GREMLIN Database
GHXP - Guanine/hypoxanthine permease GhxP
UniProt: P0AF52 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11939
Length: 449 (386)
Sequences: 10718 (6281)
Seq/√Len: 319.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_F310_G3.6191.00
161_V187_S3.3611.00
29_V339_T3.3271.00
397_F410_I3.1961.00
393_V414_T3.1081.00
76_G338_I2.9751.00
125_S300_T2.9521.00
25_V335_L2.8371.00
73_I341_G2.5981.00
74_V308_F2.5551.00
78_W304_M2.5071.00
131_S296_G2.4981.00
331_G336_T2.4641.00
167_N175_A2.3591.00
230_F233_P2.3401.00
172_L175_A2.3171.00
210_I214_S2.2911.00
67_V317_A2.2371.00
73_I338_I2.2081.00
119_V123_V2.2021.00
32_G339_T2.1771.00
231_A234_S2.1671.00
52_K97_F2.1151.00
123_V127_T2.0991.00
326_G336_T2.0891.00
208_L214_S2.0671.00
191_L368_Y2.0651.00
179_F184_V2.0611.00
261_V265_V2.0531.00
375_S378_A2.0371.00
201_K204_G2.0121.00
69_G345_L2.0111.00
342_V346_L2.0011.00
394_T411_G1.9991.00
185_I189_V1.9651.00
208_L211_I1.9501.00
119_V307_V1.9491.00
424_E427_K1.9321.00
115_F307_V1.9241.00
215_I219_I1.9101.00
126_A300_T1.8991.00
71_G305_S1.8931.00
239_N242_S1.8731.00
403_N406_T1.8651.00
309_S314_A1.8561.00
122_T307_V1.8561.00
214_S218_L1.8401.00
190_G364_P1.8211.00
116_L261_V1.8161.00
213_I217_G1.8151.00
189_V193_V1.8061.00
265_V271_D1.7941.00
84_A340_V1.7721.00
264_L271_D1.7651.00
31_A331_G1.7641.00
190_G213_I1.7561.00
397_F401_T1.7551.00
191_L364_P1.7261.00
74_V78_W1.7151.00
205_G208_L1.7011.00
216_V220_F1.6961.00
214_S217_G1.6871.00
339_T343_L1.6801.00
83_L319_V1.6781.00
187_S364_P1.6781.00
25_V29_V1.6681.00
228_G231_A1.6501.00
240_G245_G1.6491.00
69_G341_G1.6471.00
261_V264_L1.6291.00
24_T332_K1.6151.00
72_S341_G1.6131.00
261_V271_D1.6111.00
31_A336_T1.5911.00
93_A315_A1.5421.00
248_D251_G1.5331.00
209_T213_I1.5281.00
27_Q332_K1.5201.00
208_L221_D1.4941.00
396_V400_L1.4941.00
74_V301_T1.4921.00
198_E372_L1.4661.00
308_F312_V1.4621.00
33_L343_L1.4561.00
378_A382_F1.4531.00
385_F389_M1.4521.00
192_A196_G1.4481.00
208_L212_G1.4451.00
25_V339_T1.4391.00
210_I218_L1.4381.00
118_G307_V1.4321.00
38_A325_A1.4271.00
89_I92_T1.4081.00
240_G243_L1.3801.00
279_V327_T1.3741.00
194_I209_T1.3711.00
122_T300_T1.3671.00
186_M213_I1.3561.00
124_I129_I1.3471.00
210_I213_I1.3471.00
260_S264_L1.3401.00
419_R427_K1.3381.00
208_L218_L1.3361.00
29_V33_L1.3311.00
161_V363_A1.3241.00
294_D297_K1.3231.00
36_F343_L1.3181.00
150_G370_G1.3061.00
217_G222_P1.3011.00
229_V235_L1.2991.00
108_P248_D1.2981.00
392_L396_V1.2961.00
195_I368_Y1.2941.00
218_L221_D1.2921.00
220_F224_V1.2731.00
71_G317_A1.2731.00
304_M308_F1.2721.00
191_L195_I1.2541.00
247_L250_M1.2501.00
123_V126_A1.2451.00
219_I223_N1.2451.00
183_P360_Y1.2361.00
335_L339_T1.2321.00
76_G337_A1.2321.00
180_A183_P1.2261.00
375_S379_K1.2251.00
210_I221_D1.2221.00
74_V304_M1.2181.00
194_I198_E1.2141.00
28_E332_K1.2071.00
289_D327_T1.2031.00
159_N173_P1.1991.00
196_G200_L1.1991.00
242_S245_G1.1871.00
213_I218_L1.1861.00
77_L338_I1.1831.00
198_E368_Y1.1821.00
69_G73_I1.1821.00
214_S221_D1.1771.00
219_I222_P1.1711.00
245_G248_D1.1681.00
175_A178_D1.1641.00
26_R30_V1.1621.00
338_I342_V1.1621.00
151_L399_V1.1611.00
417_I421_V1.1611.00
154_L367_M1.1611.00
128_G132_W1.1581.00
188_L192_A1.1581.00
393_V397_F1.1561.00
244_I247_L1.1561.00
194_I368_Y1.1531.00
206_I210_I1.1521.00
167_N171_G1.1511.00
262_L271_D1.1491.00
376_N379_K1.1471.00
221_D224_V1.1361.00
217_G221_D1.1321.00
215_I218_L1.1311.00
256_V259_P1.1301.00
297_K300_T1.1261.00
206_I365_A1.1211.00
161_V367_M1.1191.00
78_W301_T1.1161.00
120_L258_L1.1131.00
131_S135_R1.1091.00
251_G255_P1.1061.00
341_G345_L1.0971.00
207_L210_I1.0961.00
260_S263_A1.0921.00
258_L261_V1.0891.00
300_T304_M1.0891.00
249_I252_A1.0891.00
99_L260_S1.0861.00
147_I395_A1.0861.00
178_D181_T1.0841.00
257_V260_S1.0771.00
99_L264_L1.0731.00
112_G249_I1.0711.00
326_G331_G1.0701.00
265_V269_V1.0681.00
171_G174_V1.0671.00
87_C322_E1.0671.00
211_I218_L1.0641.00
386_V422_S1.0631.00
181_T185_I1.0631.00
211_I214_S1.0621.00
92_T264_L1.0601.00
204_G208_L1.0571.00
182_F185_I1.0531.00
120_L265_V1.0521.00
122_T303_S1.0521.00
276_I280_A1.0501.00
113_A257_V1.0491.00
49_M89_I1.0481.00
391_G395_A1.0461.00
190_G361_A1.0461.00
106_S109_V1.0451.00
262_L265_V1.0381.00
227_S230_F1.0381.00
346_L349_F1.0291.00
187_S367_M1.0201.00
116_L257_V1.0201.00
304_M307_V1.0181.00
241_N245_G1.0161.00
157_A367_M1.0151.00
420_L425_W1.0081.00
143_H379_K1.0041.00
205_G209_T1.0031.00
250_M253_L1.0011.00
140_G387_D1.0001.00
181_T184_V0.9981.00
31_A35_T0.9981.00
336_T340_V0.9971.00
222_P226_F0.9941.00
209_T214_S0.9931.00
205_G210_I0.9921.00
384_D387_D0.9911.00
418_G422_S0.9911.00
276_I298_A0.9741.00
243_L246_S0.9721.00
151_L395_A0.9711.00
230_F234_S0.9691.00
122_T126_A0.9681.00
147_I150_G0.9651.00
184_V188_L0.9641.00
210_I223_N0.9591.00
398_I407_G0.9591.00
75_M86_G0.9531.00
268_A316_P0.9481.00
248_D253_L0.9471.00
251_G254_N0.9461.00
144_G394_T0.9461.00
266_M271_D0.9431.00
83_L327_T0.9421.00
70_L308_F0.9421.00
213_I361_A0.9401.00
213_I216_V0.9311.00
184_V187_S0.9281.00
216_V219_I0.9281.00
347_I350_L0.9271.00
207_L211_I0.9211.00
139_H143_H0.9171.00
267_T270_F0.9151.00
114_V310_G0.9151.00
266_M270_F0.9011.00
165_I168_P0.9001.00
117_M264_L0.8991.00
231_A235_L0.8991.00
229_V233_P0.8971.00
305_S317_A0.8971.00
217_G223_N0.8941.00
189_V216_V0.8941.00
59_A315_A0.8921.00
96_A316_P0.8921.00
171_G175_A0.8911.00
264_L269_V0.8911.00
59_A63_A0.8901.00
339_T342_V0.8901.00
252_A255_P0.8901.00
155_L400_L0.8891.00
183_P187_S0.8871.00
128_G296_G0.8871.00
160_G363_A0.8871.00
305_S308_F0.8871.00
24_T27_Q0.8841.00
379_K383_A0.8831.00
324_A328_A0.8821.00
214_S223_N0.8801.00
199_K203_P0.8801.00
307_V310_G0.8771.00
245_G252_A0.8761.00
159_N166_K0.8721.00
185_I188_L0.8721.00
168_P171_G0.8691.00
393_V410_I0.8591.00
377_V395_A0.8581.00
113_A117_M0.8561.00
269_V272_A0.8551.00
70_L312_V0.8531.00
263_A270_F0.8531.00
230_F235_L0.8531.00
353_L356_L0.8511.00
124_I265_V0.8491.00
221_D226_F0.8461.00
247_L251_G0.8461.00
288_K291_Q0.8461.00
179_F182_F0.8461.00
387_D390_A0.8451.00
276_I279_V0.8441.00
195_I389_M0.8431.00
154_L370_G0.8421.00
155_L159_N0.8411.00
335_L338_I0.8411.00
52_K96_A0.8401.00
115_F311_L0.8391.00
248_D254_N0.8381.00
239_N243_L0.8361.00
195_I371_L0.8341.00
208_L223_N0.8321.00
113_A260_S0.8311.00
374_L377_V0.8291.00
48_G52_K0.8271.00
63_A107_V0.8261.00
259_P263_A0.8261.00
243_L247_L0.8231.00
59_A100_V0.8221.00
197_L208_L0.8211.00
247_L311_L0.8171.00
46_V344_F0.8171.00
206_I209_T0.8161.00
263_A271_D0.8161.00
414_T418_G0.8161.00
381_D388_A0.8151.00
112_G116_L0.8131.00
229_V232_M0.8131.00
88_A318_A0.8131.00
81_L298_A0.8121.00
207_L221_D0.8081.00
307_V311_L0.8081.00
117_M316_P0.8051.00
86_G302_D0.7991.00
232_M235_L0.7971.00
277_R281_G0.7971.00
117_M265_V0.7951.00
117_M268_A0.7951.00
218_L222_P0.7941.00
78_W300_T0.7921.00
150_G374_L0.7911.00
29_V335_L0.7891.00
78_W297_K0.7891.00
205_G214_S0.7881.00
208_L224_V0.7871.00
358_P361_A0.7861.00
388_A392_L0.7851.00
261_V269_V0.7851.00
265_V272_A0.7851.00
110_A114_V0.7841.00
262_L266_M0.7841.00
97_F101_L0.7821.00
401_T406_T0.7821.00
46_V49_M0.7801.00
409_M413_A0.7741.00
406_T409_M0.7741.00
264_L272_A0.7731.00
45_V48_G0.7731.00
220_F223_N0.7731.00
32_G36_F0.7670.99
195_I199_K0.7660.99
207_L214_S0.7660.99
263_A267_T0.7640.99
210_I224_V0.7630.99
206_I214_S0.7620.99
53_A60_V0.7590.99
68_A72_S0.7570.99
65_C69_G0.7540.99
27_Q31_A0.7540.99
187_S360_Y0.7530.99
197_L201_K0.7490.99
229_V234_S0.7480.99
28_E333_T0.7460.99
266_M269_V0.7440.99
241_N250_M0.7420.99
111_L310_G0.7410.99
264_L267_T0.7390.99
211_I215_I0.7380.99
267_T271_D0.7350.99
218_L223_N0.7340.99
265_V268_A0.7330.99
419_R424_E0.7320.99
98_S102_G0.7310.99
222_P225_H0.7310.99
240_G244_I0.7310.99
146_G278_A0.7250.99
176_L179_F0.7220.99
102_G260_S0.7220.99
258_L265_V0.7210.99
347_I354_S0.7190.99
46_V92_T0.7150.99
81_L292_I0.7090.99
62_V348_L0.7070.99
268_A306_S0.7060.99
325_A329_A0.7060.99
125_S131_S0.7060.99
166_K172_L0.7040.99
124_I299_L0.7040.99
386_V419_R0.7040.99
210_I217_G0.7020.99
92_T96_A0.7020.99
285_L288_K0.7010.99
281_G286_L0.7010.99
49_M52_K0.6990.99
148_G398_I0.6990.99
245_G250_M0.6960.99
135_R291_Q0.6900.99
211_I221_D0.6900.99
378_A383_A0.6900.99
196_G421_V0.6860.99
67_V71_G0.6850.99
346_L350_L0.6840.99
112_G252_A0.6790.99
114_V316_P0.6780.99
250_M254_N0.6770.99
240_G252_A0.6770.99
32_G343_L0.6760.99
340_V347_I0.6750.99
148_G399_V0.6730.99
148_G395_A0.6720.99
268_A272_A0.6720.99
245_G249_I0.6690.99
193_V197_L0.6680.99
73_I77_L0.6670.99
386_V418_G0.6670.99
397_F406_T0.6660.99
155_L174_V0.6640.99
209_T217_G0.6620.99
221_D225_H0.6620.99
368_Y372_L0.6610.99
81_L294_D0.6610.99
240_G250_M0.6610.99
263_A266_M0.6600.98
241_N246_S0.6580.98
308_F311_L0.6560.98
194_I364_P0.6540.98
260_S267_T0.6540.98
211_I224_V0.6490.98
140_G144_G0.6490.98
262_L272_A0.6490.98
89_I319_V0.6480.98
268_A271_D0.6470.98
266_M272_A0.6450.98
245_G311_L0.6450.98
388_A391_G0.6440.98
228_G234_S0.6420.98
189_V213_I0.6400.98
378_A381_D0.6400.98
259_P262_L0.6400.98
46_V64_T0.6380.98
116_L120_L0.6380.98
260_S270_F0.6340.98
261_V270_F0.6310.98
85_I317_A0.6270.98
243_L248_D0.6270.98
47_P58_A0.6250.98
264_L268_A0.6240.98
260_S271_D0.6210.98
22_G26_R0.6200.98
419_R423_G0.6200.98
108_P111_L0.6200.98
85_I337_A0.6180.98
92_T117_M0.6120.98
286_L292_I0.6110.98
48_G51_G0.6100.97
103_Q106_S0.6100.97
75_M85_I0.6090.97
154_L392_L0.6090.97
241_N244_I0.6080.97
277_R280_A0.6070.97
214_S224_V0.6050.97
108_P246_S0.6040.97
111_L114_V0.6030.97
303_S307_V0.6030.97
180_A184_V0.6010.97
75_M301_T0.6010.97
68_A344_F0.6000.97
118_G306_S0.6000.97
258_L264_L0.5990.97
125_S303_S0.5970.97
96_A110_A0.5960.97
31_A329_A0.5950.97
198_E205_G0.5950.97
197_L202_V0.5940.97
249_I253_L0.5920.97
380_I388_A0.5910.97
121_F268_A0.5900.97
415_L419_R0.5880.97
65_C344_F0.5880.97
210_I222_P0.5870.97
100_V110_A0.5870.97
190_G194_I0.5860.97
120_L261_V0.5850.97
26_R29_V0.5850.97
173_P176_L0.5850.97
49_M68_A0.5820.97
377_V391_G0.5780.97
280_A284_N0.5780.97
203_P329_A0.5780.97
410_I414_T0.5760.96
262_L269_V0.5750.96
172_L177_G0.5740.96
73_I76_G0.5740.96
305_S309_S0.5740.96
197_L205_G0.5720.96
91_L96_A0.5720.96
88_A322_E0.5710.96
281_G379_K0.5700.96
83_L331_G0.5700.96
205_G221_D0.5690.96
89_I320_Y0.5690.96
71_G309_S0.5690.96
227_S231_A0.5680.96
257_V261_V0.5650.96
239_N252_A0.5640.96
70_L309_S0.5620.96
174_V177_G0.5610.96
134_L137_L0.5610.96
421_V425_W0.5600.96
264_L270_F0.5590.96
306_S316_P0.5580.96
155_L158_A0.5560.96
138_P415_L0.5550.96
85_I91_L0.5550.96
416_V420_L0.5540.96
300_T307_V0.5540.96
144_G391_G0.5520.96
120_L124_I0.5520.96
227_S232_M0.5510.95
75_M302_D0.5480.95
240_G246_S0.5480.95
228_G232_M0.5480.95
147_I374_L0.5450.95
132_W135_R0.5450.95
128_G131_S0.5440.95
256_V260_S0.5440.95
195_I198_E0.5440.95
63_A313_G0.5430.95
214_S357_V0.5430.95
110_A113_A0.5430.95
190_G193_V0.5420.95
328_A372_L0.5420.95
263_A269_V0.5410.95
261_V272_A0.5410.95
166_K173_P0.5400.95
235_L240_G0.5400.95
303_S306_S0.5350.95
186_M190_G0.5350.95
193_V209_T0.5340.95
246_S251_G0.5330.95
386_V390_A0.5330.95
194_I206_I0.5330.95
206_I217_G0.5330.95
258_L270_F0.5330.95
49_M96_A0.5320.95
192_A195_I0.5320.95
96_A100_V0.5320.95
381_D385_F0.5310.94
33_L339_T0.5310.94
213_I222_P0.5300.94
90_S95_T0.5290.94
189_V192_A0.5290.94
27_Q30_V0.5290.94
75_M317_A0.5280.94
247_L312_V0.5270.94
190_G209_T0.5260.94
136_N424_E0.5250.94
45_V340_V0.5240.94
83_L285_L0.5240.94
100_V106_S0.5230.94
94_F97_F0.5230.94
95_T264_L0.5220.94
75_M79_A0.5220.94
272_A318_A0.5180.94
423_G426_R0.5160.94
259_P269_V0.5140.94
208_L220_F0.5120.93
94_F98_S0.5120.93
218_L356_L0.5110.93
83_L291_Q0.5100.93
55_F60_V0.5090.93
30_V34_T0.5080.93
200_L204_G0.5080.93
59_A107_V0.5080.93
205_G213_I0.5070.93
248_D252_A0.5050.93
418_G421_V0.5050.93
87_C91_L0.5020.93
385_F388_A0.5010.93
143_H376_N0.5000.93
243_L251_G0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.8486 100 0.538 Contact Map
4z7fA 2 0.3252 9 0.972 Contact Map
3o7qA 1 0.4143 8.8 0.972 Contact Map
2zy9A 2 0.2561 7.1 0.973 Contact Map
3orgA 2 0.5612 3.9 0.976 Contact Map
4b19A 1 0.0668 3.9 0.976 Contact Map
4bx9C 1 0.0735 3.6 0.977 Contact Map
1btsA 1 0.0468 3.4 0.977 Contact Map
4rgwA 1 0 3.2 0.977 Contact Map
4huqS 1 0.3185 2.8 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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