GREMLIN Database
NUOH - NADH-quinone oxidoreductase subunit H
UniProt: P0AFD4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12088
Length: 325 (307)
Sequences: 5434 (2585)
Seq/√Len: 147.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_S178_D4.8521.00
196_F252_M3.9341.00
40_L287_A3.8121.00
200_A281_M3.7761.00
33_S60_L3.7731.00
250_A271_F3.6531.00
43_F287_A3.4191.00
253_V271_F3.2231.00
142_S227_I2.7741.00
250_A275_T2.7411.00
257_F278_F2.5821.00
171_A188_N2.4671.00
61_V64_M2.4251.00
204_V285_I2.4201.00
199_F252_M2.4051.00
182_S188_N2.3911.00
94_L244_G2.3731.00
189_V257_F2.3671.00
72_D233_K2.3571.00
178_D181_N2.3281.00
207_C282_F2.2751.00
262_G270_W2.1781.00
189_V196_F2.1661.00
249_S278_F2.1581.00
94_L243_I2.1321.00
223_D226_H2.1281.00
246_V279_M2.0851.00
120_L161_G2.0751.00
90_A129_A2.0291.00
169_A317_A2.0251.00
82_I132_F2.0001.00
97_A247_T1.9391.00
25_V243_I1.9381.00
201_I305_C1.9311.00
134_G146_A1.9161.00
266_P270_W1.8801.00
203_G248_I1.8771.00
181_N184_A1.8691.00
68_F235_G1.8571.00
90_A240_G1.8361.00
96_L118_F1.8251.00
200_A204_V1.8151.00
277_F281_M1.8021.00
32_M279_M1.7931.00
31_F60_L1.7471.00
118_F122_M1.7321.00
195_G256_F1.7311.00
39_L280_M1.7181.00
35_G280_M1.7031.00
192_Q316_T1.7011.00
29_G243_I1.6991.00
66_K70_K1.6221.00
166_G195_G1.6191.00
186_V190_I1.5991.00
187_W274_K1.5891.00
175_N178_D1.5871.00
152_Q297_V1.5791.00
100_I118_F1.5671.00
108_V177_T1.5521.00
226_H234_F1.5431.00
234_F238_F1.5021.00
43_F284_L1.4971.00
214_Q297_V1.4921.00
19_V23_L1.4741.00
195_G312_N1.4691.00
167_V179_I1.4581.00
266_P269_I1.4521.00
262_G265_L1.4191.00
42_L47_Y1.4181.00
119_F123_A1.4151.00
159_F202_A1.4141.00
29_G239_V1.4031.00
217_A221_L1.4011.00
162_L313_L1.3931.00
149_A215_P1.3701.00
39_L283_I1.3571.00
284_L288_S1.3511.00
203_G252_M1.3501.00
171_A179_I1.3501.00
89_I93_S1.3451.00
39_L43_F1.3401.00
214_Q292_P1.3361.00
171_A182_S1.3281.00
104_S107_W1.2971.00
164_L255_L1.2931.00
252_M278_F1.2921.00
217_A220_E1.2821.00
112_L118_F1.2811.00
169_A320_I1.2811.00
145_G215_P1.2641.00
84_T233_K1.2621.00
47_Y50_N1.2561.00
193_F197_I1.2531.00
160_L202_A1.2481.00
300_F305_C1.2461.00
23_L26_V1.2441.00
54_W58_L1.2311.00
139_N142_S1.2191.00
159_F309_T1.2171.00
96_L122_M1.2051.00
131_L150_S1.2021.00
253_V257_F1.1861.00
170_Q192_Q1.1851.00
294_Y298_M1.1811.00
205_A212_F1.1791.00
199_F248_I1.1781.00
61_V65_I1.1771.00
28_C246_V1.1741.00
36_E209_R1.1681.00
222_A227_I1.1671.00
245_I279_M1.1561.00
38_R42_L1.1531.00
177_T181_N1.1501.00
99_A118_F1.1421.00
166_G309_T1.1340.99
265_L269_I1.1270.99
27_T61_V1.1260.99
280_M284_L1.1240.99
98_F247_T1.1230.99
83_F87_P1.1220.99
245_I282_F1.1210.99
178_D182_S1.1150.99
36_E286_R1.1110.99
68_F232_M1.1090.99
133_A136_S1.1070.99
59_Q63_D1.1000.99
86_A133_A1.0880.99
111_D175_N1.0860.99
28_C276_A1.0810.99
34_F57_S1.0810.99
193_F196_F1.0760.99
207_C248_I1.0690.99
198_T308_L1.0690.99
184_A261_Q1.0680.99
159_F301_G1.0660.99
42_L50_N1.0650.99
253_V275_T1.0570.99
183_Q188_N1.0560.99
111_D177_T1.0540.99
65_I69_F1.0460.99
183_Q258_G1.0460.99
214_Q296_Q1.0430.99
31_F57_S1.0390.99
127_V153_T1.0360.99
250_A254_T1.0350.99
232_M235_G1.0330.99
116_I168_V1.0280.99
214_Q221_L1.0260.99
75_P83_F1.0250.99
33_S242_Y1.0250.99
86_A132_F1.0220.99
75_P78_S1.0200.99
278_F281_M1.0190.99
35_G39_L1.0150.99
259_G274_K1.0120.99
159_F306_L1.0110.99
91_F95_L1.0100.99
91_F236_L1.0040.99
173_S179_I1.0000.99
16_L20_V0.9960.99
52_V59_Q0.9930.99
34_F60_L0.9920.99
257_F274_K0.9900.99
133_A229_Y0.9890.99
188_N191_P0.9880.99
197_I201_I0.9870.99
162_L310_L0.9790.98
133_A237_F0.9790.98
147_M215_P0.9760.98
187_W258_G0.9660.98
221_L225_Y0.9600.98
74_I84_T0.9540.98
168_V174_F0.9540.98
166_G313_L0.9530.98
186_V191_P0.9480.98
86_A136_S0.9450.98
293_R298_M0.9430.98
163_S198_T0.9380.98
267_P270_W0.9360.98
115_G175_N0.9350.98
271_F275_T0.9290.98
23_L27_T0.9250.98
217_A291_R0.9230.98
128_Y294_Y0.9210.98
38_R70_K0.9180.98
42_L55_G0.9180.98
200_A282_F0.9180.98
100_I115_G0.9160.98
312_N316_T0.9140.98
91_F240_G0.9080.98
213_D291_R0.8940.97
183_Q187_W0.8940.97
284_L289_L0.8890.97
213_D216_E0.8840.97
199_F256_F0.8800.97
40_L286_R0.8790.97
170_Q320_I0.8770.97
64_M69_F0.8710.97
67_M235_G0.8700.97
316_T320_I0.8690.97
119_F176_M0.8690.97
86_A129_A0.8690.97
93_S122_M0.8680.97
262_G266_P0.8680.97
210_H289_L0.8650.97
152_Q208_H0.8640.97
192_Q312_N0.8630.97
64_M68_F0.8620.97
26_V95_L0.8540.96
35_G283_I0.8530.96
163_S202_A0.8480.96
116_I176_M0.8470.96
200_A252_M0.8450.96
292_P296_Q0.8410.96
90_A237_F0.8400.96
181_N185_H0.8350.96
38_R50_N0.8340.96
152_Q156_Y0.8340.96
41_G47_Y0.8330.96
31_F61_V0.8320.96
159_F305_C0.8310.96
187_W259_G0.8290.96
226_H238_F0.8260.96
120_L164_L0.8260.96
209_R213_D0.8220.96
166_G192_Q0.8180.95
67_M238_F0.8160.95
187_W190_I0.8150.95
215_P225_Y0.8140.95
50_N55_G0.8110.95
308_L312_N0.8040.95
196_F256_F0.8030.95
34_F42_L0.8020.95
84_T88_M0.8010.95
180_V260_W0.8000.95
103_V109_V0.7970.95
44_Q49_P0.7960.95
64_M239_V0.7940.95
59_Q66_K0.7920.95
231_G235_G0.7920.95
49_P59_Q0.7860.94
281_M285_I0.7800.94
37_R46_R0.7790.94
63_D66_K0.7770.94
108_V111_D0.7690.94
130_V149_A0.7640.93
135_W138_N0.7640.93
30_A40_L0.7630.93
33_S36_E0.7630.93
31_F34_F0.7570.93
79_D138_N0.7520.93
258_G274_K0.7500.93
219_Q222_A0.7500.93
15_I19_V0.7490.93
235_G239_V0.7440.93
21_I109_V0.7430.92
109_V239_V0.7420.92
36_E40_L0.7400.92
37_R63_D0.7350.92
83_F229_Y0.7350.92
180_V259_G0.7340.92
112_L119_F0.7340.92
253_V274_K0.7330.92
94_L247_T0.7290.92
238_F286_R0.7270.92
206_V209_R0.7260.92
112_L237_F0.7250.92
58_L61_V0.7240.91
204_V282_F0.7230.91
105_P181_N0.7190.91
123_A126_A0.7170.91
182_S185_H0.7170.91
163_S166_G0.7170.91
299_S303_K0.7170.91
265_L268_F0.7150.91
34_F40_L0.7140.91
36_E242_Y0.7130.91
78_S83_F0.7120.91
199_F203_G0.7090.91
220_E291_R0.7080.91
101_V250_A0.7070.91
37_R216_E0.7050.90
293_R296_Q0.7050.90
100_I119_F0.7040.90
149_A217_A0.7020.90
28_C31_F0.7020.90
205_A297_V0.7000.90
200_A278_F0.7000.90
13_L16_L0.6990.90
53_G58_L0.6980.90
160_L301_G0.6970.90
277_F280_M0.6940.90
111_D115_G0.6920.90
26_V30_A0.6910.89
262_G267_P0.6910.89
166_G312_N0.6910.89
216_E224_G0.6910.89
268_F272_A0.6890.89
92_T315_V0.6890.89
184_A188_N0.6850.89
139_N282_F0.6840.89
91_F227_I0.6820.89
116_I179_I0.6820.89
40_L45_N0.6820.89
219_Q223_D0.6820.89
253_V267_P0.6810.89
152_Q155_S0.6800.89
90_A126_A0.6800.89
44_Q228_E0.6750.88
196_F257_F0.6740.88
271_F274_K0.6720.88
279_M283_I0.6700.88
248_I252_M0.6670.88
176_M251_L0.6660.88
260_W274_K0.6630.87
22_L26_V0.6630.87
156_Y205_A0.6620.87
87_P229_Y0.6600.87
28_C279_M0.6600.87
137_S229_Y0.6570.87
149_A221_L0.6570.87
155_S298_M0.6570.87
74_I80_R0.6560.87
295_D298_M0.6560.87
82_I86_A0.6560.87
96_L178_D0.6530.87
47_Y51_R0.6530.87
160_L163_S0.6520.87
142_S223_D0.6510.87
309_T316_T0.6430.86
101_V109_V0.6420.86
145_G149_A0.6410.86
13_L17_K0.6410.86
25_V29_G0.6390.86
266_P273_L0.6330.85
37_R48_G0.6310.85
210_H219_Q0.6310.85
34_F55_G0.6310.85
291_R295_D0.6300.85
213_D221_L0.6290.85
18_A110_A0.6290.85
101_V247_T0.6280.85
170_Q191_P0.6260.84
27_T30_A0.6250.84
30_A34_F0.6240.84
18_A21_I0.6240.84
315_V318_A0.6230.84
83_F133_A0.6230.84
30_A64_M0.6220.84
42_L283_I0.6210.84
198_T201_I0.6200.84
165_M313_L0.6200.84
275_T279_M0.6170.83
75_P87_P0.6150.83
21_I103_V0.6140.83
179_I255_L0.6130.83
85_L88_M0.6120.83
89_I92_T0.6110.83
70_K303_K0.6090.83
166_G316_T0.6060.82
273_L276_A0.6050.82
72_D83_F0.6010.82
129_A132_F0.5980.82
130_V208_H0.5980.82
161_G164_L0.5970.81
116_I164_L0.5950.81
90_A130_V0.5940.81
64_M235_G0.5910.81
200_A284_L0.5880.80
167_V255_L0.5880.80
24_V28_C0.5870.80
145_G222_A0.5830.80
137_S142_S0.5820.80
165_M168_V0.5810.80
38_R57_S0.5810.80
95_L243_I0.5790.79
223_D238_F0.5780.79
53_G59_Q0.5780.79
301_G304_I0.5770.79
306_L309_T0.5750.79
213_D220_E0.5730.79
163_S195_G0.5720.79
132_F136_S0.5710.79
272_A275_T0.5700.78
171_A178_D0.5690.78
90_A97_A0.5690.78
62_A140_K0.5680.78
297_V306_L0.5670.78
63_D291_R0.5650.78
214_Q217_A0.5640.78
41_G46_R0.5630.78
125_L304_I0.5600.77
207_C244_G0.5600.77
123_A252_M0.5590.77
16_L196_F0.5550.77
17_K21_I0.5540.76
225_Y238_F0.5540.76
283_I286_R0.5540.76
14_T17_K0.5530.76
34_F38_R0.5500.76
65_I68_F0.5470.76
103_V250_A0.5460.75
292_P301_G0.5460.75
13_L277_F0.5460.75
116_I174_F0.5450.75
129_A161_G0.5420.75
93_S96_L0.5410.75
167_V192_Q0.5400.75
254_T259_G0.5400.75
85_L89_I0.5390.74
209_R242_Y0.5380.74
77_F231_G0.5380.74
155_S306_L0.5370.74
291_R294_Y0.5370.74
18_A22_L0.5360.74
42_L161_G0.5350.74
30_A239_V0.5340.74
14_T20_V0.5330.74
119_F247_T0.5330.74
194_F312_N0.5310.73
100_I201_I0.5310.73
74_I78_S0.5300.73
249_S253_V0.5300.73
183_Q259_G0.5290.73
129_A146_A0.5290.73
159_F294_Y0.5290.73
117_L294_Y0.5280.73
150_S159_F0.5270.73
208_H241_E0.5270.73
46_R224_G0.5270.73
269_I273_L0.5260.73
197_I313_L0.5240.72
142_S320_I0.5230.72
21_I24_V0.5230.72
95_L239_V0.5200.72
208_H244_G0.5200.72
86_A124_G0.5190.72
263_P266_P0.5180.72
100_I103_V0.5180.72
103_V272_A0.5170.71
60_L67_M0.5170.71
60_L283_I0.5150.71
253_V278_F0.5150.71
81_V320_I0.5150.71
53_G235_G0.5130.71
197_I277_F0.5130.71
181_N259_G0.5110.71
14_T320_I0.5110.71
93_S126_A0.5100.70
297_V302_W0.5100.70
146_A240_G0.5100.70
221_L226_H0.5100.70
128_Y160_L0.5090.70
97_A114_I0.5080.70
242_Y286_R0.5060.70
120_L129_A0.5060.70
194_F198_T0.5050.70
151_A205_A0.5040.70
153_T161_G0.5030.69
177_T185_H0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he8H 1 0.8215 100 0.079 Contact Map
2jpkA 1 0.1077 7.4 0.97 Contact Map
3mp7A 1 0.1631 6.2 0.972 Contact Map
1q90G 1 0.0923 4.8 0.973 Contact Map
4h25C 1 0.0677 4.2 0.974 Contact Map
1q2fA 1 0.0954 3.8 0.974 Contact Map
1vryA 1 0.1877 3.3 0.975 Contact Map
2ll2A 1 0.08 2.8 0.976 Contact Map
3dacP 1 0.04 2.3 0.977 Contact Map
3w4tA 1 0.9385 1.9 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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