GREMLIN Database
NUOB - NADH-quinone oxidoreductase subunit B
UniProt: P0AFC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12083
Length: 220 (171)
Sequences: 444 (133)
Seq/√Len: 10.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_Y123_V5.1741.00
60_G65_Y5.1631.00
167_Q171_L3.2570.96
109_V143_Q3.0000.93
128_A168_A2.7530.90
68_M165_Y2.6640.88
122_W131_N2.5230.85
125_S131_N2.5150.85
41_K44_D2.5070.84
155_I168_A2.3770.81
61_L68_M2.3090.79
79_A83_A2.0320.69
97_V126_M1.9840.67
54_I176_I1.9600.66
71_S166_M1.9070.64
99_A145_V1.8600.62
85_V89_S1.7870.59
93_A121_K1.7630.58
73_T78_V1.7610.58
101_T164_A1.7440.57
83_A173_Q1.7250.56
75_V175_S1.7120.55
132_S161_R1.6890.54
128_A131_N1.6580.53
88_A145_V1.6440.52
75_V163_E1.5770.49
101_T107_A1.5050.46
192_V195_A1.4790.45
47_N89_S1.4640.44
135_M143_Q1.4490.43
81_F161_R1.4100.42
40_G89_S1.3760.40
33_V43_N1.3700.40
74_A78_V1.3440.39
61_L102_C1.3420.38
59_F173_Q1.3390.38
128_A155_I1.3140.37
121_K155_I1.3030.37
131_N136_Y1.2990.37
144_G151_V1.2990.37
44_D174_E1.2960.36
75_V111_Q1.2940.36
189_D193_Y1.2870.36
65_Y103_F1.2860.36
97_V165_Y1.2790.36
71_S78_V1.2760.36
95_L156_P1.2670.35
92_Q116_Q1.2280.34
32_E95_L1.2210.33
58_N86_L1.2070.33
65_Y72_F1.2040.33
140_S143_Q1.1950.32
37_V153_V1.1940.32
105_K126_M1.1830.32
37_V113_L1.1800.32
58_N65_Y1.1740.31
122_W140_S1.1730.31
25_V28_P1.1700.31
51_K177_G1.1570.31
128_A141_V1.1550.31
111_Q115_D1.1480.30
73_T125_S1.1480.30
102_C145_V1.1450.30
57_Y93_A1.1410.30
56_P106_M1.1330.30
96_M99_A1.1170.29
113_L131_N1.1130.29
139_Y151_V1.1130.29
52_N122_W1.1050.29
108_P142_V1.0970.28
105_K117_M1.0930.28
43_N175_S1.0840.28
128_A136_Y1.0810.28
90_P100_G1.0600.27
81_F170_M1.0520.27
89_S119_E1.0440.26
132_S143_Q1.0370.26
68_M185_W1.0370.26
33_V37_V1.0340.26
45_M195_A1.0330.26
48_W113_L1.0220.26
42_L121_K1.0200.26
189_D195_A1.0180.26
58_N88_A1.0180.26
117_M123_V1.0120.25
76_H121_K1.0120.25
133_G139_Y1.0120.25
95_L165_Y1.0090.25
163_E173_Q1.0060.25
61_L131_N1.0050.25
146_D154_Y0.9850.24
62_S86_L0.9810.24
57_Y66_V0.9740.24
66_V102_C0.9710.24
70_T162_P0.9660.24
47_N175_S0.9660.24
68_M86_L0.9650.24
47_N57_Y0.9630.24
79_A85_V0.9610.24
74_A88_A0.9600.24
62_S69_V0.9560.23
74_A186_V0.9530.23
76_H166_M0.9490.23
64_C159_P0.9480.23
98_V130_A0.9410.23
122_W143_Q0.9410.23
42_L49_G0.9400.23
129_C133_G0.9370.23
86_L165_Y0.9350.23
61_L65_Y0.9350.23
75_V87_R0.9250.22
34_N185_W0.9190.22
88_A93_A0.9180.22
122_W130_A0.9150.22
113_L124_I0.9080.22
114_Y151_V0.9070.22
135_M162_P0.9040.22
49_G52_N0.9030.22
164_A168_A0.8990.22
78_V83_A0.8990.22
177_G188_G0.8990.22
33_V36_N0.8980.22
52_N79_A0.8950.21
104_T137_D0.8920.21
42_L46_V0.8860.21
106_M159_P0.8820.21
71_S187_V0.8680.21
116_Q120_P0.8640.21
58_N137_D0.8610.20
40_G54_I0.8600.20
45_M76_H0.8530.20
96_M149_I0.8450.20
104_T110_I0.8360.20
141_V164_A0.8300.20
136_Y147_K0.8260.19
93_A145_V0.8250.19
31_Q74_A0.8170.19
34_N168_A0.8080.19
25_V29_L0.8020.19
68_M125_S0.7900.18
69_V104_T0.7870.18
112_R115_D0.7860.18
41_K46_V0.7840.18
153_V162_P0.7830.18
129_C150_P0.7830.18
78_V110_I0.7800.18
133_G152_D0.7790.18
115_D170_M0.7790.18
45_M176_I0.7780.18
85_V112_R0.7740.18
42_L119_E0.7720.18
24_I27_D0.7700.18
125_S128_A0.7650.18
38_F166_M0.7610.18
107_A111_Q0.7590.18
62_S96_M0.7570.17
30_E38_F0.7570.17
99_A165_Y0.7540.17
155_I173_Q0.7440.17
129_C152_D0.7350.17
89_S106_M0.7340.17
74_A86_L0.7310.17
42_L57_Y0.7300.17
117_M133_G0.7290.17
133_G150_P0.7290.17
62_S101_T0.7270.17
136_Y156_P0.7240.17
72_F97_V0.7200.17
73_T135_M0.7180.16
166_M180_R0.7170.16
38_F43_N0.7150.16
39_M179_E0.7100.16
35_K193_Y0.7070.16
116_Q155_I0.7070.16
123_V151_V0.7070.16
26_T33_V0.7070.16
149_I180_R0.7050.16
65_Y176_I0.7020.16
73_T167_Q0.6950.16
47_N121_K0.6950.16
59_F155_I0.6860.16
169_L184_S0.6850.16
35_K175_S0.6840.16
103_F138_I0.6810.16
65_Y69_V0.6810.16
95_L124_I0.6780.15
125_S141_V0.6770.15
66_V110_I0.6720.15
128_A164_A0.6720.15
111_Q149_I0.6720.15
58_N72_F0.6700.15
73_T171_L0.6630.15
58_N69_V0.6590.15
117_M120_P0.6570.15
114_Y146_D0.6490.15
144_G154_Y0.6490.15
91_R100_G0.6470.15
48_W103_F0.6440.15
62_S65_Y0.6430.15
120_P123_V0.6410.15
183_L187_V0.6310.14
104_T162_P0.6200.14
135_M138_I0.6140.14
101_T168_A0.6140.14
101_T141_V0.6130.14
43_N188_G0.6100.14
24_I29_L0.6080.14
30_E34_N0.6060.14
94_D99_A0.6020.14
190_Q195_A0.6000.14
30_E33_V0.5940.14
54_I177_G0.5920.14
114_Y144_G0.5890.13
80_R100_G0.5890.13
78_V166_M0.5820.13
50_R75_V0.5810.13
89_S92_Q0.5780.13
72_F86_L0.5760.13
80_R90_P0.5760.13
104_T117_M0.5740.13
93_A155_I0.5720.13
144_G150_P0.5690.13
50_R87_R0.5680.13
54_I124_I0.5670.13
56_P86_L0.5650.13
43_N92_Q0.5620.13
83_A169_L0.5550.13
113_L145_V0.5530.13
131_N141_V0.5520.13
61_L128_A0.5490.13
138_I143_Q0.5470.13
183_L188_G0.5440.12
102_C106_M0.5320.12
92_Q149_I0.5300.12
145_V151_V0.5300.12
130_A139_Y0.5260.12
45_M54_I0.5250.12
171_L174_E0.5240.12
144_G159_P0.5230.12
98_V187_V0.5230.12
69_V113_L0.5230.12
48_W87_R0.5200.12
40_G97_V0.5170.12
110_I145_V0.5150.12
54_I95_L0.5150.12
88_A115_D0.5130.12
57_Y69_V0.5090.12
72_F137_D0.5080.12
101_T140_S0.5080.12
50_R76_H0.5080.12
167_Q178_K0.5070.12
155_I161_R0.5060.12
82_G90_P0.5020.12
118_L170_M0.5020.12
56_P126_M0.5020.12
126_M142_V0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v6 1 0.6591 100 0.432 Contact Map
1h2aS 1 0.7727 100 0.625 Contact Map
2wpnA 1 0.7773 100 0.636 Contact Map
3ayxB 2 0.7545 100 0.641 Contact Map
4uqlA 1 0.7636 100 0.65 Contact Map
4ue3S 2 0.7591 100 0.65 Contact Map
3ze9A 1 0.7545 100 0.66 Contact Map
3myrA 3 0.7591 100 0.661 Contact Map
1yq9A 2 0.7636 100 0.665 Contact Map
4u9hS 1 0.7636 100 0.666 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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