GREMLIN Database
NUON - NADH-quinone oxidoreductase subunit N
UniProt: P0AFF0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12093
Length: 485 (444)
Sequences: 20188 (12501)
Seq/√Len: 593.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
339_G379_M4.7331.00
118_L131_G4.5251.00
185_S188_A4.0491.00
77_T121_N3.8311.00
144_G156_S3.6201.00
332_G390_L3.3381.00
293_N357_D3.2031.00
84_S113_A3.1951.00
158_K229_D3.1871.00
281_I417_G3.0761.00
183_D188_A3.0071.00
329_Y394_G2.9531.00
292_T360_F2.8441.00
277_A314_I2.7291.00
115_G134_L2.7201.00
298_L344_V2.7031.00
356_A361_S2.6751.00
377_T429_A2.6701.00
173_G209_L2.6391.00
13_P16_I2.5871.00
77_T117_I2.5731.00
80_V120_A2.5461.00
358_S361_S2.5381.00
220_L310_L2.5051.00
380_M425_Y2.2901.00
68_R123_N2.2861.00
91_A105_F2.2791.00
297_L359_L2.2771.00
70_D255_M2.2601.00
289_L423_Y2.2361.00
42_V85_L2.1881.00
311_V414_V2.1561.00
81_L117_I2.1111.00
70_D73_A2.0841.00
231_Y239_S2.0461.00
188_A191_K1.9971.00
312_A398_V1.9831.00
271_V275_I1.9691.00
328_V394_G1.9581.00
231_Y246_S1.9321.00
215_G220_L1.9141.00
16_I21_V1.9091.00
42_V46_N1.8831.00
292_T358_S1.8711.00
301_S424_Y1.8601.00
24_V27_S1.8601.00
282_I417_G1.8581.00
427_R431_S1.8471.00
369_R372_L1.8351.00
470_W473_P1.8221.00
294_I428_V1.8161.00
285_N304_S1.8121.00
325_A401_V1.7671.00
125_L189_L1.7581.00
274_A314_I1.7351.00
408_W412_G1.7291.00
17_V27_S1.7211.00
291_Q296_R1.7191.00
451_S455_I1.7151.00
14_L17_V1.7071.00
45_L82_L1.7061.00
79_L334_L1.7021.00
366_F373_A1.7011.00
219_S227_T1.6781.00
176_L206_G1.6731.00
399_L414_V1.6661.00
211_I215_G1.6651.00
188_A192_N1.6571.00
17_V21_V1.6561.00
123_N187_V1.6541.00
268_A271_V1.6501.00
17_V114_L1.6451.00
335_F463_L1.6361.00
41_S44_G1.6281.00
16_I27_S1.6181.00
278_F413_A1.6071.00
462_L466_V1.6031.00
122_A127_S1.5931.00
221_V279_A1.5891.00
44_G48_A1.5781.00
246_S302_S1.5611.00
40_L44_G1.4951.00
75_L331_A1.4731.00
313_L326_V1.4701.00
68_R71_G1.4671.00
108_L141_G1.4651.00
180_Q206_G1.4621.00
400_A404_Q1.4611.00
402_G411_V1.4521.00
19_L40_L1.4511.00
273_L314_I1.4481.00
378_V461_A1.4471.00
16_I19_L1.4351.00
149_Q152_S1.4311.00
376_M380_M1.4191.00
88_C106_Y1.4121.00
309_L326_V1.4061.00
48_A81_L1.4031.00
124_H184_L1.4001.00
285_N417_G1.3991.00
124_H185_S1.3981.00
220_L276_I1.3971.00
274_A410_L1.3891.00
88_C109_V1.3861.00
201_P205_A1.3811.00
173_G213_G1.3811.00
451_S454_G1.3791.00
458_L462_L1.3771.00
270_R274_A1.3771.00
142_L238_V1.3761.00
373_A434_L1.3671.00
178_Y184_L1.3641.00
70_D257_L1.3611.00
311_V402_G1.3611.00
66_L123_N1.3601.00
28_I31_R1.3541.00
69_V121_N1.3511.00
459_I463_L1.3501.00
336_S382_S1.3501.00
21_V27_S1.3411.00
173_G210_M1.3411.00
211_I273_L1.3331.00
155_A233_G1.3321.00
46_N50_V1.3321.00
41_S45_L1.3261.00
128_L186_F1.3211.00
34_H37_N1.3141.00
373_A429_A1.3081.00
312_A322_S1.3081.00
173_G206_G1.2871.00
251_F255_M1.2861.00
175_A179_A1.2791.00
75_L327_G1.2771.00
322_S401_V1.2751.00
20_T24_V1.2651.00
376_M428_V1.2611.00
340_A379_M1.2541.00
170_L213_G1.2511.00
39_T43_I1.2461.00
312_A326_V1.2411.00
73_A251_F1.2391.00
34_H38_A1.2381.00
151_R232_Q1.2311.00
343_V376_M1.2281.00
101_N104_E1.2271.00
35_F39_T1.2241.00
450_Y453_G1.2211.00
83_A338_L1.2181.00
229_D296_R1.2171.00
162_L225_L1.2061.00
37_N41_S1.2041.00
316_L322_S1.1991.00
380_M429_A1.1961.00
126_A184_L1.1911.00
359_L432_L1.1861.00
283_F287_M1.1841.00
90_F342_G1.1831.00
379_M461_A1.1801.00
83_A334_L1.1791.00
176_L202_L1.1781.00
56_G59_G1.1741.00
456_V459_I1.1671.00
180_Q202_L1.1561.00
38_A41_S1.1511.00
383_L425_Y1.1481.00
332_G394_G1.1451.00
129_F171_L1.1391.00
304_S421_G1.1361.00
125_L174_M1.1331.00
128_L252_G1.1301.00
93_P96_E1.1301.00
187_V191_K1.1301.00
58_A62_D1.1261.00
57_Q62_D1.1251.00
409_W412_G1.1201.00
325_A397_Y1.1191.00
21_V24_V1.1151.00
112_A116_G1.1141.00
215_G276_I1.1131.00
397_Y400_A1.1131.00
375_V461_A1.1121.00
216_F223_F1.1121.00
45_L49_L1.1051.00
170_L174_M1.1041.00
35_F38_A1.1031.00
284_G307_G1.0991.00
154_E158_K1.0981.00
81_L85_L1.0961.00
86_A459_I1.0921.00
348_S357_D1.0911.00
403_V411_V1.0901.00
275_I279_A1.0901.00
93_P452_A1.0891.00
174_M210_M1.0881.00
48_A52_L1.0881.00
371_I374_A1.0761.00
277_A307_G1.0731.00
37_N40_L1.0731.00
76_Y330_L1.0671.00
343_V457_V1.0661.00
463_L467_L1.0631.00
346_L372_L1.0541.00
377_T433_Y1.0511.00
181_S189_L1.0501.00
371_I458_L1.0491.00
111_I138_P1.0461.00
236_A295_K1.0441.00
146_A149_Q1.0391.00
53_W56_G1.0341.00
109_V241_F1.0291.00
249_A252_G1.0281.00
59_G62_D1.0271.00
169_F209_L1.0251.00
452_A456_V1.0241.00
412_G416_V1.0221.00
421_G424_Y1.0151.00
381_L386_I1.0141.00
33_N36_L1.0131.00
166_A216_F1.0131.00
206_G210_M1.0111.00
204_L269_I1.0111.00
36_L40_L1.0111.00
375_V457_V1.0081.00
201_P204_L1.0051.00
69_V74_M1.0041.00
19_L23_V1.0021.00
116_G245_A0.9991.00
363_R438_E0.9971.00
376_M433_Y0.9971.00
149_Q232_Q0.9961.00
184_L188_A0.9961.00
371_I375_V0.9931.00
267_E270_R0.9891.00
350_P369_R0.9881.00
31_R34_H0.9871.00
390_L467_L0.9851.00
123_N185_S0.9851.00
37_N44_G0.9781.00
178_Y181_S0.9761.00
85_L89_T0.9761.00
54_F57_Q0.9731.00
150_K154_E0.9711.00
80_V113_A0.9691.00
333_Y337_S0.9681.00
346_L457_V0.9631.00
253_V257_L0.9601.00
186_F190_G0.9581.00
110_L114_L0.9571.00
37_N106_Y0.9561.00
373_A433_Y0.9541.00
82_L86_A0.9531.00
12_L17_V0.9511.00
243_A337_S0.9501.00
90_F345_S0.9471.00
294_I344_V0.9471.00
461_A465_L0.9471.00
177_V206_G0.9471.00
228_P300_Y0.9421.00
221_V283_F0.9391.00
309_L330_L0.9381.00
265_D268_A0.9381.00
169_F212_V0.9351.00
312_A325_A0.9351.00
240_T342_G0.9331.00
279_A283_F0.9321.00
231_Y243_A0.9321.00
277_A311_V0.9291.00
440_P443_D0.9271.00
44_G47_A0.9261.00
197_M200_E0.9251.00
29_A32_R0.9221.00
37_N47_A0.9151.00
57_Q60_A0.9141.00
84_S109_V0.9131.00
16_I20_T0.9121.00
53_W57_Q0.9111.00
347_M365_L0.9111.00
328_V332_G0.9081.00
248_I251_F0.9081.00
73_A77_T0.9081.00
28_I32_R0.9081.00
363_R431_S0.9061.00
305_H421_G0.9061.00
254_V313_L0.9061.00
43_I47_A0.9031.00
72_F327_G0.9031.00
33_N37_N0.9011.00
49_L78_G0.9001.00
41_S88_C0.9001.00
339_G460_S0.8981.00
204_L268_A0.8961.00
231_Y302_S0.8961.00
70_D256_R0.8961.00
274_A277_A0.8951.00
244_T247_K0.8941.00
271_V274_A0.8931.00
176_L180_Q0.8881.00
375_V458_L0.8881.00
227_T231_Y0.8871.00
281_I311_V0.8861.00
417_G420_I0.8841.00
266_S270_R0.8831.00
297_L428_V0.8811.00
396_F400_A0.8811.00
115_G138_P0.8801.00
466_V470_W0.8781.00
285_N424_Y0.8741.00
153_L156_S0.8731.00
19_L27_S0.8711.00
140_F156_S0.8711.00
294_I362_Y0.8711.00
285_N420_I0.8691.00
45_L81_L0.8681.00
293_N358_S0.8671.00
425_Y428_V0.8651.00
93_P450_Y0.8631.00
199_N203_L0.8611.00
183_D186_F0.8591.00
129_F133_E0.8561.00
200_E204_L0.8551.00
17_V20_T0.8541.00
211_I253_V0.8531.00
67_M121_N0.8521.00
284_G287_M0.8511.00
390_L464_V0.8501.00
48_A51_S0.8491.00
58_A61_M0.8491.00
320_E324_E0.8491.00
56_G62_D0.8481.00
117_I121_N0.8481.00
66_L185_S0.8471.00
243_A302_S0.8461.00
286_L420_I0.8421.00
41_S47_A0.8351.00
277_A310_L0.8351.00
129_F174_M0.8341.00
204_L208_G0.8341.00
302_S333_Y0.8321.00
308_Y398_V0.8291.00
429_A434_L0.8291.00
441_G444_A0.8251.00
288_A424_Y0.8241.00
207_F269_I0.8241.00
208_G212_V0.8191.00
278_F410_L0.8181.00
143_V230_V0.8171.00
305_H329_Y0.8171.00
374_A433_Y0.8161.00
16_I24_V0.8161.00
87_T342_G0.8161.00
373_A377_T0.8131.00
112_A139_L0.8121.00
125_L258_F0.8111.00
35_F40_L0.8091.00
115_G131_G0.8061.00
205_A209_L0.8061.00
305_H424_Y0.8061.00
281_I307_G0.8051.00
455_I459_I0.8041.00
21_V111_I0.8021.00
63_V126_A0.8001.00
399_L411_V0.8001.00
454_G458_L0.7981.00
76_Y252_G0.7961.00
374_A378_V0.7951.00
18_G114_L0.7941.00
38_A42_V0.7941.00
367_W370_P0.7921.00
151_R233_G0.7911.00
346_L449_Q0.7911.00
132_I170_L0.7881.00
183_D189_L0.7861.00
336_S391_G0.7861.00
336_S464_V0.7831.00
380_M428_V0.7821.00
78_G82_L0.7811.00
177_V189_L0.7791.00
284_G304_S0.7781.00
466_V473_P0.7761.00
34_H41_S0.7721.00
199_N202_L0.7661.00
140_F163_S0.7651.00
56_G60_A0.7641.00
54_F64_T0.7621.00
372_L449_Q0.7621.00
382_S389_T0.7621.00
86_A456_V0.7621.00
278_F311_V0.7591.00
455_I458_L0.7581.00
200_E203_L0.7571.00
356_A362_Y0.7571.00
368_H437_P0.7541.00
247_K251_F0.7531.00
116_G135_I0.7531.00
384_A422_L0.7531.00
419_A423_Y0.7521.00
274_A278_F0.7481.00
80_V116_G0.7461.00
24_V28_I0.7461.00
298_L340_A0.7431.00
143_V234_A0.7401.00
94_W237_P0.7381.00
301_S333_Y0.7371.00
37_N43_I0.7371.00
41_S48_A0.7371.00
359_L431_S0.7341.00
33_N44_G0.7311.00
92_Y452_A0.7311.00
103_D107_L0.7291.00
35_F41_S0.7291.00
12_L16_I0.7291.00
18_G22_V0.7271.00
166_A213_G0.7261.00
151_R154_E0.7261.00
374_A377_T0.7211.00
79_L331_A0.7211.00
27_S30_W0.7211.00
44_G50_V0.7211.00
164_A167_S0.7201.00
34_H45_L0.7171.00
363_R435_H0.7161.00
413_A417_G0.7161.00
426_L430_V0.7161.00
354_P362_Y0.7131.00
350_P453_G0.7121.00
282_I286_L0.7101.00
274_A311_V0.7091.00
239_S242_L0.7071.00
177_V210_M0.7071.00
385_G395_K0.7061.00
371_I454_G0.7051.00
388_M469_V0.7041.00
218_L250_I0.7021.00
105_F237_P0.7021.00
285_N301_S0.7001.00
124_H127_S0.7001.00
14_L114_L0.7001.00
47_A51_S0.6961.00
322_S326_V0.6951.00
203_L206_G0.6941.00
272_V275_I0.6941.00
438_E441_G0.6941.00
81_L113_A0.6891.00
205_A208_G0.6891.00
449_Q454_G0.6891.00
26_L29_A0.6881.00
232_Q293_N0.6881.00
422_L426_L0.6881.00
255_M310_L0.6871.00
255_M263_V0.6871.00
232_Q296_R0.6851.00
329_Y336_S0.6831.00
143_V242_L0.6791.00
291_Q300_Y0.6781.00
87_T240_T0.6781.00
72_F76_Y0.6781.00
66_L124_H0.6771.00
250_I309_L0.6761.00
375_V379_M0.6751.00
123_N127_S0.6751.00
236_A345_S0.6721.00
278_F282_I0.6711.00
308_Y417_G0.6701.00
89_T456_V0.6701.00
246_S306_L0.6671.00
277_A281_I0.6661.00
42_V45_L0.6661.00
171_L175_A0.6661.00
69_V73_A0.6651.00
157_I161_I0.6631.00
21_V25_M0.6621.00
366_F433_Y0.6611.00
83_A241_F0.6581.00
439_Q442_R0.6581.00
68_R187_V0.6571.00
461_A464_V0.6561.00
439_Q443_D0.6561.00
467_L474_L0.6551.00
239_S295_K0.6541.00
74_M78_G0.6521.00
37_N50_V0.6501.00
41_S51_S0.6491.00
13_P27_S0.6491.00
28_I34_H0.6481.00
294_I432_L0.6451.00
202_L206_G0.6431.00
282_I413_A0.6421.00
389_T393_I0.6381.00
249_A253_V0.6381.00
27_S31_R0.6361.00
451_S456_V0.6331.00
254_V323_M0.6331.00
399_L418_S0.6311.00
38_A44_G0.6291.00
250_I330_L0.6261.00
343_V375_V0.6241.00
251_F256_R0.6221.00
80_V117_I0.6211.00
331_A474_L0.6211.00
346_L350_P0.6201.00
33_N41_S0.6191.00
207_F211_I0.6171.00
112_A241_F0.6131.00
87_T237_P0.6131.00
22_V25_M0.6131.00
378_V465_L0.6101.00
346_L453_G0.6091.00
45_L51_S0.6091.00
429_A433_Y0.6071.00
128_L170_L0.6061.00
197_M201_P0.6061.00
287_M300_Y0.6061.00
102_K106_Y0.6051.00
26_L30_W0.6051.00
53_W58_A0.6031.00
385_G389_T0.6011.00
49_L52_L0.6011.00
105_F145_Y0.6001.00
78_G81_L0.6001.00
39_T44_G0.5981.00
228_P303_I0.5981.00
231_Y299_G0.5971.00
305_H337_S0.5971.00
84_S241_F0.5951.00
33_N38_A0.5951.00
285_N421_G0.5951.00
401_V405_A0.5951.00
382_S391_G0.5951.00
24_V31_R0.5951.00
54_F59_G0.5941.00
440_P444_A0.5921.00
251_F257_L0.5911.00
139_L245_A0.5911.00
359_L428_V0.5911.00
214_L252_G0.5891.00
76_Y80_V0.5891.00
37_N48_A0.5891.00
19_L22_V0.5881.00
111_I115_G0.5871.00
82_L463_L0.5851.00
225_L228_P0.5841.00
45_L85_L0.5841.00
35_F44_G0.5841.00
44_G81_L0.5841.00
339_G457_V0.5831.00
80_V84_S0.5831.00
239_S333_Y0.5821.00
234_A239_S0.5821.00
395_K418_S0.5791.00
15_L19_L0.5781.00
268_A272_V0.5771.00
343_V379_M0.5771.00
377_T434_L0.5761.00
342_G456_V0.5761.00
379_M464_V0.5751.00
287_M291_Q0.5731.00
387_P392_F0.5711.00
198_L201_P0.5691.00
336_S383_L0.5681.00
87_T109_V0.5681.00
86_A338_L0.5671.00
97_G101_N0.5671.00
129_F167_S0.5661.00
281_I308_Y0.5661.00
301_S337_S0.5661.00
20_T23_V0.5651.00
91_A237_P0.5641.00
40_L47_A0.5641.00
125_L177_V0.5631.00
48_A78_G0.5631.00
34_H44_G0.5631.00
291_Q297_L0.5611.00
302_S306_L0.5601.00
13_P17_V0.5601.00
33_N47_A0.5590.99
189_L192_N0.5580.99
375_V454_G0.5560.99
25_M29_A0.5560.99
301_S305_H0.5560.99
322_S325_A0.5550.99
393_I397_Y0.5550.99
55_V59_G0.5540.99
113_A117_I0.5540.99
119_L248_I0.5540.99
36_L39_T0.5500.99
23_V27_S0.5490.99
154_E229_D0.5480.99
335_F390_L0.5480.99
202_L205_A0.5470.99
176_L205_A0.5460.99
349_S450_Y0.5460.99
349_S453_G0.5460.99
249_A255_M0.5450.99
286_L290_S0.5450.99
415_V418_S0.5450.99
252_G256_R0.5410.99
39_T42_V0.5410.99
403_V408_W0.5410.99
72_F254_V0.5410.99
333_Y341_F0.5390.99
12_L19_L0.5380.99
187_V190_G0.5370.99
227_T230_V0.5370.99
25_M28_I0.5360.99
287_M290_S0.5360.99
105_F238_V0.5330.99
381_L426_L0.5330.99
243_A341_F0.5310.99
12_L15_L0.5300.99
172_F176_L0.5300.99
321_M404_Q0.5290.99
14_L27_S0.5290.99
37_N51_S0.5280.99
133_E217_K0.5280.99
139_L142_L0.5270.99
108_L138_P0.5270.99
377_T381_L0.5270.99
13_P21_V0.5270.99
37_N45_L0.5260.99
362_Y432_L0.5260.99
235_P295_K0.5250.99
305_H308_Y0.5240.99
104_E108_L0.5240.99
343_V372_L0.5240.99
135_I248_I0.5210.99
247_K250_I0.5200.99
39_T46_N0.5190.99
21_V29_A0.5190.99
131_G134_L0.5190.99
90_F240_T0.5190.99
51_S74_M0.5180.99
127_S130_L0.5180.99
122_A131_G0.5170.99
465_L469_V0.5170.99
370_P373_A0.5170.99
430_V435_H0.5170.99
91_A94_W0.5150.99
423_Y427_R0.5150.99
33_N48_A0.5150.99
365_L369_R0.5150.99
108_L111_I0.5150.99
329_Y332_G0.5140.99
264_G267_E0.5140.99
32_R35_F0.5130.99
20_T25_M0.5130.99
26_L31_R0.5120.99
125_L186_F0.5100.99
83_A87_T0.5100.99
292_T301_S0.5090.99
13_P20_T0.5090.99
452_A455_I0.5090.99
44_G49_L0.5080.99
39_T50_V0.5080.99
52_L78_G0.5070.99
89_T455_I0.5070.99
409_W413_A0.5050.99
339_G461_A0.5040.99
181_S185_S0.5030.99
253_V310_L0.5030.99
14_L21_V0.5020.99
139_L242_L0.5020.99
232_Q243_A0.5020.99
262_P265_D0.5020.99
236_A239_S0.5010.99
209_L213_G0.5010.99
380_M384_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoN 1 0.9711 100 0.143 Contact Map
3rkoM 1 0.9588 100 0.185 Contact Map
3rkoL 1 0.9567 100 0.204 Contact Map
4he8L 1 0.9526 100 0.217 Contact Map
4he8M 1 0.9175 100 0.221 Contact Map
4he8N 1 0.8722 100 0.271 Contact Map
4he8K 1 0.1918 30.8 0.963 Contact Map
3rkoK 1 0.2 24.2 0.965 Contact Map
2gfpA 2 0.7134 11.9 0.97 Contact Map
4he8J 1 0.3093 7.4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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