GREMLIN Database
PARC - DNA topoisomerase 4 subunit A
UniProt: P0AFI2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10686
Length: 752 (675)
Sequences: 5214 (2596)
Seq/√Len: 99.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_L82_C5.7721.00
370_L448_Q5.5461.00
186_R473_G4.5021.00
197_D462_K4.3851.00
190_Q469_A4.2751.00
194_A201_T4.0981.00
647_T672_I3.6651.00
60_F101_D3.5821.00
194_A209_I3.4671.00
449_G456_K3.3221.00
139_G367_E3.1351.00
449_G453_S3.0571.00
191_A210_V3.0101.00
446_Q456_K2.9881.00
245_W316_F2.9841.00
109_P295_T2.9661.00
195_L347_L2.9491.00
195_L201_T2.8581.00
367_E371_K2.8221.00
599_D629_H2.8181.00
388_E406_R2.8121.00
391_E395_N2.7671.00
144_V155_K2.7111.00
193_I466_Q2.6961.00
202_T205_Q2.6631.00
66_T123_S2.6471.00
446_Q449_G2.6361.00
648_Q679_A2.5721.00
648_Q678_E2.5691.00
142_D360_R2.5651.00
161_L166_L2.5631.00
625_P667_K2.5531.00
65_R73_K2.5471.00
204_D233_E2.5291.00
186_R475_D2.5281.00
56_A130_E2.5181.00
642_M654_M2.4941.00
381_V409_L2.4851.00
506_Q530_S2.4761.00
359_R363_N2.4701.00
206_L343_L2.4621.00
203_L342_N2.4011.00
467_A471_A2.3911.00
246_K255_S2.3881.00
415_E419_E2.3791.00
189_A465_L2.3731.00
639_A657_V2.3271.00
244_V479_P2.3221.00
196_I458_N2.3191.00
245_W252_V2.3151.00
186_R190_Q2.3121.00
186_R469_A2.3111.00
206_L344_L2.2971.00
670_K673_N2.2831.00
371_K412_T2.2511.00
97_Y474_D2.2421.00
194_A198_Q2.2281.00
456_K459_N2.1841.00
101_D124_R2.1681.00
283_D302_R2.1651.00
138_Q365_R2.1551.00
250_G308_M2.1531.00
131_L472_Y2.1501.00
355_R458_N2.1501.00
180_I329_L2.1261.00
597_A645_A2.1171.00
548_S629_H2.1081.00
439_E443_E2.1021.00
254_I299_I2.0981.00
372_R436_E2.0951.00
201_T205_Q2.0861.00
443_E447_L2.0831.00
204_D229_R2.0801.00
448_Q452_A2.0751.00
127_K471_A2.0671.00
63_S86_M2.0581.00
368_K371_K2.0431.00
636_I657_V2.0361.00
663_L666_G2.0341.00
500_V557_P2.0241.00
145_P152_Q2.0231.00
376_L433_I2.0221.00
166_L188_V2.0201.00
188_V210_V1.9941.00
198_Q205_Q1.9871.00
645_A671_I1.9871.00
362_L447_L1.9761.00
400_K415_E1.9631.00
45_I85_A1.9501.00
537_G541_Q1.9441.00
145_P149_G1.9381.00
636_I639_A1.9371.00
435_G439_E1.9321.00
637_E641_D1.9211.00
599_D628_A1.9191.00
245_W312_M1.9111.00
358_V461_L1.9091.00
229_R233_E1.9071.00
240_R322_E1.9071.00
195_L348_S1.9071.00
597_A683_E1.9051.00
355_R454_E1.8961.00
265_R268_E1.8891.00
359_R451_L1.8831.00
34_I349_E1.8761.00
497_S538_K1.8721.00
599_D679_A1.8711.00
203_L233_E1.8601.00
243_A254_I1.8531.00
431_M435_G1.8521.00
344_L348_S1.8431.00
459_N463_K1.8421.00
81_A85_A1.8411.00
373_L437_Q1.8321.00
392_I402_A1.8321.00
342_N345_E1.8101.00
450_I460_L1.8081.00
193_I462_K1.8051.00
339_A345_E1.8041.00
201_T209_I1.8031.00
672_I680_A1.7901.00
334_L341_K1.7901.00
549_T579_G1.7671.00
349_E352_V1.7611.00
457_M460_L1.7351.00
257_L297_L1.7351.00
603_G671_I1.7271.00
363_N367_E1.7241.00
80_S84_E1.7181.00
453_S456_K1.7071.00
61_K65_R1.6941.00
438_S442_K1.6911.00
65_R69_D1.6821.00
142_D155_K1.6791.00
180_I346_I1.6621.00
205_Q208_D1.6541.00
195_L351_L1.6531.00
348_S352_V1.6491.00
192_A351_L1.6491.00
161_L468_D1.6481.00
86_M123_S1.6411.00
203_L344_L1.6411.00
34_I346_I1.6381.00
434_R438_S1.6061.00
381_V385_N1.6041.00
547_D582_V1.5961.00
445_D449_G1.5821.00
212_G228_I1.5741.00
429_E432_K1.5731.00
395_N402_A1.5691.00
602_Y670_K1.5651.00
595_L643_L1.5581.00
240_R324_S1.5291.00
170_T179_D1.5241.00
225_R482_E1.5221.00
365_R447_L1.5091.00
595_L603_G1.5041.00
131_L134_S1.5011.00
642_M656_P1.4921.00
446_Q450_I1.4921.00
48_A69_D1.4911.00
361_R464_E1.4771.00
244_V256_A1.4721.00
335_D352_V1.4631.00
329_L346_I1.4371.00
443_E446_Q1.4371.00
389_V403_L1.4301.00
226_A230_K1.4201.00
65_R151_L1.4201.00
230_K233_E1.4191.00
89_M95_Y1.4191.00
377_E441_E1.4101.00
65_R72_G1.4081.00
282_V299_I1.4071.00
507_M526_K1.3921.00
198_Q201_T1.3911.00
192_A347_L1.3911.00
320_D323_K1.3860.99
498_E539_S1.3810.99
334_L349_E1.3760.99
87_V115_F1.3670.99
380_L437_Q1.3600.99
366_L444_R1.3580.99
288_E298_V1.3530.99
269_Q272_A1.3500.99
359_R457_M1.3460.99
538_K541_Q1.3450.99
454_E458_N1.3370.99
63_S123_S1.3370.99
437_Q441_E1.3360.99
345_E348_S1.3220.99
401_P405_S1.3170.99
474_D477_R1.3170.99
418_L423_R1.3160.99
133_L157_L1.3160.99
65_R118_M1.3130.99
595_L660_L1.3120.99
593_K662_Q1.3110.99
442_K446_Q1.3090.99
69_D73_K1.2970.99
445_D448_Q1.2850.99
466_Q470_Q1.2800.99
220_E244_V1.2760.99
549_T577_P1.2760.99
48_A71_L1.2710.99
247_K252_V1.2710.99
462_K466_Q1.2700.99
179_D326_R1.2670.99
645_A680_A1.2670.99
270_I285_L1.2670.99
290_D293_N1.2580.99
506_Q532_K1.2550.99
270_I299_I1.2510.99
449_G452_A1.2480.99
73_K151_L1.2430.99
232_Y327_I1.2410.99
392_I406_R1.2410.99
388_E391_E1.2390.99
96_R474_D1.2380.99
266_V297_L1.2340.99
267_L297_L1.2290.99
554_A614_R1.2290.99
377_E437_Q1.2270.99
238_S324_S1.2220.99
623_T666_G1.2210.99
439_E442_K1.2210.99
288_E296_R1.2160.99
466_Q469_A1.2150.99
597_A680_A1.2120.99
596_M630_V1.2050.99
350_W354_R1.2050.99
355_R457_M1.1990.99
232_Y343_L1.1970.98
400_K411_E1.1970.98
248_E296_R1.1940.98
330_N340_V1.1930.98
380_L434_R1.1900.98
546_V633_P1.1860.98
248_E253_V1.1850.98
9_A12_E1.1850.98
243_A321_L1.1850.98
404_M414_A1.1830.98
463_K466_Q1.1750.98
195_L344_L1.1740.98
47_Y50_S1.1690.98
306_V311_V1.1670.98
139_G363_N1.1650.98
385_N409_L1.1640.98
548_S580_A1.1640.98
220_E481_Q1.1630.98
203_L207_L1.1590.98
194_A205_Q1.1570.98
267_L285_L1.1530.98
442_K445_D1.1520.98
649_A678_E1.1520.98
463_K467_A1.1450.98
18_Y28_D1.1450.98
594_L633_P1.1440.98
375_I416_A1.1440.98
352_V355_R1.1410.98
27_M332_I1.1380.98
59_K124_R1.1350.98
203_L206_L1.1270.98
647_T678_E1.1240.98
225_R228_I1.1160.98
241_M323_K1.1140.98
450_I456_K1.1130.98
245_W254_I1.1130.98
286_R300_V1.1120.98
376_L440_L1.1120.98
11_H15_E1.1090.98
374_H410_T1.1030.97
548_S581_T1.1010.97
380_L433_I1.0990.97
363_N370_L1.0970.97
52_L69_D1.0970.97
430_E434_R1.0920.97
189_A469_A1.0900.97
251_A300_V1.0890.97
593_K605_V1.0880.97
100_V123_S1.0870.97
71_L147_F1.0830.97
605_V662_Q1.0800.97
56_A127_K1.0800.97
644_L652_M1.0760.97
160_R354_R1.0740.97
228_I239_V1.0710.97
247_K312_M1.0700.97
393_I422_L1.0670.97
379_L433_I1.0670.97
497_S539_S1.0620.97
181_P329_L1.0570.97
467_A470_Q1.0540.97
16_N20_N1.0530.97
231_I327_I1.0480.97
544_V552_S1.0450.96
61_K150_T1.0450.96
301_P306_V1.0440.96
139_G360_R1.0440.96
220_E241_M1.0430.96
137_G365_R1.0420.96
219_A243_A1.0390.96
132_L159_A1.0380.96
597_A671_I1.0380.96
386_I394_R1.0370.96
358_V464_E1.0360.96
161_L189_A1.0350.96
595_L636_I1.0330.96
331_M346_I1.0300.96
602_Y667_K1.0300.96
46_V133_L1.0240.96
48_A82_C1.0240.96
399_P426_A1.0230.96
647_T680_A1.0210.96
358_V457_M1.0150.96
373_L444_R1.0140.96
227_E230_K1.0140.96
268_E272_A1.0130.96
600_A627_N1.0060.96
221_I478_S1.0060.96
492_H556_D1.0040.96
128_Y163_N1.0010.95
301_P311_V0.9990.95
54_L66_T0.9980.95
239_V327_I0.9980.95
99_L132_L0.9980.95
70_V82_C0.9980.95
364_Y368_K0.9950.95
396_E402_A0.9890.95
42_Q94_S0.9860.95
373_L441_E0.9830.95
254_I321_L0.9830.95
34_I341_K0.9830.95
606_C610_D0.9810.95
241_M478_S0.9780.95
190_Q193_I0.9780.95
546_V552_S0.9780.95
55_N58_A0.9760.95
207_L233_E0.9740.95
362_L450_I0.9730.95
634_V683_E0.9670.95
166_L185_L0.9640.94
600_A628_A0.9620.94
367_E370_L0.9620.94
269_Q320_D0.9620.94
404_M411_E0.9620.94
537_G557_P0.9610.94
402_A405_S0.9600.94
596_M633_P0.9560.94
225_R229_R0.9540.94
385_N388_E0.9540.94
455_R459_N0.9490.94
438_S441_E0.9490.94
607_T610_D0.9460.94
456_K460_L0.9450.94
551_R577_P0.9440.94
455_R463_K0.9420.94
383_F430_E0.9400.94
607_T662_Q0.9390.94
334_L339_A0.9380.94
193_I469_A0.9370.94
591_D609_N0.9360.94
606_C611_L0.9280.93
71_L80_S0.9260.93
212_G480_L0.9250.93
182_P216_P0.9240.93
224_S227_E0.9220.93
189_A192_A0.9220.93
52_L65_R0.9200.93
545_F585_M0.9190.93
48_A74_Y0.9120.93
290_D295_T0.9110.93
192_A465_L0.9110.93
637_E640_S0.9060.92
596_M621_L0.9050.92
525_Y531_F0.9050.92
97_Y128_Y0.9030.92
194_A208_D0.9020.92
398_E401_P0.8980.92
125_L129_S0.8940.92
220_E479_P0.8930.92
52_L66_T0.8930.92
372_R376_L0.8910.92
365_R443_E0.8890.92
435_G438_S0.8880.92
611_L621_L0.8870.92
663_L667_K0.8870.92
459_N470_Q0.8860.92
69_D147_F0.8860.92
411_E415_E0.8840.91
416_A420_L0.8820.91
581_T629_H0.8820.91
242_R322_E0.8820.91
198_Q202_T0.8810.91
602_Y625_P0.8800.91
238_S326_R0.8770.91
261_V266_V0.8760.91
347_L351_L0.8750.91
502_I557_P0.8740.91
210_V343_L0.8710.91
549_T580_A0.8710.91
387_D394_R0.8700.91
164_I331_M0.8700.91
13_F17_A0.8680.91
641_D687_A0.8670.91
52_L147_F0.8660.91
226_A229_R0.8630.90
221_I241_M0.8630.90
592_Q635_V0.8610.90
224_S228_I0.8580.90
253_V298_V0.8580.90
384_L430_E0.8550.90
218_E244_V0.8550.90
539_S557_P0.8540.90
61_K73_K0.8540.90
420_L424_H0.8530.90
655_F660_L0.8510.90
446_Q453_S0.8510.90
446_Q460_L0.8500.90
193_I197_D0.8470.90
198_Q209_I0.8440.89
59_K150_T0.8420.89
197_D466_Q0.8400.89
134_S354_R0.8390.89
632_P683_E0.8370.89
500_V539_S0.8330.89
285_L299_I0.8330.89
446_Q463_K0.8320.89
57_S130_E0.8310.89
366_L448_Q0.8310.89
221_I239_V0.8300.89
265_R269_Q0.8290.89
164_I346_I0.8270.88
186_R470_Q0.8260.88
651_R675_P0.8260.88
201_T351_L0.8260.88
51_E74_Y0.8240.88
110_D263_G0.8220.88
99_L163_N0.8210.88
468_D472_Y0.8210.88
498_E514_K0.8210.88
250_G301_P0.8200.88
381_V408_G0.8200.88
499_P538_K0.8180.88
55_N130_E0.8180.88
23_M27_M0.8170.88
202_T344_L0.8170.88
389_V407_F0.8160.88
66_T71_L0.8160.88
452_A456_K0.8150.88
421_K424_H0.8130.88
537_G587_M0.8120.88
166_L189_A0.8110.87
190_Q466_Q0.8100.87
97_Y475_D0.8080.87
608_F635_V0.8080.87
47_Y51_E0.8030.87
267_L271_A0.8020.87
192_A350_W0.8020.87
228_I231_I0.8020.87
134_S160_R0.7990.87
160_R468_D0.7980.87
497_S540_N0.7980.87
441_E445_D0.7970.87
203_L209_I0.7970.87
598_S622_I0.7960.86
196_I462_K0.7950.86
272_A276_N0.7930.86
252_V312_M0.7930.86
502_I560_L0.7930.86
432_K435_G0.7930.86
390_I394_R0.7920.86
35_G156_M0.7920.86
312_M316_F0.7910.86
28_D169_T0.7890.86
504_L585_M0.7890.86
595_L671_I0.7880.86
362_L451_L0.7880.86
597_A603_G0.7850.86
328_N340_V0.7840.86
52_L73_K0.7840.86
611_L663_L0.7820.86
504_L535_V0.7820.86
385_N392_I0.7820.86
390_I393_I0.7810.85
450_I457_M0.7780.85
377_E410_T0.7760.85
245_W308_M0.7750.85
48_A52_L0.7740.85
392_I414_A0.7730.85
362_L460_L0.7700.85
547_D553_Y0.7690.85
356_D363_N0.7680.84
449_G454_E0.7680.84
185_L468_D0.7680.84
211_Q225_R0.7660.84
645_A672_I0.7660.84
190_Q473_G0.7660.84
630_V633_P0.7640.84
207_L344_L0.7630.84
570_L582_V0.7620.84
147_F150_T0.7620.84
388_E407_F0.7600.84
383_F433_I0.7590.84
135_E138_Q0.7580.84
60_F103_Q0.7560.84
97_Y473_G0.7560.84
362_L443_E0.7560.84
208_D225_R0.7560.84
210_V342_N0.7560.84
61_K151_L0.7550.83
128_Y185_L0.7530.83
160_R467_A0.7530.83
636_I641_D0.7520.83
243_A257_L0.7520.83
139_G371_K0.7510.83
598_S628_A0.7510.83
126_S129_S0.7500.83
360_R363_N0.7490.83
615_N619_K0.7480.83
24_Y28_D0.7470.83
190_Q470_Q0.7470.83
341_K345_E0.7450.83
339_A349_E0.7440.83
71_L85_A0.7430.82
233_E344_L0.7410.82
279_L314_H0.7410.82
111_D114_S0.7400.82
310_Q493_D0.7400.82
504_L533_A0.7390.82
188_V191_A0.7390.82
594_L608_F0.7350.82
192_A461_L0.7350.82
190_Q211_Q0.7330.82
389_V393_I0.7330.82
195_L199_P0.7330.82
388_E392_I0.7320.82
449_G459_N0.7320.82
647_T651_R0.7320.82
191_A206_L0.7310.81
66_T72_G0.7300.81
111_D262_S0.7290.81
600_A679_A0.7270.81
67_V118_M0.7260.81
576_L582_V0.7250.81
57_S124_R0.7250.81
535_V585_M0.7240.81
209_I344_L0.7240.81
128_Y161_L0.7220.81
341_K349_E0.7200.80
510_V570_L0.7190.80
95_Y98_P0.7190.80
146_N150_T0.7190.80
392_I407_F0.7160.80
262_S266_V0.7160.80
378_G409_L0.7140.80
239_V324_S0.7130.80
72_G151_L0.7130.80
547_D580_A0.7120.80
69_D72_G0.7110.80
387_D393_I0.7090.79
513_A517_D0.7080.79
389_V409_L0.7080.79
185_L189_A0.7080.79
373_L377_E0.7080.79
204_D207_L0.7040.79
197_D455_R0.7040.79
109_P257_L0.7040.79
418_L424_H0.7030.79
189_A468_D0.7020.79
446_Q459_N0.7020.79
98_P126_S0.6970.78
52_L61_K0.6950.78
263_G287_D0.6940.78
382_A386_I0.6940.78
622_I630_V0.6930.78
379_L428_L0.6930.78
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63_S71_L0.6920.78
438_S445_D0.6910.78
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366_L370_L0.6890.77
207_L210_V0.6890.77
592_Q637_E0.6880.77
431_M434_R0.6880.77
33_F156_M0.6860.77
449_G457_M0.6860.77
84_E88_L0.6840.77
54_L71_L0.6830.77
53_G58_A0.6830.77
247_K308_M0.6810.77
392_I423_R0.6810.77
545_F574_L0.6810.77
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135_E140_T0.6810.77
593_K639_A0.6800.77
464_E467_A0.6800.77
385_N389_V0.6790.76
264_A267_L0.6780.76
25_V174_V0.6780.76
65_R150_T0.6780.76
640_S656_P0.6770.76
48_A70_V0.6770.76
382_A389_V0.6770.76
512_S562_S0.6770.76
358_V361_R0.6770.76
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646_I682_G0.6750.76
535_V543_V0.6750.76
502_I535_V0.6740.76
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553_Y618_G0.6730.76
387_D390_I0.6720.76
190_Q209_I0.6720.76
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67_V79_D0.6700.76
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391_E394_R0.6700.76
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583_D596_M0.6670.75
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605_V657_V0.6620.75
28_D332_I0.6610.75
509_W569_P0.6610.75
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378_G410_T0.6600.74
501_T515_G0.6600.74
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514_K517_D0.6500.73
554_A613_A0.6500.73
219_A244_V0.6500.73
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453_S459_N0.6490.73
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634_V685_G0.6180.70
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384_L394_R0.6140.69
403_L408_G0.6130.69
218_E257_L0.6130.69
125_L147_F0.6120.69
103_Q568_E0.6120.69
427_K430_E0.6120.69
379_L416_A0.6110.69
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386_I390_I0.6100.69
355_R359_R0.6100.69
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204_D208_D0.5730.64
546_V621_L0.5730.64
128_Y131_L0.5710.63
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555_I574_L0.5670.63
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673_N676_S0.5670.63
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179_D325_Y0.5640.63
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575_T617_A0.5640.63
647_T674_I0.5640.63
524_N566_Q0.5630.62
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81_A93_F0.5610.62
42_Q82_C0.5600.62
280_P302_R0.5600.62
161_L192_A0.5590.62
523_L531_F0.5590.62
436_E439_E0.5590.62
529_D567_G0.5590.62
42_Q84_E0.5590.62
376_L436_E0.5590.62
505_S529_D0.5580.62
186_R474_D0.5580.62
507_M528_G0.5580.62
459_N462_K0.5580.62
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365_R446_Q0.5560.61
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407_F410_T0.5560.61
641_D656_P0.5560.61
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274_M284_D0.5550.61
661_P669_N0.5550.61
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634_V684_D0.5540.61
189_A457_M0.5540.61
108_A291_H0.5530.61
48_A66_T0.5520.61
541_Q589_S0.5520.61
594_L635_V0.5510.61
419_E423_R0.5510.61
643_L657_V0.5510.61
495_L558_I0.5510.61
110_D287_D0.5510.61
277_K280_P0.5500.61
205_Q466_Q0.5500.61
18_Y354_R0.5500.61
426_A431_M0.5500.61
535_V587_M0.5490.60
351_L462_K0.5490.60
427_K431_M0.5490.60
643_L685_G0.5480.60
314_H318_T0.5470.60
358_V460_L0.5470.60
335_D341_K0.5460.60
452_A459_N0.5460.60
160_R464_E0.5450.60
279_L319_T0.5450.60
267_L274_M0.5450.60
132_L157_L0.5440.60
597_A634_V0.5440.60
18_Y328_N0.5440.60
498_E512_S0.5430.60
268_E271_A0.5430.60
449_G455_R0.5420.59
400_K418_L0.5420.59
196_I351_L0.5420.59
632_P645_A0.5420.59
636_I640_S0.5400.59
94_S268_E0.5390.59
191_A347_L0.5390.59
383_F429_E0.5380.59
180_I347_L0.5380.59
387_D391_E0.5380.59
586_L594_L0.5380.59
16_N22_S0.5380.59
286_R296_R0.5370.59
52_L55_N0.5370.59
228_I232_Y0.5370.59
446_Q452_A0.5370.59
631_M634_V0.5360.59
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548_S583_D0.5360.59
359_R454_E0.5360.59
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285_L297_L0.5360.59
271_A275_R0.5360.59
420_L427_K0.5360.59
190_Q475_D0.5350.59
503_V518_I0.5350.59
48_A54_L0.5340.58
373_L440_L0.5340.58
197_D459_N0.5330.58
105_N108_A0.5330.58
24_Y27_M0.5330.58
52_L123_S0.5320.58
22_S66_T0.5310.58
631_M680_A0.5310.58
489_M494_M0.5310.58
73_K150_T0.5310.58
10_L20_N0.5300.58
205_Q455_R0.5290.58
28_D81_A0.5290.58
640_S658_S0.5290.58
45_I95_Y0.5280.58
267_L287_D0.5270.57
188_V675_P0.5270.57
455_R458_N0.5270.57
161_L354_R0.5270.57
533_A585_M0.5260.57
430_E433_I0.5260.57
63_S151_L0.5260.57
588_E591_D0.5260.57
260_Q418_L0.5260.57
604_F666_G0.5260.57
57_S65_R0.5260.57
201_T344_L0.5250.57
351_L458_N0.5250.57
231_I343_L0.5240.57
203_L345_E0.5240.57
18_Y103_Q0.5240.57
380_L438_S0.5240.57
270_I279_L0.5240.57
176_M330_N0.5230.57
34_I474_D0.5230.57
497_S589_S0.5220.57
50_S130_E0.5220.57
139_G152_Q0.5220.57
386_I440_L0.5220.57
159_A354_R0.5210.57
311_V314_H0.5210.57
291_H512_S0.5200.56
370_L373_L0.5190.56
385_N390_I0.5190.56
354_R554_A0.5190.56
279_L321_L0.5190.56
180_I331_M0.5190.56
461_L468_D0.5180.56
61_K118_M0.5180.56
19_L25_V0.5170.56
24_Y332_I0.5170.56
292_E296_R0.5160.56
164_I180_I0.5160.56
125_L130_E0.5160.56
645_A655_F0.5150.56
192_A195_L0.5150.56
188_V192_A0.5140.56
243_A266_V0.5140.56
517_D536_K0.5130.55
324_S327_I0.5130.55
127_K130_E0.5120.55
74_Y136_L0.5110.55
596_M611_L0.5110.55
432_K439_E0.5110.55
102_G106_W0.5110.55
217_T259_H0.5100.55
80_S115_F0.5100.55
161_L350_W0.5090.55
54_L123_S0.5090.55
375_I412_T0.5090.55
236_R328_N0.5090.55
285_L288_E0.5070.55
624_L628_A0.5070.55
331_M341_K0.5070.55
189_A354_R0.5070.55
420_L431_M0.5070.55
442_K463_K0.5070.55
261_V323_K0.5060.54
51_E61_K0.5060.54
83_Y118_M0.5060.54
66_T82_C0.5060.54
170_T260_Q0.5060.54
301_P308_M0.5060.54
19_L269_Q0.5060.54
554_A619_K0.5050.54
123_S126_S0.5050.54
331_M342_N0.5050.54
341_K346_I0.5050.54
13_F24_Y0.5050.54
385_N407_F0.5050.54
388_E395_N0.5050.54
649_A679_A0.5050.54
580_A624_L0.5040.54
468_D471_A0.5030.54
545_F582_V0.5030.54
655_F671_I0.5020.54
545_F666_G0.5010.54
627_N631_M0.5000.54
246_K253_V0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zvuA 2 0.8989 100 0.144 Contact Map
2xkjE 2 0.6396 100 0.243 Contact Map
2inrA 2 0.5824 100 0.255 Contact Map
2xcsB 2 0.629 100 0.257 Contact Map
2novA 2 0.5918 100 0.261 Contact Map
4i3hA 2 0.6343 100 0.265 Contact Map
3ilwA 2 0.5997 100 0.274 Contact Map
4ckkA 2 0.5904 100 0.293 Contact Map
4gfhA 2 0.6011 100 0.334 Contact Map
3l4jA 1 0.5997 100 0.352 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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