GREMLIN Database
YJFL - UPF0719 inner membrane protein YjfL
UniProt: P0AF80 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12487
Length: 132 (124)
Sequences: 758 (536)
Seq/√Len: 48.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_K108_N4.5771.00
52_S117_T4.2281.00
116_G120_L3.4421.00
47_A104_I3.3961.00
35_N38_Q3.0211.00
49_L116_G2.9601.00
60_I123_G2.8051.00
102_E106_N2.7931.00
38_Q42_N2.6591.00
53_G112_G2.5861.00
46_A107_H2.4561.00
49_L112_G2.3781.00
61_P82_A2.3021.00
99_A102_E2.2811.00
57_G123_G2.2441.00
66_A129_C1.9850.99
65_A130_M1.9280.99
76_F80_G1.8320.99
64_S68_N1.8110.99
49_L109_T1.7990.99
74_D77_A1.7750.99
28_Y54_T1.7530.99
56_L120_L1.6870.98
16_I72_I1.5960.97
69_A74_D1.5140.96
61_P123_G1.5130.96
93_V97_M1.4680.96
39_L42_N1.4600.96
66_A75_Y1.4210.95
108_N111_A1.3920.94
60_I63_S1.3210.92
63_S124_I1.3120.92
113_M116_G1.3010.92
24_F58_Y1.2680.91
12_A72_I1.2220.89
73_P80_G1.2100.89
20_M79_G1.1860.88
60_I120_L1.1750.87
82_A126_N1.1670.87
21_V59_V1.1550.86
13_Y66_A1.1530.86
103_K106_N1.1490.86
98_P114_F1.1440.86
24_F83_L1.1330.85
80_G84_V1.1220.85
45_T113_M1.1210.84
84_V91_A1.0760.82
73_P121_A1.0480.80
32_T36_E1.0460.80
73_P84_V1.0450.80
16_I76_F1.0430.80
45_T109_T1.0400.80
11_S88_L1.0280.79
16_I19_A1.0250.79
29_S116_G0.9980.77
54_T126_N0.9920.76
13_Y69_A0.9690.75
25_L55_L0.9690.75
113_M117_T0.9520.73
34_H130_M0.9480.73
61_P126_N0.9300.72
41_K128_A0.9280.71
42_N56_L0.9270.71
61_P86_Q0.9240.71
36_E90_F0.9200.71
107_H110_A0.9110.70
24_F54_T0.9090.70
13_Y89_V0.9000.69
10_F65_A0.8960.69
66_A85_I0.8840.68
85_I114_F0.8790.67
89_V122_G0.8780.67
64_S123_G0.8760.67
103_K111_A0.8760.67
49_L117_T0.8670.66
80_G125_F0.8660.66
39_L44_N0.8610.66
26_F30_K0.8370.63
18_V88_L0.8300.63
20_M76_F0.8250.62
78_W87_L0.8170.62
69_A86_Q0.8130.61
10_F69_A0.7910.59
36_E121_A0.7780.58
90_F98_P0.7700.57
64_S127_A0.7620.56
53_G116_G0.7590.56
48_S94_R0.7580.56
57_G90_F0.7580.56
9_A88_L0.7530.55
16_I75_Y0.7520.55
94_R97_M0.7480.55
101_S124_I0.7430.54
7_L35_N0.7380.54
88_L91_A0.7380.54
46_A124_I0.7330.53
112_G116_G0.7310.53
105_I115_M0.7250.52
27_I34_H0.7210.52
32_T78_W0.7180.52
59_V75_Y0.7160.52
14_F22_I0.7110.51
75_Y83_L0.7100.51
18_V22_I0.7070.51
72_I76_F0.7050.50
14_F117_T0.7040.50
65_A81_I0.7000.50
85_I88_L0.6920.49
31_I91_A0.6850.48
8_L11_S0.6840.48
10_F129_C0.6810.48
55_L92_G0.6790.48
57_G71_S0.6740.47
47_A111_A0.6710.47
13_Y129_C0.6650.46
125_F129_C0.6630.46
46_A114_F0.6610.46
17_G75_Y0.6610.46
74_D81_I0.6520.45
19_A84_V0.6510.45
100_L111_A0.6390.44
78_W82_A0.6330.43
62_L79_G0.6320.43
92_G109_T0.6300.43
75_Y129_C0.6290.43
18_V81_I0.6280.43
72_I83_L0.6260.43
97_M111_A0.6250.42
16_I23_I0.6210.42
80_G83_L0.6200.42
69_A78_W0.6130.41
34_H47_A0.6060.41
10_F123_G0.5960.40
98_P125_F0.5950.40
78_W86_Q0.5940.39
39_L86_Q0.5910.39
77_A80_G0.5880.39
76_F79_G0.5860.39
28_Y97_M0.5830.38
33_P42_N0.5820.38
87_L91_A0.5820.38
19_A26_F0.5820.38
38_Q92_G0.5810.38
7_L21_V0.5780.38
10_F13_Y0.5770.38
12_A56_L0.5770.38
9_A12_A0.5760.38
122_G126_N0.5750.38
48_S92_G0.5740.38
94_R112_G0.5660.37
21_V27_I0.5650.37
101_S104_I0.5640.37
28_Y82_A0.5630.37
39_L51_F0.5610.36
7_L127_A0.5590.36
15_F51_F0.5560.36
13_Y74_D0.5530.36
84_V109_T0.5520.35
60_I121_A0.5520.35
56_L124_I0.5510.35
106_N117_T0.5480.35
58_Y126_N0.5420.35
43_N78_W0.5420.35
37_W98_P0.5410.34
57_G130_M0.5410.34
54_T82_A0.5410.34
34_H122_G0.5350.34
50_A95_L0.5350.34
25_L51_F0.5320.34
19_A85_I0.5290.33
61_P121_A0.5260.33
62_L86_Q0.5250.33
19_A44_N0.5250.33
40_I47_A0.5190.33
23_I30_K0.5190.33
29_S37_W0.5160.32
76_F89_V0.5120.32
14_F24_F0.5110.32
65_A70_V0.5090.32
63_S127_A0.5040.31
82_A112_G0.5030.31
60_I126_N0.5030.31
56_L113_M0.5020.31
56_L109_T0.5010.31
102_E105_I0.5010.31
12_A45_T0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q90A 1 0.3333 9.5 0.927 Contact Map
4a01A 2 0.9015 6.5 0.932 Contact Map
3qnqA 2 0.3333 5.7 0.934 Contact Map
4n7wA 2 0.7045 4.5 0.937 Contact Map
3l1lA 2 0.6667 2.9 0.943 Contact Map
1ciiA 1 0.6818 2.7 0.944 Contact Map
4tllA 1 0.1515 2.2 0.946 Contact Map
3wvfA 1 0.1894 2.1 0.947 Contact Map
3zuxA 1 0.6591 2 0.947 Contact Map
4xnjA 1 0.6818 1.8 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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