GREMLIN Database
NAGD - Ribonucleotide monophosphatase NagD
UniProt: P0AF24 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10634
Length: 250 (243)
Sequences: 4232 (2890)
Seq/√Len: 185.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_K195_E5.2061.00
210_G217_T5.1221.00
32_M67_V3.3251.00
197_V218_I3.3071.00
208_L212_Q2.9851.00
179_P183_R2.8921.00
142_A160_C2.8311.00
216_E238_S2.8171.00
50_Q65_D2.3961.00
164_E170_K2.3401.00
86_K105_T2.3201.00
30_G34_K2.2461.00
5_N189_M2.2391.00
164_E171_P2.2331.00
243_S246_E2.0061.00
207_I217_T1.9911.00
30_G33_D1.9751.00
54_N58_T1.8371.00
242_P246_E1.8331.00
29_H33_D1.8291.00
191_A196_T1.8141.00
140_F171_P1.8111.00
147_T165_K1.7611.00
221_L242_P1.7491.00
20_A25_A1.7001.00
186_L196_T1.6991.00
198_I215_L1.6941.00
50_Q54_N1.6341.00
8_C199_V1.6271.00
75_T115_I1.6131.00
39_V188_K1.6051.00
89_V99_L1.6011.00
226_S229_D1.5961.00
16_H19_V1.5631.00
161_A164_E1.5471.00
182_I209_A1.5461.00
211_F238_S1.5301.00
221_L240_I1.5171.00
46_S118_E1.5141.00
7_I41_L1.5111.00
53_A65_D1.5011.00
225_S229_D1.4981.00
10_I40_L1.4881.00
75_T141_I1.4731.00
225_S230_I1.4651.00
14_L40_L1.4581.00
123_N126_M1.4501.00
10_I15_M1.4461.00
182_I198_I1.4421.00
5_N191_A1.4401.00
49_G73_M1.4371.00
119_T126_M1.4291.00
139_R172_F1.4241.00
25_A29_H1.4181.00
161_A165_K1.4161.00
21_V243_S1.3861.00
4_K36_L1.3801.00
76_A102_A1.3731.00
92_E120_R1.3681.00
26_E245_A1.3571.00
85_K112_D1.3531.00
93_G97_H1.3411.00
6_V197_V1.3391.00
141_I174_V1.3361.00
132_Y135_A1.3171.00
31_I36_L1.3151.00
29_H62_D1.3091.00
178_S212_Q1.3091.00
86_K112_D1.2971.00
82_Q139_R1.2941.00
218_I241_Y1.2931.00
183_R193_S1.2871.00
134_V163_I1.2771.00
51_D54_N1.2591.00
184_A187_N1.2541.00
6_V36_L1.2521.00
53_A57_A1.2521.00
48_T51_D1.2371.00
47_Q55_R1.2321.00
221_L225_S1.2281.00
192_H195_E1.2121.00
208_L235_F1.2091.00
14_L61_V1.2071.00
227_L231_D1.2061.00
57_A65_D1.1921.00
87_A104_F1.1891.00
26_E29_H1.1821.00
77_D81_R1.1781.00
37_P67_V1.1741.00
32_M38_L1.1741.00
74_A181_I1.1721.00
14_L28_L1.1691.00
8_C27_F1.1681.00
54_N57_A1.1631.00
53_A68_F1.1551.00
221_L227_L1.1451.00
64_P67_V1.1411.00
97_H100_Y1.1351.00
134_V167_S1.1291.00
49_G98_E1.1221.00
24_A61_V1.1211.00
7_I185_A1.1131.00
72_A76_A1.1121.00
6_V31_I1.1111.00
10_I13_V1.1061.00
132_Y153_Y1.1021.00
182_I215_L1.0891.00
169_R172_F1.0881.00
227_L242_P1.0861.00
25_A61_V1.0811.00
127_M162_G1.0721.00
80_R104_F1.0591.00
116_V160_C1.0571.00
128_H153_Y1.0531.00
128_H154_P1.0521.00
23_G26_E1.0481.00
216_E239_W1.0351.00
185_A189_M1.0341.00
39_V189_M1.0321.00
111_P133_F1.0311.00
202_N205_T1.0291.00
40_L63_V1.0291.00
219_L225_S1.0291.00
5_N37_P1.0191.00
183_R187_N1.0151.00
147_T161_A1.0130.99
45_P71_S1.0030.99
129_K133_F1.0020.99
20_A59_A1.0010.99
230_I237_P0.9990.99
197_V216_E0.9970.99
8_C38_L0.9920.99
42_T70_T0.9900.99
69_Y184_A0.9850.99
202_N224_V0.9790.99
90_V130_A0.9790.99
75_T143_T0.9760.99
132_Y150_R0.9700.99
69_Y185_A0.9690.99
145_P173_Y0.9660.99
113_F139_R0.9650.99
8_C244_V0.9640.99
38_L67_V0.9640.99
88_Y133_F0.9610.99
118_E122_Y0.9600.99
99_L115_I0.9540.99
77_D184_A0.9530.99
78_F174_V0.9510.99
41_L198_I0.9510.99
130_A163_I0.9490.99
160_C173_Y0.9400.99
78_F141_I0.9380.99
18_N58_T0.9370.99
21_V24_A0.9300.99
75_T174_V0.9260.99
32_M62_D0.9200.99
211_F217_T0.9190.99
17_D149_G0.9180.99
147_T204_R0.9170.99
142_A156_C0.9160.99
134_V137_G0.9130.99
230_I240_I0.9080.99
57_A62_D0.9020.99
50_Q97_H0.8990.99
52_L68_F0.8960.99
13_V118_E0.8920.99
55_R59_A0.8910.99
5_N196_T0.8900.99
81_R187_N0.8890.99
18_N55_R0.8880.99
128_H132_Y0.8850.99
131_A166_I0.8850.99
23_G245_A0.8820.99
204_R224_V0.8800.99
15_M59_A0.8800.99
146_D205_T0.8760.99
100_Y106_I0.8740.99
86_K110_N0.8690.98
69_Y188_K0.8660.98
142_A173_Y0.8640.98
96_I106_I0.8610.98
207_I211_F0.8610.98
156_C160_C0.8580.98
96_I100_Y0.8570.98
41_L181_I0.8530.98
13_V182_I0.8520.98
228_D231_D0.8430.98
39_V67_V0.8430.98
93_G96_I0.8420.98
84_G105_T0.8380.98
37_P189_M0.8370.98
52_L70_T0.8360.98
203_L233_M0.8360.98
97_H101_K0.8320.98
114_V130_A0.8270.98
94_A98_E0.8240.98
86_K107_T0.8220.98
15_M40_L0.8220.98
76_A80_R0.8190.98
158_A162_G0.8040.97
87_A115_I0.8030.97
125_D129_K0.8020.97
28_L40_L0.7990.97
14_L244_V0.7950.97
158_A165_K0.7930.97
23_G243_S0.7930.97
186_L215_L0.7910.97
24_A244_V0.7910.97
219_L240_I0.7850.97
73_M98_E0.7850.97
191_A195_E0.7840.97
63_V67_V0.7740.97
13_V209_A0.7720.97
72_A75_T0.7700.97
184_A188_K0.7680.97
76_A98_E0.7650.97
211_F235_F0.7640.97
172_F180_W0.7640.97
39_V69_Y0.7610.96
186_L193_S0.7600.96
40_L61_V0.7590.96
227_L230_I0.7580.96
89_V96_I0.7580.96
148_H152_F0.7540.96
116_V140_F0.7530.96
217_T238_S0.7500.96
82_Q172_F0.7400.96
122_Y159_L0.7380.96
22_P245_A0.7370.96
79_L104_F0.7360.96
32_M64_P0.7350.96
47_Q52_L0.7350.96
98_E101_K0.7330.96
185_A209_A0.7330.96
198_I209_A0.7220.95
158_A166_I0.7200.95
134_V169_R0.7180.95
197_V239_W0.7180.95
122_Y127_M0.7170.95
7_I196_T0.7160.95
88_Y114_V0.7120.95
10_I14_L0.7120.95
138_A169_R0.7100.95
74_A184_A0.7080.95
27_F38_L0.7070.95
55_R58_T0.7070.95
24_A243_S0.7070.95
45_P117_G0.7050.95
134_V140_F0.7030.95
20_A61_V0.7010.94
122_Y126_M0.6990.94
88_Y130_A0.6980.94
71_S144_N0.6940.94
51_D97_H0.6920.94
25_A60_G0.6880.94
79_L115_I0.6870.94
116_V142_A0.6820.94
85_K104_F0.6800.93
10_I56_F0.6790.93
16_H21_V0.6790.93
71_S143_T0.6750.93
57_A63_V0.6710.93
8_C14_L0.6670.93
20_A60_G0.6670.93
91_G95_L0.6650.93
15_M56_F0.6630.93
116_V159_L0.6610.93
131_A135_A0.6600.92
136_N194_E0.6550.92
51_D94_A0.6550.92
127_M131_A0.6520.92
162_G165_K0.6510.92
237_P240_I0.6510.92
42_T52_L0.6500.92
220_V223_G0.6470.92
78_F113_F0.6460.92
133_F136_N0.6440.92
198_I210_G0.6430.91
118_E159_L0.6420.91
148_H202_N0.6380.91
77_D80_R0.6340.91
76_A104_F0.6330.91
182_I185_A0.6310.91
192_H196_T0.6270.90
77_D188_K0.6260.90
10_I52_L0.6260.90
182_I210_G0.6240.90
115_I141_I0.6220.90
44_Y52_L0.6200.90
78_F82_Q0.6200.90
145_P160_C0.6170.90
53_A64_P0.6130.89
80_R102_A0.6120.89
219_L222_S0.6120.89
50_Q101_K0.6110.89
140_F169_R0.6110.89
78_F172_F0.6080.89
7_I181_I0.6080.89
16_H155_A0.6070.89
95_L143_T0.6060.89
32_M40_L0.6040.89
148_H224_V0.6010.88
108_D129_K0.6000.88
88_Y126_M0.5980.88
203_L207_I0.5980.88
122_Y162_G0.5970.88
203_L211_F0.5960.88
87_A91_G0.5950.88
144_N156_C0.5920.88
145_P164_E0.5900.88
9_D12_G0.5860.87
145_P178_S0.5850.87
186_L213_A0.5830.87
5_N39_V0.5780.86
28_L32_M0.5760.86
193_S215_L0.5760.86
131_A163_I0.5740.86
107_T111_P0.5700.86
139_R169_R0.5690.86
24_A28_L0.5690.86
8_C28_L0.5690.86
127_M163_I0.5650.85
132_Y152_F0.5640.85
108_D111_P0.5640.85
74_A174_V0.5630.85
15_M55_R0.5630.85
137_G169_R0.5630.85
7_I215_L0.5620.85
182_I213_A0.5610.85
26_E30_G0.5600.85
66_S188_K0.5560.84
27_F245_A0.5550.84
229_D232_S0.5520.84
48_T94_A0.5500.84
27_F31_I0.5480.83
31_I35_G0.5430.83
220_V241_Y0.5420.83
134_V138_A0.5410.83
18_N59_A0.5410.83
10_I205_T0.5410.83
183_R186_L0.5360.82
128_H131_A0.5350.82
77_D187_N0.5340.82
47_Q51_D0.5330.82
187_N190_Q0.5330.82
114_V117_G0.5320.82
179_P213_A0.5300.81
69_Y74_A0.5260.81
180_W183_R0.5230.81
119_T124_W0.5230.81
4_K196_T0.5210.80
92_E95_L0.5180.80
218_I239_W0.5160.80
14_L20_A0.5150.80
39_V185_A0.5140.79
228_D232_S0.5140.79
160_C164_E0.5130.79
77_D102_A0.5060.78
7_I198_I0.5050.78
154_P158_A0.5030.78
13_V152_F0.5020.78
204_R208_L0.5010.78
89_V92_E0.5000.78
130_A134_V0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kc2A 2 0.972 100 0.37 Contact Map
2ho4A 1 0.976 100 0.405 Contact Map
1zjjA 2 0.984 100 0.446 Contact Map
4i9fA 2 0.98 100 0.469 Contact Map
2oycA 2 1 100 0.478 Contact Map
2c4nA 3 1 100 0.487 Contact Map
3pdwA 1 0.976 100 0.499 Contact Map
3eprA 3 1 100 0.5 Contact Map
1vjrA 1 1 100 0.502 Contact Map
1yv9A 2 1 100 0.518 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.