GREMLIN Database
NUOJ - NADH-quinone oxidoreductase subunit J
UniProt: P0AFE0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12090
Length: 184 (162)
Sequences: 2670 (1685)
Seq/√Len: 132.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_F52_G5.8991.00
12_A38_A4.1271.00
8_C41_G3.5651.00
17_L21_T3.5511.00
12_A35_S3.2611.00
22_H31_Y2.6371.00
142_E145_S2.5581.00
25_P70_V2.5161.00
5_F9_G2.4321.00
18_R31_Y2.3991.00
128_A131_I2.3971.00
152_L156_F2.3651.00
33_I64_M2.1701.00
10_L14_L2.1591.00
49_Y125_S2.1351.00
3_F7_I2.0501.00
12_A39_I2.0121.00
132_T136_P2.0031.00
138_V142_E2.0021.00
18_R21_T1.9201.00
100_S104_L1.8661.00
90_P93_W1.8321.00
43_F55_E1.7631.00
70_V74_L1.7321.00
11_I38_A1.6701.00
60_A160_R1.6641.00
8_C11_I1.6481.00
18_R22_H1.6371.00
40_S56_I1.6221.00
67_F70_V1.6001.00
15_A31_Y1.5631.00
4_A8_C1.5321.00
94_I97_A1.5001.00
25_P74_L1.5001.00
15_A35_S1.4961.00
15_A34_I1.4911.00
33_I62_A1.4791.00
141_V145_S1.4591.00
43_F154_V1.3891.00
30_L63_I1.3661.00
57_I63_I1.3491.00
66_L69_F1.3201.00
44_F53_A1.2991.00
47_G54_L1.2931.00
16_T35_S1.2821.00
127_K131_I1.2611.00
98_I102_I1.2601.00
49_Y126_A1.2581.00
65_V70_V1.2581.00
53_A60_A1.2511.00
35_S38_A1.2281.00
101_A105_V1.2221.00
68_V133_L1.1940.99
36_L134_F1.1920.99
14_L18_R1.1800.99
140_A145_S1.1780.99
15_A141_V1.1610.99
145_S152_L1.1530.99
93_W97_A1.1440.99
124_I127_K1.1300.99
106_V110_A1.1270.99
19_V28_A1.1250.99
114_V118_G1.1190.99
54_L58_V1.0940.99
4_A45_S1.0860.99
44_F68_V1.0860.99
137_Y140_A1.0820.99
28_A154_V1.0790.99
40_S55_E1.0700.99
104_L108_V1.0600.99
131_I136_P1.0540.99
149_L152_L1.0510.99
96_P104_L1.0410.99
31_Y53_A1.0350.98
47_G52_G1.0340.98
58_V67_F1.0330.98
89_K93_W1.0290.98
92_V96_P1.0200.98
99_L103_M1.0010.98
160_R163_R1.0000.98
52_G56_I0.9980.98
94_I120_D0.9960.98
113_G116_D0.9870.98
50_F129_V0.9680.98
61_G66_L0.9630.98
48_A142_E0.9530.97
15_A18_R0.9310.97
44_F49_Y0.9310.97
149_L156_F0.9270.97
32_L149_L0.9260.97
78_G81_I0.9170.97
55_E73_M0.9170.97
63_I70_V0.9120.97
8_C42_V0.9080.97
30_L62_A0.9040.96
97_A100_S0.9030.96
102_I106_V0.8960.96
62_A134_F0.8940.96
130_G152_L0.8840.96
144_A153_V0.8790.96
42_V45_S0.8760.96
33_I159_G0.8670.95
97_A107_I0.8580.95
120_D123_P0.8550.95
36_L144_A0.8520.95
43_F54_L0.8440.95
129_V146_M0.8420.95
25_P76_L0.8380.95
38_A42_V0.8280.94
13_I81_I0.8240.94
126_A142_E0.8210.94
63_I132_T0.8210.94
36_L65_V0.8200.94
8_C38_A0.8150.94
104_L107_I0.8010.93
22_H28_A0.7980.93
110_A114_V0.7910.93
7_I38_A0.7890.93
35_S44_F0.7870.93
65_V138_V0.7800.92
30_L34_I0.7770.92
25_P67_F0.7710.92
75_N134_F0.7690.92
80_E114_V0.7650.91
25_P58_V0.7630.91
89_K92_V0.7600.91
36_L64_M0.7600.91
76_L82_E0.7560.91
130_G134_F0.7560.91
61_G69_F0.7480.91
67_F155_A0.7480.91
125_S128_A0.7430.90
155_A159_G0.7410.90
9_G45_S0.7390.90
57_I78_G0.7360.90
51_A145_S0.7340.90
26_V70_V0.7330.90
31_Y34_I0.7290.89
56_I162_E0.7280.89
86_Q89_K0.7270.89
79_S83_Q0.7270.89
105_V108_V0.7230.89
62_A74_L0.7190.89
97_A122_T0.7120.88
101_A117_Q0.7090.88
96_P100_S0.7050.88
43_F48_A0.7020.88
50_F54_L0.7010.87
67_F74_L0.7000.87
28_A31_Y0.6900.87
104_L119_I0.6860.86
101_A120_D0.6830.86
29_L36_L0.6810.86
123_P131_I0.6780.86
70_V76_L0.6750.85
62_A156_F0.6710.85
130_G135_G0.6710.85
32_L36_L0.6680.85
14_L21_T0.6660.85
9_G12_A0.6650.85
13_I98_I0.6600.84
103_M111_I0.6590.84
48_A51_A0.6590.84
5_F158_V0.6570.84
36_L62_A0.6540.84
104_L115_N0.6530.84
27_H30_L0.6510.83
74_L158_V0.6500.83
39_I134_F0.6480.83
78_G82_E0.6460.83
123_P127_K0.6460.83
33_I60_A0.6460.83
63_I160_R0.6390.82
125_S155_A0.6360.82
29_L64_M0.6250.81
85_R89_K0.6210.80
155_A160_R0.6200.80
136_P139_L0.6200.80
52_G129_V0.6200.80
44_F111_I0.6190.80
47_G140_A0.6150.80
30_L57_I0.6140.80
27_H151_G0.6100.79
93_W96_P0.6080.79
145_S154_V0.5990.78
111_I118_G0.5960.78
91_Q118_G0.5930.77
39_I147_L0.5910.77
54_L100_S0.5890.77
34_I38_A0.5890.77
9_G13_I0.5860.76
81_I84_E0.5800.76
62_A151_G0.5780.75
71_V150_A0.5770.75
68_V71_V0.5750.75
93_W99_L0.5700.74
50_F72_M0.5690.74
4_A7_I0.5680.74
23_T91_Q0.5650.74
19_V22_H0.5640.74
94_I98_I0.5620.73
54_L124_I0.5590.73
93_W100_S0.5580.73
116_D119_I0.5570.73
4_A37_L0.5550.72
109_Y115_N0.5510.72
108_V112_L0.5490.72
100_S109_Y0.5490.72
110_A118_G0.5450.71
39_I151_G0.5440.71
29_L68_V0.5430.71
33_I70_V0.5420.71
78_G159_G0.5420.71
97_A117_Q0.5410.71
80_E83_Q0.5360.70
101_A116_D0.5360.70
52_G154_V0.5360.70
53_A126_A0.5350.70
6_Y10_L0.5350.70
80_E84_E0.5320.69
19_V32_L0.5280.69
36_L39_I0.5270.69
19_V144_A0.5240.68
14_L105_V0.5240.68
139_L142_E0.5210.68
95_G102_I0.5200.68
25_P75_N0.5190.67
109_Y117_Q0.5180.67
71_V78_G0.5170.67
64_M79_S0.5130.67
104_L126_A0.5120.66
51_A57_I0.5110.66
3_F104_L0.5100.66
15_A143_L0.5100.66
96_P112_L0.5090.66
25_P62_A0.5080.66
75_N152_L0.5080.66
64_M74_L0.5080.66
54_L146_M0.5070.66
134_F138_V0.5060.66
32_L66_L0.5050.65
29_L53_A0.5020.65
50_F69_F0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he8J 1 0.8641 100 0.268 Contact Map
3rkoJ 1 0.8913 100 0.27 Contact Map
4j05A 3 0.8152 30.8 0.934 Contact Map
2kluA 1 0.2989 29.6 0.934 Contact Map
4djkA 2 0.7826 27.4 0.935 Contact Map
3wdoA 1 0.8587 27.3 0.935 Contact Map
3l1lA 2 0.75 27.3 0.935 Contact Map
4w6vA 1 0.7337 26.7 0.935 Contact Map
3vouA 4 0.6304 23.4 0.937 Contact Map
2i68A 2 0.4185 21.6 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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