GREMLIN Database
NUDB - Dihydroneopterin triphosphate pyrophosphatase
UniProt: P0AFC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11138
Length: 150 (137)
Sequences: 405 (258)
Seq/√Len: 22.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_V102_W4.0421.00
122_K132_L3.9711.00
43_V52_A3.9341.00
57_V105_L3.3001.00
136_W139_R2.7090.99
20_D23_R2.5360.98
28_Q34_D2.5350.98
48_T51_Q2.2850.97
75_C104_C2.2810.97
50_P54_M2.2120.96
63_I70_L2.1830.95
32_D86_H2.1420.95
7_K42_S2.1010.94
82_E97_R2.0590.94
17_Y104_C2.0370.93
130_A143_E1.9880.93
64_D70_L1.9820.92
63_I113_I1.9230.91
92_A95_V1.9130.91
6_Y93_P1.8730.90
49_A52_A1.8540.90
18_A21_T1.8410.89
82_E88_R1.8220.89
77_R102_W1.8040.88
124_L132_L1.8020.88
63_I111_R1.7960.88
43_V49_A1.6730.84
81_F137_S1.6670.84
58_K64_D1.6650.84
77_R144_Q1.6380.83
49_A101_S1.5980.81
31_D119_L1.5620.80
16_I105_L1.5600.80
32_D35_F1.4940.76
49_A78_T1.4480.74
139_R143_E1.4420.74
107_L110_E1.4120.72
8_R45_E1.4010.72
16_I57_V1.3720.70
28_Q119_L1.3610.69
28_Q120_A1.3590.69
10_V43_V1.3540.69
28_Q32_D1.3470.69
23_R110_E1.3230.67
65_V105_L1.2810.65
86_H96_T1.2460.62
83_I87_L1.2290.61
43_V46_G1.2130.60
90_R98_N1.2090.60
27_L43_V1.1700.57
128_A131_A1.1680.57
126_A143_E1.1030.53
15_V38_S1.1000.53
80_E102_W1.0820.51
66_V71_T1.0760.51
61_V87_L1.0700.51
8_R44_E1.0670.50
27_L115_F1.0650.50
25_L38_S1.0650.50
107_L111_R1.0650.50
18_A23_R1.0550.50
82_E96_T1.0440.49
82_E86_H1.0390.49
99_T136_W1.0190.47
8_R43_V1.0040.46
78_T101_S0.9940.45
73_I104_C0.9860.45
89_H94_G0.9780.44
110_E113_I0.9700.44
58_K66_V0.9530.43
80_E97_R0.9320.41
31_D82_E0.9310.41
79_V87_L0.9240.41
85_S115_F0.9240.41
35_F43_V0.9060.40
7_K11_S0.9030.39
26_M132_L0.9020.39
75_C134_K0.9010.39
58_K125_D0.8860.38
19_Q114_V0.8740.38
32_D134_K0.8710.37
38_S135_S0.8600.37
27_L39_V0.8590.37
137_S144_Q0.8590.37
23_R44_E0.8570.36
18_A92_A0.8570.36
10_V20_D0.8550.36
87_L98_N0.8540.36
18_A107_L0.8500.36
54_M72_L0.8360.35
102_W142_I0.8350.35
96_T136_W0.8240.34
44_E141_A0.8230.34
28_Q82_E0.8220.34
51_Q128_A0.8190.34
141_A145_F0.8070.33
50_P114_V0.8020.33
81_F84_F0.7960.33
106_A145_F0.7960.33
87_L90_R0.7920.33
109_H112_Q0.7910.32
44_E116_T0.7900.32
90_R137_S0.7880.32
17_Y75_C0.7870.32
90_R135_S0.7790.32
15_V133_T0.7770.32
38_S90_R0.7710.31
13_L138_N0.7580.31
104_C145_F0.7550.30
86_H115_F0.7380.29
114_V140_Q0.7350.29
11_S98_N0.7230.29
64_D69_Q0.7160.28
33_P119_L0.7140.28
28_Q70_L0.7130.28
89_H109_H0.7120.28
65_V120_A0.7010.27
31_D96_T0.6990.27
84_F134_K0.6990.27
87_L91_Y0.6960.27
133_T137_S0.6910.27
126_A145_F0.6890.27
12_I15_V0.6870.27
24_V107_L0.6840.26
7_K24_V0.6790.26
87_L134_K0.6790.26
64_D109_H0.6740.26
113_I121_Y0.6690.26
76_Q127_P0.6660.25
98_N135_S0.6550.25
46_G54_M0.6440.24
40_T62_T0.6410.24
83_I135_S0.6380.24
9_P13_L0.6360.24
16_I46_G0.6320.24
48_T114_V0.6300.24
38_S98_N0.6300.24
50_P73_I0.6180.23
87_L102_W0.6180.23
40_T98_N0.6150.23
45_E131_A0.6130.23
30_R52_A0.6110.23
11_S135_S0.6080.23
140_Q144_Q0.6060.22
35_F142_I0.6060.22
66_V121_Y0.6020.22
16_I65_V0.6020.22
46_G97_R0.6020.22
6_Y125_D0.5990.22
136_W140_Q0.5970.22
73_I97_R0.5900.22
70_L73_I0.5890.22
83_I90_R0.5880.22
26_M102_W0.5880.22
6_Y92_A0.5880.22
34_D134_K0.5850.22
83_I91_Y0.5830.21
40_T61_V0.5760.21
72_L116_T0.5760.21
8_R104_C0.5720.21
71_T114_V0.5720.21
54_M128_A0.5710.21
19_Q46_G0.5680.21
31_D76_Q0.5670.21
28_Q49_A0.5660.21
14_V39_V0.5660.21
26_M133_T0.5650.21
10_V46_G0.5630.21
74_D92_A0.5580.20
72_L121_Y0.5530.20
6_Y21_T0.5510.20
92_A133_T0.5490.20
25_L83_I0.5490.20
8_R145_F0.5470.20
19_Q107_L0.5460.20
35_F83_I0.5460.20
25_L40_T0.5440.20
19_Q119_L0.5410.20
111_R136_W0.5410.20
51_Q111_R0.5400.20
12_I124_L0.5380.19
105_L119_L0.5340.19
26_M106_A0.5340.19
127_P131_A0.5330.19
46_G129_A0.5320.19
11_S16_I0.5280.19
63_I110_E0.5270.19
38_S83_I0.5250.19
10_V52_A0.5250.19
83_I115_F0.5240.19
6_Y66_V0.5230.19
91_Y135_S0.5230.19
51_Q114_V0.5190.19
75_C145_F0.5190.19
51_Q54_M0.5170.19
24_V75_C0.5140.18
28_Q134_K0.5130.18
8_R139_R0.5110.18
112_Q144_Q0.5090.18
116_T145_F0.5090.18
21_T105_L0.5090.18
104_C139_R0.5090.18
30_R119_L0.5090.18
54_M58_K0.5010.18
9_P108_P0.5010.18
94_G137_S0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o1cA 1 0.9867 99.9 0.601 Contact Map
3sonA 2 0.9067 99.8 0.677 Contact Map
1f3yA 1 0.9667 99.7 0.709 Contact Map
2azwA 1 0.9133 99.7 0.711 Contact Map
3i7uA 4 0.8533 99.7 0.716 Contact Map
4s2xA 1 0.9467 99.7 0.717 Contact Map
4mpoA 4 0.92 99.7 0.72 Contact Map
3q93A 1 0.8533 99.7 0.723 Contact Map
3eesA 2 0.84 99.7 0.724 Contact Map
1sjyA 2 0.8933 99.7 0.724 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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