GREMLIN Database
NUSA - Transcription termination/antitermination protein NusA
UniProt: P0AFF6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10665
Length: 495 (412)
Sequences: 1510 (778)
Seq/√Len: 38.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
311_A342_D6.0251.00
205_L234_A5.5691.00
207_E210_R5.1671.00
224_K239_K5.0921.00
181_G197_V4.9151.00
313_N316_Q4.8261.00
183_L195_L4.7371.00
63_L92_Y4.3741.00
67_E78_E4.0781.00
160_A197_V3.9871.00
46_R94_E3.7441.00
57_D96_Q3.6481.00
134_E185_S3.4881.00
184_Y201_K3.4371.00
63_L74_E3.2671.00
277_D282_Q3.1481.00
236_I259_V2.8881.00
299_D302_K2.8871.00
140_G152_L2.8211.00
69_T74_E2.7271.00
173_F179_V2.6991.00
129_Q156_N2.6261.00
81_R88_N2.5891.00
24_F51_R2.5531.00
248_V252_V2.5531.00
163_L166_D2.5141.00
221_I245_I2.4781.00
259_V273_I2.4631.00
88_N91_D2.3951.00
284_V305_M2.3691.00
76_T79_A2.3531.00
166_D184_Y2.2580.99
62_W95_D2.2480.99
225_A283_F2.2160.99
152_L197_V2.1670.99
213_V259_V2.1550.99
61_R94_E2.1510.99
75_I79_A2.1360.99
162_I181_G2.1020.99
163_L196_F2.0930.99
307_I336_L2.0890.99
10_E20_R2.0460.99
294_A341_V2.0150.99
68_V76_T2.0110.99
127_V131_R2.0060.99
81_R85_E1.9990.99
68_V74_E1.9500.98
133_H136_E1.9380.98
124_A188_P1.9100.98
79_A82_Y1.9070.98
124_A128_D1.9020.98
237_A283_F1.8930.98
209_F259_V1.8660.98
220_V245_I1.7960.97
29_S33_T1.7850.97
98_E101_T1.7520.97
310_E341_V1.7480.97
357_D361_K1.7330.97
152_L179_V1.7090.96
224_K276_W1.7070.96
276_W283_F1.6810.96
29_S117_K1.6500.96
205_L226_A1.6380.95
317_A328_A1.6370.95
30_A113_V1.6310.95
48_Q57_D1.6300.95
10_E14_N1.6260.95
70_Q73_K1.6220.95
75_I80_A1.5910.95
130_F134_E1.5850.95
145_V312_G1.5840.95
64_V87_L1.5830.94
203_E206_I1.5820.94
12_V158_A1.5810.94
213_V236_I1.5780.94
398_L403_V1.5750.94
84_D91_D1.5680.94
291_A328_A1.5640.94
64_V80_A1.5580.94
11_A15_E1.5510.94
66_D89_L1.5450.94
279_N282_Q1.5160.93
63_L90_G1.5140.93
127_V186_V1.5090.93
166_D196_F1.5070.93
143_K153_D1.5010.93
87_L93_V1.4950.93
342_D346_A1.4850.92
389_M404_E1.4750.92
75_I145_V1.4720.92
34_A120_E1.4700.92
206_I226_A1.4660.92
260_Q291_A1.4630.92
399_D402_T1.4580.92
142_V145_V1.4540.92
174_R177_D1.4480.91
182_V203_E1.4170.90
77_L81_R1.4130.90
46_R61_R1.4050.90
150_I173_F1.3870.89
209_F223_I1.3830.89
126_V158_A1.3820.89
373_L378_F1.3800.89
264_T268_G1.3750.89
303_H334_W1.3610.89
344_L348_H1.3270.87
230_P234_A1.3140.87
5_I38_K1.3030.86
145_V150_I1.3020.86
21_E51_R1.2980.86
28_E51_R1.2890.86
149_N161_V1.2870.86
305_M334_W1.2860.86
103_D106_T1.2710.85
80_A83_E1.2580.84
373_L377_G1.2560.84
405_A408_E1.2560.84
122_E208_L1.2510.84
305_M332_S1.2500.84
263_S270_R1.2420.83
27_L283_F1.2360.83
369_F372_V1.2130.82
168_L234_A1.2110.82
378_F384_L1.2080.82
127_V195_L1.2080.82
373_L406_L1.2050.82
121_A194_Q1.2020.81
403_V407_R1.2020.81
68_V71_P1.2010.81
199_R247_P1.1940.81
54_G300_E1.1890.81
61_R92_Y1.1870.81
378_F387_V1.1780.80
405_A409_R1.1720.80
85_E137_I1.1640.79
205_L236_I1.1630.79
87_L91_D1.1620.79
158_A176_G1.1590.79
288_M307_I1.1590.79
35_T99_S1.1550.79
398_L409_R1.1540.79
168_L171_E1.1530.79
226_A234_A1.1480.78
136_E186_V1.1470.78
222_E241_N1.1470.78
186_V288_M1.1330.77
184_Y196_F1.1320.77
109_T113_V1.1310.77
393_L403_V1.1270.77
67_E76_T1.1260.77
408_E412_N1.1260.77
136_E207_E1.1190.76
121_A259_V1.1030.75
234_A284_V1.0840.74
182_V201_K1.0830.74
202_P259_V1.0790.74
311_A340_T1.0740.73
96_Q262_V1.0700.73
183_L186_V1.0680.73
365_I369_F1.0660.73
359_F364_D1.0570.72
213_V273_I1.0540.72
84_D87_L1.0530.72
63_L89_L1.0470.71
171_E199_R1.0470.71
274_V285_I1.0470.71
372_V375_E1.0460.71
26_A121_A1.0430.71
367_E371_T1.0410.71
341_V345_Q1.0410.71
47_V58_T1.0370.71
138_I176_G1.0370.71
162_I197_V1.0250.70
225_A276_W1.0160.69
126_V156_N1.0140.69
75_I89_L1.0130.69
140_G181_G1.0120.69
250_A270_R1.0090.69
68_V72_T1.0070.68
140_G171_E1.0050.68
66_D76_T1.0000.68
280_P334_W0.9980.68
211_I216_I0.9970.68
162_I196_F0.9910.67
107_T221_I0.9890.67
42_E73_K0.9700.66
60_R95_D0.9660.65
224_K283_F0.9650.65
79_A307_I0.9650.65
233_R316_Q0.9600.65
262_V280_P0.9600.65
133_H183_L0.9570.64
219_E241_N0.9570.64
130_F268_G0.9560.64
81_R87_L0.9560.64
277_D286_N0.9540.64
80_A93_V0.9530.64
123_R233_R0.9520.64
350_A354_A0.9500.64
401_P405_A0.9470.64
309_V334_W0.9440.63
222_E332_S0.9410.63
343_D346_A0.9400.63
295_S344_L0.9400.63
255_R260_Q0.9390.63
255_R320_R0.9390.63
55_D234_A0.9380.63
282_Q285_I0.9380.63
306_D337_N0.9290.62
133_H193_A0.9280.62
205_L262_V0.9260.62
158_A195_L0.9260.62
310_E342_D0.9250.62
144_K182_V0.9230.62
291_A317_A0.9200.61
21_E25_E0.9180.61
283_F331_L0.9160.61
130_F172_N0.9160.61
112_Q214_P0.9150.61
74_E83_E0.9140.61
129_Q155_G0.9120.61
16_K63_L0.9110.61
141_V259_V0.9080.60
195_L297_V0.9060.60
229_D326_R0.8970.59
371_T375_E0.8970.59
389_M393_L0.8940.59
396_E405_A0.8930.59
70_Q336_L0.8910.59
122_E212_E0.8910.59
6_L54_G0.8790.58
221_I358_T0.8780.58
250_A271_I0.8770.58
359_F363_L0.8740.57
105_I108_Q0.8700.57
75_I93_V0.8680.57
120_E260_Q0.8680.57
70_Q74_E0.8630.56
5_I191_R0.8590.56
185_S250_A0.8590.56
44_D61_R0.8580.56
7_A10_E0.8550.56
248_V263_S0.8550.56
65_V89_L0.8550.56
310_E313_N0.8540.56
177_D262_V0.8530.56
26_A117_K0.8520.55
113_V121_A0.8510.55
23_I27_L0.8500.55
134_E142_V0.8500.55
271_I283_F0.8460.55
239_K278_D0.8430.55
122_E233_R0.8370.54
400_E403_V0.8310.54
301_D372_V0.8290.53
180_R251_C0.8260.53
106_T109_T0.8260.53
66_D74_E0.8200.53
227_A266_L0.8190.53
404_E407_R0.8190.53
209_F216_I0.8180.52
140_G204_M0.8170.52
314_L338_V0.8160.52
232_S264_T0.8150.52
321_N338_V0.8150.52
213_V233_R0.8140.52
224_K248_V0.8140.52
198_T201_K0.8140.52
13_S325_V0.8130.52
393_L400_E0.8120.52
124_A276_W0.8070.51
4_E274_V0.8060.51
229_D330_Q0.8060.51
40_E91_D0.8020.51
102_F123_R0.8020.51
141_V178_R0.8010.51
195_L263_S0.8000.51
117_K274_V0.7990.51
37_K112_Q0.7910.50
117_K120_E0.7900.50
77_L93_V0.7880.50
161_V344_L0.7850.49
187_R250_A0.7850.49
226_A284_V0.7820.49
206_I210_R0.7790.49
85_E88_N0.7790.49
16_K122_E0.7790.49
248_V260_Q0.7790.49
126_V195_L0.7780.49
370_A377_G0.7780.49
105_I113_V0.7760.49
189_E196_F0.7740.48
159_E248_V0.7740.48
40_E184_Y0.7730.48
118_V260_Q0.7670.48
103_D193_A0.7660.48
407_R411_K0.7650.48
376_E396_E0.7640.48
19_P22_K0.7630.48
296_I337_N0.7610.47
136_E150_I0.7600.47
315_A326_R0.7590.47
30_A107_T0.7580.47
35_T45_V0.7560.47
254_M260_Q0.7560.47
200_S230_P0.7540.47
295_S308_A0.7530.47
27_L252_V0.7500.46
146_N236_I0.7500.46
150_I167_M0.7450.46
66_D69_T0.7440.46
346_A352_A0.7420.46
113_V260_Q0.7420.46
316_Q337_N0.7420.46
64_V77_L0.7400.45
77_L87_L0.7400.45
145_V149_N0.7390.45
130_F311_A0.7390.45
355_A379_S0.7370.45
229_D323_Q0.7340.45
111_K323_Q0.7330.45
6_L49_I0.7320.45
225_A338_V0.7320.45
364_D369_F0.7310.45
240_T245_I0.7290.44
127_V201_K0.7280.44
39_Y232_S0.7270.44
171_E195_L0.7250.44
375_E397_G0.7240.44
67_E74_E0.7230.44
19_P85_E0.7220.44
401_P404_E0.7220.44
344_L349_Q0.7210.44
398_L407_R0.7210.44
25_E293_V0.7210.44
19_P55_D0.7190.44
48_Q81_R0.7160.43
124_A279_N0.7130.43
4_E15_E0.7090.43
380_T384_L0.7090.43
291_A325_V0.7080.43
236_I262_V0.7080.43
91_D194_Q0.7050.42
369_F398_L0.7050.42
404_E408_E0.7030.42
286_N289_A0.7020.42
252_V297_V0.7010.42
23_I26_A0.6990.42
79_A299_D0.6990.42
360_T367_E0.6970.42
202_P252_V0.6970.42
84_D93_V0.6960.42
202_P205_L0.6950.41
109_T138_I0.6950.41
154_L245_I0.6950.41
137_I140_G0.6950.41
274_V390_K0.6940.41
284_V332_S0.6940.41
19_P271_I0.6920.41
274_V397_G0.6910.41
140_G183_L0.6870.41
134_E186_V0.6870.41
403_V410_A0.6860.41
66_D77_L0.6820.40
73_K82_Y0.6820.40
166_D201_K0.6820.40
47_V275_L0.6810.40
285_I337_N0.6810.40
410_A414_L0.6780.40
144_K221_I0.6770.40
77_L84_D0.6750.40
388_P391_E0.6750.40
168_L267_G0.6730.40
392_L416_T0.6730.40
83_E95_D0.6720.39
233_R317_A0.6720.39
145_V245_I0.6710.39
146_N151_S0.6710.39
298_V305_M0.6700.39
358_T361_K0.6700.39
377_G381_L0.6690.39
54_G107_T0.6690.39
24_F49_I0.6690.39
221_I225_A0.6680.39
254_M257_A0.6670.39
144_K160_A0.6670.39
121_A124_A0.6660.39
99_S102_F0.6660.39
36_K139_T0.6630.39
283_F332_S0.6630.39
308_A311_A0.6600.38
136_E223_I0.6590.38
268_G296_I0.6590.38
32_A45_V0.6580.38
77_L80_A0.6580.38
80_A87_L0.6570.38
139_T218_E0.6570.38
383_E387_V0.6550.38
300_E334_W0.6540.38
168_L205_L0.6540.38
23_I250_A0.6540.38
252_V259_V0.6530.38
18_L131_R0.6520.38
37_K187_R0.6510.38
255_R362_Y0.6500.38
29_S109_T0.6470.37
366_D401_P0.6470.37
128_D131_R0.6440.37
251_C288_M0.6440.37
135_G250_A0.6430.37
370_A385_A0.6400.37
63_L81_R0.6400.37
89_L294_A0.6390.37
47_V180_R0.6390.37
88_N250_A0.6390.37
18_L277_D0.6380.37
152_L181_G0.6370.37
247_P256_G0.6370.37
112_Q260_Q0.6360.36
116_Q191_R0.6360.36
240_T341_V0.6340.36
129_Q133_H0.6340.36
113_V268_G0.6330.36
206_I325_V0.6330.36
119_R233_R0.6310.36
398_L402_T0.6310.36
153_D156_N0.6290.36
215_E258_R0.6290.36
386_Y393_L0.6280.36
119_R122_E0.6270.36
210_R329_S0.6270.36
245_I368_D0.6260.36
257_A284_V0.6260.36
25_E142_V0.6250.36
166_D315_A0.6250.36
80_A252_V0.6250.36
368_D372_V0.6240.35
99_S218_E0.6220.35
6_L16_K0.6220.35
237_A331_L0.6210.35
181_G184_Y0.6200.35
308_A349_Q0.6200.35
54_G112_Q0.6200.35
248_V341_V0.6180.35
33_T113_V0.6180.35
46_R49_I0.6140.35
155_G160_A0.6130.35
48_Q87_L0.6120.34
110_A114_I0.6120.34
254_M273_I0.6120.34
393_L407_R0.6110.34
365_I373_L0.6100.34
258_R317_A0.6090.34
281_A297_V0.6080.34
23_I109_T0.6060.34
325_V338_V0.6040.34
132_E372_V0.6040.34
201_K206_I0.6030.34
54_G140_G0.6010.34
149_N213_V0.5990.33
111_K265_E0.5960.33
28_E193_A0.5960.33
69_T72_T0.5960.33
28_E39_Y0.5950.33
307_I328_A0.5950.33
307_I325_V0.5930.33
154_L175_P0.5920.33
221_I296_I0.5920.33
69_T93_V0.5920.33
189_E255_R0.5920.33
229_D315_A0.5910.33
75_I132_E0.5900.33
316_Q336_L0.5900.33
260_Q264_T0.5890.33
242_D380_T0.5890.33
213_V336_L0.5880.33
389_M407_R0.5880.33
246_D251_C0.5870.32
57_D160_A0.5860.32
36_K155_G0.5860.32
154_L160_A0.5850.32
148_D219_E0.5840.32
133_H415_A0.5840.32
277_D288_M0.5830.32
377_G387_V0.5820.32
410_A413_A0.5820.32
56_F140_G0.5820.32
68_V78_E0.5810.32
8_V210_R0.5810.32
284_V289_A0.5810.32
209_F273_I0.5810.32
123_R204_M0.5800.32
191_R314_L0.5790.32
122_E323_Q0.5780.32
27_L397_G0.5780.32
375_E394_E0.5780.32
124_A137_I0.5780.32
251_C265_E0.5780.32
174_R300_E0.5760.32
105_I114_I0.5720.31
81_R84_D0.5710.31
31_L47_V0.5700.31
84_D338_V0.5700.31
13_S77_L0.5700.31
83_E87_L0.5700.31
244_R368_D0.5690.31
79_A85_E0.5690.31
30_A34_A0.5690.31
22_K121_A0.5690.31
130_F136_E0.5680.31
352_A356_I0.5670.31
147_R151_S0.5640.31
88_N92_Y0.5640.31
51_R274_V0.5630.31
119_R209_F0.5600.30
152_L321_N0.5600.30
213_V257_A0.5590.30
366_D399_D0.5590.30
365_I378_F0.5580.30
264_T274_V0.5570.30
102_F316_Q0.5560.30
99_S279_N0.5550.30
96_Q329_S0.5540.30
33_T109_T0.5540.30
274_V414_L0.5520.30
204_M230_P0.5510.30
28_E31_L0.5510.30
234_A293_V0.5500.30
107_T112_Q0.5500.30
183_L326_R0.5490.30
66_D82_Y0.5490.30
270_R315_A0.5490.30
387_V391_E0.5480.29
30_A334_W0.5470.29
32_A137_I0.5460.29
113_V209_F0.5450.29
155_G265_E0.5440.29
202_P225_A0.5440.29
195_L349_Q0.5440.29
9_V325_V0.5430.29
377_G410_A0.5430.29
129_Q197_V0.5420.29
385_A410_A0.5420.29
336_L339_M0.5420.29
205_L271_I0.5420.29
106_T213_V0.5420.29
285_I296_I0.5410.29
49_I200_S0.5410.29
50_D364_D0.5410.29
127_V188_P0.5400.29
321_N337_N0.5400.29
287_A331_L0.5390.29
46_R92_Y0.5380.29
84_D190_A0.5370.29
393_L396_E0.5370.29
252_V263_S0.5370.29
214_P290_P0.5360.29
400_E404_E0.5360.29
394_E404_E0.5360.29
40_E305_M0.5360.29
280_P305_M0.5350.29
52_K216_I0.5320.28
152_L167_M0.5320.28
78_E81_R0.5320.28
229_D234_A0.5310.28
250_A257_A0.5300.28
25_E29_S0.5290.28
102_F192_G0.5290.28
102_F284_V0.5270.28
412_N415_A0.5270.28
294_A310_E0.5250.28
105_I110_A0.5250.28
112_Q279_N0.5240.28
215_E290_P0.5220.28
206_I236_I0.5210.28
367_E379_S0.5200.27
23_I120_E0.5190.27
99_S336_L0.5190.27
79_A86_S0.5190.27
161_V196_F0.5180.27
276_W306_D0.5170.27
108_Q178_R0.5170.27
101_T308_A0.5170.27
377_G392_L0.5160.27
205_L266_L0.5140.27
127_V130_F0.5120.27
160_A181_G0.5120.27
45_V151_S0.5120.27
6_L26_A0.5100.27
377_G384_L0.5090.27
55_D334_W0.5080.27
48_Q94_E0.5070.27
389_M400_E0.5070.27
70_Q133_H0.5060.26
111_K155_G0.5060.26
113_V160_A0.5060.26
395_I406_L0.5050.26
110_A116_Q0.5050.26
31_L107_T0.5050.26
138_I336_L0.5040.26
95_D130_F0.5040.26
27_L216_I0.5040.26
358_T362_Y0.5030.26
280_P293_V0.5030.26
226_A273_I0.5030.26
289_A294_A0.5030.26
35_T58_T0.5020.26
12_V189_E0.5020.26
23_I111_K0.5020.26
50_D396_E0.5020.26
45_V336_L0.5010.26
382_E396_E0.5010.26
342_D364_D0.5010.26
359_F377_G0.5010.26
221_I240_T0.5010.26
194_Q214_P0.5010.26
382_E387_V0.5000.26
138_I183_L0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mtnA 1 0.8101 100 0.262 Contact Map
1k0rA 1 0.6323 100 0.27 Contact Map
1hh2P 2 0.6929 100 0.29 Contact Map
2asbA 1 0.4404 100 0.458 Contact Map
2cxcA 1 0.2747 100 0.747 Contact Map
2kwpA 1 0.2606 100 0.758 Contact Map
2mt4A 1 0.2505 100 0.766 Contact Map
2qndA 2 0.2828 99.5 0.895 Contact Map
4q7jD 1 0.3333 99.5 0.896 Contact Map
4toiA 2 0.3253 98.6 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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