GREMLIN Database
NARV - Respiratory nitrate reductase 2 gamma chain
UniProt: P0AF32 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10644
Length: 226 (219)
Sequences: 1080 (663)
Seq/√Len: 44.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_W108_G5.0831.00
173_G176_E4.6751.00
99_G142_L3.0441.00
20_V197_L3.0211.00
92_M149_A2.7821.00
20_V201_F2.7721.00
129_I198_L2.7141.00
8_F16_I2.6831.00
137_Q192_G2.5701.00
21_F25_S2.5391.00
76_W80_W2.4961.00
195_I204_L2.4661.00
120_R128_I2.4221.00
183_F187_L2.4101.00
83_P86_A2.4031.00
13_Y194_T2.3701.00
114_L120_R2.3431.00
78_Y84_V2.2321.00
59_G105_G2.2021.00
19_T23_L2.1941.00
55_L104_I2.1831.00
60_I102_T2.1151.00
126_P198_L2.0470.99
86_A90_M2.0210.99
63_I102_T1.9750.99
9_F190_V1.9360.99
75_H155_S1.8690.99
133_I198_L1.8560.99
90_M94_L1.8150.99
189_L193_M1.8120.99
25_S208_W1.7920.98
137_Q191_L1.7690.98
63_I99_G1.7620.98
62_G94_L1.7150.98
62_G98_C1.7070.98
55_L101_L1.6770.98
93_V97_I1.6290.97
106_G135_L1.6150.97
18_A167_I1.6100.97
114_L128_I1.5990.97
125_T129_I1.5800.96
199_F207_V1.5590.96
103_L135_L1.5520.96
61_L65_F1.5480.96
213_E216_T1.5330.96
85_A89_L1.5210.96
143_S147_F1.5040.95
45_D116_N1.4980.95
36_W209_S1.4280.94
107_A111_W1.4200.94
110_L128_I1.4130.93
75_H78_Y1.4130.93
6_N179_N1.3940.93
111_W115_T1.3830.93
116_N119_V1.3700.92
82_L86_A1.3470.92
77_M81_F1.3460.92
44_L118_R1.3400.92
23_L26_W1.3390.91
103_L139_L1.3280.91
41_S44_L1.3230.91
42_Q46_K1.3000.90
75_H84_V1.2940.90
198_L202_T1.2930.90
33_Q36_W1.2930.90
110_L114_L1.2880.90
17_C193_M1.2810.90
12_I172_G1.2700.89
102_T138_C1.2590.89
107_A135_L1.2500.88
67_H112_R1.2480.88
164_A168_V1.2160.87
20_V23_L1.2130.87
100_V104_I1.2050.86
89_L93_V1.2010.86
44_L130_I1.2000.86
156_E159_K1.1950.86
156_E161_V1.1950.86
78_Y81_F1.1950.86
75_H158_M1.1860.86
97_I101_L1.1850.86
156_E182_A1.1720.85
39_S124_T1.1650.85
87_K157_M1.1540.84
190_V194_T1.1540.84
25_S199_F1.1450.83
110_L133_I1.1440.83
17_C197_L1.1340.83
80_W83_P1.1340.83
154_G185_F1.1180.82
48_G52_W1.1150.82
15_Y172_G1.1090.81
133_I137_Q1.1050.81
133_I136_I1.1040.81
45_D49_M1.0970.81
140_L187_L1.0930.81
8_F86_A1.0900.80
25_S205_V1.0790.80
78_Y155_S1.0760.79
67_H188_H1.0710.79
77_M80_W1.0680.79
11_D175_S1.0650.79
89_L152_P1.0640.79
133_I191_L1.0620.79
21_F199_F1.0570.78
85_A152_P1.0490.78
106_G110_L1.0320.77
21_F208_W1.0230.76
76_W161_V1.0130.75
48_G111_W1.0090.75
128_I132_S1.0060.75
91_A96_G1.0050.75
40_S44_L1.0000.74
113_R206_H0.9990.74
27_L32_G0.9960.74
75_H161_V0.9950.74
47_R211_P0.9870.73
6_N186_R0.9840.73
141_G188_H0.9810.73
112_R188_H0.9760.72
123_S128_I0.9730.72
65_F69_F0.9720.72
130_I198_L0.9720.72
12_I23_L0.9520.71
213_E218_R0.9520.71
84_V161_V0.9500.70
19_T64_F0.9430.70
120_R123_S0.9400.70
12_I170_F0.9390.69
203_R214_Y0.9370.69
110_L135_L0.9260.68
123_S131_M0.9200.68
144_T160_L0.9190.68
140_L191_L0.9170.68
64_F136_I0.9030.66
60_I65_F0.8980.66
132_S136_I0.8970.66
143_S184_V0.8860.65
27_L58_I0.8720.64
45_D119_V0.8670.63
104_I125_T0.8600.63
135_L139_L0.8570.62
7_V12_I0.8560.62
23_L27_L0.8540.62
57_H206_H0.8460.61
159_K162_G0.8380.61
136_I191_L0.8360.60
147_F150_Q0.8310.60
51_I55_L0.8310.60
87_K164_A0.8290.60
39_S218_R0.8290.60
16_I108_G0.8280.60
21_F207_V0.8270.60
22_F208_W0.8270.60
115_T187_L0.8200.59
29_Y32_G0.8190.59
205_V209_S0.8160.58
77_M161_V0.8110.58
33_Q44_L0.8110.58
176_E179_N0.8100.58
32_G219_Y0.8020.57
103_L138_C0.8010.57
29_Y36_W0.7990.57
66_G70_G0.7970.57
58_I62_G0.7960.57
65_F68_L0.7910.56
218_R224_S0.7800.55
49_M54_N0.7780.55
69_F93_V0.7750.55
54_N131_M0.7740.54
173_G177_M0.7720.54
106_G134_L0.7680.54
170_F173_G0.7680.54
108_G111_W0.7630.53
6_N175_S0.7620.53
159_K180_G0.7620.53
110_L195_I0.7620.53
57_H113_R0.7530.52
135_L210_A0.7520.52
8_F12_I0.7500.52
19_T170_F0.7500.52
114_L117_Q0.7380.51
16_I19_T0.7380.51
76_W79_A0.7330.51
62_G101_L0.7280.50
156_E185_F0.7280.50
41_S203_R0.7230.50
210_A213_E0.7200.49
115_T119_V0.7180.49
52_W55_L0.7180.49
117_Q121_A0.7150.49
64_F97_I0.7120.48
30_D33_Q0.7110.48
39_S43_M0.7110.48
118_R122_T0.7090.48
84_V158_M0.7090.48
195_I215_F0.7040.48
60_I207_V0.7040.48
149_A154_G0.7030.48
86_A180_G0.7020.48
35_T130_I0.7020.48
31_Y44_L0.7000.47
36_W205_V0.7000.47
150_Q175_S0.6930.47
12_I19_T0.6910.46
9_F178_L0.6900.46
72_L164_A0.6880.46
26_W170_F0.6790.45
160_L181_V0.6770.45
164_A196_F0.6700.44
32_G218_R0.6640.44
124_T132_S0.6550.43
72_L168_V0.6540.43
178_L181_V0.6540.43
125_T132_S0.6520.43
109_L113_R0.6490.42
25_S207_V0.6460.42
22_F26_W0.6440.42
61_L64_F0.6420.42
27_L30_D0.6370.41
126_P202_T0.6370.41
100_V187_L0.6340.41
116_N213_E0.6300.41
115_T147_F0.6290.41
62_G65_F0.6290.41
13_Y197_L0.6270.40
67_H74_P0.6240.40
49_M52_W0.6210.40
139_L171_R0.6210.40
215_F218_R0.6190.40
194_T212_F0.6190.40
106_G139_L0.6160.39
166_S177_M0.6110.39
123_S197_L0.6100.39
104_I107_A0.6090.39
166_S171_R0.6080.39
67_H141_G0.6070.39
148_S167_I0.6070.39
146_P187_L0.6060.38
49_M109_L0.6060.38
216_T224_S0.6050.38
86_A94_L0.6050.38
46_K219_Y0.6030.38
62_G76_W0.6030.38
10_Y178_L0.6030.38
69_F202_T0.6020.38
43_M140_L0.6000.38
154_G182_A0.6000.38
50_V213_E0.6000.38
56_F66_G0.6000.38
151_Y154_G0.5990.38
98_C219_Y0.5990.38
24_G127_D0.5990.38
18_A82_L0.5980.38
105_G178_L0.5910.37
44_L122_T0.5860.37
112_R206_H0.5860.37
34_Y40_S0.5850.36
60_I64_F0.5810.36
97_I215_F0.5800.36
126_P129_I0.5800.36
157_M222_V0.5780.36
76_W81_F0.5770.36
127_D203_R0.5770.36
113_R123_S0.5760.36
152_P175_S0.5760.36
35_T220_Q0.5750.36
34_Y219_Y0.5740.36
44_L114_L0.5740.36
55_L91_A0.5740.36
31_Y43_M0.5720.35
49_M185_F0.5690.35
39_S42_Q0.5680.35
38_A142_L0.5680.35
62_G224_S0.5650.35
100_V171_R0.5630.35
54_N58_I0.5620.34
101_L105_G0.5620.34
68_L172_G0.5590.34
120_R133_I0.5590.34
6_N140_L0.5580.34
67_H127_D0.5580.34
84_V153_D0.5570.34
60_I134_L0.5530.34
99_G103_L0.5530.34
36_W41_S0.5530.34
96_G104_I0.5530.34
164_A181_V0.5530.34
11_D166_S0.5470.33
62_G85_A0.5460.33
52_W106_G0.5460.33
29_Y84_V0.5460.33
13_Y17_C0.5450.33
37_R40_S0.5450.33
103_L183_F0.5450.33
180_G186_R0.5430.33
27_L34_Y0.5380.32
181_V189_L0.5380.32
118_R121_A0.5380.32
20_V184_V0.5360.32
188_H206_H0.5340.32
93_V125_T0.5330.32
13_Y190_V0.5320.32
28_R105_G0.5300.32
155_S158_M0.5280.32
176_E221_I0.5250.31
88_Q222_V0.5230.31
166_S173_G0.5220.31
69_F151_Y0.5200.31
14_P28_R0.5200.31
64_F164_A0.5200.31
40_S163_W0.5190.31
126_P167_I0.5180.31
152_P184_V0.5180.31
81_F156_E0.5170.31
8_F125_T0.5160.31
6_N196_F0.5150.30
146_P154_G0.5120.30
130_I195_I0.5110.30
23_L209_S0.5100.30
147_F171_R0.5070.30
142_L190_V0.5050.30
19_T136_I0.5050.30
7_V175_S0.5050.30
77_M156_E0.5040.30
110_L126_P0.5020.29
85_A106_G0.5000.29
160_L177_M0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q16C 2 0.9912 100 0.33 Contact Map
2l2tA 2 0.1814 31.1 0.953 Contact Map
2wswA 3 0.8982 17.3 0.958 Contact Map
2kluA 1 0.2301 12.2 0.961 Contact Map
2ks1B 1 0.1814 10.2 0.962 Contact Map
4c7rA 3 0.8938 9.1 0.963 Contact Map
2m20A 2 0.2522 8.6 0.963 Contact Map
2l9uA 2 0.177 4.8 0.967 Contact Map
2a65A 2 0.5044 3.5 0.97 Contact Map
1iijA 1 0.1416 3.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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