GREMLIN Database
NUOI - NADH-quinone oxidoreductase subunit I
UniProt: P0AFD6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12089
Length: 180 (147)
Sequences: 1027 (465)
Seq/√Len: 38.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_A108_A3.8091.00
106_E116_L3.7061.00
126_K129_D3.3041.00
13_Q17_I3.1741.00
11_G15_R2.9771.00
21_G24_A2.9211.00
40_L120_F2.7881.00
80_A90_E2.5741.00
62_A79_K2.4631.00
106_E114_I2.3761.00
121_E130_L2.3451.00
15_R18_W2.2580.99
78_Q91_F2.1990.99
32_M35_E2.1160.99
16_S20_I2.0890.99
64_N77_L2.0590.99
61_V111_T2.0320.99
37_P121_E1.9700.99
108_A113_A1.8220.98
133_E136_D1.8200.98
14_V18_W1.8110.98
72_V100_I1.7050.96
147_E151_Y1.7010.96
97_S130_L1.6950.96
96_F101_F1.6020.95
124_E129_D1.5870.95
47_R119_D1.5580.94
9_G12_T1.5200.93
50_L134_K1.5130.93
61_V115_Q1.4950.93
94_I107_E1.4540.92
79_K87_W1.3770.89
37_P120_F1.3740.89
23_H26_A1.3560.88
12_T15_R1.3510.88
82_T86_R1.2880.86
149_N153_M1.2540.84
140_S144_K1.2430.84
32_M36_E1.2370.83
72_V92_F1.2270.83
65_L68_V1.2240.83
47_R101_F1.2200.82
13_Q16_S1.2190.82
124_E130_L1.2160.82
96_F132_Y1.1870.81
58_E134_K1.1760.80
61_V64_N1.1730.80
105_C109_C1.1660.79
10_F14_V1.1570.79
50_L114_I1.1530.79
86_R97_S1.1510.79
47_R124_E1.1500.78
78_Q90_E1.1490.78
48_I96_F1.1470.78
146_P149_N1.1370.78
74_C100_I1.1300.77
42_P118_P1.1290.77
89_P92_F1.1150.76
50_L113_A1.1080.76
10_F13_Q1.1000.75
50_L137_L1.0950.75
22_L152_R1.0870.74
80_A88_Y1.0830.74
79_K89_P1.0830.74
67_A76_S1.0580.72
24_A146_P1.0430.71
53_D61_V1.0320.70
150_F153_M1.0180.69
151_Y155_G1.0170.69
20_I29_E1.0150.69
134_K137_L0.9970.68
53_D56_G0.9930.67
68_V106_E0.9900.67
52_R58_E0.9810.66
64_N68_V0.9810.66
94_I100_I0.9790.66
75_I95_N0.9730.66
99_C105_C0.9720.66
48_I94_I0.9660.65
149_N154_A0.9590.65
135_E138_L0.9570.65
33_Y121_E0.9550.64
62_A89_P0.9530.64
65_L69_A0.9510.64
56_G139_I0.9410.63
67_A77_L0.9260.62
40_L44_Y0.9150.61
38_V120_F0.9120.61
67_A96_F0.9100.61
44_Y69_A0.9040.60
75_I114_I0.8960.59
75_I113_A0.8950.59
100_I107_E0.8920.59
16_S19_M0.8890.59
23_H92_F0.8860.59
123_G130_L0.8740.57
126_K133_E0.8660.57
76_S91_F0.8580.56
96_F106_E0.8550.56
47_R117_T0.8540.56
10_F131_V0.8500.55
21_G25_F0.8400.54
53_D59_R0.8240.53
43_R51_T0.8190.53
65_L134_K0.8130.52
48_I119_D0.8070.52
74_C96_F0.8020.51
18_W22_L0.7990.51
69_A104_L0.7990.51
14_V139_I0.7850.50
50_L122_M0.7770.49
24_A27_K0.7760.49
129_D133_E0.7750.49
24_A28_R0.7720.48
93_R133_E0.7670.48
31_R38_V0.7640.48
152_R155_G0.7590.47
15_R21_G0.7570.47
149_N152_R0.7550.47
49_V115_Q0.7490.46
132_Y136_D0.7480.46
94_I116_L0.7480.46
94_I98_R0.7430.46
59_R113_A0.7430.46
64_N111_T0.7400.45
96_F114_I0.7380.45
77_L93_R0.7380.45
68_V108_A0.7340.45
77_L92_F0.7320.45
43_R114_I0.7210.44
32_M37_P0.7200.44
36_E39_Y0.7190.44
95_N98_R0.7190.44
21_G28_R0.7110.43
94_I110_P0.7020.42
148_Y151_Y0.7010.42
82_T85_G0.6980.42
62_A84_D0.6980.42
15_R19_M0.6960.42
62_A81_E0.6910.41
60_C63_C0.6890.41
60_C66_C0.6890.41
63_C66_C0.6890.41
66_C70_C0.6890.41
63_C70_C0.6890.41
60_C70_C0.6890.41
103_G106_E0.6880.41
66_C102_C0.6850.41
70_C102_C0.6850.41
63_C102_C0.6850.41
60_C102_C0.6850.41
48_I117_T0.6830.40
48_I72_V0.6790.40
98_R119_D0.6760.40
31_R140_S0.6690.39
14_V128_Q0.6660.39
78_Q95_N0.6610.39
94_I135_E0.6550.38
112_T118_P0.6550.38
12_T100_I0.6550.38
22_L147_E0.6540.38
68_V89_P0.6530.38
102_C105_C0.6470.37
20_I24_A0.6440.37
39_Y128_Q0.6410.37
9_G86_R0.6360.36
65_L98_R0.6350.36
132_Y140_S0.6340.36
22_L29_E0.6310.36
124_E132_Y0.6280.36
81_E89_P0.6120.35
70_C99_C0.6080.34
66_C99_C0.6080.34
63_C99_C0.6080.34
60_C99_C0.6080.34
147_E150_F0.6070.34
64_N67_A0.6050.34
93_R106_E0.6030.34
99_C102_C0.6030.34
75_I94_I0.6010.34
66_C109_C0.5900.33
70_C109_C0.5900.33
63_C109_C0.5900.33
60_C109_C0.5900.33
73_G101_F0.5890.33
26_A42_P0.5860.32
102_C109_C0.5820.32
43_R57_E0.5760.32
65_L103_G0.5740.31
67_A75_I0.5730.31
16_S92_F0.5710.31
29_E32_M0.5710.31
129_D136_D0.5690.31
78_Q84_D0.5680.31
41_P101_F0.5670.31
86_R89_P0.5620.31
99_C110_P0.5600.30
11_G18_W0.5580.30
95_N112_T0.5580.30
22_L26_A0.5570.30
76_S82_T0.5550.30
77_L95_N0.5490.30
61_V92_F0.5470.29
51_T58_E0.5420.29
83_K152_R0.5350.29
57_E106_E0.5340.28
86_R95_N0.5310.28
149_N155_G0.5260.28
125_Y135_E0.5230.28
74_C89_P0.5220.28
26_A32_M0.5220.28
104_L120_F0.5210.28
18_W24_A0.5200.27
29_E79_K0.5190.27
77_L112_T0.5190.27
52_R56_G0.5170.27
18_W26_A0.5120.27
91_F133_E0.5030.26
108_A120_F0.5020.26
47_R96_F0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v9 1 0.7833 100 0.546 Contact Map
5c4iB 1 0.6 99.5 0.737 Contact Map
1gteA 4 0.6389 99.5 0.738 Contact Map
1xerA 2 0.5389 99.4 0.752 Contact Map
2c42A 2 0.9222 99.4 0.754 Contact Map
4omfG 2 0.6111 99.3 0.762 Contact Map
1jb0C 1 0.4444 99.3 0.762 Contact Map
2gmhA 1 0.6778 99.3 0.763 Contact Map
3i9v3 1 0.8333 99.3 0.764 Contact Map
2fgoA 1 0.4167 99.3 0.768 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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