0.528	0.58
267_L	287_D	0.527	0.57
188_V	675_P	0.527	0.57
455_R	458_N	0.527	0.57
161_L	354_R	0.527	0.57
533_A	585_M	0.526	0.57
430_E	433_I	0.526	0.57
63_S	151_L	0.526	0.57
588_E	591_D	0.526	0.57
260_Q	418_L	0.526	0.57
604_F	666_G	0.526	0.57
57_S	65_R	0.526	0.57
201_T	344_L	0.525	0.57
351_L	458_N	0.525	0.57
231_I	343_L	0.524	0.57
203_L	345_E	0.524	0.57
18_Y	103_Q	0.524	0.57
380_L	438_S	0.524	0.57
270_I	279_L	0.524	0.57
176_M	330_N	0.523	0.57
34_I	474_D	0.523	0.57
497_S	589_S	0.522	0.57
50_S	130_E	0.522	0.57
139_G	152_Q	0.522	0.57
386_I	440_L	0.522	0.57
159_A	354_R	0.521	0.57
311_V	314_H	0.521	0.57
291_H	512_S	0.520	0.56
370_L	373_L	0.519	0.56
385_N	390_I	0.519	0.56
354_R	554_A	0.519	0.56
279_L	321_L	0.519	0.56
180_I	331_M	0.519	0.56
461_L	468_D	0.518	0.56
61_K	118_M	0.518	0.56
19_L	25_V	0.517	0.56
24_Y	332_I	0.517	0.56
292_E	296_R	0.516	0.56
164_I	180_I	0.516	0.56
125_L	130_E	0.516	0.56
645_A	655_F	0.515	0.56
192_A	195_L	0.515	0.56
188_V	192_A	0.514	0.56
243_A	266_V	0.514	0.56
517_D	536_K	0.513	0.55
324_S	327_I	0.513	0.55
127_K	130_E	0.512	0.55
74_Y	136_L	0.511	0.55
596_M	611_L	0.511	0.55
432_K	439_E	0.511	0.55
102_G	106_W	0.511	0.55
217_T	259_H	0.510	0.55
80_S	115_F	0.510	0.55
161_L	350_W	0.509	0.55
54_L	123_S	0.509	0.55
375_I	412_T	0.509	0.55
236_R	328_N	0.509	0.55
285_L	288_E	0.507	0.55
624_L	628_A	0.507	0.55
331_M	341_K	0.507	0.55
189_A	354_R	0.507	0.55
420_L	431_M	0.507	0.55
442_K	463_K	0.507	0.55
261_V	323_K	0.506	0.54
51_E	61_K	0.506	0.54
83_Y	118_M	0.506	0.54
66_T	82_C	0.506	0.54
170_T	260_Q	0.506	0.54
301_P	308_M	0.506	0.54
19_L	269_Q	0.506	0.54
554_A	619_K	0.505	0.54
123_S	126_S	0.505	0.54
331_M	342_N	0.505	0.54
341_K	346_I	0.505	0.54
13_F	24_Y	0.505	0.54
385_N	407_F	0.505	0.54
388_E	395_N	0.505	0.54
649_A	679_A	0.505	0.54
580_A	624_L	0.504	0.54
468_D	471_A	0.503	0.54
545_F	582_V	0.503	0.54
655_F	671_I	0.502	0.54
545_F	666_G	0.501	0.54
627_N	631_M	0.500	0.54
246_K	253_V	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zvuA	2	0.8989	100	0.144	Contact Map
2xkjE	2	0.6396	100	0.243	Contact Map
2inrA	2	0.5824	100	0.255	Contact Map
2xcsB	2	0.629	100	0.257	Contact Map
2novA	2	0.5918	100	0.261	Contact Map
4i3hA	2	0.6343	100	0.265	Contact Map
3ilwA	2	0.5997	100	0.274	Contact Map
4ckkA	2	0.5904	100	0.293	Contact Map
4gfhA	2	0.6011	100	0.334	Contact Map
3l4jA	1	0.5997	100	0.352	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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