GREMLIN Database
OGT - Methylated-DNA--protein-cysteine methyltransferase
UniProt: P0AFH0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10668
Length: 171 (156)
Sequences: 5683 (4195)
Seq/√Len: 335.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_G150_T3.4231.00
68_E74_L3.3071.00
92_E117_R3.0171.00
161_W165_H2.9191.00
96_T99_T2.6821.00
106_M114_Q2.6611.00
109_G145_R2.5021.00
21_D83_A2.4661.00
160_E164_R2.3011.00
106_M110_Q2.2721.00
10_A15_P2.2371.00
109_G113_E2.0831.00
84_T137_V2.0581.00
106_M111_L2.0491.00
21_D25_R2.0271.00
96_T111_L1.9681.00
96_T114_Q1.9271.00
7_E63_S1.9061.00
86_G94_W1.9011.00
68_E73_N1.8561.00
18_V26_L1.7641.00
65_K77_I1.7571.00
20_C59_P1.7251.00
25_R83_A1.7191.00
110_Q113_E1.6591.00
87_T90_Q1.6561.00
29_V136_V1.6521.00
117_R120_A1.6261.00
8_K15_P1.6091.00
61_G65_K1.5841.00
9_I67_R1.5801.00
95_K98_R1.5361.00
149_M156_V1.5221.00
100_I142_V1.5141.00
90_Q130_S1.4631.00
21_D27_R1.4571.00
97_L128_N1.4411.00
109_G121_A1.4251.00
121_A125_G1.4111.00
151_G156_V1.3981.00
100_I106_M1.3901.00
96_T115_L1.3821.00
134_S154_G1.3721.00
12_P70_F1.3701.00
86_G90_Q1.3671.00
99_T114_Q1.3671.00
65_K80_L1.3551.00
61_G64_D1.3411.00
31_W158_R1.3361.00
93_V111_L1.3321.00
161_W164_R1.3311.00
106_M142_V1.3261.00
164_R167_G1.3071.00
126_A129_G1.2531.00
129_G150_T1.2341.00
62_L136_V1.2271.00
18_V62_L1.2091.00
23_Q83_A1.2041.00
91_R95_K1.1931.00
65_K74_L1.1791.00
11_T16_L1.1441.00
19_I28_A1.1281.00
31_W134_S1.1241.00
126_A150_T1.1221.00
157_Q160_E1.1081.00
95_K99_T1.1051.00
22_E25_R1.0971.00
126_A130_S1.0941.00
113_E118_P1.0811.00
63_S67_R1.0791.00
20_C62_L1.0751.00
84_T91_R1.0711.00
98_R137_V1.0551.00
84_T133_I1.0431.00
19_I27_R1.0271.00
11_T14_G1.0251.00
82_T133_I1.0221.00
65_K75_S1.0201.00
105_V163_L1.0171.00
84_T132_P1.0131.00
33_E158_R1.0121.00
26_L62_L1.0021.00
128_N143_I1.0021.00
64_D68_E1.0011.00
20_C56_A1.0011.00
129_G155_G0.9971.00
13_L161_W0.9921.00
9_I63_S0.9861.00
80_L136_V0.9841.00
125_G129_G0.9721.00
88_P91_R0.9671.00
15_P32_E0.9641.00
150_T156_V0.9601.00
66_L70_F0.9551.00
56_A59_P0.9501.00
67_R71_A0.9471.00
8_K17_W0.9421.00
55_S60_G0.9421.00
90_Q94_W0.9281.00
13_L158_R0.9041.00
115_L124_V0.9011.00
69_Y165_H0.9001.00
16_L29_V0.8961.00
18_V59_P0.8841.00
75_S102_C0.8831.00
158_R161_W0.8821.00
101_P104_Q0.8801.00
13_L16_L0.8761.00
29_V66_L0.8731.00
96_T106_M0.8701.00
115_L120_A0.8681.00
29_V133_I0.8681.00
129_G153_A0.8651.00
65_K78_D0.8631.00
89_F127_A0.8401.00
111_L128_N0.8391.00
7_E59_P0.8281.00
27_R85_G0.8251.00
58_N81_P0.8151.00
26_L136_V0.8091.00
144_G148_T0.8071.00
17_W32_E0.8011.00
88_P92_E0.7991.00
93_V115_L0.7961.00
90_Q126_A0.7851.00
131_N139_C0.7761.00
164_R168_Y0.7751.00
89_F123_A0.7671.00
59_P62_L0.7641.00
92_E95_K0.7571.00
128_N134_S0.7571.00
144_G151_G0.7551.00
58_N62_L0.7440.99
134_S153_A0.7420.99
128_N152_Y0.7380.99
6_E19_I0.7370.99
7_E60_G0.7370.99
58_N61_G0.7300.99
134_S158_R0.7210.99
89_F93_V0.7210.99
149_M160_E0.7190.99
25_R58_N0.7180.99
135_I165_H0.7130.99
9_I16_L0.7110.99
94_W97_L0.7090.99
92_E115_L0.6990.99
18_V29_V0.6980.99
20_C58_N0.6700.99
62_L65_K0.6700.99
85_G91_R0.6660.99
93_V124_V0.6650.99
29_V134_S0.6620.99
120_A123_A0.6590.99
9_I18_V0.6570.99
39_V42_L0.6570.99
50_G54_I0.6560.99
8_K32_E0.6540.99
34_Y38_M0.6520.99
5_L58_N0.6500.99
110_Q114_Q0.6480.99
144_G149_M0.6480.99
25_R82_T0.6400.98
111_L115_L0.6390.98
30_E37_R0.6340.98
30_E134_S0.6310.98
107_H145_R0.6300.98
109_G125_G0.6280.98
30_E34_Y0.6270.98
97_L111_L0.6260.98
28_A134_S0.6260.98
74_L77_I0.6240.98
111_L124_V0.6220.98
67_R70_F0.6200.98
135_I162_L0.6200.98
111_L125_G0.6200.98
17_W30_E0.6120.98
74_L102_C0.6070.98
34_Y37_R0.6040.98
69_Y135_I0.6040.98
37_R41_L0.6030.98
25_R81_P0.5990.98
66_L69_Y0.5960.98
70_F165_H0.5960.98
27_R83_A0.5930.97
20_C23_Q0.5910.97
57_T60_G0.5900.97
62_L80_L0.5850.97
105_V168_Y0.5850.97
82_T98_R0.5800.97
86_G91_R0.5770.97
150_T153_A0.5760.97
5_L22_E0.5750.97
133_I137_V0.5720.97
36_E40_Q0.5710.97
64_D67_R0.5680.97
131_N155_G0.5670.97
102_C165_H0.5670.97
50_G53_R0.5630.97
26_L58_N0.5610.96
106_M128_N0.5580.96
30_E41_L0.5560.96
84_T98_R0.5560.96
36_E130_S0.5550.96
69_Y102_C0.5530.96
111_L114_Q0.5460.96
37_R40_Q0.5460.96
38_M42_L0.5450.96
121_A126_A0.5430.96
107_H110_Q0.5430.96
111_L142_V0.5430.96
65_K68_E0.5420.96
77_I102_C0.5390.96
105_V143_I0.5330.95
133_I136_V0.5310.95
55_S58_N0.5300.95
69_Y77_I0.5290.95
66_L136_V0.5290.95
139_C155_G0.5270.95
66_L135_I0.5260.95
12_P71_A0.5250.95
156_V160_E0.5230.95
69_Y74_L0.5200.95
107_H144_G0.5200.95
84_T94_W0.5190.95
12_P165_H0.5180.95
144_G156_V0.5170.94
150_T159_K0.5160.94
69_Y72_G0.5120.94
5_L55_S0.5100.94
100_I128_N0.5090.94
16_L31_W0.5050.94
31_W152_Y0.5030.94
52_E55_S0.5010.93
35_S39_V0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sfeA 1 0.9649 100 0.15 Contact Map
4bhbA 1 0.924 100 0.166 Contact Map
3l00A 1 0.8655 100 0.177 Contact Map
1eh6A 1 0.9181 100 0.18 Contact Map
1wrjA 1 0.8713 100 0.19 Contact Map
2g7hA 1 0.8655 100 0.299 Contact Map
1mgtA 1 0.924 100 0.318 Contact Map
2kifA 1 0.5029 100 0.402 Contact Map
3gvaA 1 0.5088 100 0.405 Contact Map
3ugoA 1 0.4211 49.4 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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