GREMLIN Database
LPTF - Lipopolysaccharide export system permease protein LptF
UniProt: P0AF98 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12535
Length: 366 (339)
Sequences: 4439 (3266)
Seq/√Len: 177.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_D209_Q7.3181.00
162_E171_D6.3681.00
192_S208_N4.7931.00
210_G227_F4.5261.00
163_S170_K4.0491.00
267_N332_W3.8691.00
176_Q186_S3.7751.00
4_I97_V3.7011.00
168_D192_S3.6711.00
3_I88_M3.4681.00
78_K82_E3.1631.00
255_W266_L3.1631.00
196_T206_T3.1521.00
76_L102_A3.0171.00
15_Q71_G2.8351.00
5_R9_R2.8351.00
194_H208_N2.7821.00
127_H130_E2.6271.00
9_R13_K2.6151.00
168_D194_H2.6021.00
178_R183_A2.5321.00
265_E269_R2.3491.00
106_A280_A2.3251.00
71_G75_T2.3201.00
186_S212_R2.3191.00
123_W127_H2.3151.00
214_E223_R2.2641.00
193_G207_L2.1381.00
320_G330_W2.1221.00
268_W317_K2.1071.00
271_T332_W2.0921.00
88_M93_L2.0771.00
107_V111_I2.0741.00
278_M338_Y2.0421.00
67_S71_G1.9891.00
275_T309_F1.9781.00
186_S214_E1.9381.00
146_Q163_S1.8931.00
157_S176_Q1.8831.00
53_G57_P1.8781.00
8_V105_L1.8721.00
44_P47_L1.8671.00
169_F193_G1.8501.00
38_A48_V1.8301.00
22_L63_I1.8241.00
336_L340_A1.8191.00
19_L67_S1.7951.00
190_A207_L1.7291.00
336_L339_L1.7291.00
99_V284_V1.7201.00
206_T229_D1.7111.00
259_T263_R1.7081.00
340_A344_V1.7011.00
116_N120_A1.6501.00
45_A49_L1.6491.00
110_A277_F1.6471.00
19_L60_A1.6191.00
49_L53_G1.6031.00
112_V116_N1.5851.00
212_R225_T1.5841.00
23_L56_V1.5761.00
344_V348_W1.5681.00
111_I115_V1.5671.00
10_E79_L1.5331.00
73_L302_A1.5241.00
197_Q203_Q1.5111.00
10_E78_K1.5051.00
97_V100_K1.4981.00
18_I70_L1.4951.00
54_L124_S1.4901.00
210_G225_T1.4881.00
282_M342_A1.4741.00
79_L88_M1.4661.00
273_V276_V1.4561.00
317_K321_G1.4511.00
68_L276_V1.4501.00
50_S54_L1.4431.00
115_V119_W1.4411.00
250_D253_T1.4291.00
27_F52_L1.4251.00
188_V212_R1.4221.00
61_Q117_V1.4181.00
209_Q228_Q1.4171.00
171_D191_D1.4111.00
14_S75_T1.3841.00
211_T224_I1.3491.00
100_K104_I1.3441.00
69_F279_M1.3421.00
264_A321_G1.3371.00
212_R223_R1.3311.00
19_L23_L1.3291.00
96_A100_K1.3251.00
47_L50_S1.3241.00
264_A269_R1.3091.00
115_V120_A1.3071.00
12_L16_L1.3061.00
4_I100_K1.2961.00
15_Q109_T1.2891.00
204_V229_D1.2881.00
161_I169_F1.2571.00
47_L131_V1.2531.00
110_A273_V1.2481.00
251_M266_L1.2471.00
170_K192_S1.2421.00
64_L113_A1.2251.00
260_D263_R1.2211.00
102_A280_A1.2161.00
58_E125_S1.2101.00
172_V193_G1.1921.00
194_H206_T1.1901.00
274_F335_N1.1901.00
332_W335_N1.1771.00
217_A220_R1.1671.00
326_D329_L1.1621.00
249_M253_T1.1611.00
328_T336_L1.1601.00
195_L236_H1.1481.00
320_G331_M1.1461.00
337_I340_A1.1441.00
266_L270_I1.1441.00
281_L342_A1.1401.00
208_N229_D1.1371.00
80_Y85_I1.1361.00
343_I347_L1.1281.00
103_M106_A1.1281.00
204_V231_Q1.1201.00
169_F172_V1.1191.00
316_L319_N1.1161.00
316_L330_W1.1111.00
51_L128_Q1.1051.00
72_L280_A1.1041.00
314_T318_S1.1031.00
206_T227_F1.1021.00
274_F332_W1.1001.00
246_T262_A1.0991.00
188_V210_G1.0981.00
278_M339_L1.0931.00
171_D189_V1.0931.00
4_I101_A1.0831.00
54_L127_H1.0811.00
30_K34_I1.0741.00
267_N328_T1.0701.00
216_T219_L1.0651.00
216_T221_D1.0651.00
68_L72_L1.0561.00
3_I93_L1.0551.00
34_I52_L1.0491.00
265_E268_W1.0481.00
195_L205_V1.0461.00
88_M98_L1.0371.00
129_D248_Q1.0360.99
38_A41_G1.0340.99
94_S97_V1.0330.99
271_T335_N1.0330.99
60_A116_N1.0210.99
316_L334_V1.0160.99
74_M298_S1.0110.99
179_P183_A1.0100.99
76_L284_V1.0050.99
26_F59_M0.9980.99
246_T249_M0.9960.99
51_L132_L0.9860.99
342_A346_N0.9860.99
165_D168_D0.9840.99
309_F335_N0.9820.99
123_W126_R0.9790.99
118_M269_R0.9720.99
282_M308_L0.9710.99
114_A118_M0.9590.99
50_S127_H0.9560.99
47_L135_A0.9530.99
130_E134_E0.9470.99
18_I22_L0.9460.99
83_S292_R0.9460.99
26_F31_L0.9410.99
249_M254_L0.9380.99
46_N50_S0.9370.99
11_T105_L0.9370.99
87_V90_A0.9370.99
251_M255_W0.9340.99
164_V169_F0.9310.99
225_T228_Q0.9300.99
339_L342_A0.9180.99
174_L207_L0.9180.99
11_T68_L0.9110.99
7_L88_M0.9080.99
29_Q32_V0.9070.99
325_L330_W0.9020.99
178_R185_P0.9010.99
251_M269_R0.8990.99
215_G222_F0.8980.99
24_L28_C0.8960.99
6_Y88_M0.8930.99
183_A217_A0.8900.98
4_I7_L0.8870.98
89_H95_K0.8870.98
83_S290_N0.8870.98
307_L310_F0.8860.98
304_L308_L0.8850.98
85_I288_V0.8840.98
26_F63_I0.8830.98
10_E13_K0.8820.98
285_P349_D0.8780.98
120_A124_S0.8770.98
68_L109_T0.8760.98
263_R267_N0.8750.98
11_T75_T0.8690.98
177_I184_R0.8640.98
232_A235_G0.8610.98
314_T317_K0.8610.98
104_I108_F0.8560.98
14_S71_G0.8530.98
119_W122_P0.8520.98
126_R130_E0.8520.98
291_P296_V0.8420.98
267_N271_T0.8400.98
329_L336_L0.8400.98
34_I43_I0.8390.98
339_L343_I0.8330.98
61_Q121_G0.8290.98
189_V211_T0.8270.98
69_F283_V0.8260.98
149_F152_A0.8260.98
207_L210_G0.8240.97
75_T79_L0.8160.97
251_M270_I0.8140.97
227_F230_Y0.8120.97
31_L45_A0.8060.97
6_Y10_E0.8040.97
210_G228_Q0.7970.97
309_F338_Y0.7930.97
120_A123_W0.7920.97
10_E75_T0.7890.97
326_D330_W0.7850.97
4_I15_Q0.7820.97
211_T226_D0.7810.97
95_K284_V0.7810.97
258_D263_R0.7800.96
254_L269_R0.7800.96
278_M309_F0.7740.96
88_M91_C0.7740.96
197_Q204_V0.7720.96
316_L331_M0.7710.96
268_W313_Q0.7700.96
13_K17_A0.7690.96
66_L306_Y0.7680.96
107_V277_F0.7680.96
311_L315_S0.7630.96
83_S86_T0.7620.96
108_F111_I0.7610.96
76_L98_L0.7600.96
106_A109_T0.7600.96
312_I316_L0.7590.96
192_S209_Q0.7570.96
55_G58_E0.7570.96
278_M342_A0.7560.96
25_I292_R0.7510.96
157_S174_L0.7500.96
27_F56_V0.7500.96
68_L321_G0.7490.96
275_T342_A0.7480.96
33_R36_G0.7480.96
338_Y345_L0.7470.96
80_Y287_S0.7450.95
45_A208_N0.7450.95
282_M338_Y0.7440.95
209_Q224_I0.7440.95
162_E170_K0.7400.95
190_A210_G0.7360.95
172_V190_A0.7320.95
344_V347_L0.7300.95
26_F30_K0.7290.95
243_P281_L0.7240.95
86_T292_R0.7220.95
15_Q67_S0.7210.95
251_M254_L0.7210.95
244_N253_T0.7200.95
118_M251_M0.7200.95
278_M335_N0.7200.95
83_S293_Q0.7180.94
73_L275_T0.7160.94
184_R205_V0.7160.94
3_I6_Y0.7150.94
279_M338_Y0.7050.94
6_Y79_L0.7040.94
55_G128_Q0.7020.94
221_D255_W0.7020.94
145_A148_Q0.6950.93
43_I48_V0.6940.93
119_W252_R0.6890.93
275_T335_N0.6880.93
103_M281_L0.6840.93
196_T204_V0.6820.93
46_N49_L0.6800.93
70_L87_V0.6790.93
132_L136_K0.6790.93
309_F313_Q0.6790.93
285_P288_V0.6780.93
310_F313_Q0.6780.93
8_V11_T0.6780.93
103_M277_F0.6760.92
34_I38_A0.6710.92
264_A320_G0.6700.92
36_G78_K0.6700.92
279_M302_A0.6700.92
248_Q254_L0.6690.92
63_I67_S0.6570.91
177_I205_V0.6570.91
99_V103_M0.6560.91
80_Y288_V0.6550.91
308_L338_Y0.6550.91
276_V279_M0.6530.91
149_F160_F0.6520.91
313_Q335_N0.6510.91
91_C95_K0.6500.91
316_L337_I0.6490.91
127_H131_V0.6470.91
76_L287_S0.6460.91
35_L38_A0.6440.91
52_L135_A0.6430.91
190_A218_L0.6420.90
121_G125_S0.6420.90
126_R138_N0.6410.90
57_P65_P0.6390.90
208_N227_F0.6370.90
118_M270_I0.6350.90
301_P305_L0.6340.90
173_F187_V0.6340.90
51_L131_V0.6340.90
131_V135_A0.6320.90
313_Q317_K0.6310.90
209_Q212_R0.6310.90
267_N331_M0.6310.90
9_R216_T0.6310.90
73_L316_L0.6300.90
285_P342_A0.6300.90
43_I76_L0.6280.89
172_V207_L0.6280.89
245_D248_Q0.6260.89
12_L46_N0.6250.89
242_D333_T0.6240.89
126_R165_D0.6230.89
29_Q59_M0.6230.89
157_S230_Y0.6230.89
214_E221_D0.6220.89
196_T203_Q0.6220.89
247_D265_E0.6210.89
290_N293_Q0.6210.89
285_P346_N0.6200.89
279_M331_M0.6200.89
113_A286_L0.6190.89
225_T230_Y0.6190.89
187_V213_F0.6180.89
192_S341_L0.6180.89
246_T254_L0.6170.89
14_S26_F0.6170.89
50_S131_V0.6160.89
11_T15_Q0.6160.89
288_V291_P0.6110.88
161_I172_V0.6100.88
22_L147_G0.6090.88
144_L205_V0.6070.88
10_E86_T0.6060.88
252_R255_W0.6060.88
71_G102_A0.6060.88
34_I128_Q0.6050.88
4_I283_V0.6030.88
335_N338_Y0.5980.87
95_K101_A0.5960.87
161_I193_G0.5960.87
74_M78_K0.5950.87
6_Y65_P0.5940.87
327_P331_M0.5940.87
77_G87_V0.5940.87
215_G221_D0.5930.87
205_V236_H0.5930.87
85_I94_S0.5920.87
239_V249_M0.5910.86
235_G238_A0.5880.86
281_L346_N0.5860.86
112_V255_W0.5860.86
309_F316_L0.5830.86
334_V338_Y0.5820.86
253_T256_N0.5810.86
101_A283_V0.5780.85
264_A331_M0.5760.85
80_Y295_R0.5760.85
57_P101_A0.5760.85
87_V91_C0.5750.85
24_L42_D0.5750.85
73_L286_L0.5740.85
36_G39_V0.5730.85
98_L266_L0.5730.85
265_E286_L0.5720.85
292_R297_L0.5710.85
249_M262_A0.5700.84
126_R245_D0.5690.84
78_K90_A0.5690.84
15_Q54_L0.5680.84
186_S256_N0.5660.84
9_R277_F0.5660.84
129_D322_K0.5650.84
252_R256_N0.5640.84
321_G324_K0.5630.84
113_A276_V0.5630.84
58_E62_L0.5610.84
67_S77_G0.5610.84
52_L169_F0.5600.83
99_V102_A0.5590.83
8_V101_A0.5590.83
122_P269_R0.5580.83
69_F306_Y0.5580.83
110_A114_A0.5570.83
85_I294_G0.5560.83
118_M250_D0.5550.83
54_L213_F0.5550.83
305_L338_Y0.5550.83
270_I273_V0.5530.83
288_V298_S0.5530.83
179_P204_V0.5530.83
260_D323_G0.5520.83
259_T262_A0.5520.83
277_F285_P0.5520.83
95_K285_P0.5510.82
264_A268_W0.5510.82
12_L105_L0.5500.82
72_L283_V0.5490.82
297_L302_A0.5470.82
7_L79_L0.5460.82
91_C224_I0.5460.82
114_A273_V0.5430.82
73_L212_R0.5430.82
195_L234_I0.5430.82
23_L60_A0.5420.81
57_P124_S0.5420.81
113_A275_T0.5420.81
195_L203_Q0.5420.81
168_D208_N0.5400.81
328_T332_W0.5390.81
307_L335_N0.5380.81
151_Q159_L0.5370.81
108_F214_E0.5370.81
4_I16_L0.5360.81
192_S206_T0.5360.81
82_E312_I0.5360.81
283_V345_L0.5350.81
152_A334_V0.5350.81
31_L67_S0.5340.80
35_L48_V0.5340.80
299_M306_Y0.5330.80
114_A270_I0.5330.80
193_G205_V0.5330.80
108_F112_V0.5330.80
84_E254_L0.5320.80
186_S312_I0.5320.80
165_D260_D0.5310.80
82_E279_M0.5310.80
86_T285_P0.5300.80
59_M62_L0.5300.80
272_L312_I0.5280.80
149_F193_G0.5270.80
31_L56_V0.5270.80
149_F210_G0.5260.79
129_D132_L0.5260.79
67_S73_L0.5260.79
106_A277_F0.5250.79
331_M338_Y0.5240.79
308_L312_I0.5230.79
41_G135_A0.5220.79
56_V328_T0.5220.79
299_M302_A0.5220.79
206_T209_Q0.5220.79
330_W333_T0.5210.79
176_Q185_P0.5210.79
193_G246_T0.5200.79
31_L264_A0.5200.79
129_D245_D0.5190.79
11_T102_A0.5180.78
53_G131_V0.5180.78
335_N339_L0.5180.78
255_W270_I0.5170.78
42_D316_L0.5170.78
51_L203_Q0.5160.78
310_F314_T0.5140.78
30_K33_R0.5140.78
139_P142_A0.5140.78
66_L307_L0.5130.78
104_I111_I0.5130.78
65_P79_L0.5130.78
39_V43_I0.5130.78
142_A148_Q0.5120.78
123_W308_L0.5120.78
121_G124_S0.5120.78
57_P274_F0.5110.77
176_Q188_V0.5100.77
86_T291_P0.5100.77
161_I164_V0.5100.77
120_A176_Q0.5080.77
330_W337_I0.5070.77
72_L319_N0.5060.77
58_E247_D0.5060.77
53_G207_L0.5060.77
20_F229_D0.5050.77
319_N325_L0.5040.77
27_F60_A0.5030.76
117_V122_P0.5020.76
112_V347_L0.5010.76
41_G292_R0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cadC 1 0.1858 8.1 0.966 Contact Map
1oedE 1 0.2322 6.4 0.968 Contact Map
1oedC 1 0.2322 6 0.968 Contact Map
1oedA 1 0.235 5.9 0.968 Contact Map
1oedB 1 0.2322 5.6 0.969 Contact Map
4us3A 1 0.2787 4.7 0.97 Contact Map
2l9uA 2 0.1066 4.5 0.97 Contact Map
3wvfA 1 0.2923 4 0.971 Contact Map
2mofA 1 0.112 3.8 0.971 Contact Map
3m73A 3 0.2131 3.3 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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