GREMLIN Database
NUPC - Nucleoside permease NupC
UniProt: P0AFF2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11971
Length: 400 (396)
Sequences: 1656 (931)
Seq/√Len: 46.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_F269_A5.0021.00
305_E336_S4.5231.00
303_S306_A4.3281.00
370_Q373_V3.9121.00
268_N285_Q3.8471.00
285_Q327_D3.7791.00
24_D27_K3.7341.00
98_I253_V3.6841.00
327_D330_K3.5151.00
168_T206_F3.3231.00
309_V343_I3.3041.00
23_S380_K3.2681.00
163_R376_R2.9921.00
154_Y161_I2.9851.00
275_T282_I2.9071.00
309_V339_A2.8761.00
21_V383_Y2.8451.00
13_V298_V2.7951.00
78_V258_I2.7331.00
11_L391_L2.6771.00
299_M390_V2.6391.00
247_F251_I2.6321.00
116_V120_A2.5961.00
379_L383_Y2.5781.00
19_L25_R2.5191.00
23_S213_N2.4971.00
204_S388_V2.4831.00
36_L207_I2.4551.00
107_I235_F2.4231.00
58_K62_E2.3791.00
159_G369_E2.3391.00
158_L367_N2.3171.00
353_F379_L2.2841.00
315_T327_D2.2711.00
243_I259_G2.2621.00
18_A211_L2.2381.00
110_H232_G2.1581.00
111_I235_F2.0571.00
328_L338_R2.0400.99
23_S163_R2.0340.99
67_L104_L2.0330.99
244_L252_I2.0310.99
18_A208_V2.0220.99
107_I239_L2.0110.99
299_M394_S1.9940.99
193_Y345_V1.9890.99
141_S153_A1.9880.99
293_Y310_G1.9490.99
73_E76_N1.9450.99
249_V252_I1.8820.99
72_N93_K1.8550.99
239_L263_L1.8520.99
201_N392_S1.8400.99
212_I384_G1.8320.99
52_V56_F1.8160.99
351_A389_S1.8100.99
163_R373_V1.8080.99
135_E210_S1.7640.98
8_V12_A1.7640.98
345_V392_S1.7540.98
212_I383_Y1.7410.98
131_M136_S1.7210.98
45_W399_V1.6860.98
286_G290_Y1.6770.98
317_L386_T1.6750.98
248_K251_I1.6690.98
284_F288_L1.6550.98
162_S215_Y1.6420.98
6_H297_W1.6370.98
46_F50_S1.6350.98
201_N204_S1.6220.97
147_Q355_S1.6060.97
120_A123_F1.6060.97
274_V278_F1.6020.97
164_N215_Y1.6000.97
148_S249_V1.5790.97
122_G133_K1.5660.97
18_A387_L1.5460.96
166_M373_V1.5410.96
101_I145_L1.5380.96
112_R115_P1.5350.96
95_L254_A1.5300.96
262_A354_S1.5280.96
34_I38_V1.5210.96
21_V212_I1.5200.96
33_V207_I1.5120.96
124_L128_V1.5100.96
81_S86_G1.5100.96
331_I334_T1.5020.96
106_G110_H1.5010.96
147_Q359_I1.5000.96
24_D216_R1.4620.95
351_A386_T1.4550.95
71_A75_T1.4480.95
19_L28_I1.4450.95
116_V119_R1.4340.95
9_L297_W1.4330.95
293_Y303_S1.4240.94
56_F59_G1.4120.94
379_L382_V1.4040.94
167_Y384_G1.4040.94
282_I287_I1.4030.94
174_M359_I1.3940.94
71_A262_A1.3910.94
65_E69_G1.3830.93
252_I256_M1.3680.93
28_I211_L1.3600.93
148_S252_I1.3580.93
5_L9_L1.3500.93
235_F239_L1.3470.93
249_V253_V1.3380.92
318_V353_F1.3370.92
396_A399_V1.3310.92
247_F255_A1.3290.92
250_A254_A1.3290.92
158_L366_L1.3250.92
147_Q354_S1.3240.92
266_A270_L1.3190.92
150_N172_T1.2980.91
297_W303_S1.2920.91
75_T92_L1.2840.91
103_A239_L1.2730.90
29_R32_Y1.2620.90
304_S308_Q1.2560.90
73_E265_A1.2540.90
79_F91_F1.2520.90
120_A124_L1.2490.89
290_Y307_L1.2480.89
90_F354_S1.2350.89
238_M242_Y1.2270.89
190_E332_A1.2180.88
141_S145_L1.2090.88
66_K69_G1.2090.88
338_R342_I1.1920.87
162_S217_V1.1900.87
148_S362_A1.1890.87
296_A313_M1.1880.87
66_K70_F1.1880.87
237_E371_G1.1830.87
138_N150_N1.1830.87
97_P180_S1.1760.86
50_S53_G1.1650.86
16_I20_L1.1630.86
237_E241_E1.1580.85
162_S165_R1.1550.85
284_F318_V1.1470.85
293_Y307_L1.1340.84
264_I319_S1.1330.84
312_I331_I1.1280.84
305_E335_L1.1260.84
168_T172_T1.1250.84
270_L273_T1.1250.84
180_S249_V1.1220.84
267_L284_F1.1160.83
389_S392_S1.1070.83
184_A322_F1.1000.82
103_A243_I1.0980.82
151_F173_A1.0970.82
45_W49_N1.0940.82
319_S323_V1.0900.82
382_V386_T1.0810.81
328_L343_I1.0790.81
259_G357_G1.0790.81
301_V309_V1.0640.80
303_S310_G1.0640.80
121_I143_L1.0580.80
43_L204_S1.0540.80
20_L25_R1.0520.79
41_V395_I1.0450.79
325_M348_V1.0400.79
162_S216_R1.0390.79
285_Q315_T1.0380.79
201_N345_V1.0350.78
39_I128_V1.0300.78
46_F52_V1.0260.78
15_A33_V1.0240.78
186_M191_P1.0230.77
356_I359_I1.0210.77
7_F338_R1.0180.77
62_E65_E1.0170.77
31_R35_Q1.0140.77
113_V337_P1.0120.77
332_A340_E1.0060.76
283_S286_G1.0050.76
320_N354_S1.0000.76
17_L295_I0.9990.76
353_F382_V0.9970.76
188_M326_M0.9950.75
63_M66_K0.9930.75
81_S85_Q0.9910.75
99_V246_G0.9900.75
118_I157_I0.9880.75
138_N172_T0.9860.75
56_F60_F0.9840.75
147_Q358_I0.9830.75
86_G89_F0.9810.74
275_T283_S0.9770.74
388_V392_S0.9760.74
14_V208_V0.9740.74
382_V385_S0.9740.74
363_V374_V0.9740.74
68_L183_G0.9710.74
111_I114_L0.9630.73
125_L129_N0.9630.73
22_S211_L0.9580.73
60_F63_M0.9550.72
271_F282_I0.9530.72
168_T209_L0.9450.72
252_I362_A0.9450.72
142_S176_T0.9420.71
282_I286_G0.9360.71
311_S315_T0.9350.71
147_Q317_L0.9330.71
188_M356_I0.9280.70
75_T262_A0.9240.70
36_L129_N0.9150.69
131_M206_F0.9130.69
182_V194_V0.9110.69
316_K322_F0.9100.69
44_A310_G0.9070.68
172_T202_M0.9060.68
174_M385_S0.9040.68
153_A253_V0.9040.68
44_A339_A0.9030.68
29_R34_I0.8980.68
9_L155_K0.8970.68
41_V399_V0.8950.67
371_G385_S0.8940.67
19_L211_L0.8930.67
14_V391_L0.8910.67
36_L49_N0.8900.67
139_A206_F0.8840.66
15_A211_L0.8820.66
17_L366_L0.8810.66
163_R377_F0.8780.66
256_M353_F0.8760.66
208_V384_G0.8750.66
158_L169_M0.8740.66
356_I382_V0.8720.65
335_L340_E0.8690.65
274_V277_W0.8660.65
356_I378_G0.8640.65
17_L383_Y0.8620.65
181_I354_S0.8600.64
285_Q330_K0.8590.64
163_R213_N0.8570.64
109_Q156_D0.8570.64
145_L153_A0.8540.64
356_I374_V0.8520.64
43_L105_I0.8480.63
77_F90_F0.8470.63
69_G72_N0.8440.63
71_A97_P0.8440.63
207_I389_S0.8410.63
13_V16_I0.8390.62
94_V250_A0.8390.62
198_L201_N0.8370.62
35_Q129_N0.8360.62
257_L261_I0.8350.62
11_L392_S0.8300.62
140_V184_A0.8300.62
337_P341_G0.8280.61
245_A248_K0.8280.61
92_L96_C0.8250.61
76_N81_S0.8230.61
270_L276_G0.8180.60
38_V298_V0.8170.60
118_I177_V0.8150.60
201_N389_S0.8150.60
122_G136_S0.8130.60
233_Q376_R0.8120.60
308_Q331_I0.8110.60
42_L45_W0.8060.59
50_S54_L0.8060.59
142_S182_V0.8050.59
114_L156_D0.8030.59
107_I263_L0.8020.59
339_A343_I0.8010.59
6_H9_L0.8010.59
240_G244_L0.7970.58
105_I145_L0.7930.58
81_S84_D0.7890.58
280_Y290_Y0.7860.57
129_N169_M0.7800.57
234_S282_I0.7770.56
60_F195_V0.7760.56
161_I169_M0.7710.56
148_S181_I0.7710.56
204_S392_S0.7690.56
289_G311_S0.7690.56
39_I244_L0.7680.56
176_T190_E0.7670.55
250_A310_G0.7650.55
28_I60_F0.7640.55
264_I311_S0.7600.55
171_A291_I0.7580.55
29_R130_G0.7570.55
166_M370_Q0.7560.54
304_S336_S0.7560.54
157_I385_S0.7560.54
122_G125_L0.7540.54
352_N355_S0.7520.54
134_L161_I0.7510.54
160_K285_Q0.7510.54
147_Q250_A0.7500.54
55_G58_K0.7490.54
177_V181_I0.7480.54
194_V210_S0.7480.54
63_M107_I0.7470.54
40_E204_S0.7470.54
134_L150_N0.7460.53
345_V396_A0.7450.53
299_M342_I0.7420.53
59_G63_M0.7410.53
35_Q38_V0.7390.53
308_Q335_L0.7360.52
54_L58_K0.7310.52
164_N210_S0.7310.52
345_V389_S0.7310.52
44_A331_I0.7300.52
14_V299_M0.7300.52
182_V186_M0.7290.52
105_I114_L0.7270.52
342_I380_K0.7270.52
195_V199_V0.7270.52
164_N202_M0.7260.51
105_I176_T0.7260.51
317_L351_A0.7240.51
138_N169_M0.7220.51
182_V198_L0.7210.51
106_G232_G0.7200.51
7_F195_V0.7190.51
15_A398_L0.7180.51
211_L298_V0.7170.51
89_F258_I0.7140.50
358_I361_G0.7110.50
135_E168_T0.7100.50
91_F254_A0.7100.50
11_L204_S0.7070.50
142_S172_T0.7060.49
79_F96_C0.7050.49
215_Y219_A0.7040.49
101_I260_F0.7030.49
295_I390_V0.7010.49
208_V357_G0.7000.49
337_P340_E0.6920.48
289_G310_G0.6910.48
46_F286_G0.6910.48
265_A269_A0.6900.48
113_V291_I0.6880.48
104_L255_A0.6880.48
272_A303_S0.6870.48
213_N304_S0.6850.47
263_L332_A0.6840.47
19_L23_S0.6840.47
114_L118_I0.6830.47
171_A349_S0.6820.47
386_T389_S0.6810.47
70_F266_A0.6790.47
114_L189_L0.6790.47
357_G389_S0.6780.47
16_I19_L0.6770.47
61_S261_I0.6760.47
139_A320_N0.6760.47
178_S181_I0.6750.46
256_M358_I0.6750.46
112_R116_V0.6750.46
134_L137_F0.6730.46
390_V393_A0.6700.46
94_V184_A0.6690.46
372_N376_R0.6680.46
172_T338_R0.6680.46
105_I313_M0.6670.46
30_I145_L0.6670.46
132_G219_A0.6670.46
287_I291_I0.6640.45
59_G62_E0.6630.45
134_L222_E0.6610.45
258_I273_T0.6600.45
73_E268_N0.6580.45
83_N92_L0.6570.45
273_T277_W0.6560.45
78_V257_L0.6560.45
141_S201_N0.6490.44
26_K127_K0.6490.44
113_V116_V0.6490.44
72_N76_N0.6460.44
31_R130_G0.6460.44
193_Y392_S0.6450.43
307_L310_G0.6450.43
268_N283_S0.6440.43
342_I391_L0.6440.43
170_A179_M0.6440.43
357_G378_G0.6410.43
312_I324_A0.6410.43
81_S89_F0.6400.43
16_I211_L0.6380.43
35_Q155_K0.6360.43
320_N324_A0.6360.43
140_V143_L0.6350.42
295_I298_V0.6330.42
123_F128_V0.6310.42
37_L395_I0.6310.42
232_G241_E0.6310.42
27_K345_V0.6300.42
177_V292_F0.6300.42
15_A28_I0.6290.42
147_Q240_G0.6290.42
163_R370_Q0.6280.42
75_T196_A0.6250.42
301_V343_I0.6240.41
362_A374_V0.6230.41
94_V322_F0.6220.41
134_L220_S0.6200.41
53_G135_E0.6200.41
102_S176_T0.6200.41
104_L263_L0.6200.41
138_N205_T0.6180.41
147_Q310_G0.6170.41
8_V398_L0.6170.41
193_Y204_S0.6170.41
254_A257_L0.6150.41
8_V372_N0.6140.40
247_F254_A0.6140.40
250_A253_V0.6110.40
125_L382_V0.6100.40
55_G99_V0.6090.40
44_A303_S0.6080.40
180_S356_I0.6070.40
320_N323_V0.6060.40
207_I378_G0.6060.40
287_I310_G0.6050.40
109_Q115_P0.6050.40
244_L251_I0.6040.40
394_S397_A0.6030.39
43_L46_F0.6020.39
158_L270_L0.6020.39
28_I224_I0.6010.39
20_L251_I0.6010.39
321_E324_A0.6010.39
15_A366_L0.6000.39
57_V122_G0.6000.39
301_V339_A0.5990.39
158_L330_K0.5990.39
142_S202_M0.5980.39
29_R129_N0.5970.39
15_A37_L0.5960.39
122_G161_I0.5950.39
320_N352_N0.5940.39
112_R256_M0.5930.38
131_M164_N0.5930.38
342_I386_T0.5910.38
174_M381_L0.5890.38
367_N373_V0.5890.38
55_G59_G0.5850.38
178_S315_T0.5850.38
41_V45_W0.5850.38
54_L192_K0.5850.38
36_L140_V0.5820.37
7_F398_L0.5820.37
46_F342_I0.5810.37
42_L130_G0.5810.37
97_P202_M0.5800.37
66_K269_A0.5800.37
46_F56_F0.5790.37
219_A222_E0.5790.37
275_T281_S0.5780.37
359_I363_V0.5780.37
132_G165_R0.5780.37
136_S146_G0.5780.37
316_K352_N0.5750.37
95_L250_A0.5740.37
360_A395_I0.5740.37
170_A359_I0.5730.37
351_A355_S0.5730.37
213_N377_F0.5730.37
161_I396_A0.5700.36
142_S150_N0.5690.36
84_D87_L0.5680.36
155_K301_V0.5680.36
44_A341_G0.5680.36
270_L308_Q0.5680.36
100_F135_E0.5670.36
52_V55_G0.5660.36
238_M314_A0.5650.36
113_V279_G0.5640.36
15_A207_I0.5630.36
339_A344_S0.5630.36
9_L13_V0.5620.36
85_Q330_K0.5620.36
395_I398_L0.5600.35
189_L347_L0.5600.35
208_V360_A0.5600.35
181_I322_F0.5590.35
65_E353_F0.5580.35
15_A30_I0.5560.35
337_P399_V0.5560.35
63_M67_L0.5550.35
253_V262_A0.5530.35
219_A258_I0.5530.35
152_I249_V0.5520.35
315_T320_N0.5520.35
189_L348_V0.5500.35
246_G250_A0.5490.34
142_S173_A0.5480.34
150_N362_A0.5480.34
82_M92_L0.5470.34
288_L318_V0.5470.34
9_L298_V0.5470.34
5_L123_F0.5450.34
101_I152_I0.5450.34
386_T390_V0.5430.34
302_P308_Q0.5430.34
110_H224_I0.5430.34
102_S152_I0.5430.34
140_V172_T0.5430.34
99_V125_L0.5420.34
107_I111_I0.5420.34
83_N88_A0.5420.34
154_Y169_M0.5410.34
44_A389_S0.5390.34
305_E339_A0.5390.34
19_L396_A0.5380.33
42_L46_F0.5380.33
116_V393_A0.5370.33
165_R284_F0.5360.33
137_F153_A0.5350.33
85_Q212_I0.5350.33
143_L202_M0.5340.33
142_S151_F0.5330.33
200_L393_A0.5330.33
98_I250_A0.5320.33
239_L396_A0.5310.33
355_S358_I0.5300.33
78_V254_A0.5290.33
139_A201_N0.5290.33
32_Y199_V0.5290.33
374_V382_V0.5290.33
354_S358_I0.5270.32
38_V42_L0.5270.32
11_L282_I0.5270.32
129_N172_T0.5250.32
114_L201_N0.5240.32
325_M347_L0.5240.32
167_Y186_M0.5220.32
267_L361_G0.5220.32
158_L271_F0.5220.32
326_M329_Q0.5210.32
5_L14_V0.5200.32
153_A205_T0.5190.32
19_L281_S0.5190.32
176_T338_R0.5190.32
204_S399_V0.5180.32
156_D368_E0.5180.32
100_F310_G0.5180.32
35_Q128_V0.5180.32
71_A208_V0.5170.32
98_I322_F0.5170.32
36_L40_E0.5170.32
145_L150_N0.5170.32
44_A385_S0.5160.32
8_V226_M0.5160.32
97_P183_G0.5160.32
65_E190_E0.5150.31
113_V372_N0.5150.31
161_I198_L0.5150.31
30_I34_I0.5140.31
354_S376_R0.5140.31
6_H398_L0.5120.31
218_D222_E0.5120.31
238_M243_I0.5110.31
87_L337_P0.5110.31
137_F142_S0.5100.31
236_F353_F0.5090.31
95_L102_S0.5090.31
183_G187_T0.5090.31
295_I376_R0.5090.31
10_A396_A0.5080.31
29_R282_I0.5080.31
89_F93_K0.5080.31
78_V101_I0.5070.31
208_V387_L0.5070.31
193_Y341_G0.5060.31
70_F265_A0.5060.31
252_I361_G0.5040.31
107_I255_A0.5040.31
24_D311_S0.5030.30
131_M210_S0.5020.30
33_V158_L0.5020.30
5_L216_R0.5010.30
145_L362_A0.5010.30
256_M386_T0.5010.30
129_N215_Y0.5010.30
169_M337_P0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.965 100 0.119 Contact Map
2cfqA 1 0.8775 31.7 0.978 Contact Map
4ikvA 1 0.425 25 0.979 Contact Map
4oh3A 2 0.4125 21.6 0.979 Contact Map
2mofA 1 0.0825 14.9 0.981 Contact Map
4zw9A 1 0.39 13.6 0.981 Contact Map
4j05A 3 0.3725 11.6 0.982 Contact Map
4fc4A 3 0.4 6.3 0.984 Contact Map
4w6vA 1 0.4125 6.1 0.984 Contact Map
4r1iA 2 0.9325 4.7 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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