GREMLIN Database
NTRC - Nitrogen regulation protein NR(I)
UniProt: P0AFB8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10385
Length: 469 (440)
Sequences: 9909 (6864)
Seq/√Len: 327.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
287_R292_K3.9181.00
213_E223_I3.6251.00
169_E312_R3.5571.00
441_T451_L3.4231.00
31_T48_P3.3891.00
286_Q290_E2.9991.00
227_R262_Y2.7971.00
198_A250_T2.7811.00
260_Q269_P2.6901.00
260_Q271_K2.6481.00
16_R34_E2.6291.00
154_I177_V2.6061.00
282_Q287_R2.6041.00
36_G60_M2.5361.00
61_D64_A2.4911.00
431_R435_T2.4861.00
35_N38_E2.4671.00
328_V361_E2.4631.00
261_F272_V2.4571.00
229_E263_R2.4411.00
202_K247_D2.4391.00
228_F255_V2.3941.00
67_K96_Q2.3411.00
447_E450_R2.3351.00
16_R32_T2.2751.00
341_H377_L2.2591.00
441_T448_A2.2531.00
319_P345_E2.2461.00
99_F118_A2.2411.00
156_R372_A2.2271.00
283_N286_Q2.2251.00
34_E38_E2.2021.00
237_F279_A2.1841.00
5_I29_T2.1341.00
262_Y269_P2.1061.00
9_V39_V2.0841.00
340_L364_C2.0541.00
233_G273_D2.0441.00
322_A340_L2.0371.00
287_R290_E2.0341.00
177_V308_L2.0001.00
433_L437_A1.9991.00
319_P349_T1.9951.00
7_W33_F1.9741.00
353_W363_T1.9631.00
213_E266_G1.9191.00
286_Q289_Q1.9121.00
155_G184_H1.8841.00
243_D282_Q1.8731.00
351_L354_P1.8681.00
323_R345_E1.8491.00
20_E32_T1.8471.00
44_A72_R1.8401.00
440_H451_L1.8331.00
143_E320_R1.8091.00
187_R273_D1.8051.00
37_A59_G1.7811.00
40_L68_Q1.7721.00
31_T42_A1.7341.00
257_A361_E1.7321.00
5_I31_T1.7121.00
256_L276_I1.7051.00
315_R318_I1.6981.00
20_E24_A1.6881.00
315_R319_P1.6841.00
324_H328_V1.6731.00
68_Q71_Q1.6611.00
322_A364_C1.6541.00
213_E263_R1.6451.00
339_L375_E1.6441.00
430_E462_K1.6381.00
167_N307_H1.6301.00
228_F236_L1.6281.00
225_Q229_E1.6111.00
50_V115_V1.6071.00
427_P465_E1.6031.00
43_L69_I1.5891.00
167_N305_R1.5891.00
343_E378_I1.5871.00
341_H344_T1.5821.00
73_H76_L1.5791.00
172_T308_L1.5621.00
144_A316_E1.5591.00
26_A112_V1.5181.00
315_R352_A1.5161.00
232_D272_V1.5031.00
212_H217_F1.5011.00
92_S96_Q1.5011.00
351_L359_Q1.4971.00
344_T348_L1.4891.00
266_G270_V1.4871.00
206_E251_R1.4871.00
345_E349_T1.4801.00
457_N461_R1.4701.00
255_V261_F1.4681.00
51_L69_I1.4591.00
124_E128_P1.4571.00
53_S65_L1.4531.00
344_T378_I1.4511.00
278_A301_L1.4501.00
33_F42_A1.4431.00
347_A378_I1.4331.00
437_A441_T1.4291.00
79_I114_L1.4201.00
68_Q72_R1.4201.00
232_D273_D1.4171.00
436_T440_H1.4091.00
377_L380_D1.4041.00
224_R267_Y1.3991.00
332_E365_R1.3981.00
42_A48_P1.3951.00
52_L115_V1.3931.00
150_V306_V1.3831.00
263_R266_G1.3831.00
175_E254_R1.3761.00
157_L304_I1.3731.00
321_L325_F1.3691.00
149_D152_R1.3631.00
242_G280_T1.3621.00
190_A233_G1.3591.00
161_S332_E1.3541.00
376_V381_L1.3471.00
307_H313_E1.3371.00
152_R155_G1.3361.00
147_M151_F1.3341.00
142_G147_M1.3211.00
202_K245_P1.3111.00
340_L345_E1.3111.00
36_G65_L1.3081.00
53_S80_I1.3051.00
229_E270_V1.3041.00
435_T439_R1.3031.00
346_A350_R1.3001.00
35_N59_G1.2971.00
162_I365_R1.2971.00
338_K374_Q1.2951.00
6_V28_L1.2841.00
447_E451_L1.2801.00
31_T46_K1.2721.00
51_L76_L1.2671.00
284_L293_F1.2661.00
22_A108_I1.2641.00
326_L340_L1.2621.00
341_H375_E1.2621.00
344_T376_V1.2571.00
205_I248_V1.2401.00
371_A380_D1.2401.00
57_M60_M1.2341.00
153_I370_M1.2331.00
87_L91_V1.2271.00
28_L116_E1.2221.00
89_A101_Y1.2211.00
261_F271_K1.2201.00
208_E224_R1.2161.00
316_E349_T1.2151.00
329_A368_T1.2111.00
325_F361_E1.2041.00
330_A338_K1.1961.00
285_E289_Q1.1921.00
437_A451_L1.1861.00
323_R327_Q1.1821.00
151_F154_I1.1821.00
128_P131_V1.1811.00
142_G151_F1.1751.00
242_G284_L1.1731.00
55_I89_A1.1701.00
192_F234_G1.1641.00
154_I180_A1.1631.00
327_Q331_R1.1531.00
455_G458_T1.1511.00
66_L78_V1.1491.00
139_D183_R1.1491.00
319_P322_A1.1481.00
425_A429_L1.1481.00
64_A67_K1.1471.00
5_I46_K1.1411.00
140_I151_F1.1411.00
10_D16_R1.1391.00
141_I324_H1.1381.00
289_Q295_E1.1371.00
169_E310_P1.1361.00
326_L368_T1.1351.00
162_I333_L1.1261.00
446_Q450_R1.1261.00
437_A452_L1.1241.00
180_A184_H1.1241.00
127_Q132_Q1.1221.00
179_H194_A1.1221.00
56_R84_H1.1201.00
40_L60_M1.1191.00
445_K460_T1.1171.00
421_L424_E1.1121.00
159_R186_P1.1091.00
315_R349_T1.1081.00
63_L93_A1.1071.00
66_L80_I1.1071.00
343_E377_L1.1061.00
212_H216_A1.1031.00
161_S187_R1.1001.00
150_V308_L1.0981.00
26_A116_E1.0971.00
382_P385_L1.0971.00
461_R465_E1.0951.00
52_L111_A1.0941.00
457_N460_T1.0931.00
458_T462_K1.0911.00
330_A336_E1.0881.00
444_H447_E1.0851.00
207_S212_H1.0811.00
53_S78_V1.0791.00
140_I177_V1.0771.00
325_F329_A1.0721.00
198_A243_D1.0701.00
437_A448_A1.0701.00
212_H264_V1.0701.00
36_G57_M1.0681.00
23_L115_V1.0631.00
422_L425_A1.0601.00
229_E261_F1.0591.00
166_I277_I1.0561.00
432_T436_T1.0531.00
205_I209_L1.0531.00
329_A364_C1.0481.00
50_V119_I1.0411.00
5_I48_P1.0391.00
36_G40_L1.0391.00
422_L426_Q1.0361.00
150_V177_V1.0341.00
154_I306_V1.0321.00
243_D281_H1.0301.00
33_F39_V1.0271.00
154_I181_L1.0241.00
166_I177_V1.0231.00
426_Q429_L1.0221.00
10_D57_M1.0221.00
146_A149_D1.0211.00
232_D274_V1.0201.00
285_E384_E1.0201.00
169_E172_T1.0171.00
259_G271_K1.0141.00
455_G461_R1.0141.00
38_E41_E1.0091.00
429_L433_L1.0021.00
217_F220_A1.0001.00
92_S95_Q1.0001.00
41_E45_S0.9991.00
42_A46_K0.9991.00
165_L278_A0.9981.00
42_A45_S0.9971.00
163_S259_G0.9961.00
235_T277_I0.9921.00
216_A264_V0.9911.00
49_D122_Y0.9901.00
8_V30_C0.9871.00
214_K222_T0.9851.00
263_R270_V0.9841.00
69_I78_V0.9781.00
438_L448_A0.9741.00
444_H456_R0.9731.00
122_Y126_Q0.9701.00
140_I176_L0.9701.00
230_Q267_Y0.9681.00
318_I322_A0.9651.00
145_P149_D0.9631.00
346_A349_T0.9621.00
175_E194_A0.9601.00
162_I303_V0.9581.00
196_N243_D0.9561.00
302_N305_R0.9561.00
446_Q456_R0.9481.00
113_A117_R0.9471.00
318_I348_L0.9421.00
433_L452_L0.9391.00
367_L371_A0.9351.00
67_K92_S0.9331.00
323_R339_L0.9291.00
147_M150_V0.9211.00
330_A337_A0.9151.00
127_Q131_V0.9121.00
367_L376_V0.9111.00
38_E42_A0.9111.00
193_I231_A0.9101.00
124_E127_Q0.9091.00
53_S57_M0.9071.00
434_L462_K0.9041.00
91_V95_Q0.9031.00
164_V181_L0.9021.00
432_T435_T0.9021.00
342_P345_E0.9011.00
65_L69_I0.9001.00
13_S16_R0.9001.00
340_L376_V0.8991.00
438_L463_L0.8981.00
60_M64_A0.8981.00
436_T439_R0.8971.00
434_L459_L0.8971.00
161_S186_P0.8931.00
52_L79_I0.8921.00
120_S123_Q0.8871.00
60_M68_Q0.8831.00
303_V362_N0.8801.00
15_I106_F0.8801.00
41_E44_A0.8791.00
179_H183_R0.8771.00
228_F274_V0.8751.00
50_V77_P0.8701.00
67_K71_Q0.8691.00
150_V154_I0.8681.00
207_S217_F0.8651.00
366_W370_M0.8571.00
244_M248_V0.8541.00
205_I244_M0.8531.00
37_A41_E0.8501.00
435_T468_M0.8501.00
427_P466_L0.8501.00
53_S69_I0.8471.00
148_Q152_R0.8451.00
11_D54_D0.8431.00
325_F364_C0.8431.00
64_A68_Q0.8421.00
141_I320_R0.8391.00
167_N285_E0.8381.00
445_K452_L0.8381.00
120_S125_Q0.8371.00
228_F272_V0.8371.00
194_A254_R0.8361.00
448_A451_L0.8331.00
212_H220_A0.8311.00
35_N57_M0.8281.00
288_V298_F0.8281.00
441_T447_E0.8271.00
124_E131_V0.8261.00
236_L276_I0.8261.00
142_G177_V0.8261.00
225_Q230_Q0.8251.00
438_L445_K0.8241.00
460_T464_K0.8241.00
55_I80_I0.8231.00
142_G320_R0.8211.00
163_S278_A0.8171.00
276_I301_L0.8171.00
445_K463_L0.8161.00
261_F270_V0.8151.00
9_V65_L0.8151.00
458_T461_R0.8141.00
361_E365_R0.8091.00
143_E148_Q0.8061.00
285_E298_F0.8041.00
445_K457_N0.8031.00
95_Q100_D0.8021.00
166_I308_L0.8011.00
302_N366_W0.8011.00
11_D83_A0.8001.00
456_R460_T0.7981.00
319_P323_R0.7961.00
223_I268_A0.7931.00
40_L65_L0.7901.00
33_F38_E0.7891.00
431_R466_L0.7891.00
425_A428_E0.7881.00
340_L344_T0.7871.00
236_L255_V0.7861.00
107_D110_E0.7811.00
148_Q151_F0.7811.00
329_A361_E0.7801.00
66_L98_A0.7791.00
7_W48_P0.7781.00
54_D104_K0.7711.00
196_N244_M0.7711.00
335_V338_K0.7701.00
342_P346_A0.7701.00
19_L111_A0.7701.00
285_E295_E0.7691.00
52_L81_M0.7661.00
212_H224_R0.7651.00
6_V23_L0.7641.00
9_V51_L0.7641.00
37_A60_M0.7621.00
33_F36_G0.7601.00
10_D15_I0.7601.00
439_R443_G0.7601.00
8_V19_L0.7591.00
43_L51_L0.7591.00
193_I230_Q0.7591.00
162_I304_I0.7570.99
454_W458_T0.7550.99
162_I369_V0.7550.99
145_P148_Q0.7540.99
254_R258_D0.7530.99
225_Q267_Y0.7530.99
230_Q266_G0.7510.99
70_K77_P0.7460.99
223_I263_R0.7440.99
11_D82_T0.7380.99
157_L164_V0.7380.99
335_V368_T0.7380.99
88_D92_S0.7350.99
13_S17_W0.7330.99
151_F177_V0.7330.99
201_P264_V0.7330.99
43_L76_L0.7320.99
22_A112_V0.7310.99
151_F180_A0.7310.99
329_A333_L0.7300.99
310_P313_E0.7290.99
347_A351_L0.7290.99
285_E305_R0.7270.99
8_V20_E0.7270.99
63_L92_S0.7270.99
87_L90_A0.7250.99
43_L73_H0.7250.99
338_K368_T0.7220.99
363_T367_L0.7210.99
212_H223_I0.7170.99
116_E120_S0.7170.99
156_R370_M0.7160.99
438_L443_G0.7150.99
62_G104_K0.7140.99
5_I49_D0.7140.99
227_R230_Q0.7120.99
462_K466_L0.7100.99
426_Q433_L0.7100.99
367_L381_L0.7080.99
85_S103_P0.7060.99
434_L452_L0.7050.99
424_E428_E0.7010.99
140_I147_M0.6990.99
318_I349_T0.6990.99
423_S437_A0.6980.99
347_A381_L0.6980.99
146_A313_E0.6960.99
99_F114_L0.6960.99
36_G59_G0.6940.99
55_I61_D0.6940.99
158_S185_S0.6900.99
322_A345_E0.6890.99
298_F302_N0.6890.99
28_L112_V0.6880.99
201_P204_L0.6880.99
11_D104_K0.6870.99
175_E258_D0.6860.99
176_L180_A0.6860.99
228_F261_F0.6840.99
166_I178_A0.6820.99
120_S124_E0.6810.99
459_L463_L0.6790.99
455_G460_T0.6790.99
330_A335_V0.6780.99
19_L81_M0.6780.99
216_A220_A0.6770.99
142_G154_I0.6760.99
77_P121_H0.6750.99
153_I156_R0.6740.99
137_T184_H0.6730.99
81_M106_F0.6720.99
315_R320_R0.6710.99
101_Y110_E0.6700.99
100_D114_L0.6690.99
11_D62_G0.6670.99
382_P386_F0.6650.99
44_A68_Q0.6640.99
428_E432_T0.6620.99
150_V153_I0.6610.99
51_L78_V0.6610.99
322_A367_L0.6570.99
424_E432_T0.6570.99
158_S184_H0.6560.99
152_R372_A0.6560.99
137_T180_A0.6550.99
244_M252_L0.6550.99
285_E288_V0.6520.98
242_G281_H0.6510.98
12_D15_I0.6510.98
53_S66_L0.6500.98
212_H221_N0.6490.98
9_V57_M0.6440.98
13_S34_E0.6420.98
459_L462_K0.6400.98
103_P110_E0.6400.98
434_L463_L0.6390.98
282_Q292_K0.6380.98
54_D83_A0.6380.98
137_T151_F0.6360.98
454_W462_K0.6340.98
77_P125_Q0.6340.98
242_G282_Q0.6330.98
330_A368_T0.6320.98
425_A433_L0.6320.98
443_G463_L0.6310.98
328_V332_E0.6300.98
114_L118_A0.6300.98
237_F277_I0.6260.98
215_G220_A0.6260.98
18_V22_A0.6260.98
178_A192_F0.6240.98
110_E114_L0.6210.98
102_L106_F0.6190.98
242_G279_A0.6190.98
21_R25_G0.6180.98
77_P122_Y0.6160.98
320_R323_R0.6110.98
232_D271_K0.6110.98
110_E113_A0.6090.98
460_T463_L0.6080.98
43_L48_P0.6080.98
143_E316_E0.6060.98
51_L65_L0.6060.98
195_L236_L0.6040.98
156_R380_D0.6040.98
145_P316_E0.6040.98
304_I370_M0.6010.97
421_L453_G0.6000.97
170_S243_D0.5980.97
125_Q128_P0.5980.97
218_T281_H0.5970.97
454_W459_L0.5970.97
363_T381_L0.5960.97
224_R230_Q0.5950.97
359_Q384_E0.5950.97
161_S333_L0.5940.97
224_R227_R0.5940.97
156_R335_V0.5940.97
427_P431_R0.5930.97
329_A332_E0.5920.97
227_R269_P0.5920.97
241_I301_L0.5900.97
85_S90_A0.5890.97
326_L337_A0.5860.97
422_L429_L0.5860.97
85_S101_Y0.5860.97
195_L227_R0.5850.97
82_T104_K0.5850.97
7_W39_V0.5840.97
119_I122_Y0.5830.97
297_L301_L0.5830.97
57_M62_G0.5820.97
106_F111_A0.5820.97
445_K456_R0.5810.97
444_H460_T0.5810.97
329_A365_R0.5800.97
20_E30_C0.5800.97
214_K221_N0.5790.97
48_P76_L0.5790.97
163_S303_V0.5790.97
6_V119_I0.5790.97
128_P132_Q0.5780.97
242_G293_F0.5770.97
39_V65_L0.5770.97
327_Q337_A0.5760.97
363_T385_L0.5750.97
160_S369_V0.5740.97
121_H125_Q0.5730.97
246_L250_T0.5730.97
108_I112_V0.5710.97
333_L368_T0.5700.97
456_R461_R0.5680.96
191_P230_Q0.5680.96
228_F276_I0.5670.96
322_A326_L0.5660.96
218_T279_A0.5650.96
351_L385_L0.5650.96
255_V258_D0.5650.96
461_R464_K0.5640.96
326_L364_C0.5640.96
223_I266_G0.5640.96
187_R190_A0.5620.96
14_S18_V0.5620.96
457_N464_K0.5610.96
214_K220_A0.5580.96
99_F121_H0.5580.96
23_L30_C0.5570.96
90_A98_A0.5560.96
24_A30_C0.5550.96
204_L218_T0.5550.96
422_L433_L0.5540.96
144_A317_D0.5540.96
347_A385_L0.5530.96
62_G82_T0.5520.96
180_A183_R0.5510.96
139_D180_A0.5510.96
337_A368_T0.5510.96
208_E227_R0.5500.96
195_L209_L0.5490.96
213_E216_A0.5490.96
200_I209_L0.5490.96
326_L330_A0.5480.96
89_A92_S0.5450.96
147_M177_V0.5430.95
209_L248_V0.5430.95
196_N250_T0.5430.95
153_I304_I0.5390.95
324_H327_Q0.5390.95
185_S275_R0.5380.95
214_K223_I0.5380.95
316_E319_P0.5380.95
428_E431_R0.5350.95
160_S333_L0.5340.95
259_G274_V0.5340.95
422_L452_L0.5340.95
444_H448_A0.5330.95
159_R185_S0.5320.95
452_L458_T0.5300.95
347_A382_P0.5290.95
6_V50_V0.5270.95
11_D57_M0.5270.95
217_F224_R0.5260.95
69_I76_L0.5260.95
304_I369_V0.5260.95
216_A223_I0.5250.95
113_A124_E0.5240.94
77_P118_A0.5240.94
140_I180_A0.5230.94
311_L360_L0.5220.94
430_E434_L0.5210.94
149_D153_I0.5200.94
39_V51_L0.5200.94
176_L357_V0.5200.94
35_N58_P0.5190.94
232_D259_G0.5180.94
445_K459_L0.5180.94
190_A232_D0.5180.94
9_V36_G0.5170.94
434_L466_L0.5150.94
63_L89_A0.5150.94
229_E232_D0.5140.94
17_W20_E0.5140.94
8_V32_T0.5140.94
457_N462_K0.5130.94
40_L44_A0.5130.94
130_N133_L0.5110.94
87_L103_P0.5110.94
320_R324_H0.5110.94
161_S273_D0.5110.94
117_R124_E0.5100.94
196_N199_A0.5100.94
83_A104_K0.5090.94
452_L462_K0.5080.94
62_G83_A0.5080.94
347_A350_R0.5080.94
213_E270_V0.5060.93
423_S426_Q0.5060.93
315_R350_R0.5060.93
134_N137_T0.5050.93
172_T176_L0.5050.93
344_T367_L0.5050.93
70_K75_M0.5040.93
207_S215_G0.5040.93
55_I106_F0.5040.93
433_L445_K0.5040.93
222_T267_Y0.5030.93
242_G287_R0.5030.93
343_E346_A0.5030.93
56_R86_D0.5020.93
24_A29_T0.5010.93
248_V251_R0.5010.93
255_V272_V0.5010.93
88_D110_E0.5000.93
261_F269_P0.5000.93
197_M205_I0.5000.93
423_S462_K0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4uA 2 0.8124 100 0.122 Contact Map
3dzdA 2 0.7846 100 0.286 Contact Map
1ojlA 3 0.6418 100 0.465 Contact Map
4fwgA 3 0.6226 100 0.631 Contact Map
1r6bX 1 0.8252 100 0.662 Contact Map
3pxiA 3 0.7719 100 0.667 Contact Map
1qvrA 3 0.806 100 0.668 Contact Map
4qhsA 3 0.5203 100 0.674 Contact Map
4ciuA 1 0.8038 100 0.675 Contact Map
4qosA 1 0.5117 100 0.676 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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