GREMLIN Database
NUOM - NADH-quinone oxidoreductase subunit M
UniProt: P0AFE8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11773
Length: 509 (455)
Sequences: 19974 (12435)
Seq/√Len: 583.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_D273_R4.9061.00
354_G391_F4.7761.00
129_G142_F4.5921.00
91_V132_L3.8521.00
155_A171_A3.6821.00
347_A402_G3.3511.00
98_G124_L3.2271.00
310_D369_R3.1901.00
173_K246_D3.1891.00
298_I428_G3.1191.00
344_Q406_G2.9891.00
309_T372_R2.8561.00
13_G35_T2.7881.00
389_L440_L2.7631.00
294_G331_Y2.7491.00
315_I359_C2.7061.00
11_F125_G2.6841.00
368_T373_M2.6711.00
126_G145_M2.6341.00
237_V327_L2.6081.00
188_A226_G2.5951.00
91_V128_I2.5901.00
94_T131_F2.5851.00
37_G99_V2.5611.00
370_D373_M2.4911.00
105_S116_F2.4101.00
392_A436_S2.3541.00
314_L371_M2.3341.00
328_I425_S2.2871.00
208_E211_L2.2861.00
95_G128_I2.2691.00
306_F434_V2.2681.00
82_A134_I2.2621.00
248_H264_L2.0881.00
264_L319_S2.0511.00
248_H256_S2.0311.00
288_P292_W2.0121.00
329_A410_I2.0031.00
40_L96_L1.9971.00
309_T370_D1.9091.00
232_A237_V1.9061.00
299_F428_G1.8941.00
343_I406_G1.8811.00
462_L466_F1.8811.00
302_A321_S1.8761.00
136_M274_F1.8701.00
381_M384_L1.8681.00
318_T435_Y1.8521.00
438_A442_R1.8241.00
291_M331_Y1.7981.00
311_I439_M1.7921.00
37_G41_A1.7841.00
84_D87_S1.7801.00
332_T337_A1.7771.00
43_S95_G1.7741.00
340_G413_G1.7551.00
481_Y484_P1.7411.00
191_A223_L1.7271.00
209_E213_T1.7251.00
87_S269_Y1.7101.00
236_P244_L1.7041.00
209_E212_N1.6921.00
93_L349_G1.6881.00
170_A250_Q1.6621.00
308_Q313_R1.6431.00
139_F270_G1.6401.00
228_F232_A1.6371.00
411_L425_S1.6371.00
238_V296_I1.6331.00
133_A138_L1.6211.00
285_E288_P1.6211.00
378_W385_P1.6191.00
119_N152_F1.6161.00
350_L474_L1.6141.00
89_L346_I1.6091.00
414_S422_T1.5731.00
295_V424_I1.5701.00
272_L330_I1.5631.00
473_V477_L1.5551.00
82_A85_G1.5491.00
290_A331_Y1.5461.00
384_L459_G1.5401.00
218_G222_L1.5261.00
412_F416_Q1.5171.00
47_W51_G1.4991.00
388_S392_A1.4721.00
231_F270_G1.4701.00
44_L48_L1.4591.00
390_F472_V1.4511.00
102_V120_L1.4381.00
302_A428_G1.4371.00
271_L327_L1.4341.00
135_D203_W1.4321.00
228_F290_A1.4261.00
27_V30_W1.4261.00
102_V117_H1.4191.00
388_S439_M1.4171.00
7_I125_G1.4141.00
188_A230_A1.4121.00
330_I341_A1.4121.00
107_K110_E1.4071.00
237_V293_L1.4051.00
291_M421_I1.3981.00
210_L213_T1.3981.00
41_A45_Q1.3921.00
89_L342_V1.3791.00
351_S394_A1.3771.00
287_A291_M1.3741.00
35_T39_T1.3711.00
130_V266_T1.3671.00
188_A227_F1.3661.00
39_T43_S1.3611.00
153_L255_G1.3531.00
355_L391_F1.3521.00
135_D204_T1.3471.00
326_V341_A1.3431.00
83_I132_L1.3361.00
385_P445_F1.3361.00
204_T209_E1.3341.00
36_M40_L1.3281.00
470_L474_L1.3281.00
104_C357_I1.3271.00
272_L341_A1.3191.00
462_L465_L1.3161.00
332_T414_S1.3071.00
193_V203_W1.3061.00
337_A413_G1.3061.00
469_L473_V1.3051.00
48_L52_Y1.3051.00
139_F205_F1.3031.00
385_P440_L1.3001.00
246_D313_R1.2901.00
483_Q487_D1.2871.00
329_A341_A1.2801.00
329_A337_A1.2801.00
177_Y242_G1.2711.00
188_A223_L1.2691.00
26_K30_W1.2621.00
166_T250_Q1.2611.00
14_G17_C1.2601.00
97_L353_A1.2551.00
328_I414_S1.2531.00
185_M230_A1.2521.00
26_K29_R1.2501.00
18_W21_E1.2481.00
14_G122_W1.2431.00
80_H134_I1.2391.00
461_S464_E1.2321.00
25_V29_R1.2281.00
7_I10_P1.2221.00
123_I127_V1.2201.00
300_Y304_M1.2141.00
467_M470_L1.2141.00
387_L472_V1.2101.00
32_A117_H1.2101.00
100_L470_L1.2091.00
199_A223_L1.1941.00
393_V398_M1.1931.00
358_L388_S1.1931.00
136_M189_I1.1921.00
392_A440_L1.1891.00
391_F472_V1.1881.00
90_M345_M1.1861.00
45_Q48_L1.1821.00
340_G409_M1.1821.00
191_A219_V1.1821.00
97_L349_G1.1811.00
36_M39_T1.1781.00
484_P487_D1.1701.00
292_W296_I1.1681.00
365_R381_M1.1671.00
347_A406_G1.1661.00
208_E212_N1.1601.00
321_S432_A1.1591.00
383_W386_A1.1581.00
232_A293_L1.1521.00
238_V300_Y1.1521.00
395_T436_S1.1481.00
189_I227_F1.1461.00
169_T173_K1.1401.00
6_L10_P1.1361.00
36_M102_V1.1331.00
14_G18_W1.1311.00
371_M443_A1.1271.00
95_G99_V1.1251.00
474_L478_L1.1191.00
389_L444_Y1.1171.00
23_F26_K1.1161.00
363_Y369_R1.1151.00
463_R467_M1.1151.00
294_G324_G1.1041.00
40_L95_G1.1041.00
17_C21_E1.1001.00
14_G118_L1.1001.00
137_F203_W1.0971.00
140_F186_L1.0941.00
388_S444_Y1.0831.00
45_Q49_Q1.0831.00
107_K463_R1.0801.00
223_L227_F1.0781.00
216_S220_E1.0751.00
40_L44_L1.0751.00
384_L460_M1.0681.00
83_I88_L1.0651.00
68_D78_S1.0621.00
34_I38_L1.0621.00
420_V423_V1.0621.00
167_R250_Q1.0611.00
6_L42_L1.0611.00
181_S233_V1.0551.00
358_L468_I1.0521.00
86_L272_L1.0521.00
150_M263_L1.0511.00
409_M412_F1.0491.00
30_W34_I1.0471.00
415_F422_T1.0401.00
233_V240_L1.0391.00
387_L469_L1.0391.00
99_V103_L1.0351.00
87_S273_R1.0321.00
432_A435_Y1.0311.00
383_W469_L1.0291.00
301_G324_G1.0271.00
185_M189_I1.0231.00
387_L468_I1.0201.00
268_A326_V1.0161.00
13_G17_C1.0161.00
202_V205_F1.0121.00
423_V427_F1.0081.00
97_L261_G1.0071.00
9_I13_G1.0041.00
383_W387_L1.0031.00
217_S221_Y1.0011.00
122_W149_P0.9981.00
94_T124_L0.9981.00
121_M125_G0.9961.00
288_P291_M0.9941.00
46_L49_Q0.9851.00
192_L223_L0.9831.00
96_L100_L0.9811.00
257_V357_I0.9811.00
366_I374_M0.9811.00
284_A287_A0.9791.00
120_L258_D0.9751.00
402_G478_L0.9721.00
385_P444_Y0.9711.00
39_T46_L0.9691.00
199_A219_V0.9691.00
361_Q384_L0.9691.00
225_L229_I0.9681.00
136_M210_L0.9671.00
159_H167_R0.9671.00
86_L342_V0.9621.00
134_I204_T0.9621.00
228_F271_L0.9601.00
32_A36_M0.9561.00
268_A327_L0.9551.00
245_P317_Y0.9541.00
31_I35_T0.9531.00
348_H352_A0.9521.00
221_Y286_F0.9521.00
43_S46_L0.9511.00
77_I137_F0.9491.00
70_P73_P0.9481.00
354_G471_L0.9481.00
371_M442_R0.9481.00
235_M268_A0.9451.00
32_A35_T0.9431.00
28_P32_A0.9421.00
265_K269_Y0.9381.00
216_S219_V0.9371.00
428_G431_F0.9331.00
311_I359_C0.9301.00
362_L377_L0.9291.00
93_L346_I0.9291.00
104_C360_G0.9281.00
215_M218_G0.9261.00
302_A431_F0.9261.00
271_L330_I0.9251.00
38_L42_L0.9241.00
310_D370_D0.9211.00
277_P280_P0.9211.00
46_L50_G0.9211.00
128_I132_L0.9201.00
28_P31_I0.9191.00
364_E458_P0.9171.00
477_L481_Y0.9171.00
107_K461_S0.9171.00
375_G442_R0.9151.00
42_L46_L0.9111.00
221_Y285_E0.9101.00
48_L51_G0.9101.00
253_T312_K0.9101.00
218_G221_Y0.9091.00
294_G328_I0.9071.00
466_F470_L0.9051.00
302_A435_Y0.9051.00
101_A357_I0.9051.00
375_G449_K0.9041.00
322_H344_Q0.9011.00
25_V28_P0.8981.00
168_I171_A0.8961.00
295_V328_I0.8961.00
184_V226_G0.8951.00
87_S91_V0.8921.00
184_V229_I0.8921.00
151_Y171_A0.8911.00
140_F189_I0.8901.00
380_K448_A0.8901.00
222_L226_G0.8901.00
326_V345_M0.8891.00
244_L248_H0.8891.00
296_I300_Y0.8861.00
329_A340_G0.8851.00
260_A352_A0.8841.00
361_Q468_I0.8831.00
472_V476_V0.8821.00
126_G142_F0.8801.00
343_I347_A0.8781.00
291_M294_G0.8781.00
248_H319_S0.8771.00
50_G88_L0.8761.00
295_V421_I0.8761.00
402_G475_L0.8721.00
92_V96_L0.8711.00
140_F144_E0.8701.00
126_G149_P0.8681.00
298_I324_G0.8671.00
154_I247_A0.8651.00
269_Y273_R0.8641.00
165_K169_T0.8631.00
217_S220_E0.8621.00
361_Q460_M0.8611.00
214_P217_S0.8611.00
22_R25_V0.8601.00
298_I328_I0.8591.00
365_R464_E0.8551.00
29_R33_L0.8541.00
411_L422_T0.8501.00
294_G327_L0.8481.00
322_H432_A0.8471.00
311_I374_M0.8451.00
325_F410_I0.8441.00
408_F412_F0.8431.00
436_S439_M0.8391.00
221_Y225_L0.8391.00
335_Q339_Q0.8341.00
319_S348_H0.8321.00
357_I467_M0.8301.00
334_S337_A0.8301.00
314_L439_M0.8261.00
43_S91_V0.8251.00
81_L132_L0.8231.00
123_I150_M0.8231.00
80_H135_D0.8221.00
379_S382_K0.8211.00
392_A439_M0.8201.00
268_A345_M0.8171.00
334_S413_G0.8121.00
18_W118_L0.8121.00
305_A435_Y0.8081.00
98_G120_L0.8051.00
301_G304_M0.8011.00
100_L467_M0.7991.00
322_H435_Y0.7971.00
449_K452_I0.7961.00
186_L190_L0.7941.00
90_M269_Y0.7921.00
303_W431_F0.7911.00
7_I81_L0.7861.00
127_V263_L0.7861.00
179_Q182_G0.7851.00
127_V146_M0.7841.00
315_I355_L0.7841.00
66_E80_H0.7841.00
465_L469_L0.7831.00
351_S403_N0.7831.00
44_L92_V0.7811.00
397_G407_E0.7801.00
143_W185_M0.7801.00
39_T42_L0.7771.00
146_M263_L0.7751.00
291_M328_I0.7711.00
274_F278_L0.7701.00
301_G321_S0.7691.00
291_M295_V0.7681.00
262_I265_K0.7651.00
166_T169_T0.7651.00
386_A444_Y0.7651.00
472_V475_L0.7611.00
375_G446_G0.7591.00
224_M286_F0.7551.00
33_L36_M0.7541.00
261_G265_K0.7541.00
385_P389_L0.7541.00
440_L445_F0.7521.00
116_F254_A0.7461.00
94_T127_V0.7421.00
10_P13_G0.7411.00
43_S50_G0.7411.00
424_I428_G0.7401.00
83_I87_S0.7401.00
295_V299_F0.7381.00
131_F269_Y0.7381.00
390_F476_V0.7361.00
251_A260_A0.7341.00
108_E254_A0.7321.00
394_A401_T0.7321.00
7_I132_L0.7311.00
47_W92_V0.7311.00
308_Q317_Y0.7291.00
192_L227_F0.7281.00
33_L37_G0.7271.00
30_W33_L0.7271.00
151_Y178_T0.7261.00
181_S230_A0.7231.00
106_W463_R0.7231.00
396_L433_S0.7221.00
14_G125_G0.7221.00
289_I292_W0.7211.00
29_R32_A0.7191.00
332_T417_V0.7191.00
460_M465_L0.7191.00
344_Q351_S0.7161.00
88_L92_V0.7161.00
146_M266_T0.7151.00
127_V262_I0.7151.00
268_A323_M0.7141.00
466_F469_L0.7131.00
459_G465_L0.7101.00
386_A390_F0.7081.00
101_A257_V0.7021.00
383_W465_L0.7011.00
134_I138_L0.7001.00
135_D138_L0.6961.00
39_T128_I0.6941.00
272_L338_Y0.6941.00
401_T405_V0.6921.00
154_I251_A0.6921.00
116_F255_G0.6921.00
351_S475_L0.6921.00
36_M46_L0.6911.00
325_F428_G0.6911.00
136_M192_L0.6901.00
302_A318_T0.6881.00
204_T208_E0.6881.00
437_L441_H0.6871.00
264_L269_Y0.6871.00
318_T348_H0.6851.00
9_I35_T0.6841.00
368_T374_M0.6841.00
68_D71_W0.6831.00
80_H204_T0.6831.00
123_I258_D0.6821.00
477_L484_P0.6801.00
433_S437_L0.6781.00
193_V200_T0.6781.00
299_F303_W0.6771.00
43_S92_V0.6741.00
8_L12_I0.6731.00
22_R26_K0.6721.00
27_V31_I0.6711.00
294_G298_I0.6711.00
143_W266_T0.6681.00
39_T95_G0.6681.00
251_A256_S0.6681.00
387_L465_L0.6681.00
400_G480_F0.6661.00
13_G39_T0.6661.00
123_I263_L0.6651.00
13_G31_I0.6611.00
13_G121_M0.6601.00
32_A102_V0.6601.00
172_T176_I0.6581.00
256_S259_L0.6581.00
67_F70_P0.6571.00
191_A199_A0.6531.00
154_I259_L0.6531.00
387_L391_F0.6531.00
31_I34_I0.6531.00
256_S264_L0.6521.00
450_S453_A0.6511.00
304_M317_Y0.6491.00
377_L381_M0.6491.00
389_L445_F0.6471.00
139_F185_M0.6451.00
311_I443_A0.6431.00
219_V223_L0.6421.00
440_L444_Y0.6421.00
220_E223_L0.6411.00
224_M228_F0.6411.00
115_F119_N0.6401.00
253_T360_G0.6391.00
411_L426_T0.6391.00
40_L47_W0.6391.00
13_G18_W0.6391.00
66_E69_M0.6391.00
100_L471_L0.6391.00
478_L485_I0.6391.00
96_L474_L0.6381.00
337_A341_A0.6371.00
191_A222_L0.6351.00
322_H352_A0.6351.00
319_S323_M0.6341.00
378_W389_L0.6341.00
261_G353_A0.6311.00
358_L387_L0.6301.00
405_V409_M0.6281.00
381_M459_G0.6271.00
97_L258_D0.6261.00
86_L90_M0.6251.00
9_I38_L0.6221.00
43_S47_W0.6221.00
336_L416_Q0.6221.00
248_H261_G0.6211.00
260_A348_H0.6191.00
222_L225_L0.6181.00
378_W444_Y0.6171.00
281_N285_E0.6151.00
244_L247_A0.6141.00
364_E464_E0.6141.00
298_I325_F0.6131.00
385_P443_A0.6131.00
430_V434_V0.6121.00
116_F156_L0.6101.00
68_D73_P0.6091.00
228_F293_L0.6061.00
220_E282_A0.6051.00
94_T128_I0.6041.00
253_T256_S0.6031.00
95_G124_L0.6011.00
386_A389_L0.6001.00
70_P78_S0.5981.00
256_S312_K0.5981.00
434_V438_A0.5971.00
346_I485_I0.5971.00
35_T121_M0.5971.00
10_P39_T0.5961.00
462_L467_M0.5961.00
285_E289_I0.5961.00
344_Q347_A0.5951.00
202_V210_L0.5941.00
302_A432_A0.5931.00
318_T322_H0.5931.00
245_P320_V0.5881.00
105_S109_I0.5881.00
354_G468_I0.5861.00
103_L467_M0.5861.00
304_M307_A0.5841.00
411_L429_L0.5841.00
299_F424_I0.5841.00
25_V32_A0.5821.00
202_V209_E0.5821.00
12_I16_L0.5811.00
25_V30_W0.5801.00
242_G245_P0.5801.00
343_I409_M0.5801.00
350_L402_G0.5801.00
252_P312_K0.5791.00
397_G401_T0.5781.00
371_M439_M0.5781.00
39_T45_Q0.5761.00
413_G417_V0.5761.00
397_G403_N0.5751.00
92_V95_G0.5751.00
90_M94_T0.5751.00
351_S395_T0.5741.00
361_Q464_E0.5741.00
248_H316_A0.5741.00
65_S68_D0.5741.00
73_P76_G0.5731.00
6_L39_T0.5721.00
409_M486_L0.5721.00
304_M308_Q0.5721.00
476_V480_F0.5711.00
201_G204_T0.5711.00
71_W76_G0.5711.00
308_Q314_L0.5701.00
376_G448_A0.5701.00
382_K386_A0.5691.00
40_L52_Y0.5691.00
235_M271_L0.5661.00
428_G432_A0.5661.00
476_V479_G0.5651.00
394_A403_N0.5651.00
134_I208_E0.5640.99
33_L103_L0.5630.99
238_V301_G0.5620.99
244_L264_L0.5620.99
292_W295_V0.5610.99
358_L391_F0.5600.99
70_P76_G0.5590.99
100_L353_A0.5590.99
20_T23_F0.5550.99
361_Q365_R0.5530.99
10_P14_G0.5530.99
190_L198_N0.5530.99
98_G258_D0.5530.99
483_Q486_L0.5520.99
219_V222_L0.5490.99
136_M205_F0.5480.99
303_W307_A0.5470.99
200_T204_T0.5460.99
105_S254_A0.5440.99
101_A254_A0.5440.99
112_Y157_W0.5430.99
322_H325_F0.5430.99
318_T352_A0.5430.99
396_L437_L0.5420.99
311_I362_L0.5390.99
19_Q22_R0.5380.99
86_L269_Y0.5380.99
101_A120_L0.5380.99
309_T318_T0.5360.99
224_M279_F0.5360.99
413_G416_Q0.5350.99
63_W66_E0.5340.99
256_S348_H0.5340.99
192_L278_L0.5340.99
350_L471_L0.5320.99
169_T246_D0.5320.99
358_L384_L0.5310.99
426_T429_L0.5300.99
420_V424_I0.5300.99
228_F286_F0.5300.99
405_V479_G0.5300.99
133_A142_F0.5300.99
144_E234_K0.5280.99
380_K457_L0.5270.99
273_R277_P0.5260.99
94_T98_G0.5260.99
119_N149_P0.5260.99
405_V480_F0.5260.99
134_I273_R0.5260.99
265_K268_A0.5240.99
124_L128_I0.5230.99
29_R40_L0.5220.99
66_E70_P0.5200.99
32_A39_T0.5200.99
427_F431_F0.5190.99
371_M374_M0.5190.99
399_P404_F0.5190.99
150_M154_I0.5180.99
251_A258_D0.5180.99
390_F394_A0.5180.99
40_L99_V0.5180.99
407_E429_L0.5170.99
325_F425_S0.5160.99
264_L268_A0.5160.99
177_Y233_V0.5150.99
339_Q486_L0.5140.99
337_A340_G0.5140.99
103_L466_F0.5130.99
6_L18_W0.5130.99
363_Y367_H0.5130.99
266_T270_G0.5110.99
382_K385_P0.5110.99
7_I14_G0.5110.99
265_K323_M0.5100.99
441_H446_G0.5100.99
140_F182_G0.5090.99
170_A246_D0.5090.99
199_A203_W0.5080.99
83_I91_V0.5080.99
416_Q419_P0.5070.99
159_H165_K0.5070.99
393_V437_L0.5070.99
15_F18_W0.5070.99
33_L99_V0.5050.99
21_E25_V0.5050.99
379_S448_A0.5050.99
376_G382_K0.5040.99
362_L381_M0.5040.99
392_A396_L0.5040.99
71_W74_R0.5040.99
224_M278_L0.5020.99
30_W35_T0.5020.99
297_G327_L0.5020.99
396_L401_T0.5020.99
217_S285_E0.5020.99
256_S260_A0.5010.99
93_L345_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoM 1 0.9902 100 0.133 Contact Map
4he8M 1 0.9077 100 0.218 Contact Map
3rkoL 1 0.945 100 0.229 Contact Map
4he8L 1 0.9332 100 0.235 Contact Map
3rkoN 1 0.8919 100 0.241 Contact Map
4he8N 1 0.835 100 0.303 Contact Map
3rkoK 1 0.1965 40.2 0.964 Contact Map
4he8K 1 0.1866 31.3 0.966 Contact Map
4b4aA 1 0.2711 6.3 0.975 Contact Map
4he8J 1 0.2927 4.7 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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