GREMLIN Database
NARJ - Nitrate reductase molybdenum cofactor assembly chaperone NarJ
UniProt: P0AF26 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10641
Length: 236 (187)
Sequences: 665 (494)
Seq/√Len: 36.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_F157_L4.6861.00
113_H116_L4.0491.00
26_F51_T3.9041.00
55_P59_Q3.6861.00
6_I25_M3.3981.00
26_F48_R3.1891.00
96_A100_Q2.9361.00
45_I156_V2.8351.00
49_D153_R2.5731.00
7_V161_L2.5531.00
148_Q159_D2.5071.00
46_F156_V2.3411.00
144_S162_L2.3280.99
99_E104_Q2.2980.99
23_Q51_T2.2630.99
63_S67_D2.2280.99
7_V157_L2.2220.99
18_L50_L2.1990.99
141_A144_S2.1990.99
16_A59_Q2.1610.99
96_A99_E2.0940.99
46_F50_L2.0550.99
49_D61_Q2.0420.99
117_Y132_G1.8880.98
21_H24_E1.8020.97
4_L164_L1.8000.97
142_L179_A1.7900.97
43_L157_L1.7790.97
121_L129_A1.7760.97
65_L152_S1.7510.96
5_V8_S1.7290.96
22_Q51_T1.6770.95
72_T146_R1.6160.94
131_E135_D1.5760.93
23_Q27_E1.5750.93
105_L116_L1.5300.92
143_L158_F1.5060.92
16_A20_Q1.5050.92
56_L60_A1.4940.91
22_Q47_L1.4730.91
68_R78_E1.4580.90
94_L97_Q1.4470.90
42_A45_I1.4350.90
94_L125_P1.4300.90
4_L121_L1.4250.89
54_D57_D1.4030.89
97_Q132_G1.3750.88
81_H90_A1.3670.87
177_K181_E1.3500.87
25_M29_I1.3300.86
6_I60_A1.3260.86
184_D187_P1.2970.84
50_L58_A1.2800.83
8_S21_H1.2610.83
26_F44_G1.2560.82
146_R185_D1.2460.82
95_L99_E1.2420.82
77_F94_L1.2390.81
98_Y120_Y1.2260.81
69_G150_R1.2220.81
12_E113_H1.2200.80
53_M61_Q1.2170.80
81_H94_L1.2150.80
25_M28_A1.2150.80
86_D91_M1.2080.80
95_L105_L1.1970.79
74_L115_P1.1900.79
62_Y82_G1.1740.78
170_D175_A1.1670.77
79_H139_I1.1610.77
137_A174_V1.1410.76
9_R21_H1.1360.75
20_Q23_Q1.1340.75
70_R78_E1.1340.75
29_I40_A1.1230.75
72_T143_L1.1200.74
41_H171_S1.1200.74
56_L91_M1.1150.74
7_V160_L1.1010.73
30_A44_G1.0950.73
4_L124_L1.0950.73
45_I125_P1.0920.72
182_A188_Q1.0700.71
91_M110_L1.0640.70
10_L77_F1.0610.70
81_H86_D1.0600.70
61_Q154_Y1.0250.68
101_H123_Q1.0210.67
47_L53_M1.0210.67
59_Q150_R1.0120.66
4_L103_L1.0100.66
5_V24_E1.0050.66
83_E189_A1.0030.66
142_L186_T0.9960.65
38_E127_S0.9910.65
79_H154_Y0.9810.64
130_V134_K0.9790.64
101_H120_Y0.9610.62
160_L166_N0.9480.61
83_E146_R0.9440.61
80_V139_I0.9430.61
148_Q155_A0.9390.61
139_I189_A0.9280.60
80_V136_I0.9230.59
50_L67_D0.9060.58
78_E117_Y0.9040.58
41_H45_I0.9030.58
56_L72_T0.9030.58
21_H60_A0.9000.57
74_L142_L0.8930.57
124_L128_E0.8810.56
6_I160_L0.8780.55
74_L110_L0.8770.55
5_V98_Y0.8670.54
44_G47_L0.8610.54
103_L124_L0.8420.52
53_M58_A0.8410.52
21_H25_M0.8380.52
28_A67_D0.8360.52
3_E35_L0.8360.52
138_P142_L0.8320.51
28_A31_A0.8320.51
172_D175_A0.8300.51
89_Q136_I0.8290.51
172_D191_D0.8140.50
176_E180_D0.8120.50
126_Q143_L0.8080.49
144_S158_F0.8080.49
31_A57_D0.8040.49
73_S99_E0.8010.49
17_A21_H0.8010.49
69_G184_D0.7880.48
19_W23_Q0.7840.47
75_L101_H0.7820.47
90_A105_L0.7800.47
5_V103_L0.7780.47
105_L120_Y0.7750.46
46_F61_Q0.7710.46
97_Q117_Y0.7710.46
3_E44_G0.7680.46
134_K142_L0.7600.45
137_A165_A0.7560.45
92_V191_D0.7510.44
104_Q181_E0.7450.44
69_G72_T0.7420.44
6_I29_I0.7380.43
67_D107_S0.7350.43
10_L90_A0.7330.43
137_A183_R0.7310.43
70_R90_A0.7300.43
73_S139_I0.7250.42
6_I135_D0.7230.42
60_A64_E0.7190.42
56_L103_L0.7180.42
162_L168_A0.7170.42
98_Y118_L0.7140.41
78_E137_A0.7100.41
3_E17_A0.7090.41
42_A156_V0.7080.41
64_E69_G0.7060.41
17_A20_Q0.7030.40
95_L144_S0.7030.40
90_A110_L0.6990.40
27_E128_E0.6910.39
182_A189_A0.6790.38
72_T79_H0.6790.38
11_L136_I0.6750.38
154_Y168_A0.6730.38
27_E140_L0.6690.38
85_R114_L0.6670.37
10_L79_H0.6630.37
44_G50_L0.6620.37
22_Q157_L0.6610.37
11_L133_L0.6600.37
182_A186_T0.6600.37
98_Y161_L0.6530.36
120_Y192_A0.6520.36
43_L190_L0.6510.36
81_H98_Y0.6500.36
140_L190_L0.6500.36
93_D150_R0.6500.36
144_S167_T0.6470.36
12_E161_L0.6460.36
7_V164_L0.6450.36
50_L157_L0.6440.35
84_S189_A0.6430.35
86_D162_L0.6430.35
4_L9_R0.6420.35
73_S89_Q0.6420.35
117_Y140_L0.6410.35
74_L161_L0.6370.35
79_H94_L0.6360.35
8_S130_V0.6340.35
29_I35_L0.6330.35
136_I184_D0.6300.34
15_D151_E0.6280.34
98_Y111_P0.6280.34
5_V123_Q0.6270.34
36_P163_K0.6260.34
109_E143_L0.6220.34
39_D163_K0.6200.34
27_E42_A0.6200.34
100_Q175_A0.6170.33
3_E29_I0.6160.33
6_I130_V0.6150.33
29_I122_A0.6140.33
188_Q192_A0.6110.33
31_A127_S0.6080.33
114_L178_I0.6060.33
148_Q175_A0.6040.32
5_V9_R0.6020.32
138_P145_A0.6000.32
119_E155_A0.5980.32
8_S19_W0.5980.32
73_S81_H0.5970.32
77_F93_D0.5970.32
167_T170_D0.5960.32
55_P73_S0.5920.31
18_L41_H0.5910.31
3_E39_D0.5890.31
20_Q127_S0.5890.31
50_L125_P0.5880.31
53_M57_D0.5830.31
149_Q173_K0.5810.31
89_Q117_Y0.5790.30
8_S113_H0.5790.30
19_W25_M0.5770.30
100_Q151_E0.5730.30
30_A37_K0.5720.30
12_E143_L0.5690.30
117_Y136_I0.5690.30
181_E184_D0.5680.30
68_R83_E0.5680.30
41_H48_R0.5670.30
132_G190_L0.5650.29
94_L103_L0.5580.29
75_L81_H0.5570.29
62_Y67_D0.5570.29
89_Q92_V0.5560.29
83_E183_R0.5560.29
75_L138_P0.5540.29
83_E86_D0.5520.29
38_E44_G0.5510.28
134_K181_E0.5500.28
48_R61_Q0.5490.28
111_P143_L0.5470.28
20_Q27_E0.5470.28
70_R185_D0.5430.28
68_R138_P0.5410.28
98_Y129_A0.5400.28
79_H86_D0.5360.27
9_R178_I0.5330.27
121_L139_I0.5320.27
71_A75_L0.5310.27
58_A133_L0.5310.27
100_Q125_P0.5270.27
15_D19_W0.5270.27
41_H127_S0.5250.27
78_E83_E0.5240.27
30_A41_H0.5230.27
155_A161_L0.5230.27
25_M70_R0.5220.26
75_L115_P0.5190.26
103_L150_R0.5180.26
64_E167_T0.5170.26
5_V164_L0.5170.26
86_D139_I0.5150.26
101_H125_P0.5140.26
18_L59_Q0.5110.26
37_K151_E0.5100.26
103_L123_Q0.5090.26
145_A149_Q0.5080.26
104_Q122_A0.5080.26
131_E177_K0.5050.25
181_E185_D0.5050.25
52_T57_D0.5040.25
69_G75_L0.5020.25
178_I182_A0.5010.25
3_E176_E0.5000.25
8_S122_A0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o9xA 2 0.6314 99.9 0.697 Contact Map
1n1cA 2 0.7542 99.9 0.725 Contact Map
1s9uA 1 0.7415 99.8 0.744 Contact Map
2xolA 2 0.6398 97.5 0.901 Contact Map
4jcyA 2 0.1949 17.9 0.964 Contact Map
2yskA 2 0.5678 9.7 0.968 Contact Map
3v57A 1 0.2331 8.1 0.969 Contact Map
2nxoA 2 0.2585 6.9 0.97 Contact Map
3ivpA 2 0.2331 5.7 0.971 Contact Map
3viqB 1 0.322 5.5 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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