GREMLIN Database
OSMY - Osmotically-inducible protein Y
UniProt: P0AFH8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11391
Length: 201 (181)
Sequences: 953 (663)
Seq/√Len: 49.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_T161_T5.4581.00
63_V106_A4.4841.00
81_K90_S3.4311.00
22_A25_S3.2231.00
60_T82_T2.9311.00
182_E186_K2.8971.00
137_A141_E2.6321.00
138_T161_T2.5271.00
147_L154_S2.4091.00
51_G55_D2.3811.00
93_V119_L2.2811.00
89_L102_A2.2141.00
182_E196_N2.1771.00
101_E104_K2.1251.00
172_V198_L2.1181.00
77_D127_G2.1141.00
175_Q179_D2.0851.00
59_I87_V2.0501.00
157_V172_V2.0481.00
120_H167_Q2.0401.00
157_V181_A2.0301.00
103_V117_D1.9290.99
106_A109_V1.9180.99
145_K188_V1.8800.99
178_S198_L1.8210.99
81_K158_K1.8180.99
57_S60_T1.7980.99
89_L106_A1.7380.99
178_S182_E1.7280.99
77_D132_Y1.7020.98
142_I185_A1.6630.98
59_I82_T1.6610.98
127_G132_Y1.6590.98
87_V112_V1.6480.98
149_D184_I1.6420.98
149_D180_R1.6350.98
59_I112_V1.6020.98
131_G134_G1.5260.97
120_H165_V1.4610.96
96_Q100_E1.4240.95
86_V114_S1.4010.95
88_T169_S1.3970.95
183_S186_K1.3790.94
47_M177_Q1.3740.94
152_V180_R1.3650.94
46_S53_F1.3580.94
103_V107_K1.3520.94
43_V50_V1.3490.94
24_G27_Y1.3180.93
57_S82_T1.3160.93
77_D162_T1.3120.93
70_H101_E1.2960.92
152_V157_V1.2960.92
159_V168_L1.2600.91
185_A194_V1.2570.91
92_F163_D1.2520.91
112_V115_V1.2520.91
63_V109_V1.2520.91
107_K114_S1.2450.90
151_I180_R1.2420.90
49_K55_D1.2260.90
67_L102_A1.2240.90
78_I102_A1.2200.90
179_D196_N1.2140.89
141_E145_K1.2040.89
165_V195_K1.2040.89
99_A103_V1.2030.89
88_T167_Q1.1950.89
167_Q195_K1.1840.88
146_L152_V1.1650.87
139_T143_K1.1610.87
106_A115_V1.1600.87
83_D169_S1.1540.87
26_A29_E1.1490.87
137_A140_S1.1460.86
178_S196_N1.1440.86
77_D92_F1.1360.86
63_V87_V1.1340.86
35_T38_S1.1200.85
21_V24_G1.1190.85
183_S187_A1.1070.84
38_S44_D1.0970.84
172_V178_S1.0870.83
92_F131_G1.0790.83
17_L20_A1.0710.82
141_E189_D1.0650.82
96_Q99_A1.0620.82
93_V99_A1.0470.81
92_F127_G1.0380.80
95_S98_Q1.0270.80
140_S144_A1.0240.79
84_Q171_T1.0110.79
95_S121_V0.9990.78
168_L185_A0.9970.78
30_N37_E0.9880.77
104_K107_K0.9840.77
85_K188_V0.9730.76
102_A119_L0.9600.75
89_L119_L0.9500.74
92_F162_T0.9480.74
51_G109_V0.9420.73
38_S41_Q0.9400.73
30_N38_S0.9360.73
18_T21_V0.9350.73
134_G141_E0.9290.72
94_E98_Q0.9260.72
66_A70_H0.9230.72
141_E190_G0.9180.72
85_K111_G0.9150.71
55_D62_K0.9130.71
161_T166_V0.9120.71
30_N40_G0.9090.71
143_K159_V0.9010.70
147_L153_P0.8990.70
78_I89_L0.8990.70
48_N83_D0.8950.70
80_V106_A0.8840.69
103_V121_V0.8740.68
55_D111_G0.8710.67
37_E41_Q0.8580.66
85_K113_T0.8450.65
142_I166_V0.8420.65
182_E194_V0.8380.64
93_V102_A0.8350.64
16_M19_S0.8270.63
84_Q199_K0.8260.63
51_G62_K0.8240.63
36_N39_A0.8150.62
152_V181_A0.8120.62
105_V138_T0.8050.61
81_K160_E0.7970.61
41_Q44_D0.7930.60
134_G164_G0.7810.59
76_T93_V0.7760.58
90_S127_G0.7750.58
70_H73_I0.7670.58
121_V195_K0.7650.57
73_I98_Q0.7610.57
157_V198_L0.7510.56
164_G192_K0.7370.55
136_T161_T0.7370.55
166_V191_V0.7330.54
142_I188_V0.7320.54
16_M20_A0.7320.54
158_K161_T0.7320.54
121_V124_A0.7280.54
25_S29_E0.7280.54
52_N85_K0.7230.53
145_K184_I0.7190.53
55_D58_A0.7110.52
138_T177_Q0.7010.51
117_D134_G0.6980.51
13_L18_T0.6960.50
138_T164_G0.6930.50
99_A119_L0.6910.50
26_A30_N0.6900.50
186_K193_S0.6880.50
168_L181_A0.6860.49
127_G131_G0.6850.49
43_V53_F0.6850.49
152_V177_Q0.6810.49
64_K80_V0.6760.48
145_K187_A0.6700.48
15_V18_T0.6690.48
52_N84_Q0.6690.48
21_V26_A0.6680.48
59_I111_G0.6680.48
15_V19_S0.6680.48
58_A62_K0.6650.47
151_I176_A0.6650.47
40_G46_S0.6640.47
46_S194_V0.6630.47
137_A144_A0.6610.47
168_L198_L0.6580.47
146_L165_V0.6560.46
62_K109_V0.6540.46
19_S179_D0.6540.46
20_A25_S0.6540.46
93_V121_V0.6540.46
67_L95_S0.6510.46
80_V169_S0.6490.46
40_G44_D0.6430.45
110_E159_V0.6410.45
136_T140_S0.6360.44
36_N44_D0.6340.44
79_S162_T0.6310.44
35_T39_A0.6260.43
39_A42_K0.6220.43
14_A21_V0.6220.43
16_M21_V0.6170.42
19_S130_K0.6160.42
139_T158_K0.6150.42
50_V53_F0.6150.42
51_G58_A0.6140.42
29_E90_S0.6110.42
84_Q143_K0.6090.42
133_A144_A0.6070.41
13_L16_M0.6040.41
149_D156_H0.6030.41
183_S188_V0.6030.41
115_V121_V0.6020.41
17_L115_V0.6020.41
95_S129_V0.6000.41
67_L80_V0.6000.41
23_T28_A0.5980.41
15_V128_S0.5960.40
148_A193_S0.5950.40
63_V89_L0.5930.40
123_D128_S0.5900.40
131_G164_G0.5890.40
139_T159_V0.5860.39
86_V116_S0.5850.39
89_L103_V0.5820.39
40_G43_V0.5800.39
88_T118_K0.5780.39
127_G163_D0.5780.39
100_E104_K0.5770.38
138_T141_E0.5760.38
51_G177_Q0.5740.38
154_S188_V0.5730.38
138_T185_A0.5710.38
86_V115_V0.5710.38
12_L95_S0.5710.38
165_V193_S0.5700.38
29_E36_N0.5690.38
19_S121_V0.5680.38
135_D161_T0.5680.38
115_V119_L0.5670.38
40_G65_A0.5660.37
117_D167_Q0.5650.37
191_V194_V0.5600.37
62_K105_V0.5600.37
173_D195_K0.5600.37
60_T64_K0.5580.37
79_S90_S0.5570.37
139_T166_V0.5550.36
61_A65_A0.5550.36
63_V115_V0.5510.36
173_D176_A0.5500.36
167_Q197_D0.5500.36
116_S197_D0.5480.36
138_T166_V0.5460.36
14_A20_A0.5440.35
59_I160_E0.5430.35
78_I94_E0.5420.35
20_A176_A0.5410.35
91_G170_G0.5410.35
36_N130_K0.5410.35
45_S153_P0.5390.35
103_V115_V0.5360.35
122_R163_D0.5350.35
30_N35_T0.5340.34
29_E171_T0.5310.34
136_T139_T0.5250.34
110_E115_V0.5240.34
90_S177_Q0.5240.34
144_A148_A0.5240.34
82_T85_K0.5220.33
41_Q45_S0.5220.33
122_R152_V0.5220.33
39_A66_A0.5210.33
182_E198_L0.5170.33
129_V151_I0.5170.33
43_V122_R0.5170.33
101_E105_V0.5140.33
153_P156_H0.5140.33
120_H163_D0.5130.33
88_T195_K0.5120.32
169_S197_D0.5070.32
63_V82_T0.5060.32
21_V153_P0.5030.32
169_S195_K0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kgsA 1 0.607 99.9 0.614 Contact Map
4alzA 1 0.6219 99.9 0.616 Contact Map
2l26A 1 0.597 98.4 0.83 Contact Map
4qq0A 1 0.8358 95.9 0.888 Contact Map
4wzzA 1 0.6915 62.5 0.932 Contact Map
4yv7A 1 0.6766 52 0.936 Contact Map
4uu4A 1 0.6866 49.7 0.937 Contact Map
4kysA 1 0.6119 49.4 0.937 Contact Map
4r9fA 1 0.6816 34.4 0.942 Contact Map
3tlkA 1 0.7363 27.7 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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