GREMLIN Database
TABA - Toxin-antitoxin biofilm protein TabA
UniProt: P0AF96 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12530
Length: 150 (147)
Sequences: 1164 (893)
Seq/√Len: 73.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_E43_R3.1021.00
43_R148_L3.0621.00
34_K50_E2.8741.00
4_G8_N2.7791.00
50_E141_R2.6351.00
19_Q40_E2.6221.00
46_Y143_A2.5531.00
22_E26_A2.4911.00
54_E59_R2.3971.00
45_F67_Y2.2971.00
28_V31_E2.2471.00
66_R148_L2.1181.00
52_M139_Q2.0511.00
5_N118_D2.0001.00
133_A137_P1.9931.00
49_S144_V1.9751.00
81_T111_T1.9381.00
38_D42_N1.9321.00
51_D131_L1.8381.00
51_D140_V1.8141.00
70_I147_M1.7871.00
36_K42_N1.7551.00
68_L123_Y1.7551.00
71_Q122_F1.7251.00
89_A104_P1.7241.00
73_V116_E1.6651.00
114_L120_V1.6601.00
53_T137_P1.6341.00
129_K132_C1.6321.00
66_R96_A1.5760.99
77_Q115_N1.5590.99
20_A145_V1.5320.99
33_P37_H1.5280.99
70_I121_V1.5220.99
61_A109_E1.5020.99
102_F130_P1.5020.99
80_M114_L1.4790.99
37_H48_I1.4600.99
41_G67_Y1.4530.99
63_Y103_L1.4170.99
75_K116_E1.4110.99
63_Y101_A1.4030.99
79_G113_I1.3990.98
65_A85_Q1.3860.98
54_E58_A1.3790.98
60_R92_T1.3770.98
39_I46_Y1.3700.98
23_H46_Y1.3640.98
17_L21_I1.3570.98
36_K45_F1.3560.98
4_G119_F1.3220.98
88_G127_V1.3220.98
50_E139_Q1.3190.98
55_P58_A1.2980.98
16_E44_L1.2940.97
60_R102_F1.2750.97
77_Q138_A1.2570.97
48_I141_R1.2540.97
9_L21_I1.2460.97
63_Y127_V1.2370.97
38_D41_G1.1620.95
2_I123_Y1.1560.95
95_L98_K1.1540.95
115_N118_D1.1530.95
4_G12_W1.1350.95
20_A70_I1.1310.95
17_L70_I1.1070.94
80_M122_F1.1030.94
36_K47_L1.0940.93
61_A127_V1.0920.93
80_M120_V1.0740.93
94_W101_A1.0730.93
56_Y111_T1.0700.93
49_S131_L1.0680.93
65_A101_A1.0600.92
74_L143_A1.0420.92
71_Q80_M1.0390.92
23_H27_H1.0180.91
24_I72_I1.0040.90
63_Y85_Q0.9950.90
73_V76_G0.9910.90
54_E131_L0.9820.89
21_I72_I0.9740.89
63_Y126_E0.9470.87
59_R131_L0.9460.87
34_K37_H0.9350.87
32_T48_I0.9280.86
49_S71_Q0.9190.86
14_P17_L0.8940.84
98_K141_R0.8780.83
65_A94_W0.8750.83
11_P125_G0.8710.83
77_Q135_G0.8700.82
78_E114_L0.8700.82
4_G125_G0.8660.82
92_T102_F0.8640.82
29_T32_T0.8600.82
23_H39_I0.8550.81
112_V122_F0.8500.81
53_T140_V0.8490.81
53_T80_M0.8330.80
16_E116_E0.8330.80
53_T133_A0.8320.80
113_I134_V0.8260.79
81_T109_E0.8250.79
22_E25_K0.8150.78
66_R104_P0.8070.77
52_M137_P0.8040.77
48_I71_Q0.8000.77
71_Q130_P0.7960.76
19_Q22_E0.7800.75
46_Y72_I0.7800.75
4_G14_P0.7780.75
59_R129_K0.7780.75
98_K102_F0.7580.73
18_R22_E0.7550.73
82_F122_F0.7500.72
77_Q113_I0.7460.72
17_L147_M0.7330.70
10_Q25_K0.7290.70
71_Q120_V0.7240.69
79_G111_T0.7230.69
103_L126_E0.7230.69
53_T73_V0.7220.69
131_L140_V0.7140.68
61_A129_K0.7070.68
13_L17_L0.7050.67
39_I67_Y0.7020.67
65_A96_A0.6980.67
92_T95_L0.6880.65
34_K141_R0.6850.65
80_M90_P0.6770.64
44_L147_M0.6770.64
35_G141_R0.6740.64
91_D104_P0.6720.64
60_R71_Q0.6690.63
12_W119_F0.6680.63
35_G48_I0.6620.63
9_L143_A0.6620.63
24_I46_Y0.6570.62
60_R91_D0.6570.62
3_I15_Q0.6550.62
68_L71_Q0.6550.62
68_L124_P0.6530.61
55_P133_A0.6520.61
45_F49_S0.6510.61
9_L70_I0.6460.61
40_E67_Y0.6450.61
114_L140_V0.6430.60
2_I8_N0.6400.60
69_D128_H0.6380.60
28_V32_T0.6300.59
7_H89_A0.6270.58
48_I143_A0.6260.58
53_T76_G0.6220.58
142_K146_K0.6140.57
83_S103_L0.6100.56
71_Q144_V0.6080.56
42_N148_L0.6080.56
35_G130_P0.6070.56
41_G45_F0.6040.56
76_G140_V0.6000.55
91_D101_A0.5980.55
97_D111_T0.5970.55
89_A96_A0.5960.55
51_D73_V0.5960.55
77_Q114_L0.5910.54
81_T129_K0.5890.54
36_K63_Y0.5870.53
16_E43_R0.5860.53
53_T78_E0.5860.53
54_E57_E0.5860.53
65_A93_D0.5800.53
112_V120_V0.5790.52
90_P104_P0.5730.52
6_I72_I0.5720.52
93_D101_A0.5670.51
27_H145_V0.5570.50
25_K33_P0.5520.49
135_G138_A0.5520.49
4_G9_L0.5510.49
71_Q119_F0.5490.49
27_H32_T0.5480.49
25_K130_P0.5470.48
93_D96_A0.5460.48
17_L68_L0.5460.48
73_V114_L0.5440.48
61_A102_F0.5430.48
15_Q18_R0.5410.48
19_Q136_A0.5400.48
70_I116_E0.5400.48
73_V140_V0.5390.47
51_D61_A0.5380.47
18_R32_T0.5370.47
40_E45_F0.5360.47
51_D63_Y0.5360.47
64_H128_H0.5350.47
44_L145_V0.5340.47
22_E66_R0.5330.47
114_L122_F0.5320.47
73_V144_V0.5320.47
42_N67_Y0.5320.47
120_V126_E0.5270.46
82_F126_E0.5250.46
10_Q30_A0.5230.45
14_P129_K0.5210.45
82_F120_V0.5210.45
62_E69_D0.5200.45
133_A138_A0.5190.45
10_Q18_R0.5180.45
59_R88_G0.5140.44
7_H10_Q0.5140.44
4_G16_E0.5130.44
29_T74_L0.5130.44
15_Q22_E0.5110.44
68_L122_F0.5080.44
64_H69_D0.5060.43
122_F131_L0.5040.43
90_P115_N0.5010.43
9_L12_W0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s4cA 2 0.9933 100 0.076 Contact Map
4tsdB 2 1 100 0.134 Contact Map
2gu9A 2 0.6467 31.9 0.931 Contact Map
1o4tA 2 0.68 26.4 0.934 Contact Map
3gbgA 1 0.5667 21.4 0.937 Contact Map
4emkC 1 0.3133 21.1 0.937 Contact Map
2vpvA 5 0.58 20.1 0.938 Contact Map
2fqpA 3 0.6333 19.8 0.938 Contact Map
4rd7A 2 0.7333 17 0.94 Contact Map
2y0oA 2 0.8267 16.9 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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