GREMLIN Database
NUOK - NADH-quinone oxidoreductase subunit K
UniProt: P0AFE4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12091
Length: 100 (96)
Sequences: 1573 (747)
Seq/√Len: 76.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_G34_G6.1621.00
4_L52_Y2.9341.00
89_N94_S2.6391.00
32_L45_A2.5651.00
43_A65_A2.5181.00
4_L48_V2.3001.00
46_F61_M2.2721.00
15_F38_M2.2491.00
45_A49_A2.1731.00
91_N94_S2.1081.00
9_I13_I2.0491.00
42_S45_A1.9821.00
7_G48_V1.9481.00
31_M92_I1.8111.00
19_L38_M1.7521.00
45_A48_V1.7431.00
83_L95_V1.7291.00
24_I40_N1.7031.00
87_R97_E1.6891.00
10_L14_L1.6701.00
20_T24_I1.6331.00
11_A45_A1.5900.99
46_F58_G1.5600.99
30_F33_I1.5510.99
23_V30_F1.5290.99
40_N66_I1.5110.99
40_N83_L1.4650.99
20_T77_L1.4140.99
4_L53_W1.3810.99
82_Q85_R1.3560.98
62_Y66_I1.3250.98
8_L45_A1.3150.98
19_L22_L1.2750.98
22_L34_G1.2720.97
28_L92_I1.2360.97
10_L44_L1.1530.96
50_G56_T1.1090.94
75_I82_Q1.0730.93
8_L12_A1.0730.93
89_N96_S1.0500.93
14_L77_L1.0250.92
32_L80_L1.0190.92
19_L84_H0.9980.91
13_I17_L0.9930.90
28_L35_L0.9880.90
18_G38_M0.9770.90
18_G31_M0.9750.90
63_I67_S0.9740.90
20_T66_I0.9470.88
26_R66_I0.9380.88
69_A76_G0.9300.87
22_L38_M0.9210.87
11_A56_T0.9160.87
37_I49_A0.9110.86
74_S79_L0.9040.86
8_L49_A0.8970.85
40_N73_A0.8960.85
46_F90_L0.8840.85
22_L31_M0.8680.83
40_N43_A0.8630.83
44_L48_V0.8580.83
92_I95_V0.8560.83
45_A62_Y0.8540.82
10_L63_I0.8510.82
41_A44_L0.8140.79
28_L73_A0.8140.79
10_L48_V0.7920.77
46_F59_Q0.7690.75
16_V20_T0.7680.75
22_L66_I0.7620.75
11_A41_A0.7600.74
50_G81_L0.7530.74
17_L21_G0.7450.73
25_R57_D0.7450.73
30_F79_L0.7410.73
7_G67_S0.7290.71
78_A82_Q0.7250.71
6_H9_I0.7170.70
38_M76_G0.7150.70
18_G34_G0.7130.70
76_G87_R0.7110.69
87_R95_V0.7010.68
35_L78_A0.6910.67
6_H10_L0.6870.67
50_G60_V0.6820.66
43_A62_Y0.6790.66
12_A16_V0.6660.64
7_G79_L0.6640.64
32_L71_A0.6600.64
54_G57_D0.6490.62
25_R30_F0.6470.62
26_R63_I0.6430.62
27_N90_L0.6420.62
54_G95_V0.6250.60
11_A29_L0.6160.58
24_I63_I0.6160.58
21_G67_S0.6130.58
11_A17_L0.6040.57
30_F73_A0.6030.57
95_V98_M0.5990.56
49_A71_A0.5930.56
64_L70_A0.5900.55
64_L67_S0.5850.55
35_L39_I0.5820.54
62_Y91_N0.5820.54
26_R85_R0.5800.54
48_V52_Y0.5750.53
42_S99_R0.5740.53
67_S82_Q0.5720.53
51_S82_Q0.5720.53
11_A15_F0.5710.53
21_G53_W0.5650.52
18_G40_N0.5640.52
37_I71_A0.5620.52
52_Y65_A0.5580.51
72_E75_I0.5580.51
43_A49_A0.5520.50
66_I82_Q0.5430.49
29_L95_V0.5420.49
26_R93_D0.5410.49
69_A73_A0.5410.49
9_I12_A0.5400.49
42_S53_W0.5370.48
78_A96_S0.5360.48
34_G63_I0.5310.48
50_G61_M0.5300.48
83_L86_R0.5260.47
73_A80_L0.5260.47
11_A44_L0.5240.47
12_A73_A0.5210.46
39_I68_L0.5210.46
28_L93_D0.5190.46
40_N75_I0.5180.46
57_D97_E0.5170.46
87_R94_S0.5150.46
27_N33_I0.5150.46
33_I65_A0.5140.46
65_A77_L0.5120.45
31_M90_L0.5110.45
78_A86_R0.5070.45
30_F50_G0.5050.44
31_M42_S0.5030.44
6_H98_M0.5010.44
52_Y56_T0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoK 1 1 99.9 0.367 Contact Map
4he8K 1 0.95 99.9 0.439 Contact Map
3rkoM 1 0.99 9.8 0.932 Contact Map
3rkoL 1 0.95 9.7 0.932 Contact Map
3rkoN 1 0.93 8.4 0.934 Contact Map
4he8M 1 0.96 8.1 0.934 Contact Map
2kluA 1 0.49 5.9 0.938 Contact Map
4he8L 1 0.95 5.6 0.938 Contact Map
4cz8A 2 0.84 3.7 0.944 Contact Map
1m5wA 5 0.62 3.1 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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