GREMLIN Database
NIKC - Nickel transport system permease protein NikC
UniProt: P0AFA9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12077
Length: 277 (253)
Sequences: 28653 (18128)
Seq/√Len: 1139.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_V184_L2.8511.00
104_D154_R2.6921.00
160_L165_F2.4901.00
170_R176_H2.4861.00
174_A178_R2.4781.00
178_R182_D2.4621.00
92_I107_T2.4181.00
80_A138_I2.3891.00
160_L163_R2.3751.00
84_L142_A2.3611.00
175_G178_R2.3221.00
73_V212_F2.3171.00
177_V181_V2.2621.00
40_D43_S2.1751.00
226_V230_D2.1561.00
164_E167_L2.1511.00
166_V179_V2.0811.00
166_V184_L2.0501.00
50_A53_W2.0271.00
94_G157_V2.0141.00
66_R227_M1.9951.00
197_T260_G1.9941.00
95_S99_I1.9511.00
99_I176_H1.9021.00
99_I103_V1.8971.00
62_D65_S1.8911.00
87_T91_V1.8771.00
149_Y199_D1.8541.00
35_D38_A1.8321.00
160_L188_V1.7761.00
57_D61_R1.7721.00
19_A23_L1.7641.00
98_L176_H1.7641.00
165_F187_A1.7631.00
97_G157_V1.7541.00
102_R106_A1.7341.00
25_A71_T1.7341.00
59_L66_R1.6721.00
95_S103_V1.6601.00
88_L91_V1.6551.00
64_F68_M1.6501.00
88_L146_W1.6481.00
161_R184_L1.6441.00
54_L244_W1.6431.00
85_V145_H1.6031.00
76_G80_A1.5911.00
52_H62_D1.5861.00
69_A72_R1.5791.00
156_L159_S1.5641.00
63_I244_W1.5601.00
103_V107_T1.5551.00
138_I142_A1.5531.00
111_A150_A1.5381.00
231_A241_Q1.5191.00
86_L196_A1.5181.00
98_L180_F1.5151.00
58_H230_D1.5061.00
11_V262_A1.5001.00
107_T150_A1.4901.00
61_R65_S1.4831.00
159_S163_R1.4781.00
93_G97_G1.4681.00
89_G149_Y1.4511.00
228_I245_P1.4451.00
27_T30_W1.4241.00
82_L196_A1.4001.00
14_A255_A1.3981.00
121_I125_F1.3731.00
109_R112_D1.3631.00
154_R158_I1.3591.00
93_G153_V1.3591.00
102_R105_Q1.3541.00
168_A172_S1.3491.00
97_G161_R1.3221.00
73_V76_G1.3221.00
92_I150_A1.3141.00
89_G153_V1.3111.00
194_V264_R1.3101.00
135_T139_I1.3021.00
54_L64_F1.2901.00
43_S46_L1.2871.00
160_L166_V1.2821.00
201_G253_V1.2811.00
67_L248_A1.2721.00
126_M140_A1.2711.00
263_L266_H1.2701.00
12_R16_I1.2681.00
96_A107_T1.2651.00
94_G180_F1.2631.00
21_L250_F1.2631.00
152_M195_L1.2601.00
239_P243_F1.2541.00
142_A146_W1.2501.00
23_L27_T1.2361.00
193_L267_L1.2311.00
160_L184_L1.2261.00
264_R268_D1.2251.00
61_R66_R1.2081.00
169_S183_H1.2041.00
49_D54_L1.1971.00
9_W12_R1.1961.00
169_S174_A1.1751.00
77_S207_V1.1641.00
169_S179_V1.1571.00
157_V188_V1.1431.00
94_G185_A1.1341.00
114_F147_A1.1281.00
61_R69_A1.1271.00
153_V192_L1.1211.00
167_L170_R1.1121.00
262_A266_H1.1071.00
18_I251_I1.1051.00
105_Q109_R1.0991.00
153_V157_V1.0971.00
100_G161_R1.0911.00
90_L153_V1.0891.00
178_R181_V1.0831.00
133_G136_N1.0821.00
245_P249_L1.0701.00
54_L67_L1.0641.00
156_L160_L1.0601.00
91_V94_G1.0591.00
227_M241_Q1.0501.00
140_A144_S1.0491.00
231_A242_M1.0441.00
123_S140_A1.0401.00
72_R76_G1.0381.00
110_V114_F1.0381.00
146_W150_A1.0381.00
56_T62_D1.0371.00
117_F122_L1.0371.00
104_D108_M1.0341.00
135_T138_I1.0311.00
172_S183_H1.0271.00
28_S69_A1.0231.00
13_L16_I1.0231.00
81_C142_A1.0211.00
108_M150_A1.0181.00
63_I241_Q1.0161.00
14_A262_A1.0101.00
100_G162_Q1.0051.00
16_I20_L1.0011.00
32_L65_S0.9981.00
170_R179_V0.9911.00
63_I227_M0.9811.00
14_A254_M0.9751.00
21_L252_S0.9751.00
169_S172_S0.9691.00
240_L244_W0.9681.00
81_C85_V0.9641.00
66_R241_Q0.9621.00
104_D158_I0.9611.00
153_V188_V0.9611.00
18_I255_A0.9591.00
76_G134_L0.9581.00
20_L24_I0.9571.00
16_I19_A0.9511.00
200_I256_F0.9501.00
17_I255_A0.9471.00
65_S69_A0.9431.00
67_L244_W0.9401.00
76_G79_M0.9361.00
130_L136_N0.9321.00
49_D53_W0.9301.00
70_A227_M0.9301.00
81_C141_I0.9221.00
34_Y51_Q0.9211.00
49_D52_H0.9211.00
52_H56_T0.9181.00
119_T206_H0.9171.00
14_A258_L0.9171.00
174_A179_V0.9151.00
176_H179_V0.9101.00
244_W247_L0.9071.00
106_A110_V0.9061.00
15_L19_A0.9061.00
190_P264_R0.9041.00
105_Q108_M0.9041.00
103_V106_A0.8971.00
46_L49_D0.8921.00
93_G157_V0.8911.00
58_H234_Y0.8901.00
255_A259_V0.8741.00
56_T60_G0.8711.00
15_L259_V0.8631.00
11_V258_L0.8581.00
42_P46_L0.8571.00
141_I206_H0.8561.00
87_T90_L0.8541.00
24_I68_M0.8521.00
66_R69_A0.8501.00
111_A147_A0.8501.00
195_L199_D0.8491.00
86_L90_L0.8491.00
68_M72_R0.8481.00
90_L192_L0.8471.00
17_I251_I0.8471.00
188_V191_S0.8411.00
181_V184_L0.8381.00
86_L91_V0.8371.00
34_Y65_S0.8351.00
134_L138_I0.8341.00
256_F260_G0.8281.00
193_L260_G0.8231.00
119_T123_S0.8181.00
34_Y52_H0.8161.00
91_V95_S0.8141.00
157_V161_R0.8071.00
30_W239_P0.8011.00
227_M245_P0.7991.00
163_R167_L0.7931.00
86_L149_Y0.7921.00
71_T252_S0.7891.00
155_S158_I0.7881.00
65_S68_M0.7861.00
101_G104_D0.7841.00
81_C203_M0.7821.00
176_H180_F0.7821.00
79_M83_L0.7821.00
126_M136_N0.7821.00
139_I142_A0.7811.00
43_S52_H0.7811.00
160_L187_A0.7771.00
84_L138_I0.7761.00
92_I146_W0.7751.00
96_A104_D0.7751.00
174_A183_H0.7751.00
97_G158_I0.7741.00
243_F247_L0.7721.00
33_P65_S0.7631.00
115_M147_A0.7611.00
136_N139_I0.7611.00
44_R48_P0.7601.00
11_V15_L0.7511.00
264_R271_L0.7491.00
229_N232_R0.7491.00
74_S78_V0.7461.00
27_T31_W0.7451.00
179_V184_L0.7451.00
265_D271_L0.7391.00
167_L171_L0.7381.00
80_A212_F0.7311.00
68_M71_T0.7271.00
101_G105_Q0.7221.00
249_L253_V0.7221.00
244_W248_A0.7211.00
22_A247_L0.7191.00
80_A83_L0.7191.00
156_L191_S0.7181.00
153_V156_L0.7131.00
10_S14_A0.7081.00
230_D233_Q0.7001.00
88_L142_A0.7001.00
53_W64_F0.6991.00
251_I255_A0.6991.00
24_I71_T0.6981.00
201_G256_F0.6971.00
26_L30_W0.6941.00
131_G135_T0.6911.00
49_D247_L0.6801.00
21_L251_I0.6801.00
156_L188_V0.6761.00
243_F246_G0.6741.00
89_G93_G0.6731.00
145_H148_W0.6731.00
259_V263_L0.6701.00
57_D238_Q0.6701.00
53_W62_D0.6681.00
14_A17_I0.6671.00
144_S147_A0.6641.00
197_T256_F0.6631.00
85_V142_A0.6631.00
45_L48_P0.6621.00
13_L17_I0.6591.00
100_G104_D0.6591.00
177_V180_F0.6571.00
28_S31_W0.6541.00
205_L208_A0.6521.00
34_Y237_T0.6511.00
48_P240_L0.6491.00
205_L209_G0.6471.00
137_V207_V0.6451.00
207_V211_S0.6421.00
253_V257_N0.6391.00
88_L92_I0.6381.00
98_L161_R0.6371.00
9_W13_L0.6351.00
33_P64_F0.6351.00
119_T122_L0.6351.00
67_L245_P0.6321.00
96_A108_M0.6281.00
158_I161_R0.6281.00
18_I256_F0.6251.00
42_P45_L0.6251.00
100_G158_I0.6191.00
106_A109_R0.6181.00
208_A226_V0.6181.00
82_L199_D0.6151.00
24_I28_S0.6131.00
29_Q72_R0.6131.00
12_R15_L0.6081.00
82_L200_I0.6081.00
107_T111_A0.6061.00
242_M246_G0.6041.00
111_A146_W0.6031.00
108_M111_A0.6021.00
206_H209_G0.6011.00
99_I180_F0.5961.00
80_A135_T0.5951.00
174_A177_V0.5901.00
78_V203_M0.5891.00
97_G104_D0.5881.00
125_F129_V0.5871.00
98_L181_V0.5871.00
148_W199_D0.5871.00
45_L238_Q0.5871.00
75_L79_M0.5861.00
37_Q41_L0.5861.00
17_I21_L0.5851.00
41_L44_R0.5851.00
109_R113_M0.5831.00
149_Y153_V0.5821.00
114_F146_W0.5811.00
131_G136_N0.5801.00
40_D52_H0.5801.00
143_L146_W0.5791.00
47_S240_L0.5781.00
229_N233_Q0.5781.00
227_M230_D0.5771.00
265_D272_V0.5751.00
149_Y195_L0.5751.00
71_T75_L0.5731.00
119_T143_L0.5671.00
203_M206_H0.5671.00
122_L144_S0.5651.00
204_M208_A0.5611.00
72_R75_L0.5591.00
25_A246_G0.5591.00
83_L87_T0.5581.00
194_V197_T0.5561.00
32_L69_A0.5561.00
230_D234_Y0.5491.00
166_V170_R0.5481.00
136_N140_A0.5451.00
208_A229_N0.5431.00
86_L192_L0.5431.00
208_A230_D0.5421.00
14_A18_I0.5411.00
77_S137_V0.5381.00
112_D115_M0.5371.00
139_I143_L0.5371.00
89_G150_A0.5371.00
82_L86_L0.5361.00
29_Q69_A0.5351.00
258_L262_A0.5331.00
66_R70_A0.5321.00
40_D44_R0.5311.00
227_M231_A0.5301.00
18_I259_V0.5281.00
228_I249_L0.5281.00
108_M112_D0.5271.00
145_H199_D0.5261.00
240_L243_F0.5251.00
96_A154_R0.5241.00
10_S258_L0.5181.00
45_L241_Q0.5161.00
46_L56_T0.5161.00
175_G179_V0.5151.00
92_I95_S0.5151.00
21_L25_A0.5151.00
147_A150_A0.5141.00
199_D203_M0.5101.00
181_V186_G0.5071.00
78_V200_I0.5071.00
148_W195_L0.5061.00
152_M156_L0.5061.00
44_R47_S0.5051.00
189_I193_L0.5041.00
39_I59_L0.5011.00
142_A145_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.9061 99.9 0.577 Contact Map
3tuiA 2 0.7329 99.9 0.613 Contact Map
3d31C 2 0.8339 99.9 0.63 Contact Map
3rlfF 1 0.9061 99.9 0.633 Contact Map
3rlfG 1 0.935 99.9 0.638 Contact Map
4tquN 1 0.9278 99.8 0.642 Contact Map
2onkC 2 0.852 99.8 0.642 Contact Map
4ymuD 2 0.7545 99.8 0.648 Contact Map
3j9pD 4 0.7798 62 0.933 Contact Map
2k1eA 3 0.361 14.6 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.