GREMLIN Database
ODO2 - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
UniProt: P0AFG6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10980
Length: 405 (396)
Sequences: 7907 (4981)
Seq/√Len: 250.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
301_E305_K3.5831.00
27_P59_A3.4471.00
290_L298_K3.4321.00
353_D360_G3.3461.00
58_D78_R3.3251.00
248_R390_T3.2841.00
304_V308_D3.2401.00
63_D66_T3.1071.00
25_K35_E2.9741.00
177_K265_N2.9561.00
178_R260_D2.9211.00
357_A362_V2.6901.00
59_A76_R2.6841.00
305_K315_D2.6781.00
298_K301_E2.6721.00
255_S264_H2.5651.00
125_H150_L2.5521.00
187_R190_E2.5351.00
239_V269_V2.5171.00
207_E354_R2.5151.00
249_Y390_T2.5141.00
128_D131_A2.4911.00
25_K57_L2.4471.00
242_V321_F2.4071.00
32_V54_D2.3951.00
357_A364_I2.3931.00
24_H36_V2.3671.00
5_D76_R2.3131.00
353_D366_P2.2481.00
22_T64_E2.2301.00
208_V370_L2.1861.00
179_V263_Y2.1671.00
61_L76_R2.1421.00
266_Y286_D2.1251.00
5_D73_I2.1241.00
290_L294_D2.0671.00
62_E72_Q2.0661.00
30_A56_I2.0591.00
209_N365_L2.0331.00
201_M373_S2.0241.00
319_G342_Q1.9571.00
358_V363_E1.9511.00
358_V361_Q1.9181.00
247_K288_D1.8881.00
270_S281_T1.8871.00
26_K29_D1.8841.00
22_T39_E1.8801.00
143_R147_E1.8731.00
121_L147_E1.8671.00
57_L75_G1.8641.00
246_L321_F1.8631.00
181_M256_I1.8601.00
243_V267_F1.8421.00
175_S265_N1.8371.00
61_L73_I1.8361.00
242_V391_I1.8091.00
32_V35_E1.8011.00
131_A149_H1.7891.00
222_E226_K1.7791.00
20_V38_V1.7731.00
57_L60_V1.7581.00
239_V287_V1.7521.00
277_R309_G1.7331.00
33_R54_D1.7261.00
178_R262_V1.7091.00
243_V287_V1.7041.00
184_L188_V1.6941.00
120_R124_E1.6861.00
187_R191_R1.6841.00
69_T72_Q1.6731.00
390_T393_E1.6631.00
268_D285_R1.6581.00
239_V271_M1.6541.00
122_L129_A1.6321.00
238_Y348_M1.6281.00
225_E231_R1.6271.00
212_P215_D1.6251.00
194_E198_S1.6241.00
291_G294_D1.6211.00
191_R194_E1.6051.00
251_E263_Y1.6011.00
239_V299_I1.6001.00
254_A263_Y1.5891.00
306_G311_L1.5881.00
284_L298_K1.5741.00
214_M234_F1.5721.00
244_E394_L1.5671.00
177_K263_Y1.5591.00
38_V74_L1.5591.00
271_M299_I1.5551.00
4_V53_A1.5491.00
24_H39_E1.5471.00
286_D289_T1.5251.00
114_L129_A1.5181.00
196_K201_M1.4911.00
355_P362_V1.4831.00
219_Q399_T1.4781.00
62_E68_V1.4641.00
254_A378_L1.4601.00
147_E151_A1.4301.00
199_T338_I1.4291.00
249_Y386_G1.4061.00
251_E383_E1.3921.00
121_L146_V1.3891.00
239_V323_I1.3851.00
336_P347_G1.3821.00
343_S378_L1.3711.00
185_R188_V1.3691.00
389_V393_E1.3651.00
134_G141_L1.3641.00
211_K365_L1.3561.00
39_E48_E1.3511.00
245_A391_I1.3491.00
205_F333_M1.3381.00
299_I303_A1.3301.00
321_F344_A1.3291.00
193_L197_N1.3271.00
257_D260_D1.3221.00
353_D364_I1.3101.00
6_I75_G1.3001.00
127_L132_I1.2921.00
176_E262_V1.2861.00
27_P63_D1.2821.00
176_E265_N1.2811.00
261_V378_L1.2661.00
221_G231_R1.2651.00
354_R367_M1.2651.00
204_T384_S1.2581.00
242_V387_F1.2481.00
121_L125_H1.2451.00
56_I78_R1.2361.00
370_L391_I1.2301.00
190_E194_E1.2291.00
180_P260_D1.2281.00
346_L391_I1.2141.00
178_R257_D1.2121.00
144_E148_K1.2111.00
266_Y288_D1.2111.00
339_N342_Q1.2101.00
7_L73_I1.2051.00
26_K60_V1.2041.00
355_P364_I1.2031.00
218_K222_E1.2001.00
215_D219_Q1.1891.00
209_N358_V1.1871.00
213_I237_F1.1861.00
185_R380_D1.1851.00
36_V48_E1.1831.00
270_S342_Q1.1811.00
240_K244_E1.1721.00
21_A46_V1.1571.00
204_T374_Y1.1551.00
199_T340_P1.1551.00
17_D67_T1.1441.00
125_H147_E1.1341.00
207_E332_L1.1271.00
62_E66_T1.1261.00
256_I378_L1.1241.00
223_A400_R1.1201.00
242_V344_A1.1171.00
211_K215_D1.1161.00
392_K396_E1.1141.00
210_M213_I1.1101.00
203_T373_S1.1061.00
134_G140_R1.1051.00
56_I81_N1.1021.00
215_D218_K1.0941.00
268_D286_D1.0931.00
144_E147_E1.0911.00
186_K259_D1.0861.00
390_T394_L1.0841.00
218_K221_G1.0751.00
203_T335_T1.0731.00
303_A307_R1.0641.00
204_T331_S1.0591.00
257_D262_V1.0591.00
312_T315_D1.0591.00
27_P60_V1.0501.00
274_S386_G1.0481.00
252_V379_I1.0451.00
332_L352_K1.0451.00
351_I366_P1.0411.00
348_M368_M1.0361.00
6_I77_L1.0331.00
210_M368_M1.0321.00
206_N392_K1.0301.00
267_F288_D1.0251.00
127_L150_L1.0201.00
356_M367_M1.0161.00
236_S292_M1.0151.00
211_K366_P1.0131.00
239_V284_L1.0111.00
274_S329_F1.0081.00
53_A77_L1.0011.00
382_R386_G1.0001.00
252_V344_A0.9981.00
136_G145_D0.9961.00
210_M351_I0.9881.00
148_K152_K0.9871.00
170_A173_A0.9861.00
202_L374_Y0.9861.00
244_E247_K0.9851.00
193_L199_T0.9851.00
129_A141_L0.9841.00
8_V18_A0.9801.00
280_V311_L0.9791.00
20_V74_L0.9771.00
27_P58_D0.9741.00
346_L372_L0.9731.00
239_V295_I0.9691.00
122_L127_L0.9651.00
176_E266_Y0.9621.00
248_R394_L0.9591.00
228_H297_K0.9591.00
205_F335_T0.9591.00
301_E304_V0.9571.00
133_K149_H0.9501.00
23_W60_V0.9481.00
112_D141_L0.9471.00
274_S382_R0.9451.00
305_K312_T0.9401.00
31_V51_A0.9401.00
208_V392_K0.9401.00
96_S99_A0.9391.00
321_F346_L0.9361.00
122_L141_L0.9341.00
356_M365_L0.9341.00
26_K64_E0.9341.00
286_D290_L0.9331.00
358_V365_L0.9291.00
268_D283_V0.9281.00
15_V18_A0.9231.00
372_L388_L0.9211.00
186_K190_E0.9201.00
127_L146_V0.9161.00
31_V57_L0.9141.00
321_F387_F0.9131.00
68_V72_Q0.9121.00
214_M366_P0.9111.00
188_V192_L0.9101.00
176_E264_H0.9101.00
114_L122_L0.9091.00
11_L18_A0.9091.00
6_I37_L0.9081.00
220_Y232_L0.9081.00
293_A297_K0.9071.00
20_V62_E0.9061.00
201_M338_I0.8991.00
294_D297_K0.8991.00
244_E401_L0.8981.00
280_V316_L0.8951.00
17_D69_T0.8921.00
353_D359_N0.8911.00
129_A132_I0.8891.00
37_L75_G0.8881.00
19_T67_T0.8871.00
117_A143_R0.8871.00
134_G139_G0.8841.00
376_H381_G0.8841.00
135_T145_D0.8841.00
88_S91_S0.8821.00
196_K200_A0.8821.00
247_K267_F0.8781.00
204_T388_L0.8751.00
242_V346_L0.8721.00
284_L299_I0.8711.00
326_G334_S0.8660.99
58_D76_R0.8590.99
37_L51_A0.8500.99
122_L146_V0.8460.99
270_S319_G0.8420.99
332_L369_Y0.8400.99
122_L132_I0.8400.99
148_K151_A0.8380.99
24_H48_E0.8350.99
360_G364_I0.8340.99
118_I146_V0.8320.99
34_D50_P0.8270.99
284_L290_L0.8260.99
321_F372_L0.8250.99
374_Y384_S0.8210.99
219_Q397_D0.8200.99
135_T139_G0.8150.99
132_I149_H0.8100.99
114_L118_I0.8100.99
40_I49_V0.8030.99
153_A156_K0.8000.99
253_N320_N0.8000.99
183_R186_K0.7980.99
216_L237_F0.7980.99
136_G139_G0.7980.99
60_V66_T0.7960.99
332_L350_A0.7930.99
135_T142_T0.7920.99
60_V63_D0.7920.99
208_V395_L0.7910.99
311_L316_L0.7900.99
118_I143_R0.7880.99
175_S266_Y0.7870.99
94_K97_T0.7860.99
344_A372_L0.7860.99
203_T371_A0.7840.99
90_K93_E0.7790.99
4_V79_E0.7780.99
25_K29_D0.7780.99
204_T349_H0.7780.99
181_M258_G0.7780.99
196_K199_T0.7760.99
196_K337_I0.7750.99
195_A201_M0.7730.99
8_V40_I0.7720.99
30_A54_D0.7710.99
11_L40_I0.7690.99
230_I297_K0.7680.99
19_T65_G0.7660.99
326_G347_G0.7610.99
236_S295_I0.7580.99
238_Y368_M0.7550.99
118_I122_L0.7520.99
134_G145_D0.7520.99
16_A69_T0.7500.99
169_P173_A0.7470.98
207_E352_K0.7470.98
192_L281_T0.7450.98
249_Y383_E0.7440.98
221_G225_E0.7430.98
268_D342_Q0.7430.98
171_L174_R0.7420.98
252_V383_E0.7410.98
285_R314_E0.7400.98
268_D319_G0.7360.98
181_M261_V0.7340.98
184_L275_T0.7330.98
348_M370_L0.7310.98
238_Y395_L0.7300.98
333_M369_Y0.7270.98
210_M395_L0.7250.98
121_L127_L0.7230.98
273_V307_R0.7230.98
244_E248_R0.7230.98
184_L277_R0.7220.98
206_N331_S0.7220.98
246_L267_F0.7220.98
169_P174_R0.7210.98
205_F371_A0.7160.98
154_P157_E0.7160.98
196_K203_T0.7130.98
344_A379_I0.7130.98
242_V245_A0.7130.98
21_A65_G0.7130.98
232_L237_F0.7110.98
294_D298_K0.7100.98
33_R51_A0.7080.98
146_V149_H0.7060.98
191_R339_N0.7060.98
223_A227_R0.7060.98
179_V251_E0.7060.98
10_D13_E0.7050.98
122_L128_D0.7040.98
275_T280_V0.7040.98
305_K310_K0.7030.98
196_K373_S0.7000.98
313_V317_T0.6980.98
234_F351_I0.6970.98
222_E225_E0.6970.98
121_L143_R0.6960.98
314_E317_T0.6960.98
232_L236_S0.6940.98
322_T342_Q0.6910.97
353_D357_A0.6910.97
223_A226_K0.6900.97
290_L301_E0.6880.97
300_K304_V0.6860.97
301_E315_D0.6860.97
387_F391_I0.6850.97
210_M366_P0.6840.97
252_V387_F0.6840.97
195_A340_P0.6810.97
283_V319_G0.6810.97
189_A256_I0.6810.97
207_E367_M0.6810.97
169_P172_A0.6790.97
252_V343_S0.6760.97
114_L141_L0.6760.97
319_G339_N0.6750.97
245_A390_T0.6750.97
31_V77_L0.6750.97
397_D400_R0.6750.97
24_H27_P0.6740.97
170_A174_R0.6740.97
251_E254_A0.6730.97
207_E369_Y0.6730.97
56_I80_G0.6720.97
163_A166_A0.6680.97
246_L252_V0.6650.97
225_E228_H0.6640.97
193_L196_K0.6640.97
212_P399_T0.6630.97
220_Y223_A0.6620.97
246_L387_F0.6620.97
238_Y323_I0.6590.97
30_A80_G0.6590.97
370_L388_L0.6580.97
4_V7_L0.6580.97
204_T326_G0.6570.97
112_D130_S0.6560.97
305_K311_L0.6560.97
283_V318_G0.6560.97
5_D61_L0.6550.97
118_I141_L0.6550.97
372_L384_S0.6550.97
150_L153_A0.6540.97
93_E96_S0.6540.97
51_A54_D0.6510.96
51_A77_L0.6480.96
398_P401_L0.6470.96
89_A93_E0.6470.96
27_P76_R0.6460.96
151_A154_P0.6460.96
157_E160_P0.6460.96
112_D129_A0.6430.96
235_M328_V0.6400.96
93_E97_T0.6390.96
58_D80_G0.6390.96
95_A99_A0.6370.96
319_G340_P0.6340.96
326_G331_S0.6340.96
147_E150_L0.6330.96
116_P119_R0.6330.96
11_L49_V0.6320.96
8_V68_V0.6320.96
226_K229_G0.6310.96
268_D315_D0.6310.96
213_I395_L0.6300.96
18_A45_V0.6260.96
20_V60_V0.6250.95
18_A40_I0.6240.95
89_A92_E0.6240.95
36_V39_E0.6240.95
360_G366_P0.6230.95
11_L14_S0.6220.95
125_H151_A0.6210.95
235_M238_Y0.6210.95
206_N388_L0.6210.95
162_A168_Q0.6180.95
214_M351_I0.6160.95
212_P365_L0.6150.95
34_D54_D0.6130.95
393_E400_R0.6120.95
203_T347_G0.6110.95
80_G83_A0.6070.95
193_L200_A0.6060.95
338_I344_A0.6050.95
386_G389_V0.6040.95
87_T91_S0.6030.95
282_P319_G0.6030.95
312_T317_T0.6030.95
181_M257_D0.6020.94
383_E386_G0.6020.94
146_V150_L0.6000.94
235_M271_M0.6000.94
285_R315_D0.6000.94
165_P168_Q0.5980.94
271_M323_I0.5980.94
198_S340_P0.5970.94
93_E99_A0.5960.94
297_K301_E0.5930.94
36_V50_P0.5930.94
391_I395_L0.5910.94
235_M323_I0.5900.94
10_D14_S0.5890.94
283_V342_Q0.5890.94
109_Q113_A0.5880.94
161_A167_A0.5870.94
84_G96_S0.5870.94
18_A42_T0.5870.94
217_R221_G0.5860.94
245_A394_L0.5860.94
88_S93_E0.5840.94
155_A158_S0.5820.93
181_M260_D0.5820.93
39_E46_V0.5820.93
235_M325_N0.5810.93
358_V362_V0.5800.93
353_D358_V0.5790.93
269_V321_F0.5790.93
136_G142_T0.5790.93
298_K305_K0.5790.93
141_L145_D0.5770.93
285_R298_K0.5760.93
358_V364_I0.5760.93
61_L74_L0.5750.93
131_A153_A0.5720.93
132_I145_D0.5680.93
91_S95_A0.5660.92
88_S92_E0.5650.92
21_A24_H0.5650.92
354_R369_Y0.5640.92
243_V247_K0.5630.92
241_A395_L0.5630.92
211_K356_M0.5630.92
149_H153_A0.5630.92
132_I146_V0.5620.92
97_T100_Q0.5610.92
329_F385_V0.5600.92
132_I141_L0.5590.92
117_A121_L0.5590.92
326_G349_H0.5590.92
161_A166_A0.5590.92
61_L72_Q0.5560.92
353_D362_V0.5560.92
255_S262_V0.5550.92
349_H385_V0.5540.92
139_G145_D0.5530.92
25_K75_G0.5520.92
92_E96_S0.5520.92
272_A279_L0.5510.91
352_K356_M0.5510.91
97_T101_R0.5510.91
6_I52_S0.5500.91
140_R145_D0.5490.91
38_V49_V0.5490.91
162_A165_P0.5490.91
274_S383_E0.5470.91
23_W62_E0.5470.91
334_S349_H0.5460.91
79_E82_S0.5460.91
115_S142_T0.5450.91
209_N356_M0.5450.91
185_R189_A0.5450.91
333_M371_A0.5430.91
23_W38_V0.5420.91
131_A154_P0.5420.91
104_A107_E0.5420.91
333_M336_P0.5410.91
8_V75_G0.5410.91
7_L71_R0.5400.91
78_R81_N0.5400.91
20_V52_S0.5390.91
161_A164_A0.5390.91
175_S286_D0.5380.90
289_T294_D0.5370.90
227_R230_I0.5360.90
205_F369_Y0.5350.90
8_V47_L0.5350.90
136_G141_L0.5350.90
15_V70_S0.5340.90
370_L395_L0.5340.90
30_A57_L0.5340.90
357_A360_G0.5330.90
8_V74_L0.5320.90
355_P365_L0.5310.90
162_A166_A0.5310.90
180_P183_R0.5280.90
347_G373_S0.5280.90
336_P373_S0.5270.90
267_F320_N0.5270.90
95_A98_P0.5260.90
106_L110_N0.5260.90
191_R340_P0.5260.90
84_G90_K0.5260.90
12_P47_L0.5250.89
313_V316_L0.5250.89
244_E390_T0.5230.89
141_L146_V0.5220.89
273_V302_L0.5220.89
264_H320_N0.5210.89
295_I302_L0.5210.89
94_K98_P0.5200.89
158_S161_A0.5190.89
195_A338_I0.5180.89
200_A377_R0.5160.89
132_I136_G0.5160.89
361_Q364_I0.5150.89
4_V78_R0.5130.88
346_L370_L0.5130.88
221_G230_I0.5130.88
191_R341_P0.5110.88
281_T342_Q0.5110.88
136_G140_R0.5110.88
98_P102_Q0.5090.88
61_L75_G0.5070.88
181_M378_L0.5060.88
87_T90_K0.5060.88
195_A199_T0.5050.88
159_A162_A0.5050.88
106_L109_Q0.5040.87
127_L131_A0.5030.87
343_S379_I0.5030.87
233_G296_E0.5020.87
209_N212_P0.5010.87
216_L399_T0.5010.87
357_A365_L0.5000.87
179_V261_V0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dvaI 1 0.1037 100 0.141 Contact Map
1sczA 4 0.5753 100 0.45 Contact Map
2ii3A 4 0.5679 100 0.451 Contact Map
3maeA 3 0.5901 100 0.455 Contact Map
4n72A 3 0.6025 100 0.458 Contact Map
1dpbA 4 0.5951 100 0.458 Contact Map
3b8kA 1 0.5852 100 0.465 Contact Map
3l60A 3 0.5556 100 0.469 Contact Map
3rqcA 4 0.5383 100 0.482 Contact Map
2xt6A 2 0.4667 100 0.509 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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