GREMLIN Database
NAGC - N-acetylglucosamine repressor
UniProt: P0AF20 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10636
Length: 406 (367)
Sequences: 6626 (4918)
Seq/√Len: 256.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_D108_K3.9541.00
112_E381_R3.3851.00
177_G180_E3.2951.00
193_G236_I3.2701.00
63_K82_E3.1291.00
217_L341_A3.0541.00
149_A390_V3.0011.00
257_C264_C2.8001.00
103_F387_F2.7511.00
89_I133_I2.7251.00
259_C264_C2.6811.00
159_D162_S2.6101.00
150_I186_F2.5701.00
239_N334_N2.5581.00
27_I33_I2.5391.00
216_I329_A2.5141.00
63_K80_V2.4981.00
248_I328_I2.4841.00
277_R317_Y2.4401.00
316_E354_A2.3481.00
130_L185_R2.3441.00
179_V183_E2.3301.00
319_G323_G2.3251.00
101_T383_A2.2751.00
320_R358_C2.2691.00
127_H185_R2.2261.00
90_G383_A2.1891.00
265_L325_T2.1341.00
113_E135_Q2.1081.00
337_K374_V2.1001.00
27_I62_I2.0901.00
212_C337_K2.0871.00
100_I136_F2.0681.00
113_E139_S2.0541.00
100_I132_A2.0041.00
23_V38_I1.9751.00
209_S215_S1.9631.00
57_I64_E1.9361.00
230_S235_F1.9241.00
326_I338_I1.9051.00
200_A229_I1.8701.00
180_E184_E1.8431.00
247_H257_C1.8291.00
152_V182_L1.8151.00
20_S59_R1.8121.00
87_H110_L1.8081.00
319_G355_I1.8001.00
134_A185_R1.7881.00
256_R262_F1.7801.00
65_V80_V1.7791.00
20_S55_Q1.7721.00
257_C260_G1.7611.00
53_T62_I1.7591.00
150_I188_V1.7471.00
153_I198_S1.7341.00
218_V326_I1.7151.00
247_H259_C1.7061.00
213_E336_Q1.6891.00
193_G198_S1.6671.00
214_D336_Q1.6581.00
200_A227_G1.6571.00
323_G358_C1.6411.00
181_A184_E1.6401.00
64_E77_I1.6351.00
194_H244_E1.6251.00
199_L217_L1.6251.00
193_G197_R1.6231.00
89_I147_L1.6171.00
147_L188_V1.6071.00
352_L356_E1.6041.00
215_S229_I1.6001.00
359_I373_V1.5981.00
247_H264_C1.5971.00
206_F388_A1.5761.00
111_A136_F1.5681.00
249_Q328_I1.5661.00
356_E360_N1.5621.00
324_K328_I1.5581.00
111_A139_S1.5521.00
238_R336_Q1.5461.00
38_I49_V1.5431.00
302_K306_K1.5421.00
296_T299_T1.5351.00
30_Y41_Q1.5311.00
213_E231_N1.5291.00
91_V129_L1.5081.00
53_T79_I1.5031.00
224_T269_A1.5001.00
84_R104_D1.4991.00
278_V314_V1.4921.00
337_K372_P1.4911.00
37_Q40_E1.4631.00
304_A315_I1.4411.00
97_D114_H1.4361.00
319_G354_A1.4331.00
305_N350_V1.4301.00
349_K353_P1.4241.00
357_S361_T1.4221.00
86_F148_I1.4211.00
143_K146_E1.3951.00
354_A357_S1.3851.00
26_L33_I1.3741.00
200_A215_S1.3731.00
299_T302_K1.3551.00
57_I79_I1.3501.00
303_A308_D1.3361.00
102_L136_F1.3361.00
260_G264_C1.3281.00
91_V133_I1.3261.00
19_N52_I1.3201.00
130_L186_F1.3151.00
134_A144_L1.3041.00
99_T114_H1.2931.00
203_E207_G1.2921.00
101_T109_V1.2901.00
255_E267_T1.2881.00
26_L41_Q1.2871.00
176_W181_A1.2791.00
255_E276_Q1.2771.00
35_R79_I1.2731.00
202_A378_L1.2631.00
88_A391_K1.2491.00
91_V100_I1.2481.00
157_L168_M1.2471.00
237_G243_G1.2431.00
205_Y392_R1.2271.00
255_E268_I1.2271.00
20_S52_I1.2271.00
194_H223_G1.2271.00
134_A186_F1.2231.00
113_E132_A1.2181.00
90_G386_A1.2171.00
198_S386_A1.2141.00
212_C336_Q1.2121.00
358_C361_T1.1941.00
115_Y135_Q1.1911.00
274_I318_V1.1821.00
329_A332_L1.1811.00
348_D352_L1.1771.00
277_R280_N1.1741.00
358_C362_Q1.1611.00
25_R29_Q1.1601.00
237_G242_V1.1311.00
182_L190_C1.1291.00
23_V49_V1.1271.00
298_K302_K1.1261.00
316_E357_S1.1261.00
22_A42_S1.1261.00
90_G151_S1.1221.00
37_Q41_Q1.1211.00
115_Y132_A1.1201.00
33_I41_Q1.1191.00
35_R64_E1.1161.00
64_E79_I1.1131.00
223_G244_E1.1051.00
278_V311_A1.1051.00
216_I226_A1.1031.00
32_P80_V1.1021.00
66_D78_S1.0991.00
135_Q139_S1.0961.00
24_Y81_T1.0931.00
132_A135_Q1.0881.00
215_S339_V1.0861.00
330_I338_I1.0831.00
123_Q181_A1.0791.00
231_N235_F1.0741.00
87_H142_R1.0711.00
126_E181_A1.0651.00
164_K177_G1.0621.00
187_K190_C1.0601.00
83_T106_S1.0571.00
353_P356_E1.0571.00
255_E277_R1.0511.00
352_L375_R1.0491.00
125_L173_V1.0441.00
247_H260_G1.0421.00
330_I359_I1.0411.00
122_Q173_V1.0301.00
277_R314_V1.0301.00
330_I371_L1.0261.00
197_R234_I1.0261.00
26_L42_S1.0251.00
87_H146_E1.0191.00
299_T303_A1.0141.00
127_H131_N1.0051.00
281_L314_V1.0031.00
46_P50_T1.0021.00
191_F393_A0.9971.00
102_L140_Y0.9961.00
214_D231_N0.9951.00
204_H232_G0.9901.00
257_C263_G0.9901.00
204_H229_I0.9901.00
103_F109_V0.9891.00
252_P324_K0.9881.00
199_L341_A0.9831.00
60_G82_E0.9741.00
216_I228_I0.9691.00
235_F333_F0.9661.00
177_G181_A0.9611.00
142_R146_E0.9531.00
228_I235_F0.9501.00
89_I137_I0.9501.00
379_D382_S0.9451.00
203_E378_L0.9441.00
134_A138_D0.9411.00
312_S316_E0.9391.00
277_R281_L0.9381.00
36_I76_A0.9381.00
109_V112_E0.9351.00
354_A358_C0.9321.00
115_Y128_A0.9321.00
204_H215_S0.9311.00
340_I345_T0.9271.00
323_G327_A0.9211.00
121_T124_T0.9201.00
151_S198_S0.9191.00
173_V176_W0.9181.00
326_I359_I0.9171.00
183_E187_K0.9171.00
89_I150_I0.9141.00
88_A390_V0.9121.00
302_K305_N0.9111.00
195_D225_G0.9101.00
151_S390_V0.9101.00
122_Q176_W0.9101.00
89_I102_L0.9051.00
27_I38_I0.9021.00
137_I147_L0.9021.00
353_P357_S0.9001.00
128_A132_A0.9001.00
264_C267_T0.9001.00
181_A185_R0.8951.00
251_E268_I0.8911.00
228_I333_F0.8901.00
220_V322_L0.8901.00
91_V150_I0.8801.00
32_P78_S0.8791.00
99_T112_E0.8781.00
218_V245_I0.8771.00
183_E190_C0.8741.00
207_G210_Q0.8731.00
196_I219_R0.8681.00
61_L85_N0.8661.00
168_M171_I0.8651.00
54_R58_E0.8631.00
339_V376_S0.8621.00
98_A117_L0.8621.00
111_A140_Y0.8611.00
28_D81_T0.8601.00
63_K83_T0.8591.00
88_A103_F0.8591.00
277_R318_V0.8580.99
281_L313_E0.8580.99
214_D238_R0.8570.99
223_G266_E0.8560.99
131_N135_Q0.8550.99
320_R354_A0.8540.99
304_A350_V0.8540.99
323_G359_I0.8520.99
44_L49_V0.8500.99
348_D375_R0.8500.99
164_K175_N0.8480.99
276_Q280_N0.8450.99
93_L98_A0.8440.99
304_A312_S0.8440.99
324_K362_Q0.8430.99
124_T127_H0.8430.99
257_C267_T0.8430.99
225_G244_E0.8390.99
19_N44_L0.8390.99
249_Q252_P0.8360.99
251_E254_G0.8310.99
349_K375_R0.8300.99
196_I227_G0.8250.99
137_I144_L0.8240.99
261_N362_Q0.8230.99
237_G334_N0.8210.99
57_I62_I0.8180.99
310_L313_E0.8180.99
198_S389_L0.8170.99
339_V374_V0.8160.99
115_Y131_N0.8160.99
27_I79_I0.8140.99
130_L182_L0.8140.99
68_Q76_A0.8130.99
212_C215_S0.8050.99
346_E380_H0.8030.99
213_E232_G0.8020.99
191_F390_V0.8000.99
278_V300_I0.7980.99
317_Y321_H0.7960.99
80_V106_S0.7960.99
46_P51_K0.7920.99
130_L134_A0.7910.99
301_C304_A0.7910.99
88_A148_I0.7910.99
197_R227_G0.7900.99
214_D230_S0.7840.99
154_L158_V0.7840.99
220_V344_I0.7820.99
210_Q377_E0.7800.99
203_E376_S0.7780.99
348_D353_P0.7730.99
223_G246_G0.7720.99
378_L382_S0.7690.99
194_H225_G0.7650.99
319_G351_L0.7640.99
133_I150_I0.7560.99
36_I40_E0.7540.99
199_L382_S0.7520.99
322_L355_I0.7490.99
259_C263_G0.7470.99
304_A307_G0.7460.99
101_T112_E0.7450.99
30_Y33_I0.7430.99
301_C305_N0.7400.99
154_L165_I0.7360.98
207_G211_D0.7360.98
136_F140_Y0.7340.98
274_I300_I0.7330.98
242_V334_N0.7320.98
254_G268_I0.7310.98
305_N349_K0.7310.98
376_S382_S0.7310.98
163_G177_G0.7300.98
304_A311_A0.7290.98
279_L293_D0.7270.98
248_I325_T0.7260.98
260_G263_G0.7260.98
261_N264_C0.7250.98
274_I314_V0.7250.98
82_E85_N0.7250.98
334_N371_L0.7250.98
22_A26_L0.7220.98
320_R324_K0.7200.98
26_L38_I0.7200.98
195_D219_R0.7130.98
98_A115_Y0.7080.98
126_E178_L0.7070.98
320_R357_S0.7060.98
251_E255_E0.7040.98
249_Q261_N0.7000.98
281_L285_G0.6970.98
128_A131_N0.6950.98
113_E136_F0.6940.98
123_Q127_H0.6930.98
351_L354_A0.6910.98
316_E358_C0.6910.98
308_D311_A0.6900.98
295_C299_T0.6900.98
249_Q362_Q0.6890.98
45_A48_S0.6880.98
378_L384_I0.6880.98
275_E300_I0.6870.98
184_E187_K0.6860.98
257_C261_N0.6840.98
157_L241_N0.6830.98
313_E317_Y0.6820.97
155_P170_H0.6800.97
193_G389_L0.6800.97
118_P128_A0.6800.97
103_F384_I0.6790.97
92_R194_H0.6790.97
104_D110_L0.6790.97
34_S76_A0.6760.97
205_Y388_A0.6750.97
25_R28_D0.6730.97
194_H197_R0.6720.97
221_H343_E0.6720.97
84_R110_L0.6710.97
68_Q71_T0.6700.97
259_C267_T0.6700.97
83_T104_D0.6690.97
254_G264_C0.6690.97
179_V192_V0.6670.97
102_L111_A0.6660.97
102_L147_L0.6660.97
19_N22_A0.6640.97
350_V354_A0.6640.97
300_I315_I0.6620.97
65_V78_S0.6600.97
94_G343_E0.6600.97
275_E297_I0.6580.97
208_A377_E0.6560.97
83_T108_K0.6560.97
297_I300_I0.6550.97
156_G266_E0.6550.97
214_D235_F0.6530.97
247_H263_G0.6520.97
245_I332_L0.6510.97
68_Q72_G0.6490.97
103_F107_S0.6480.97
35_R46_P0.6460.97
360_N370_N0.6450.96
109_V384_I0.6440.96
352_L355_I0.6430.96
137_I140_Y0.6420.96
245_I265_L0.6390.96
303_A306_K0.6390.96
53_T57_I0.6390.96
163_G179_V0.6380.96
92_R153_I0.6360.96
254_G262_F0.6350.96
265_L318_V0.6320.96
197_R244_E0.6310.96
23_V52_I0.6210.96
336_Q372_P0.6210.96
313_E316_E0.6200.96
61_L105_L0.6180.96
151_S191_F0.6170.95
90_G387_F0.6160.95
238_R335_P0.6150.95
247_H254_G0.6140.95
212_C372_P0.6130.95
228_I243_G0.6110.95
323_G362_Q0.6090.95
238_R334_N0.6090.95
42_S49_V0.6080.95
215_S337_K0.6080.95
131_N134_A0.6070.95
224_T318_V0.6060.95
255_E280_N0.6050.95
321_H325_T0.6030.95
203_E377_E0.6020.95
26_L30_Y0.6000.95
316_E319_G0.5980.95
250_V325_T0.5970.95
281_L310_L0.5960.95
301_C315_I0.5940.94
327_A331_N0.5940.94
349_K352_L0.5930.94
134_A137_I0.5920.94
271_N275_E0.5900.94
268_I277_R0.5880.94
35_R223_G0.5860.94
132_A136_F0.5850.94
148_I390_V0.5830.94
141_Q144_L0.5820.94
298_K346_E0.5800.94
92_R343_E0.5790.94
98_A125_L0.5780.94
218_V226_A0.5780.94
85_N146_E0.5780.94
208_A211_D0.5760.94
254_G257_C0.5740.93
94_G222_R0.5740.93
92_R99_T0.5730.93
99_T383_A0.5720.93
217_L339_V0.5720.93
172_Q175_N0.5710.93
82_E86_F0.5710.93
303_A311_A0.5700.93
206_F384_I0.5700.93
49_V53_T0.5700.93
55_Q59_R0.5690.93
87_H102_L0.5690.93
257_C262_F0.5680.93
374_V377_E0.5680.93
297_I301_C0.5670.93
208_A339_V0.5670.93
191_F389_L0.5660.93
100_I115_Y0.5660.93
251_E324_K0.5660.93
155_P168_M0.5650.93
182_L186_F0.5640.93
216_I338_I0.5630.93
83_T86_F0.5620.93
327_A362_Q0.5610.93
55_Q58_E0.5600.93
149_A191_F0.5580.92
24_Y61_L0.5570.92
334_N363_A0.5570.92
363_A368_R0.5530.92
201_L389_L0.5520.92
180_E183_E0.5520.92
297_I343_E0.5510.92
300_I304_A0.5510.92
117_L125_L0.5490.92
102_L142_R0.5490.92
268_I321_H0.5480.92
253_L320_R0.5480.92
98_A129_L0.5480.92
94_G97_D0.5470.92
348_D354_A0.5460.92
225_G266_E0.5440.91
159_D166_H0.5440.91
226_A245_I0.5440.91
200_A217_L0.5430.91
149_A387_F0.5410.91
51_K54_R0.5410.91
292_L295_C0.5400.91
371_L375_R0.5390.91
327_A358_C0.5390.91
341_A376_S0.5380.91
199_L385_G0.5380.91
86_F146_E0.5370.91
95_R222_R0.5370.91
267_T276_Q0.5360.91
51_K55_Q0.5350.91
126_E176_W0.5350.91
35_R50_T0.5340.91
112_E383_A0.5340.91
348_D351_L0.5330.91
349_K356_E0.5330.91
57_I61_L0.5330.91
26_L29_Q0.5320.91
250_V321_H0.5320.91
309_S313_E0.5310.90
131_N138_D0.5310.90
204_H213_E0.5300.90
248_I265_L0.5290.90
312_S350_V0.5280.90
319_G358_C0.5280.90
273_A276_Q0.5270.90
84_R146_E0.5270.90
129_L182_L0.5270.90
90_G153_I0.5250.90
67_Q78_S0.5240.90
314_V318_V0.5220.90
249_Q254_G0.5210.90
237_G240_G0.5180.89
275_E279_L0.5160.89
204_H214_D0.5160.89
93_L152_V0.5140.89
271_N343_E0.5140.89
280_N285_G0.5140.89
197_R201_L0.5130.89
250_V268_I0.5130.89
326_I355_I0.5130.89
92_R219_R0.5130.89
272_A276_Q0.5120.89
141_Q146_E0.5090.89
357_S360_N0.5070.88
74_R314_V0.5070.88
144_L188_V0.5070.88
326_I329_A0.5060.88
88_A149_A0.5050.88
54_R57_I0.5040.88
208_A374_V0.5030.88
249_Q324_K0.5030.88
199_L219_R0.5030.88
207_G374_V0.5030.88
263_G267_T0.5030.88
279_L285_G0.5020.88
177_G183_E0.5020.88
92_R97_D0.5020.88
230_S335_P0.5010.88
195_D223_G0.5000.88
275_E295_C0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z05A 2 0.9704 100 0.169 Contact Map
1z6rA 3 0.9384 100 0.176 Contact Map
2hoeA 2 0.867 100 0.256 Contact Map
4ijaA 2 0.9089 100 0.289 Contact Map
3o8mA 1 0.9113 100 0.394 Contact Map
2yhwA 2 0.7414 100 0.405 Contact Map
1bdgA 1 0.867 100 0.409 Contact Map
2ap1A 2 0.7217 100 0.416 Contact Map
4db3A 2 0.7365 100 0.418 Contact Map
3f9mA 1 0.8719 100 0.418 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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