GREMLIN Database
NUOA - NADH-quinone oxidoreductase subunit A
UniProt: P0AFC3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12082
Length: 147 (112)
Sequences: 4168 (1955)
Seq/√Len: 184.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_E117_L4.5461.00
88_W103_A3.7591.00
26_L30_M3.4881.00
34_G38_G3.0941.00
25_G29_L3.0291.00
116_Y119_R2.6811.00
95_S99_G2.6331.00
116_Y120_I2.5101.00
67_K126_T2.3971.00
98_V102_E2.3381.00
42_R47_N2.1961.00
24_I28_C2.0331.00
85_L103_A2.0091.00
68_F71_V1.9351.00
109_V117_L1.9181.00
35_W40_R1.9061.00
21_I25_G1.8691.00
91_S94_E1.8641.00
111_L115_V1.8361.00
109_V113_G1.8281.00
101_V104_A1.7971.00
46_K113_G1.7851.00
30_M33_G1.7681.00
45_S48_V1.7661.00
48_V55_D1.7501.00
28_C32_V1.6891.00
20_L23_A1.5131.00
101_V105_I1.4761.00
43_A48_V1.4251.00
49_P65_S1.3301.00
100_F104_A1.3061.00
99_G102_E1.2691.00
37_L40_R1.2661.00
82_A117_L1.2151.00
96_G99_G1.1731.00
48_V54_I1.1661.00
22_V26_L1.1501.00
81_E110_L1.1271.00
97_W101_V1.1251.00
114_L123_L1.0931.00
118_V125_W1.0881.00
111_L117_L1.0571.00
47_N50_F1.0441.00
48_V56_S1.0401.00
75_F78_F1.0321.00
117_L123_L1.0251.00
84_Y120_I1.0030.99
85_L122_A0.9790.99
27_C85_L0.9770.99
118_V124_D0.9770.99
71_V117_L0.9700.99
50_F120_I0.9660.99
63_R69_Y0.9590.99
21_I98_V0.9440.99
115_V119_R0.9260.99
74_F122_A0.9240.99
29_L32_V0.8810.99
74_F80_V0.8720.98
75_F79_D0.8660.98
80_V83_L0.8590.98
54_I65_S0.8580.98
58_G62_L0.8570.98
65_S69_Y0.8410.98
86_F89_S0.8370.98
105_I109_V0.8320.98
32_V36_F0.8300.98
83_L86_F0.8290.98
32_V35_W0.8220.98
103_A106_F0.8180.98
65_S73_M0.8090.98
91_S97_W0.8070.97
63_R73_M0.8010.97
55_D83_L0.7990.97
28_C98_V0.7990.97
31_L35_W0.7970.97
39_G68_F0.7940.97
66_A74_F0.7910.97
88_W100_F0.7840.97
110_L114_L0.7800.97
33_G93_R0.7780.97
17_A28_C0.7750.97
20_L24_I0.7730.97
21_I24_I0.7700.97
98_V103_A0.7610.96
71_V124_D0.7590.96
34_G37_L0.7510.96
50_F116_Y0.7430.96
38_G50_F0.7370.96
15_A18_I0.7360.96
24_I27_C0.7360.96
69_Y125_W0.7340.96
48_V52_S0.7210.95
45_S54_I0.7190.95
93_R114_L0.7160.95
20_L94_E0.7080.95
98_V101_V0.7060.95
93_R124_D0.7030.94
34_G40_R0.7000.94
70_L73_M0.6940.94
54_I68_F0.6920.94
76_V112_A0.6920.94
78_F110_L0.6910.94
75_F110_L0.6870.94
68_F97_W0.6870.94
110_L113_G0.6840.94
32_V105_I0.6770.93
115_V118_V0.6660.93
62_L74_F0.6640.93
82_A111_L0.6620.92
20_L42_R0.6560.92
88_W96_G0.6530.92
85_L90_T0.6520.92
92_I97_W0.6490.92
86_F106_F0.6430.91
26_L106_F0.6350.91
18_I32_V0.6310.91
44_R119_R0.6210.90
69_Y116_Y0.6200.90
26_L29_L0.6190.90
108_F111_L0.6100.89
67_K122_A0.6100.89
15_A23_A0.6080.89
121_G126_T0.6070.89
29_L35_W0.6050.89
21_I112_A0.6010.88
95_S98_V0.5930.88
46_K72_A0.5890.87
22_V25_G0.5870.87
57_V71_V0.5870.87
38_G80_V0.5850.87
89_S96_G0.5850.87
84_Y89_S0.5830.87
61_R71_V0.5780.86
59_S62_L0.5780.86
52_S71_V0.5770.86
72_A122_A0.5720.86
103_A126_T0.5680.85
21_I96_G0.5670.85
27_C31_L0.5670.85
19_F27_C0.5660.85
42_R102_E0.5660.85
99_G103_A0.5660.85
33_G118_V0.5630.85
65_S68_F0.5620.85
52_S63_R0.5570.84
68_F119_R0.5560.84
55_D63_R0.5530.84
52_S76_V0.5510.84
19_F83_L0.5490.83
98_V112_A0.5470.83
105_I112_A0.5440.83
34_G42_R0.5410.83
67_K125_W0.5370.82
74_F117_L0.5330.82
15_A80_V0.5230.80
46_K52_S0.5150.79
67_K89_S0.5130.79
23_A72_A0.5110.79
88_W91_S0.5100.79
59_S114_L0.5080.79
106_F110_L0.5080.79
49_P59_S0.5070.78
82_A126_T0.5060.78
57_V83_L0.5060.78
90_T94_E0.5040.78
34_G75_F0.5030.78
63_R76_V0.5030.78
29_L33_G0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoA 1 0.6463 100 0.157 Contact Map
4he8A 1 0.6259 100 0.268 Contact Map
4djkA 2 0.7687 9.1 0.947 Contact Map
3mk7C 2 0.7211 8.7 0.947 Contact Map
2ls2A 1 0.1701 4.4 0.954 Contact Map
3wajA 1 0.6939 3.7 0.956 Contact Map
4jkvA 2 0.8367 3.7 0.956 Contact Map
2mv6A 1 0.3333 3.7 0.956 Contact Map
4tllB 2 0.2653 3.5 0.956 Contact Map
4tllA 1 0.1429 3.4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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