GREMLIN Database
NSRR - HTH-type transcriptional repressor NsrR
UniProt: P0AF63 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11212
Length: 141 (131)
Sequences: 5764 (3902)
Seq/√Len: 340.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_G120_D3.7941.00
91_C102_C3.0401.00
72_S125_A2.9961.00
56_T66_R2.7961.00
16_Y34_V2.7751.00
10_G83_L2.7341.00
125_A129_E2.6421.00
14_L54_Y2.5781.00
110_K118_E2.4041.00
52_A82_E2.3941.00
69_K78_D2.3511.00
14_L124_L2.1991.00
81_R120_D2.1711.00
91_C96_C2.1571.00
77_G81_R2.0721.00
13_A46_I2.0501.00
18_A128_V2.0391.00
25_M66_R1.9711.00
96_C102_C1.9191.00
29_S39_R1.9001.00
17_M55_V1.8431.00
114_S118_E1.8371.00
114_S117_T1.7261.00
16_Y26_T1.6341.00
70_P73_A1.6311.00
29_S33_D1.5851.00
110_K122_Y1.5761.00
50_S57_A1.5691.00
58_V66_R1.5401.00
69_K73_A1.5391.00
47_N51_R1.4831.00
7_T80_V1.4691.00
75_R123_T1.4621.00
20_L24_R1.4371.00
111_A115_F1.4301.00
37_V42_M1.3961.00
13_A42_M1.3501.00
75_R78_D1.3191.00
21_P71_A1.2911.00
116_L120_D1.2871.00
28_I46_I1.2741.00
112_V116_L1.2141.00
107_A122_Y1.2071.00
118_E121_N1.2011.00
7_T84_E1.1721.00
81_R116_L1.1621.00
69_K74_I1.1371.00
13_A31_V1.1281.00
113_Q117_T1.1211.00
56_T68_G1.1211.00
16_Y20_L1.1111.00
16_Y35_Y1.0971.00
117_T121_N1.0731.00
110_K130_E1.0681.00
47_N50_S1.0551.00
27_S30_E1.0501.00
20_L26_T1.0431.00
25_M58_V1.0431.00
6_F44_K1.0341.00
111_A119_L1.0301.00
9_Y37_V1.0051.00
54_Y74_I1.0001.00
109_S113_Q0.9981.00
54_Y82_E0.9851.00
80_V119_L0.9831.00
33_D39_R0.9781.00
46_I65_I0.9671.00
14_L79_V0.9601.00
8_D12_R0.9531.00
15_I128_V0.9301.00
86_L116_L0.9201.00
78_D120_D0.9181.00
6_F48_Q0.9171.00
24_R30_E0.9111.00
46_I55_V0.9041.00
76_I107_A0.9041.00
11_L76_I0.8981.00
30_E34_V0.8981.00
106_Q130_E0.8941.00
5_S41_H0.8931.00
14_L49_L0.8871.00
88_L112_V0.8801.00
30_E33_D0.8651.00
40_N43_V0.8651.00
78_D81_R0.8551.00
111_A114_S0.8481.00
110_K114_S0.8221.00
28_I43_V0.8201.00
17_M26_T0.8181.00
47_N57_A0.8091.00
70_P125_A0.8091.00
50_S55_V0.8061.00
126_D129_E0.8001.00
21_P24_R0.8001.00
6_F10_G0.7961.00
47_N65_I0.7921.00
28_I39_R0.7881.00
123_T126_D0.7851.00
48_Q52_A0.7851.00
57_A65_I0.7841.00
43_V65_I0.7811.00
76_I127_L0.7761.00
19_S128_V0.7711.00
105_K109_S0.7651.00
118_E122_Y0.7651.00
3_L108_L0.7571.00
67_L71_A0.7531.00
77_G116_L0.7501.00
43_V50_S0.7461.00
68_G74_I0.7461.00
110_K121_N0.7451.00
6_F41_H0.7380.99
109_S112_V0.7350.99
16_Y31_V0.7320.99
54_Y78_D0.7230.99
81_R85_P0.7220.99
10_G45_I0.7130.99
41_H45_I0.7060.99
39_R43_V0.7020.99
32_T37_V0.6980.99
3_L80_V0.6970.99
7_T83_L0.6840.99
110_K113_Q0.6800.99
9_Y45_I0.6780.99
16_Y30_E0.6740.99
21_P70_P0.6740.99
94_E99_T0.6730.99
74_I79_V0.6710.99
91_C105_K0.6600.99
78_D82_E0.6570.99
80_V84_E0.6560.99
8_D104_L0.6560.99
75_R120_D0.6430.99
74_I124_L0.6430.99
4_T7_T0.6420.99
71_A128_V0.6390.98
27_S62_N0.6350.98
111_A118_E0.6320.98
108_L115_F0.6280.98
87_S93_S0.6210.98
40_N44_K0.6210.98
48_Q51_R0.6200.98
117_T120_D0.6150.98
79_V124_L0.6100.98
19_S34_V0.6100.98
79_V82_E0.6090.98
15_I127_L0.6070.98
19_S103_R0.6040.98
96_C105_K0.5980.98
54_Y69_K0.5970.98
38_S41_H0.5950.98
53_G68_G0.5920.98
107_A110_K0.5920.98
4_T41_H0.5910.98
98_I101_A0.5900.97
17_M46_I0.5840.97
75_R121_N0.5840.97
114_S119_L0.5780.97
3_L7_T0.5760.97
125_A128_V0.5690.97
14_L18_A0.5660.97
31_V46_I0.5650.97
9_Y41_H0.5640.97
52_A78_D0.5630.97
4_T84_E0.5600.97
44_K47_N0.5570.96
20_L34_V0.5490.96
72_S126_D0.5460.96
89_V92_S0.5450.96
102_C105_K0.5450.96
87_S95_F0.5450.96
107_A118_E0.5420.96
50_S65_I0.5410.96
27_S59_R0.5400.96
97_H101_A0.5390.96
113_Q116_L0.5360.96
59_R108_L0.5330.95
71_A74_I0.5300.95
97_H100_P0.5290.95
55_V59_R0.5290.95
41_H59_R0.5290.95
12_R35_Y0.5270.95
72_S129_E0.5240.95
68_G71_A0.5240.95
9_Y35_Y0.5180.95
99_T105_K0.5180.95
28_I65_I0.5170.95
104_L108_L0.5150.95
69_K72_S0.5120.94
17_M31_V0.5100.94
9_Y115_F0.5100.94
98_I109_S0.5080.94
5_S90_N0.5040.94
8_D88_L0.5010.94
90_N93_S0.5000.94
71_A124_L0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hf1A 2 0.9787 100 0.227 Contact Map
1xd7A 2 0.8085 100 0.266 Contact Map
4hf0A 3 0.8652 100 0.276 Contact Map
3k69A 2 0.9645 100 0.281 Contact Map
1ylfA 5 0.8511 100 0.295 Contact Map
3lwfA 5 0.9574 100 0.301 Contact Map
4cicA 2 0.922 100 0.308 Contact Map
3t8rA 2 0.8511 99.9 0.346 Contact Map
2y75A 5 0.9007 99.9 0.382 Contact Map
2jscA 2 0.6312 98.5 0.745 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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