GREMLIN Database
NUOE - NADH-quinone oxidoreductase subunit E
UniProt: P0AFD1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12086
Length: 166 (150)
Sequences: 3290 (2120)
Seq/√Len: 173.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_H146_D4.4411.00
110_E116_K3.8181.00
112_K159_P3.3851.00
86_R125_R3.0441.00
120_T127_T2.9651.00
108_A159_P2.7451.00
110_E128_L2.6391.00
37_I79_I2.6031.00
23_E61_V2.2741.00
43_V58_I2.0011.00
112_K163_E1.9971.00
106_Q117_P1.9871.00
80_F84_V1.9381.00
55_I73_A1.9121.00
100_N140_G1.7701.00
23_E57_A1.6951.00
73_A81_R1.6761.00
59_A69_V1.6551.00
143_M153_L1.6131.00
109_L158_I1.6061.00
36_S64_I1.6001.00
105_I158_I1.5571.00
58_I69_V1.5541.00
33_R68_D1.5331.00
36_S69_V1.5121.00
85_G120_T1.5061.00
85_G127_T1.4921.00
107_A111_K1.4891.00
91_Y106_Q1.4851.00
153_L161_L1.4821.00
36_S72_V1.4571.00
88_V127_T1.4511.00
108_A112_K1.4421.00
89_I145_I1.4411.00
52_D56_H1.4381.00
113_L121_T1.4341.00
115_I121_T1.4141.00
50_V73_A1.4141.00
134_L142_N1.3991.00
88_V129_L1.3971.00
107_A110_E1.3931.00
57_A61_V1.3611.00
57_A60_D1.3611.00
134_L144_M1.3591.00
154_T157_A1.3231.00
116_K119_Q1.2911.00
67_S71_G1.2801.00
51_P54_A1.2771.00
115_I119_Q1.2551.00
139_K151_A1.2491.00
21_A46_Q1.2371.00
108_A111_K1.2321.00
56_H66_A1.2301.00
87_H125_R1.2021.00
55_I69_V1.1991.00
110_E117_P1.1971.00
104_G107_A1.1881.00
108_A155_P1.1861.00
157_A160_E1.1831.00
41_K79_I1.1821.00
16_A20_E1.1711.00
43_V54_A1.1691.00
136_N139_K1.1531.00
92_C97_C1.1041.00
47_R51_P1.0851.00
19_R23_E1.0741.00
84_V127_T1.0741.00
91_Y143_M1.0490.99
89_I126_F1.0430.99
25_E42_I1.0330.99
28_H42_I1.0290.99
32_P63_G1.0290.99
150_H161_L1.0260.99
93_D130_P1.0210.99
109_L143_M0.9960.99
160_E164_R0.9950.99
39_A62_L0.9860.99
29_Y42_I0.9800.99
143_M158_I0.9780.99
55_I70_E0.9770.99
45_K147_E0.9760.99
115_I128_L0.9750.99
52_D81_R0.9730.99
70_E81_R0.9650.99
20_E23_E0.9510.99
144_M149_T0.9480.99
144_M147_E0.9410.99
90_R131_T0.9410.99
41_K45_K0.9310.99
65_P68_D0.9230.99
82_Q119_Q0.9170.99
69_V72_V0.9100.99
20_E24_H0.8960.98
74_T81_R0.8930.98
91_Y109_L0.8890.98
103_Q107_A0.8890.98
143_M161_L0.8890.98
22_I57_A0.8860.98
89_I161_L0.8720.98
21_A24_H0.8680.98
96_V140_G0.8680.98
109_L162_L0.8680.98
33_R64_I0.8640.98
38_E41_K0.8610.98
115_I120_T0.8600.98
41_K78_Q0.8580.98
17_A21_A0.8580.98
43_V50_V0.8460.98
106_Q110_E0.8450.98
108_A158_I0.8430.98
90_R129_L0.8430.98
19_R61_V0.8360.98
96_V100_N0.8290.97
48_G80_F0.8230.97
78_Q132_C0.8180.97
50_V58_I0.8160.97
80_F129_L0.8110.97
90_R144_M0.8080.97
21_A25_E0.8060.97
136_N142_N0.8000.97
16_A19_R0.7990.97
148_D165_Y0.7930.97
19_R57_A0.7920.97
35_A39_A0.7910.97
30_E34_A0.7850.96
110_E118_G0.7840.96
50_V55_I0.7840.96
44_Q48_G0.7800.96
84_V129_L0.7760.96
139_K152_H0.7760.96
97_C137_C0.7680.96
131_T134_L0.7660.96
121_T125_R0.7640.96
64_I69_V0.7570.96
56_H60_D0.7540.95
162_L165_Y0.7480.95
145_I165_Y0.7440.95
101_G104_G0.7410.95
47_R54_A0.7380.95
159_P163_E0.7340.95
95_V98_H0.7290.95
26_M61_V0.7280.94
98_H132_C0.7260.94
24_H27_H0.7230.94
43_V46_Q0.7120.94
148_D164_R0.7110.94
42_I45_K0.7090.94
22_I39_A0.7080.94
18_E22_I0.7030.93
90_R147_E0.7030.93
92_C137_C0.7010.93
18_E46_Q0.6990.93
22_I26_M0.6910.93
94_S132_C0.6900.93
96_V99_I0.6850.93
23_E27_H0.6850.93
95_V99_I0.6810.92
121_T126_F0.6790.92
93_D106_Q0.6730.92
21_A42_I0.6620.91
24_H28_H0.6550.91
160_E163_E0.6550.91
142_N149_T0.6540.91
39_A58_I0.6500.90
93_D132_C0.6500.90
157_A161_L0.6440.90
90_R146_D0.6430.90
145_I150_H0.6400.90
43_V51_P0.6390.90
150_H162_L0.6330.89
136_N149_T0.6280.89
68_D71_G0.6250.89
27_H61_V0.6160.88
104_G155_P0.6160.88
25_E46_Q0.6150.88
80_F88_V0.6150.88
35_A38_E0.6070.87
109_L128_L0.6050.87
53_G56_H0.6050.87
62_L69_V0.6000.87
37_I41_K0.5980.86
29_Y32_P0.5900.86
113_L123_D0.5870.85
113_L126_F0.5870.85
22_I61_V0.5860.85
120_T128_L0.5820.85
126_F150_H0.5810.85
65_P140_G0.5780.85
26_M39_A0.5780.85
60_D66_A0.5780.85
30_E61_V0.5770.84
145_I161_L0.5730.84
121_T162_L0.5710.84
131_T144_M0.5700.84
126_F165_Y0.5620.83
109_L113_L0.5590.83
95_V136_N0.5520.82
143_M150_H0.5490.81
114_N122_F0.5490.81
59_A64_I0.5440.81
40_L73_A0.5420.81
118_G129_L0.5390.80
59_A62_L0.5390.80
117_P130_P0.5370.80
136_N151_A0.5320.79
29_Y39_A0.5290.79
132_C138_D0.5230.78
96_V139_K0.5230.78
105_I155_P0.5230.78
95_V139_K0.5220.78
77_S149_T0.5210.78
43_V47_R0.5200.78
142_N153_L0.5180.78
59_A66_A0.5180.78
32_P35_A0.5170.77
23_E26_M0.5170.77
75_F79_I0.5140.77
35_A62_L0.5120.77
22_I25_E0.5070.76
125_R162_L0.5060.76
89_I113_L0.5050.76
117_P128_L0.5020.75
22_I47_R0.5000.75
115_I122_F0.5000.75
82_Q85_G0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v2 1 0.9217 100 0.159 Contact Map
2auvA 1 0.512 99.9 0.584 Contact Map
1m2dA 2 0.4699 99.7 0.662 Contact Map
2k9lA 1 0.4578 48.5 0.934 Contact Map
3cuqA 1 0.8012 47.6 0.934 Contact Map
2k9mA 1 0.747 45.7 0.935 Contact Map
1iimA 3 0.4518 45.5 0.935 Contact Map
4ihuA 3 0.7169 45.4 0.935 Contact Map
2g3bA 2 0.7229 38 0.938 Contact Map
1u5tA 1 0.6687 36.9 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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