GREMLIN Database
NTRB - Nitrogen regulation protein NR(II)
UniProt: P0AFB5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10387
Length: 349 (326)
Sequences: 50095 (41680)
Seq/√Len: 2308.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_A171_I3.1261.00
197_E233_H3.1111.00
18_N109_A3.0661.00
331_E342_S3.0431.00
287_D291_G2.9841.00
286_E340_E2.9561.00
320_R324_D2.7691.00
280_A344_Y2.7021.00
335_W338_H2.6871.00
253_L288_N2.6831.00
293_P296_L2.4501.00
156_S172_I2.4391.00
282_R344_Y2.4001.00
284_D340_E2.3971.00
282_R342_S2.3871.00
263_R284_D2.3731.00
233_H326_H2.3431.00
221_I259_E2.3371.00
221_I261_I2.3311.00
125_A128_V2.3261.00
284_D342_S2.3061.00
297_Q332_F2.2911.00
196_T232_A2.2551.00
21_L106_L2.2351.00
223_D263_R2.2301.00
319_A330_I2.2261.00
156_S169_K2.1891.00
149_R175_A2.1291.00
261_I286_E2.1131.00
265_R282_R2.0991.00
195_V235_P2.0441.00
13_L31_Y2.0421.00
332_F341_F1.9961.00
205_R239_E1.9941.00
35_A38_Q1.9941.00
263_R286_E1.9701.00
121_Q125_A1.9601.00
323_I328_G1.9591.00
241_V323_I1.9481.00
149_R176_D1.9201.00
265_R284_D1.9151.00
198_S201_K1.9131.00
297_Q334_S1.8961.00
19_S39_L1.8921.00
161_D164_L1.8771.00
24_D28_A1.8761.00
219_R259_E1.8761.00
301_F330_I1.8611.00
259_E288_N1.8261.00
333_T340_E1.8041.00
19_S108_M1.7991.00
223_D261_I1.7951.00
292_I296_L1.7901.00
334_S339_T1.7481.00
323_I343_V1.7391.00
121_Q124_H1.7321.00
294_P297_Q1.7291.00
241_V319_A1.7281.00
115_R118_S1.6961.00
333_T342_S1.6881.00
329_K344_Y1.6881.00
292_I300_L1.6711.00
151_A167_Y1.6651.00
42_Q85_I1.6381.00
258_G288_N1.6261.00
21_L36_A1.6101.00
210_V243_L1.6101.00
148_L175_A1.5981.00
200_H264_T1.5961.00
299_T305_V1.5951.00
253_L260_I1.5791.00
241_V322_L1.5581.00
21_L29_I1.5541.00
156_S165_L1.5281.00
179_R183_D1.5211.00
234_D237_Q1.5191.00
34_P38_Q1.4961.00
296_L299_T1.4881.00
14_N34_P1.4781.00
324_D329_K1.4701.00
283_I343_V1.4691.00
10_G14_N1.4601.00
242_L283_I1.4551.00
50_T54_E1.4391.00
153_Q172_I1.4361.00
252_A306_S1.4301.00
37_Q44_S1.4251.00
331_E344_Y1.4101.00
194_R232_A1.4041.00
322_L326_H1.3991.00
114_Q118_S1.3971.00
253_L258_G1.3891.00
233_H238_I1.3881.00
198_S230_E1.3781.00
16_L20_I1.3721.00
93_S109_A1.3571.00
152_A172_I1.3481.00
229_P266_T1.3461.00
129_A132_D1.3441.00
155_L168_T1.3441.00
124_H128_V1.3371.00
94_V108_M1.3311.00
32_A36_A1.3291.00
296_L305_V1.3191.00
293_P336_P1.3161.00
237_Q240_Q1.3141.00
302_Y305_V1.3061.00
299_T302_Y1.3051.00
151_A170_V1.3031.00
116_R120_E1.3021.00
214_L250_L1.2961.00
93_S114_Q1.2951.00
124_H127_Q1.2931.00
334_S338_H1.2721.00
224_Y264_T1.2681.00
211_S215_P1.2631.00
159_L164_L1.2561.00
172_I176_D1.2491.00
68_E72_A1.2481.00
155_L164_L1.2461.00
57_S60_S1.2301.00
32_A37_Q1.1981.00
247_R251_Q1.1961.00
147_G174_Q1.1841.00
280_A329_K1.1721.00
43_S46_K1.1651.00
158_A164_L1.1641.00
148_L171_I1.1581.00
9_A13_L1.1551.00
241_V343_V1.1501.00
121_Q128_V1.1501.00
205_R235_P1.1491.00
123_Q126_Q1.1481.00
277_Y282_R1.1451.00
300_L332_F1.1281.00
237_Q325_Q1.1221.00
36_A40_L1.1211.00
91_I115_R1.1201.00
123_Q127_Q1.1081.00
196_T230_E1.0951.00
22_L105_L1.0951.00
200_H204_E1.0921.00
28_A51_P1.0911.00
152_A175_A1.0881.00
34_P37_Q1.0831.00
23_I106_L1.0801.00
113_N116_R1.0791.00
67_Q71_E1.0771.00
292_I332_F1.0751.00
296_L307_G1.0731.00
204_E222_R1.0651.00
169_K173_E1.0591.00
149_R172_I1.0511.00
51_P54_E1.0381.00
292_I297_Q1.0331.00
32_A47_L1.0311.00
79_N115_R1.0291.00
197_E202_V1.0251.00
37_Q43_S1.0231.00
200_H224_Y1.0191.00
22_L31_Y1.0181.00
334_S337_G1.0161.00
210_V246_V1.0071.00
292_I339_T1.0061.00
147_G151_A1.0051.00
180_N236_D1.0031.00
261_I288_N0.9991.00
170_V174_Q0.9961.00
84_V88_R0.9951.00
194_R326_H0.9911.00
152_A168_T0.9871.00
152_A156_S0.9861.00
149_R179_R0.9831.00
235_P239_E0.9761.00
24_D30_H0.9731.00
209_L243_L0.9691.00
165_L169_K0.9681.00
141_I178_L0.9671.00
301_F332_F0.9631.00
207_V211_S0.9621.00
115_R119_Q0.9611.00
237_Q322_L0.9471.00
323_I330_I0.9461.00
77_T93_S0.9461.00
63_I67_Q0.9381.00
46_K85_I0.9361.00
79_N82_T0.9281.00
251_Q308_R0.9271.00
166_E170_V0.9251.00
203_A264_T0.9221.00
240_Q322_L0.9201.00
96_A104_I0.9191.00
225_D265_R0.9161.00
206_V239_E0.9151.00
207_V222_R0.9061.00
303_P321_N0.8951.00
202_V206_V0.8901.00
174_Q177_R0.8901.00
22_L30_H0.8881.00
246_V260_I0.8871.00
112_D116_R0.8841.00
23_I29_I0.8831.00
201_K205_R0.8831.00
242_L246_V0.8771.00
199_I283_I0.8771.00
323_I345_L0.8741.00
116_R119_Q0.8731.00
282_R331_E0.8711.00
194_R233_H0.8701.00
206_V210_V0.8631.00
244_N319_A0.8631.00
19_S36_A0.8621.00
301_F341_F0.8621.00
117_L120_E0.8621.00
245_I319_A0.8591.00
69_S72_A0.8581.00
160_P164_L0.8551.00
260_I264_T0.8501.00
64_E68_E0.8481.00
242_L285_V0.8391.00
249_A260_I0.8371.00
57_S89_S0.8371.00
162_P165_L0.8371.00
137_L185_L0.8271.00
16_L107_E0.8271.00
142_K183_D0.8271.00
218_V250_L0.8241.00
58_Y61_L0.8231.00
90_H110_P0.8221.00
287_D339_T0.8221.00
225_D228_L0.8211.00
142_K179_R0.8171.00
139_H143_N0.8171.00
21_L108_M0.8161.00
328_G345_L0.8121.00
136_G303_P0.8121.00
239_E243_L0.8091.00
19_S35_A0.8091.00
291_G339_T0.8091.00
292_I298_D0.8011.00
300_L341_F0.7981.00
209_L239_E0.7971.00
31_Y44_S0.7961.00
23_I96_A0.7951.00
91_I112_D0.7881.00
78_D81_V0.7821.00
321_N324_D0.7801.00
207_V220_L0.7791.00
204_E208_T0.7791.00
245_I341_F0.7751.00
319_A323_I0.7741.00
166_E169_K0.7731.00
80_E115_R0.7721.00
251_Q306_S0.7711.00
277_Y280_A0.7701.00
143_N150_G0.7701.00
9_A12_I0.7691.00
34_P44_S0.7631.00
42_Q46_K0.7621.00
184_R237_Q0.7591.00
246_V262_L0.7571.00
237_Q326_H0.7551.00
294_P335_W0.7531.00
140_E240_Q0.7521.00
37_Q47_L0.7521.00
203_A262_L0.7521.00
208_T211_S0.7491.00
97_Q105_L0.7481.00
96_A106_L0.7451.00
80_E94_V0.7451.00
161_D165_L0.7441.00
81_V91_I0.7441.00
225_D264_T0.7421.00
23_I104_I0.7411.00
132_D136_G0.7401.00
245_I330_I0.7401.00
201_K235_P0.7401.00
202_V233_H0.7391.00
23_I52_L0.7341.00
84_V90_H0.7331.00
150_G154_L0.7331.00
28_A49_G0.7331.00
149_R153_Q0.7321.00
11_Q15_S0.7321.00
265_R277_Y0.7281.00
238_I326_H0.7281.00
180_N184_R0.7261.00
175_A179_R0.7261.00
213_E247_R0.7241.00
44_S48_F0.7221.00
218_V253_L0.7221.00
188_P317_S0.7211.00
183_D187_G0.7181.00
18_N35_A0.7181.00
328_G346_P0.7161.00
154_L167_Y0.7121.00
206_V243_L0.7111.00
197_E235_P0.7101.00
151_A171_I0.7091.00
117_L121_Q0.7081.00
170_V173_E0.7061.00
140_E244_N0.7051.00
171_I175_A0.7031.00
65_L69_S0.7031.00
53_P61_L0.6991.00
245_I343_V0.6941.00
214_L218_V0.6921.00
173_E205_R0.6911.00
80_E83_L0.6861.00
306_S311_G0.6861.00
126_Q129_A0.6831.00
23_I66_M0.6821.00
142_K186_L0.6821.00
187_G237_Q0.6801.00
210_V250_L0.6791.00
114_Q117_L0.6771.00
216_D250_L0.6721.00
199_I281_A0.6701.00
249_A285_V0.6681.00
111_M115_R0.6641.00
60_S81_V0.6631.00
12_I105_L0.6611.00
252_A290_P0.6611.00
92_L108_M0.6591.00
83_L89_S0.6591.00
151_A174_Q0.6591.00
85_I88_R0.6581.00
23_I27_L0.6561.00
40_L108_M0.6541.00
306_S310_G0.6541.00
255_P258_G0.6531.00
81_V89_S0.6511.00
210_V247_R0.6511.00
244_N247_R0.6501.00
66_M70_L0.6501.00
42_Q47_L0.6491.00
18_N107_E0.6471.00
63_I66_M0.6471.00
227_S266_T0.6451.00
253_L257_G0.6451.00
177_R239_E0.6441.00
13_L20_I0.6431.00
158_A161_D0.6411.00
259_E286_E0.6411.00
169_K172_I0.6391.00
204_E207_V0.6381.00
140_E143_N0.6371.00
50_T55_L0.6361.00
328_G343_V0.6351.00
65_L68_E0.6331.00
223_D265_R0.6321.00
155_L167_Y0.6321.00
252_A308_R0.6301.00
95_T109_A0.6291.00
194_R327_S0.6291.00
206_V246_V0.6291.00
217_N257_G0.6231.00
203_A242_L0.6221.00
141_I144_P0.6221.00
147_G150_G0.6221.00
56_L61_L0.6221.00
140_E181_L0.6221.00
33_N36_A0.6201.00
145_L182_V0.6171.00
10_G31_Y0.6151.00
277_Y344_Y0.6141.00
241_V326_H0.6141.00
155_L171_I0.6131.00
153_Q156_S0.6121.00
331_E343_V0.6121.00
143_N147_G0.6111.00
321_N325_Q0.6091.00
164_L167_Y0.6091.00
297_Q301_F0.6071.00
20_I107_E0.6061.00
251_Q310_G0.6051.00
240_Q243_L0.6041.00
19_S92_L0.6041.00
147_G170_V0.6021.00
214_L220_L0.6011.00
262_L285_V0.6001.00
248_N315_G0.5981.00
314_L318_I0.5971.00
32_A44_S0.5961.00
201_K204_E0.5951.00
113_N117_L0.5941.00
280_A346_P0.5931.00
98_R104_I0.5931.00
228_L264_T0.5911.00
176_D179_R0.5911.00
139_H244_N0.5901.00
56_L60_S0.5891.00
303_P317_S0.5881.00
12_I15_S0.5871.00
198_S228_L0.5841.00
216_D253_L0.5841.00
133_L137_L0.5831.00
186_L190_L0.5831.00
35_A39_L0.5821.00
212_M215_P0.5821.00
91_I111_M0.5801.00
176_D180_N0.5791.00
119_Q123_Q0.5791.00
193_T234_D0.5771.00
218_V222_R0.5771.00
146_G150_G0.5761.00
202_V239_E0.5751.00
156_S168_T0.5751.00
158_A167_Y0.5741.00
63_I70_L0.5741.00
297_Q341_F0.5741.00
128_V131_R0.5731.00
266_T279_L0.5721.00
25_D103_M0.5721.00
82_T91_I0.5701.00
40_L82_T0.5701.00
297_Q333_T0.5681.00
32_A40_L0.5661.00
284_D333_T0.5651.00
160_P165_L0.5651.00
204_E224_Y0.5631.00
22_L99_M0.5601.00
202_V238_I0.5581.00
187_G191_P0.5581.00
153_Q157_K0.5571.00
140_E144_P0.5561.00
20_I105_L0.5561.00
12_I22_L0.5551.00
27_L52_L0.5541.00
190_L312_T0.5531.00
219_R222_R0.5531.00
121_Q127_Q0.5521.00
36_A108_M0.5521.00
163_S167_Y0.5521.00
32_A48_F0.5501.00
203_A222_R0.5491.00
82_T89_S0.5491.00
52_L56_L0.5491.00
203_A207_V0.5481.00
197_E232_A0.5481.00
264_T283_I0.5481.00
236_D239_E0.5481.00
132_D303_P0.5481.00
294_P298_D0.5461.00
266_T281_A0.5421.00
69_S74_Q0.5421.00
293_P307_G0.5411.00
229_P281_A0.5401.00
134_V138_A0.5391.00
20_I33_N0.5381.00
290_P339_T0.5381.00
292_I334_S0.5341.00
13_L33_N0.5331.00
134_V137_L0.5291.00
167_Y170_V0.5291.00
179_R182_V0.5291.00
200_H226_P0.5291.00
21_L94_V0.5281.00
217_N256_E0.5261.00
19_S33_N0.5261.00
9_A31_Y0.5261.00
12_I16_L0.5231.00
286_E335_W0.5221.00
214_L260_I0.5221.00
323_I329_K0.5221.00
330_I341_F0.5211.00
203_A206_V0.5211.00
9_A22_L0.5201.00
19_S40_L0.5201.00
214_L217_N0.5191.00
238_I242_L0.5191.00
245_I285_V0.5181.00
140_E174_Q0.5171.00
94_V106_L0.5161.00
67_Q70_L0.5151.00
145_L178_L0.5141.00
68_E71_E0.5141.00
332_F339_T0.5131.00
140_E178_L0.5111.00
12_I20_I0.5091.00
42_Q55_L0.5091.00
91_I94_V0.5071.00
255_P288_N0.5071.00
225_D266_T0.5071.00
69_S73_G0.5061.00
166_E208_T0.5041.00
245_I323_I0.5031.00
279_L346_P0.5011.00
293_P297_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a0rA 2 0.9169 100 0.203 Contact Map
4gczA 2 0.9771 100 0.204 Contact Map
4i5sA 2 0.9083 100 0.237 Contact Map
4r3aA 1 0.8653 100 0.337 Contact Map
4q20A 2 0.6246 100 0.455 Contact Map
2c2aA 2 0.6447 100 0.46 Contact Map
4mpcA 2 0.8252 100 0.464 Contact Map
3d36A 2 0.616 100 0.468 Contact Map
3jz3A 2 0.4384 100 0.468 Contact Map
4e01A 3 0.7994 100 0.468 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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