GREMLIN Database
NUSG - Transcription termination/antitermination protein NusG
UniProt: P0AFG0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10667
Length: 181 (171)
Sequences: 2427 (1229)
Seq/√Len: 94.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_A27_R5.1861.00
38_L76_N4.1751.00
158_L178_V4.1301.00
41_E72_Q3.8451.00
31_K36_E3.6441.00
105_D109_D3.6311.00
48_E59_K3.6031.00
157_R172_E3.2911.00
150_E159_K3.2841.00
40_G72_Q3.2281.00
7_K72_Q3.0331.00
135_R179_E2.7771.00
7_K40_G2.2941.00
48_E61_E2.1841.00
103_I108_V2.1621.00
22_V89_V1.9851.00
73_M79_S1.9681.00
76_N79_S1.9611.00
13_Q90_M1.8821.00
18_F88_R1.8761.00
46_T61_E1.8711.00
95_G98_D1.8491.00
73_M83_V1.8201.00
152_D155_K1.7691.00
47_E62_R1.7531.00
157_R174_D1.7491.00
51_E62_R1.7311.00
160_V173_L1.7051.00
153_Y175_F1.6591.00
138_D177_Q1.6561.00
65_F70_L1.5721.00
70_L111_I1.5551.00
133_M145_N1.5371.00
161_S170_P1.4901.00
173_L177_Q1.4881.00
149_E161_S1.4861.00
132_E180_K1.4851.00
161_S168_A1.4481.00
29_H86_V1.4300.99
21_R24_T1.4280.99
81_H85_S1.4150.99
12_V71_V1.4050.99
77_D99_R1.4010.99
146_G160_V1.3940.99
7_K74_V1.3740.99
50_V59_K1.3500.99
53_R58_R1.3430.99
20_G46_T1.3420.99
130_P151_V1.3290.99
135_R143_D1.3040.99
26_L89_V1.2960.99
129_E132_E1.2600.99
134_V160_V1.2600.99
41_E112_M1.2300.98
159_K170_P1.1800.98
79_S83_V1.1790.98
52_I57_R1.1620.98
135_R145_N1.1570.98
64_F70_L1.1560.98
129_E180_K1.1390.97
173_L178_V1.1310.97
26_L83_V1.0880.97
164_I167_R1.0820.97
27_R42_V1.0800.96
15_F88_R1.0760.96
108_V112_M1.0510.96
84_R91_G1.0500.96
174_D177_Q1.0450.96
153_Y156_S1.0360.96
39_F42_V1.0360.96
13_Q91_G1.0170.95
65_F111_I1.0130.95
106_K110_A1.0020.95
49_V62_R0.9930.94
90_M94_G0.9870.94
49_V164_I0.9840.94
29_H33_H0.9720.94
35_M79_S0.9640.93
24_T28_E0.9630.93
38_L74_V0.9570.93
11_V103_I0.9570.93
160_V166_G0.9440.93
27_R41_E0.9420.93
80_W84_R0.9410.93
148_V178_V0.9370.92
104_S112_M0.9360.92
50_V57_R0.9330.92
165_F169_T0.9270.92
15_F18_F0.9260.92
30_I39_F0.9260.92
26_L30_I0.9160.92
22_V69_V0.9150.92
17_G22_V0.9130.91
40_G74_V0.9040.91
8_R105_D0.8990.91
30_I36_E0.8980.91
29_H87_P0.8860.90
19_E68_Y0.8860.90
38_L78_A0.8820.90
30_I71_V0.8720.89
14_A137_N0.8700.89
72_Q105_D0.8640.89
163_S168_A0.8630.89
7_K41_E0.8610.89
94_G102_P0.8470.88
143_D171_V0.8430.88
100_P141_F0.8350.87
158_L173_L0.8260.87
44_V69_V0.8230.87
18_F21_R0.8210.86
124_P156_S0.8040.85
10_Y19_E0.8040.85
13_Q18_F0.8020.85
42_V82_L0.7940.85
27_R30_I0.7900.84
157_R177_Q0.7880.84
95_G101_A0.7850.84
106_K109_D0.7830.84
155_K175_F0.7810.84
14_A18_F0.7790.83
136_V140_P0.7760.83
162_V171_V0.7760.83
12_V83_V0.7670.82
159_K172_E0.7620.82
157_R165_F0.7590.82
156_S176_S0.7580.82
16_S22_V0.7580.82
144_F162_V0.7500.81
165_F172_E0.7400.80
125_K156_S0.7380.80
140_P144_F0.7350.80
93_I106_K0.7340.80
95_G99_R0.7260.79
28_E88_R0.7230.79
22_V26_L0.7180.78
28_E95_G0.7150.78
43_M112_M0.7140.78
86_V90_M0.7080.77
151_V158_L0.7040.77
109_D113_N0.6930.76
92_F100_P0.6850.75
128_F148_V0.6830.75
18_F25_S0.6680.73
123_R134_V0.6640.73
39_F79_S0.6630.72
110_A114_R0.6610.72
77_D83_V0.6580.72
111_I116_Q0.6580.72
163_S173_L0.6570.72
136_V176_S0.6560.72
39_F83_V0.6550.71
28_E32_L0.6550.71
33_H82_L0.6530.71
20_G63_K0.6520.71
26_L86_V0.6480.71
77_D97_S0.6470.71
144_F160_V0.6460.70
152_D172_E0.6420.70
73_M80_W0.6410.70
133_M147_V0.6410.70
87_P111_I0.6400.70
132_E148_V0.6400.70
128_F178_V0.6390.70
43_M115_L0.6360.69
28_E31_K0.6360.69
160_V178_V0.6340.69
15_F69_V0.6340.69
15_F90_M0.6290.68
13_Q88_R0.6270.68
38_L79_S0.6250.68
135_R144_F0.6240.68
149_E170_P0.6230.68
126_T175_F0.6230.68
137_N179_E0.6200.67
134_V146_G0.6190.67
29_H42_V0.6190.67
17_G80_W0.6190.67
24_T27_R0.6170.67
50_V109_D0.6170.67
76_N83_V0.6170.67
84_R88_R0.6150.67
54_G58_R0.6140.67
140_P177_Q0.6130.66
25_S104_S0.6130.66
104_S107_E0.6130.66
70_L103_I0.6120.66
11_V88_R0.6090.66
129_E134_V0.6050.65
8_R128_F0.6030.65
87_P93_I0.5990.65
49_V88_R0.5960.64
137_N142_A0.5920.64
149_E160_V0.5910.64
160_V170_P0.5910.64
22_V86_V0.5880.63
27_R31_K0.5880.63
12_V28_E0.5850.63
72_Q116_Q0.5830.63
35_M137_N0.5830.63
21_R25_S0.5810.62
21_R88_R0.5810.62
50_V122_P0.5800.62
152_D157_R0.5790.62
40_G54_G0.5790.62
12_V30_I0.5780.62
101_A115_L0.5760.62
152_D159_K0.5750.62
25_S29_H0.5720.61
155_K174_D0.5690.61
114_R143_D0.5660.60
73_M101_A0.5630.60
33_H87_P0.5610.60
136_V162_V0.5610.60
16_S21_R0.5590.59
144_F163_S0.5590.59
104_S164_I0.5580.59
21_R86_V0.5540.59
18_F93_I0.5540.59
33_H78_A0.5510.58
91_G98_D0.5490.58
138_D149_E0.5480.58
64_F103_I0.5480.58
91_G102_P0.5480.58
172_E175_F0.5440.57
162_V169_T0.5420.57
138_D142_A0.5420.57
61_E159_K0.5390.57
53_R62_R0.5360.56
29_H82_L0.5350.56
147_V168_A0.5330.56
145_N179_E0.5330.56
35_M82_L0.5270.55
18_F63_K0.5230.54
128_F158_L0.5230.54
140_P159_K0.5230.54
156_S175_F0.5200.54
123_R153_Y0.5180.54
125_K153_Y0.5160.53
158_L175_F0.5160.53
162_V170_P0.5150.53
62_R136_V0.5150.53
132_E152_D0.5150.53
14_A20_G0.5150.53
21_R32_L0.5130.53
73_M94_G0.5110.53
126_T153_Y0.5100.53
63_K174_D0.5090.52
52_I176_S0.5090.52
148_V151_V0.5080.52
51_E112_M0.5060.52
93_I98_D0.5050.52
103_I163_S0.5040.52
137_N145_N0.5040.52
34_N37_D0.5020.51
80_W93_I0.5010.51
56_Q59_K0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jvvA 1 0.326 100 0.148 Contact Map
1m1hA 1 0.6188 100 0.182 Contact Map
2lq8A 1 0.9337 100 0.23 Contact Map
2ougA 1 0.7735 100 0.254 Contact Map
2xhcA 1 0.9337 100 0.267 Contact Map
3p8bB 2 0.7956 100 0.365 Contact Map
1nz8A 1 0.6243 100 0.472 Contact Map
3lpeA 1 0.4641 99.9 0.609 Contact Map
2mi6A 1 0.3425 99.5 0.711 Contact Map
1nz9A 1 0.3204 99.5 0.721 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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