GREMLIN Database
NLPI - Lipoprotein NlpI
UniProt: P0AFB1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12371
Length: 294 (233)
Sequences: 13536 (12214)
Seq/√Len: 800.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_R148_L4.2771.00
111_N114_A3.9971.00
77_L80_L3.8441.00
249_D252_S3.7001.00
211_S214_T3.4221.00
39_Q42_V3.1631.00
65_L84_D2.8281.00
103_G119_F2.6121.00
241_G257_F2.5711.00
137_G153_L2.5671.00
99_F118_A2.5311.00
69_G85_F2.4981.00
237_N256_L2.4801.00
133_H152_D2.4111.00
120_D136_R2.3611.00
171_Y186_L2.2461.00
85_F101_Y2.1161.00
153_L169_W2.1021.00
203_V219_L2.0891.00
68_R84_D2.0481.00
102_L118_A2.0441.00
136_R152_D2.0151.00
167_S185_V1.9691.00
119_F135_N1.9181.00
47_M67_E1.8791.00
154_L170_L1.8771.00
72_Y80_L1.8761.00
86_S102_L1.8251.00
140_L152_D1.8211.00
199_G218_R1.7901.00
48_E68_R1.7781.00
106_L118_A1.6871.00
140_L148_L1.6521.00
206_Y218_R1.6431.00
116_Y120_D1.6361.00
174_E185_V1.6281.00
72_Y84_D1.6041.00
202_I206_Y1.6011.00
150_Q154_L1.5961.00
106_L114_A1.5841.00
170_L185_V1.5661.00
136_R140_L1.5591.00
68_R72_Y1.5561.00
187_K202_I1.5331.00
140_L145_R1.5211.00
82_R86_S1.5181.00
186_L201_N1.5001.00
183_K187_K1.4691.00
102_L106_L1.4581.00
170_L174_E1.4221.00
174_E181_Q1.4111.00
148_L151_D1.4101.00
72_Y77_L1.3771.00
156_F166_R1.3751.00
219_L239_Y1.3701.00
116_Y143_G1.3641.00
133_H155_A1.3501.00
244_Y256_L1.3271.00
202_I218_R1.3221.00
79_A109_A1.3131.00
183_K209_N1.3021.00
62_A88_A1.2981.00
244_Y252_S1.2941.00
113_D143_G1.2821.00
216_M220_K1.2671.00
240_L244_Y1.2651.00
150_Q170_L1.2581.00
126_D129_Y1.2531.00
150_Q174_E1.2471.00
106_L111_N1.2421.00
171_Y189_H1.2351.00
206_Y214_T1.2161.00
199_G221_A1.2151.00
116_Y139_A1.2121.00
82_R102_L1.2081.00
44_L48_E1.2071.00
71_L75_L1.2001.00
241_G260_A1.1981.00
240_L256_L1.1891.00
116_Y136_R1.1731.00
95_M98_V1.1711.00
150_Q177_L1.1711.00
183_K206_Y1.1691.00
220_K240_L1.1591.00
82_R109_A1.1551.00
82_R105_Y1.1551.00
88_A98_V1.1521.00
254_T258_K1.1481.00
237_N259_L1.1431.00
116_Y140_L1.1411.00
244_Y249_D1.1371.00
80_L83_N1.1331.00
180_K209_N1.1321.00
122_V132_A1.1131.00
133_H156_F1.1091.00
181_Q184_E1.1081.00
34_L46_R1.1061.00
103_G122_V1.1031.00
137_G156_F1.1001.00
245_L257_F1.0981.00
58_D61_R1.0861.00
252_S255_A1.0801.00
87_Q90_A1.0791.00
157_Y167_S1.0761.00
69_G88_A1.0721.00
70_V101_Y1.0701.00
160_D163_D1.0671.00
150_Q173_A1.0541.00
89_L99_F1.0531.00
66_Y70_V1.0401.00
147_K177_L1.0391.00
41_E75_L1.0381.00
99_F121_S1.0351.00
203_V215_L1.0311.00
238_F242_K1.0271.00
114_A117_E1.0201.00
104_I135_N1.0191.00
139_A143_G1.0181.00
134_L169_W1.0161.00
89_L98_V1.0141.00
206_Y211_S1.0081.00
155_A158_Q1.0071.00
183_K202_I1.0021.00
34_L42_V1.0021.00
82_R106_L0.9961.00
65_L87_Q0.9881.00
157_Y166_R0.9781.00
123_L132_A0.9781.00
141_Y146_D0.9721.00
216_M247_L0.9701.00
167_S188_Q0.9691.00
172_L201_N0.9671.00
155_A159_D0.9671.00
138_I169_W0.9571.00
100_N135_N0.9481.00
203_V222_D0.9481.00
123_L133_H0.9461.00
190_F199_G0.9411.00
213_Q247_L0.9331.00
103_G115_A0.9321.00
216_M244_Y0.9151.00
92_R95_M0.9121.00
156_F159_D0.9121.00
256_L259_L0.9071.00
214_T217_E0.9061.00
44_L72_Y0.9061.00
207_L239_Y0.9041.00
171_Y182_A0.9011.00
100_N104_I0.8991.00
204_E239_Y0.8961.00
243_Y247_L0.8921.00
87_Q91_I0.8901.00
78_R105_Y0.8891.00
121_S125_L0.8691.00
163_D166_R0.8671.00
200_W239_Y0.8661.00
134_L138_I0.8651.00
146_D173_A0.8621.00
167_S189_H0.8591.00
121_S124_E0.8541.00
154_L158_Q0.8531.00
141_Y169_W0.8481.00
216_M243_Y0.8471.00
99_F122_V0.8471.00
167_S192_K0.8421.00
70_V74_S0.8371.00
66_Y101_Y0.8261.00
105_Y109_A0.8221.00
218_R221_A0.8201.00
50_I53_S0.8021.00
44_L71_L0.7991.00
205_F209_N0.7981.00
46_R49_Q0.7971.00
239_Y242_K0.7971.00
241_G253_A0.7941.00
73_D85_F0.7941.00
35_Q40_Q0.7901.00
101_Y104_I0.7881.00
65_L88_A0.7881.00
259_L262_A0.7871.00
66_Y98_V0.7871.00
199_G222_D0.7861.00
189_H192_K0.7811.00
168_L172_L0.7801.00
45_A49_Q0.7761.00
188_Q191_E0.7761.00
130_N156_F0.7731.00
173_A177_L0.7721.00
61_R65_L0.7711.00
172_L186_L0.7701.00
169_W172_L0.7681.00
168_L201_N0.7651.00
104_I119_F0.7651.00
107_T119_F0.7631.00
234_S260_A0.7631.00
88_A91_I0.7621.00
133_H159_D0.7591.00
44_L68_R0.7551.00
252_S256_L0.7521.00
35_Q47_M0.7491.00
141_Y153_L0.7491.00
200_W204_E0.7461.00
117_E121_S0.7451.00
207_L212_E0.7421.00
34_L39_Q0.7421.00
78_R108_Q0.7381.00
223_A237_N0.7361.00
223_A236_T0.7321.00
86_S90_A0.7321.00
215_L243_Y0.7271.00
44_L75_L0.7271.00
69_G81_A0.7241.00
40_Q71_L0.7201.00
96_P122_V0.7191.00
151_D155_A0.7181.00
204_E207_L0.7181.00
73_D105_Y0.7171.00
138_I153_L0.7161.00
154_L181_Q0.7161.00
48_E52_A0.7151.00
258_K262_A0.7141.00
233_L237_N0.7131.00
137_G149_A0.7121.00
70_V73_D0.7101.00
152_D155_A0.7081.00
107_T139_A0.7031.00
84_D87_Q0.7021.00
70_V85_F0.7011.00
245_L250_L0.7011.00
188_Q192_K0.6991.00
42_V45_A0.6961.00
207_L219_L0.6951.00
179_E205_F0.6941.00
222_D236_T0.6931.00
123_L136_R0.6841.00
141_Y173_A0.6841.00
157_Y170_L0.6831.00
214_T218_R0.6811.00
212_E216_M0.6801.00
183_K205_F0.6791.00
185_V188_Q0.6761.00
212_E243_Y0.6711.00
62_A69_G0.6671.00
181_Q185_V0.6651.00
67_E70_V0.6621.00
152_D156_F0.6611.00
84_D88_A0.6591.00
118_A121_S0.6581.00
138_I141_Y0.6581.00
153_L173_A0.6531.00
43_I47_M0.6521.00
135_N138_I0.6521.00
187_K191_E0.6511.00
65_L91_I0.6511.00
48_E80_L0.6501.00
80_L84_D0.6491.00
134_L166_R0.6451.00
120_D124_E0.6431.00
100_N132_A0.6421.00
86_S114_A0.6411.00
113_D117_E0.6411.00
82_R111_N0.6391.00
216_M240_L0.6381.00
50_I64_L0.6361.00
134_L156_F0.6331.00
32_V47_M0.6331.00
148_L152_D0.6321.00
112_F139_A0.6311.00
204_E208_G0.6271.00
255_A258_K0.6231.00
83_N86_S0.6231.00
46_R50_I0.6191.00
73_D101_Y0.6191.00
207_L243_Y0.6151.00
233_L236_T0.6151.00
49_Q53_S0.6151.00
104_I108_Q0.6131.00
259_L263_N0.6101.00
242_K257_F0.6091.00
207_L246_S0.6081.00
73_D78_R0.6071.00
241_G256_L0.6071.00
175_Q179_E0.6051.00
146_D176_K0.6051.00
129_Y132_A0.6051.00
114_A118_A0.6041.00
118_A122_V0.6041.00
200_W203_V0.6031.00
175_Q208_G0.6031.00
85_F105_Y0.6031.00
237_N260_A0.5991.00
122_V125_L0.5871.00
42_V46_R0.5861.00
78_R82_R0.5851.00
112_F143_G0.5831.00
217_E221_A0.5821.00
190_F202_I0.5811.00
107_T142_Y0.5811.00
51_L64_L0.5801.00
107_T135_N0.5791.00
116_Y145_R0.5771.00
175_Q205_F0.5771.00
149_A173_A0.5761.00
99_F125_L0.5691.00
242_K245_L0.5671.00
238_F260_A0.5671.00
221_A225_D0.5641.00
147_K151_D0.5631.00
184_E188_Q0.5631.00
254_T261_V0.5591.00
212_E247_L0.5581.00
217_E220_K0.5581.00
115_A139_A0.5581.00
175_Q186_L0.5551.00
40_Q43_I0.5551.00
253_A257_F0.5541.00
174_E177_L0.5521.00
201_N204_E0.5511.00
86_S106_L0.5501.00
41_E45_A0.5491.00
33_P37_T0.5431.00
220_K252_S0.5411.00
179_E183_K0.5381.00
257_F261_V0.5361.00
141_Y176_K0.5351.00
182_A205_F0.5311.00
200_W236_T0.5311.00
107_T112_F0.5271.00
32_V36_P0.5251.00
250_L254_T0.5241.00
182_A186_L0.5221.00
112_F116_Y0.5211.00
180_K184_E0.5211.00
85_F102_L0.5201.00
100_N122_V0.5181.00
95_M99_F0.5141.00
35_Q71_L0.5131.00
131_Y135_N0.5131.00
218_R222_D0.5121.00
69_G84_D0.5121.00
141_Y149_A0.5121.00
175_Q201_N0.5101.00
187_K190_F0.5091.00
244_Y247_L0.5091.00
146_D150_Q0.5071.00
264_N267_N0.5051.00
234_S264_N0.5051.00
43_I71_L0.5021.00
137_G152_D0.5011.00
215_L222_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q7aA 1 0.9048 100 0.271 Contact Map
3dssA 1 0.9218 100 0.276 Contact Map
3draA 1 0.9286 100 0.292 Contact Map
1w3bA 2 0.9286 100 0.295 Contact Map
2h6fA 1 0.9422 100 0.296 Contact Map
4l9pA 1 0.9286 100 0.296 Contact Map
1xnfA 2 0.8912 100 0.303 Contact Map
4ui9J 2 0.949 100 0.318 Contact Map
4ui9C 2 0.9388 100 0.319 Contact Map
4r7sA 1 0.8639 100 0.323 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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