GREMLIN Database
OPPC - Oligopeptide transport system permease protein OppC
UniProt: P0AFH6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10676
Length: 302 (252)
Sequences: 28594 (17933)
Seq/√Len: 1129.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_T214_I2.8121.00
134_D184_R2.6871.00
190_L195_F2.4431.00
204_V208_G2.4331.00
208_G212_R2.4311.00
200_Q206_T2.4211.00
110_A168_F2.3771.00
122_Y137_M2.3741.00
114_V172_G2.3491.00
190_L193_K2.3191.00
103_I242_F2.2941.00
205_S208_G2.2801.00
207_S211_I2.2121.00
194_E197_E2.1381.00
68_D71_M2.1161.00
196_I214_I2.0321.00
196_I209_I2.0261.00
124_S187_T1.9791.00
227_S290_G1.9641.00
129_L133_V1.9221.00
125_L129_L1.9211.00
129_L206_T1.9151.00
92_D95_V1.8951.00
117_V121_L1.8611.00
179_M229_L1.8181.00
63_A66_D1.7981.00
190_L218_V1.7471.00
247_T260_D1.7441.00
195_F217_N1.7411.00
127_G187_T1.7391.00
47_V51_L1.7311.00
87_D91_R1.7261.00
132_K136_V1.7261.00
128_Y206_T1.7231.00
96_R248_Q1.7111.00
53_V101_G1.7001.00
118_V176_W1.6591.00
118_V121_L1.6471.00
94_L98_A1.6401.00
115_A175_S1.6381.00
89_S96_R1.6361.00
84_F274_F1.6301.00
125_L133_V1.6151.00
191_K214_I1.6141.00
106_M110_A1.6021.00
82_H92_D1.6011.00
133_V137_M1.5811.00
186_Q189_S1.5591.00
88_S260_D1.5561.00
93_L274_F1.5461.00
168_F172_G1.5331.00
80_S83_Y1.5331.00
75_A79_E1.5311.00
137_M180_A1.5311.00
261_G271_L1.5271.00
141_L180_A1.5261.00
128_Y210_V1.5231.00
99_I102_R1.5181.00
116_V226_A1.5031.00
39_A292_G1.4801.00
91_R95_V1.4551.00
258_L275_P1.4541.00
189_S193_K1.4441.00
119_G179_M1.4431.00
112_A226_A1.4151.00
123_G127_G1.4011.00
42_S285_C1.3881.00
55_L58_M1.3721.00
139_R142_E1.3581.00
198_A202_G1.3391.00
151_F155_L1.3271.00
184_R188_L1.3201.00
37_R40_V1.3191.00
132_K135_S1.3161.00
71_M74_S1.3151.00
224_V294_R1.3121.00
97_V278_F1.3111.00
158_T163_N1.3111.00
103_I106_M1.3101.00
127_G191_K1.3091.00
122_Y180_A1.3021.00
84_F94_L1.2961.00
165_L169_V1.2941.00
119_G183_V1.2921.00
123_G183_V1.2921.00
126_S137_M1.2871.00
190_L196_I1.2821.00
124_S210_V1.2751.00
156_L170_A1.2681.00
269_P273_L1.2671.00
231_P283_L1.2581.00
293_L296_A1.2541.00
182_I225_Y1.2471.00
190_L214_I1.2331.00
51_L55_L1.2271.00
294_R298_D1.2271.00
172_G176_W1.2261.00
40_V44_I1.2181.00
223_V297_L1.2161.00
49_I280_V1.2141.00
199_A213_H1.2051.00
73_S76_P1.1841.00
107_V237_E1.1761.00
187_T218_V1.1661.00
91_R96_R1.1621.00
199_A204_V1.1541.00
130_G191_K1.1481.00
199_A209_I1.1461.00
144_L177_L1.1231.00
84_F97_V1.1111.00
91_R99_I1.1061.00
124_S215_V1.1051.00
183_V222_V1.0971.00
183_V187_T1.0921.00
208_G211_I1.0891.00
197_E200_Q1.0881.00
135_S139_R1.0851.00
292_G296_A1.0841.00
121_L124_S1.0701.00
46_L281_V1.0641.00
275_P279_L1.0591.00
120_T183_V1.0591.00
140_L144_L1.0561.00
186_Q190_L1.0561.00
153_V170_A1.0551.00
86_T92_D1.0511.00
170_A174_V1.0471.00
176_W180_A1.0421.00
56_A99_I1.0381.00
259_S263_N1.0341.00
261_G272_L1.0321.00
165_L168_F1.0311.00
42_S292_G1.0291.00
202_G213_H1.0261.00
46_L285_C1.0251.00
88_S264_S1.0241.00
44_I48_L1.0201.00
111_A172_G1.0171.00
147_F152_F1.0171.00
93_L271_L1.0131.00
102_R106_M1.0121.00
60_S95_V1.0111.00
72_M76_P1.0081.00
106_M164_I1.0041.00
49_I282_T1.0001.00
41_A44_I0.9981.00
270_W274_F0.9921.00
138_M180_A0.9901.00
163_N166_L0.9881.00
44_I47_V0.9831.00
134_D138_M0.9741.00
130_G192_R0.9741.00
200_Q209_I0.9731.00
97_V274_F0.9671.00
111_A115_A0.9611.00
45_V285_C0.9561.00
199_A202_G0.9541.00
183_V218_V0.9511.00
82_H86_T0.9431.00
159_F163_N0.9421.00
95_V99_I0.9421.00
96_R271_L0.9421.00
230_V286_F0.9421.00
134_D188_L0.9411.00
149_F236_F0.9391.00
248_Q271_L0.9371.00
274_F277_G0.9271.00
133_V136_V0.9261.00
45_V281_V0.9211.00
43_L47_V0.9211.00
220_G294_R0.9141.00
206_T209_I0.9141.00
204_V209_I0.9121.00
123_G187_T0.9121.00
111_A171_I0.9111.00
42_S284_F0.9081.00
136_V140_L0.9061.00
106_M109_V0.9031.00
135_S138_M0.9011.00
74_S79_E0.9001.00
48_L52_F0.8961.00
42_S288_F0.8951.00
171_I236_F0.8931.00
285_C289_I0.8871.00
218_V221_V0.8841.00
141_L177_L0.8801.00
62_F95_V0.8681.00
52_F98_A0.8601.00
120_T222_V0.8601.00
286_F290_G0.8581.00
116_V120_T0.8571.00
225_Y229_L0.8571.00
96_R99_I0.8551.00
86_T90_G0.8511.00
164_I168_F0.8491.00
54_I58_M0.8491.00
43_L289_I0.8451.00
98_A102_R0.8361.00
117_V120_T0.8341.00
211_I214_I0.8321.00
185_G188_L0.8271.00
160_F166_L0.8271.00
161_G166_L0.8221.00
116_V121_L0.8171.00
111_A233_M0.8151.00
121_L125_L0.8091.00
223_V290_G0.8061.00
122_Y176_W0.8051.00
273_L277_G0.8041.00
127_G188_L0.8031.00
101_G282_T0.8031.00
58_M269_P0.7981.00
206_T210_V0.7971.00
260_D263_N0.7961.00
95_V98_A0.7941.00
187_T191_K0.7931.00
169_V172_G0.7921.00
131_G135_S0.7911.00
149_F153_V0.7911.00
76_P79_E0.7901.00
259_S262_A0.7891.00
166_L169_V0.7841.00
193_K197_E0.7841.00
110_A242_F0.7831.00
52_F101_G0.7791.00
38_A42_S0.7781.00
116_V179_M0.7781.00
131_G134_D0.7751.00
190_L217_N0.7711.00
110_A113_L0.7681.00
197_E201_V0.7681.00
295_D301_D0.7671.00
83_Y94_L0.7651.00
114_V168_F0.7631.00
62_F82_H0.7621.00
109_V113_L0.7611.00
156_L166_L0.7611.00
126_S134_D0.7551.00
55_L59_L0.7521.00
274_F278_F0.7521.00
186_Q221_V0.7511.00
104_S108_G0.7511.00
204_V213_H0.7461.00
260_D264_S0.7441.00
100_G248_Q0.7391.00
145_N177_L0.7381.00
39_A43_L0.7371.00
238_S247_T0.7311.00
65_D69_W0.7291.00
70_A74_S0.7281.00
207_S210_V0.7251.00
62_F81_G0.7191.00
87_D268_S0.7181.00
183_V186_Q0.7181.00
118_V172_G0.7171.00
281_V285_C0.7161.00
209_I214_I0.7131.00
61_Q95_V0.7121.00
279_L283_L0.7101.00
175_S178_D0.7011.00
235_L238_S0.6941.00
98_A101_G0.6901.00
49_I281_V0.6901.00
289_I293_L0.6761.00
294_R301_D0.6731.00
39_A288_F0.6721.00
79_E83_Y0.6711.00
231_P286_F0.6711.00
50_A277_G0.6651.00
167_I237_E0.6641.00
42_S45_V0.6631.00
272_L276_A0.6601.00
149_F152_F0.6591.00
83_Y92_D0.6591.00
115_A172_G0.6561.00
273_L276_A0.6551.00
40_V43_L0.6481.00
186_Q218_V0.6471.00
130_G134_D0.6461.00
136_V139_R0.6441.00
227_S286_F0.6441.00
283_L287_N0.6421.00
119_G123_G0.6411.00
41_A45_V0.6411.00
69_W72_M0.6391.00
118_V122_Y0.6361.00
174_V177_L0.6351.00
57_P102_R0.6351.00
46_L286_F0.6351.00
128_Y191_K0.6331.00
236_F239_F0.6311.00
68_D82_H0.6251.00
70_A73_S0.6211.00
112_A229_L0.6201.00
179_M183_V0.6181.00
188_L191_K0.6161.00
71_M82_H0.6151.00
113_L117_V0.6141.00
129_L210_V0.6141.00
152_F174_V0.6131.00
97_V275_P0.6121.00
60_S99_I0.6121.00
68_D72_M0.6111.00
45_V49_I0.6071.00
237_E241_S0.6071.00
112_A230_V0.6061.00
137_M141_L0.6051.00
37_R41_A0.6051.00
224_V227_S0.6051.00
74_S81_G0.6031.00
138_M141_L0.5991.00
179_M225_Y0.5991.00
53_V276_A0.5961.00
108_G233_M0.5951.00
127_G134_D0.5941.00
204_V207_S0.5941.00
178_D229_L0.5941.00
105_L109_V0.5931.00
126_S138_M0.5921.00
130_G188_L0.5921.00
52_F56_A0.5901.00
141_L176_W0.5901.00
144_L176_W0.5881.00
233_M236_F0.5851.00
139_R143_I0.5841.00
110_A165_L0.5811.00
128_Y211_I0.5781.00
238_S259_S0.5771.00
56_A59_L0.5761.00
102_R105_L0.5741.00
235_L239_F0.5741.00
173_M176_W0.5731.00
61_Q94_L0.5681.00
234_I238_S0.5671.00
155_L159_F0.5651.00
62_F267_V0.5641.00
264_S271_L0.5641.00
101_G105_L0.5621.00
57_P99_I0.5591.00
166_L170_A0.5591.00
211_I216_P0.5571.00
66_D70_A0.5541.00
116_V222_V0.5531.00
72_M75_A0.5511.00
112_A116_V0.5481.00
96_R100_G0.5461.00
205_S209_I0.5431.00
126_S184_R0.5411.00
76_P81_G0.5401.00
288_F292_G0.5401.00
108_G230_V0.5401.00
196_I200_Q0.5361.00
142_E145_N0.5291.00
119_G180_A0.5291.00
229_L233_M0.5271.00
219_L223_V0.5251.00
175_S229_L0.5251.00
172_G175_S0.5251.00
182_I186_Q0.5241.00
291_D294_R0.5231.00
258_L279_L0.5191.00
157_V161_G0.5181.00
122_Y125_L0.5181.00
76_P80_S0.5181.00
107_V167_I0.5151.00
38_A41_A0.5151.00
270_W273_L0.5151.00
238_S260_D0.5141.00
138_M142_E0.5121.00
46_L289_I0.5111.00
192_R197_E0.5101.00
49_I53_V0.5081.00
169_V173_M0.5071.00
38_A288_F0.5061.00
50_A53_V0.5041.00
277_G280_V0.5011.00
149_F173_M0.5011.00
107_V168_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.8377 99.9 0.62 Contact Map
3d31C 2 0.7616 99.9 0.643 Contact Map
3tuiA 2 0.6689 99.9 0.656 Contact Map
2onkC 2 0.7848 99.9 0.66 Contact Map
3rlfF 1 0.9139 99.9 0.679 Contact Map
4tquN 1 0.8742 99.8 0.68 Contact Map
3rlfG 1 0.8411 99.8 0.686 Contact Map
4ymuD 2 0.6921 99.8 0.689 Contact Map
3j9pD 4 0.7351 47.1 0.945 Contact Map
2kogA 1 0.1887 35.2 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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