GREMLIN Database
OPPB - Oligopeptide transport system permease protein OppB
UniProt: P0AFH2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10675
Length: 306 (279)
Sequences: 22420 (14847)
Seq/√Len: 888.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_R62_Q3.2071.00
57_D65_S3.1481.00
57_D61_T3.0941.00
197_M224_A2.7621.00
64_F68_K2.7421.00
68_K72_H2.6411.00
20_I63_Y2.5811.00
51_A56_N2.4941.00
43_P47_A2.4731.00
103_A178_M2.4301.00
210_R216_M2.4281.00
96_V256_L2.3961.00
218_R222_R2.3481.00
115_A131_V2.3371.00
200_V205_F2.3201.00
261_Q265_N2.3031.00
200_V203_S2.2161.00
21_T63_Y2.1871.00
206_I224_A2.1861.00
128_D194_R2.1671.00
215_P218_R2.1281.00
217_R221_L2.1091.00
89_L262_L2.0861.00
237_G293_V2.0261.00
214_L218_R1.9951.00
60_M64_F1.9821.00
107_L182_S1.9771.00
85_S88_D1.9741.00
33_S50_E1.9511.00
45_V48_N1.9451.00
110_I114_S1.8701.00
201_L224_A1.8381.00
46_M50_E1.8331.00
42_P45_V1.8201.00
118_I122_K1.8011.00
126_K130_T1.7981.00
206_I219_I1.7881.00
122_K125_T1.7711.00
48_N52_K1.7641.00
61_T65_S1.7501.00
19_L283_G1.7291.00
204_N207_R1.7131.00
87_N91_A1.6871.00
122_K127_W1.6801.00
120_A197_M1.6781.00
86_V277_S1.6691.00
117_V197_M1.6671.00
84_Y88_D1.6361.00
47_A50_E1.6021.00
65_S68_K1.5871.00
200_V228_A1.5861.00
47_A51_A1.5821.00
118_I127_W1.5741.00
122_K216_M1.5671.00
69_Q74_D1.5671.00
189_I239_A1.5641.00
111_L114_S1.5421.00
127_W131_V1.5411.00
205_F227_P1.5351.00
178_M182_S1.5071.00
111_L186_I1.4841.00
121_L220_I1.4821.00
121_L216_M1.4791.00
108_A185_Y1.4761.00
208_T212_K1.4751.00
263_F278_L1.4631.00
200_V224_A1.4591.00
233_L300_I1.4551.00
99_K103_A1.4431.00
234_S297_Y1.4311.00
109_V236_M1.4311.00
266_G274_L1.4221.00
92_S95_P1.4151.00
54_H57_D1.4151.00
296_L299_V1.4071.00
145_V149_L1.4031.00
71_A74_D1.4001.00
75_F277_S1.3751.00
170_A173_F1.3721.00
96_V99_K1.3691.00
200_V206_I1.3681.00
84_Y92_S1.3561.00
150_L180_A1.3531.00
65_S69_Q1.3441.00
78_S84_Y1.3411.00
112_G193_T1.3241.00
16_L284_A1.3191.00
131_V190_A1.3041.00
112_G189_I1.3031.00
105_F236_M1.2901.00
33_S36_T1.2881.00
10_L14_P1.2831.00
70_L75_F1.2801.00
124_N128_D1.2791.00
17_F21_T1.2711.00
116_G120_A1.2691.00
57_D60_M1.2671.00
61_T64_F1.2631.00
49_I52_K1.2561.00
99_K170_A1.2551.00
75_F87_N1.2541.00
84_Y89_L1.2521.00
17_F63_Y1.2511.00
12_A287_I1.2421.00
89_L274_L1.2381.00
138_G187_A1.2321.00
194_R198_I1.2261.00
241_V286_T1.2191.00
182_S186_I1.2111.00
58_P61_T1.2091.00
192_I235_Y1.2091.00
135_A190_A1.1961.00
212_K223_H1.1921.00
120_A201_L1.1801.00
49_I53_Y1.1791.00
115_A190_A1.1781.00
295_V299_V1.1731.00
262_L274_L1.1731.00
126_K129_Y1.1641.00
77_P85_S1.1601.00
297_Y301_D1.1401.00
35_F46_M1.1391.00
20_I66_Y1.1241.00
116_G193_T1.1151.00
180_A184_A1.1131.00
175_I179_V1.1131.00
278_L282_V1.1121.00
119_A131_V1.1111.00
272_Y276_L1.1051.00
169_G173_F1.0911.00
141_I146_V1.0901.00
117_V220_I1.0791.00
193_T232_V1.0761.00
88_D92_S1.0751.00
48_N51_A1.0731.00
80_K269_N1.0711.00
197_M228_A1.0641.00
169_G172_K1.0601.00
99_K174_M1.0561.00
193_T197_M1.0551.00
54_H65_S1.0531.00
230_L297_Y1.0391.00
264_V268_L1.0381.00
25_F28_R1.0341.00
209_A214_L1.0301.00
69_Q72_H1.0301.00
36_T46_M1.0241.00
209_A219_I1.0241.00
104_A182_S1.0231.00
21_T25_F1.0061.00
199_E203_S1.0021.00
114_S117_V0.9981.00
18_I22_I0.9931.00
209_A223_H0.9921.00
89_L92_S0.9921.00
134_L138_G0.9861.00
147_A180_A0.9771.00
196_S199_E0.9601.00
14_P17_F0.9581.00
91_A95_P0.9561.00
289_F293_V0.9531.00
171_L175_I0.9451.00
79_F265_N0.9421.00
265_N269_N0.9401.00
17_F67_L0.9371.00
218_R221_L0.9331.00
150_L176_L0.9311.00
104_A108_A0.9221.00
37_G41_L0.9131.00
77_P83_D0.9121.00
93_S262_L0.9061.00
132_M190_A0.9021.00
210_R219_I0.9021.00
88_D91_A0.9011.00
240_F289_F0.8971.00
113_V193_T0.8951.00
117_V225_L0.8951.00
216_M219_I0.8881.00
104_A181_L0.8881.00
16_L287_I0.8881.00
128_D198_I0.8841.00
120_A198_I0.8831.00
196_S200_V0.8811.00
143_S250_I0.8791.00
186_I190_A0.8791.00
174_M178_M0.8701.00
86_V274_L0.8701.00
51_A57_D0.8671.00
44_E48_N0.8661.00
265_N268_L0.8591.00
28_R59_I0.8571.00
99_K102_A0.8541.00
129_Y132_M0.8531.00
228_A231_P0.8501.00
214_L219_I0.8491.00
12_A291_A0.8491.00
298_A304_I0.8471.00
233_L293_V0.8461.00
9_C291_A0.8451.00
179_V182_S0.8421.00
133_G136_M0.8381.00
73_G85_S0.8381.00
107_L178_M0.8371.00
124_N129_Y0.8361.00
37_G49_I0.8361.00
109_V114_S0.8341.00
112_G116_G0.8321.00
38_E41_L0.8291.00
193_T228_A0.8291.00
130_T134_L0.8271.00
149_L153_I0.8251.00
288_L292_I0.8221.00
129_Y133_G0.8171.00
78_S271_D0.8151.00
86_V262_L0.8141.00
207_R210_R0.8111.00
44_E47_A0.8101.00
116_G197_M0.8071.00
9_C13_I0.8041.00
102_A106_F0.7971.00
91_A94_F0.7911.00
241_V289_F0.7881.00
154_F176_L0.7881.00
263_F266_G0.7861.00
114_S118_I0.7841.00
292_I296_L0.7831.00
20_I280_I0.7821.00
172_K176_L0.7821.00
284_A288_L0.7821.00
127_W130_T0.7801.00
100_L251_E0.7771.00
90_V277_S0.7761.00
67_L70_L0.7741.00
70_L280_I0.7681.00
64_F67_L0.7661.00
152_M156_I0.7641.00
262_L278_L0.7641.00
221_L224_A0.7621.00
219_I224_A0.7621.00
97_S101_G0.7611.00
68_K71_A0.7601.00
41_L46_M0.7581.00
139_V187_A0.7541.00
209_A212_K0.7491.00
295_V298_A0.7481.00
75_F90_V0.7461.00
115_A186_I0.7421.00
109_V189_I0.7361.00
175_I178_M0.7361.00
56_N59_I0.7351.00
103_A256_L0.7351.00
32_G270_R0.7351.00
25_F59_I0.7331.00
43_P46_M0.7321.00
14_P18_I0.7301.00
28_R272_Y0.7301.00
262_L266_G0.7291.00
235_Y239_A0.7281.00
63_Y67_L0.7241.00
185_Y188_S0.7221.00
7_R10_L0.7211.00
297_Y304_I0.7211.00
266_G275_V0.7211.00
196_S228_A0.7141.00
264_V267_A0.7121.00
95_P99_K0.7061.00
113_V232_V0.7051.00
173_F176_L0.7051.00
276_L280_I0.7011.00
216_M220_I0.7001.00
135_A187_A0.6991.00
105_F240_F0.6971.00
23_S94_F0.6971.00
143_S147_A0.6941.00
282_V286_T0.6931.00
111_L115_A0.6881.00
108_A182_S0.6881.00
90_V278_L0.6871.00
252_T261_Q0.6861.00
128_D132_M0.6861.00
110_I113_V0.6831.00
207_R211_A0.6811.00
146_V183_L0.6811.00
111_L182_S0.6801.00
276_L279_T0.6751.00
100_L178_M0.6751.00
277_S281_L0.6711.00
147_A253_I0.6701.00
119_A128_D0.6701.00
79_F273_S0.6681.00
90_V281_L0.6681.00
172_K175_I0.6681.00
73_G77_P0.6671.00
247_S250_I0.6651.00
121_L221_L0.6631.00
103_A171_L0.6621.00
171_L174_M0.6621.00
66_Y70_L0.6571.00
32_G35_F0.6571.00
109_V113_V0.6531.00
21_T59_I0.6521.00
13_I17_F0.6511.00
23_S279_T0.6491.00
143_S146_V0.6461.00
25_F29_L0.6451.00
252_T264_V0.6431.00
131_V135_A0.6351.00
237_G289_F0.6351.00
143_S183_L0.6311.00
214_L223_H0.6311.00
217_R220_I0.6291.00
7_R11_E0.6241.00
10_L13_I0.6241.00
95_P98_A0.6231.00
102_A240_F0.6231.00
155_A176_L0.6221.00
112_G190_A0.6211.00
37_G40_T0.6201.00
277_S280_I0.6161.00
68_K73_G0.6151.00
11_E15_T0.6141.00
89_L93_S0.6121.00
103_A175_I0.6111.00
104_A247_S0.6021.00
155_A172_K0.6001.00
176_L180_A0.6001.00
119_A132_M0.5981.00
187_A190_A0.5981.00
193_T196_S0.5981.00
125_T128_D0.5951.00
248_M252_T0.5931.00
263_F282_V0.5921.00
45_V49_I0.5921.00
203_S207_R0.5921.00
94_F98_A0.5901.00
130_T133_G0.5881.00
98_A102_A0.5871.00
188_S235_Y0.5871.00
176_L179_V0.5861.00
67_L71_A0.5861.00
286_T290_N0.5851.00
103_A106_F0.5841.00
15_T287_I0.5841.00
196_S231_P0.5831.00
275_V279_T0.5821.00
94_F285_L0.5811.00
35_F50_E0.5801.00
41_L45_V0.5781.00
35_F49_I0.5781.00
147_A151_V0.5771.00
70_L73_G0.5741.00
19_L285_L0.5741.00
180_A250_I0.5721.00
188_S242_G0.5701.00
133_G137_T0.5691.00
101_G247_S0.5671.00
273_S277_S0.5671.00
31_P34_P0.5661.00
184_A187_A0.5631.00
138_G183_L0.5621.00
132_M135_A0.5601.00
257_P261_Q0.5591.00
193_T225_L0.5591.00
200_V227_P0.5561.00
106_F110_I0.5551.00
61_T68_K0.5541.00
195_G198_I0.5531.00
12_A288_L0.5531.00
27_M31_P0.5501.00
206_I210_R0.5491.00
8_R294_D0.5491.00
23_S27_M0.5471.00
188_S239_A0.5451.00
239_A242_G0.5431.00
185_Y242_G0.5431.00
192_I196_S0.5431.00
27_M30_A0.5421.00
42_P46_M0.5421.00
248_M264_V0.5411.00
197_M201_L0.5381.00
120_A128_D0.5381.00
143_S184_A0.5381.00
13_I18_I0.5351.00
229_L233_L0.5351.00
249_V252_T0.5331.00
189_I193_T0.5331.00
252_T265_N0.5311.00
233_L296_L0.5311.00
11_E27_M0.5301.00
12_A15_T0.5271.00
185_Y239_A0.5271.00
50_E56_N0.5271.00
197_M225_L0.5261.00
181_L250_I0.5251.00
141_I145_V0.5211.00
122_K220_I0.5181.00
11_E14_P0.5161.00
229_L232_V0.5161.00
70_L74_D0.5161.00
182_S185_Y0.5151.00
121_L201_L0.5141.00
125_T130_T0.5131.00
145_V148_P0.5121.00
93_S261_Q0.5101.00
189_I235_Y0.5101.00
214_L217_R0.5091.00
230_L304_I0.5061.00
21_T60_M0.5051.00
183_L186_I0.5051.00
215_P219_I0.5041.00
52_K83_D0.5041.00
188_S192_I0.5041.00
122_K128_D0.5021.00
74_D85_S0.5021.00
101_G105_F0.5011.00
15_T288_L0.5011.00
125_T129_Y0.5001.00
16_L288_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.683 99.9 0.645 Contact Map
4tquM 1 0.8497 99.9 0.655 Contact Map
3rlfF 1 0.8562 99.8 0.679 Contact Map
4ymuD 2 0.6863 99.8 0.69 Contact Map
2onkC 2 0.8137 99.8 0.691 Contact Map
3d31C 2 0.8039 99.8 0.703 Contact Map
4tquN 1 0.8399 99.7 0.72 Contact Map
3rlfG 1 0.8856 99.7 0.729 Contact Map
3j5pB 3 0.2157 7.2 0.961 Contact Map
3dh4A 3 0.2451 4.1 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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