GREMLIN Database
NAGA - N-acetylglucosamine-6-phosphate deacetylase
UniProt: P0AF18 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10632
Length: 382 (366)
Sequences: 15127 (12710)
Seq/√Len: 664.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
373_I378_E5.0281.00
49_A370_T4.6781.00
351_T356_K4.5501.00
371_K378_E4.4611.00
24_A29_K4.4551.00
4_L46_L4.3391.00
327_A330_E3.8061.00
7_G46_L3.3591.00
52_S363_F3.2681.00
46_L362_A3.2601.00
353_A356_K3.1461.00
349_L357_V3.1261.00
5_T43_Q3.0361.00
30_S354_A2.8231.00
330_E333_R2.7821.00
3_A22_V2.4871.00
21_V51_L2.4561.00
54_G93_T2.4421.00
352_L360_L2.4031.00
51_L362_A2.3321.00
7_G51_L2.2861.00
338_Y341_R2.2831.00
333_R337_L2.2591.00
8_R17_D2.2561.00
26_G357_V2.1901.00
345_V349_L2.1641.00
52_S361_T2.1391.00
23_I360_L2.1041.00
49_A362_A2.0791.00
333_R338_Y2.0611.00
357_V375_N2.0601.00
27_L357_V2.0511.00
266_D269_C1.9941.00
32_C35_A1.9841.00
364_T370_T1.9481.00
337_L341_R1.9381.00
49_A364_T1.8961.00
245_I249_G1.8521.00
6_Q45_S1.8391.00
22_V41_I1.8391.00
22_V30_S1.8131.00
232_A236_L1.7991.00
26_G375_N1.7951.00
88_E379_V1.7801.00
21_V352_L1.7761.00
332_L336_T1.7701.00
347_K356_K1.7641.00
199_T202_E1.7421.00
31_V354_A1.7371.00
58_V343_I1.7261.00
52_S55_F1.7211.00
52_S332_L1.6871.00
233_G236_L1.6761.00
292_I295_R1.6591.00
38_P41_I1.6421.00
341_R351_T1.6381.00
321_V331_V1.6221.00
125_A128_L1.6101.00
361_T369_I1.6061.00
16_L19_H1.6031.00
236_L239_A1.5861.00
360_L373_I1.5581.00
51_L360_L1.5491.00
272_T276_A1.5441.00
341_R346_E1.4931.00
9_I21_V1.4771.00
125_A129_H1.4751.00
233_G237_D1.4721.00
127_G130_L1.4681.00
183_K186_N1.4521.00
156_V159_L1.4451.00
10_F332_L1.4401.00
262_R265_G1.4331.00
50_I365_P1.4321.00
156_V160_C1.4151.00
183_K187_A1.4141.00
179_E183_K1.4131.00
122_P125_A1.3951.00
7_G362_A1.3801.00
15_F329_D1.3761.00
274_A277_P1.3661.00
292_I296_N1.3541.00
231_L235_I1.3501.00
44_R373_I1.3471.00
233_G239_A1.3311.00
122_P128_L1.3181.00
271_V274_A1.3171.00
326_I334_M1.3101.00
318_R322_E1.3071.00
246_I249_G1.3061.00
204_K208_R1.3021.00
232_A239_A1.2931.00
311_L316_G1.2711.00
141_G145_P1.2641.00
234_A237_D1.2641.00
150_K153_A1.2561.00
146_N149_R1.2551.00
155_L158_F1.2521.00
112_R116_E1.2451.00
337_L351_T1.2441.00
214_A218_Y1.2301.00
87_N95_Y1.2221.00
273_D276_A1.2211.00
124_Q127_G1.2091.00
179_E182_S1.2081.00
261_K264_K1.2081.00
145_P149_R1.2061.00
175_M178_A1.1991.00
6_Q47_N1.1981.00
23_I373_I1.1971.00
145_P150_K1.1911.00
334_M338_Y1.1891.00
270_L274_A1.1861.00
22_V40_E1.1841.00
6_Q48_G1.1771.00
58_V339_P1.1771.00
253_D256_N1.1751.00
4_L23_I1.1681.00
155_L159_L1.1681.00
81_E85_K1.1681.00
292_I297_G1.1641.00
44_R371_K1.1601.00
21_V360_L1.1581.00
125_A130_L1.1561.00
313_M317_V1.1521.00
157_D161_E1.1441.00
149_R152_D1.1371.00
140_K143_H1.1281.00
50_I328_L1.1271.00
362_A373_I1.1271.00
143_H146_N1.1271.00
46_L51_L1.1271.00
133_P136_N1.1261.00
56_I94_N1.1251.00
113_V117_Y1.1231.00
280_A283_E1.1201.00
169_V172_A1.1181.00
55_F313_M1.1161.00
124_Q128_L1.1141.00
146_N150_K1.1111.00
182_S186_N1.1031.00
55_F335_A1.1031.00
261_K265_G1.0981.00
213_F216_H1.0951.00
166_I170_T1.0951.00
230_G234_A1.0921.00
56_I340_A1.0891.00
122_P129_H1.0861.00
235_I238_E1.0841.00
56_I339_P1.0831.00
301_D304_G1.0781.00
124_Q130_L1.0711.00
346_E356_K1.0691.00
157_D160_C1.0671.00
206_G210_G1.0601.00
272_T275_T1.0591.00
10_F15_F1.0541.00
8_R50_I1.0531.00
267_K271_V1.0501.00
162_N165_V1.0501.00
126_L129_H1.0431.00
140_K145_P1.0361.00
13_H353_A1.0361.00
114_M117_Y1.0361.00
9_I19_H1.0311.00
123_N126_L1.0281.00
22_V29_K1.0251.00
69_N77_V1.0201.00
362_A371_K1.0101.00
4_L360_L1.0091.00
293_Y296_N1.0081.00
112_R115_R1.0081.00
158_F161_E1.0051.00
108_K112_R1.0051.00
144_N147_F1.0001.00
293_Y297_G0.9971.00
235_I239_A0.9961.00
145_P148_V0.9961.00
267_K270_L0.9921.00
215_T218_Y0.9921.00
364_T368_K0.9901.00
28_I352_L0.9891.00
266_D271_V0.9881.00
316_G335_A0.9871.00
139_K143_H0.9861.00
184_L187_A0.9801.00
231_L236_L0.9671.00
166_I172_A0.9661.00
170_T173_P0.9601.00
115_R119_A0.9601.00
144_N148_V0.9591.00
122_P127_G0.9571.00
171_L174_E0.9551.00
122_P130_L0.9521.00
96_L343_I0.9521.00
259_N262_R0.9471.00
281_N284_Q0.9441.00
187_A191_V0.9441.00
305_T308_G0.9441.00
124_Q129_H0.9421.00
148_V151_P0.9411.00
12_G337_L0.9401.00
173_P176_V0.9381.00
148_V152_D0.9331.00
312_T315_E0.9281.00
229_P232_A0.9271.00
185_A189_I0.9271.00
258_R262_R0.9251.00
131_E135_L0.9241.00
374_V379_V0.9221.00
122_P126_L0.9211.00
147_F151_P0.9201.00
330_E334_M0.9171.00
181_I184_L0.9161.00
180_V184_L0.9151.00
139_K142_T0.9111.00
131_E136_N0.9101.00
88_E374_V0.9071.00
110_G113_V0.9051.00
92_C312_T0.9051.00
260_A264_K0.9031.00
42_E378_E0.9021.00
269_C276_A0.9011.00
113_V116_E0.9011.00
147_F150_K0.8971.00
4_L373_I0.8961.00
187_A190_V0.8961.00
4_L362_A0.8951.00
316_G331_V0.8941.00
269_C274_A0.8941.00
154_A157_D0.8931.00
22_V32_C0.8931.00
129_H132_G0.8921.00
167_T170_T0.8881.00
84_Q88_E0.8871.00
162_N167_T0.8861.00
6_Q18_D0.8861.00
40_E43_Q0.8861.00
88_E372_T0.8831.00
109_Q112_R0.8821.00
267_K272_T0.8811.00
259_N263_L0.8781.00
148_V153_A0.8761.00
298_L301_D0.8751.00
286_I289_G0.8741.00
200_L204_K0.8711.00
109_Q113_V0.8711.00
111_V115_R0.8691.00
111_V114_M0.8681.00
123_N128_L0.8671.00
166_I169_V0.8651.00
116_E119_A0.8641.00
256_N259_N0.8611.00
55_F92_C0.8601.00
273_D277_P0.8601.00
155_L160_C0.8581.00
56_I349_L0.8581.00
174_E177_P0.8571.00
266_D270_L0.8561.00
7_G360_L0.8551.00
154_A158_F0.8531.00
267_K274_A0.8511.00
234_A239_A0.8491.00
295_R298_L0.8491.00
55_F361_T0.8461.00
286_I291_T0.8461.00
230_G233_G0.8451.00
132_G137_L0.8441.00
300_V304_G0.8421.00
369_I372_T0.8411.00
84_Q95_Y0.8371.00
363_F369_I0.8371.00
268_L273_D0.8361.00
13_H351_T0.8341.00
248_D252_V0.8291.00
223_Y226_G0.8291.00
22_V38_P0.8281.00
270_L273_D0.8241.00
3_A37_L0.8211.00
123_N129_H0.8191.00
231_L234_A0.8191.00
116_E120_K0.8191.00
29_K354_A0.8181.00
123_N127_G0.8161.00
28_I360_L0.8151.00
10_F329_D0.8141.00
233_G238_E0.8141.00
172_A175_M0.8131.00
234_A238_E0.8131.00
167_T172_A0.8121.00
227_R232_A0.8121.00
205_A209_A0.8111.00
194_G197_N0.8101.00
132_G135_L0.8091.00
284_Q291_T0.8071.00
19_H33_P0.8061.00
4_L51_L0.8041.00
168_K171_L0.8031.00
227_R231_L0.8021.00
188_G192_S0.8001.00
335_A339_P0.7961.00
294_Y297_G0.7961.00
191_V194_G0.7951.00
21_V31_V0.7931.00
231_L239_A0.7911.00
229_P234_A0.7911.00
131_E134_W0.7901.00
267_K273_D0.7881.00
288_A291_T0.7871.00
190_V193_A0.7821.00
232_A238_E0.7801.00
58_V342_A0.7791.00
134_W137_L0.7781.00
201_K205_A0.7751.00
62_G95_Y0.7751.00
259_N264_K0.7711.00
361_T372_T0.7701.00
126_L130_L0.7671.00
57_D60_L0.7651.00
126_L131_E0.7651.00
140_K144_N0.7641.00
219_N222_P0.7601.00
359_N375_N0.7591.00
114_M118_L0.7541.00
145_P151_P0.7541.00
312_T317_V0.7501.00
329_D333_R0.7461.00
94_N359_N0.7441.00
222_P226_G0.7431.00
279_G284_Q0.7421.00
210_G216_H0.7421.00
37_L41_I0.7421.00
170_T174_E0.7411.00
49_A371_K0.7411.00
213_F218_Y0.7371.00
317_V321_V0.7371.00
88_E124_Q0.7351.00
135_L138_V0.7341.00
50_I363_F0.7311.00
131_E138_V0.7311.00
180_V183_K0.7291.00
155_L163_A0.7291.00
5_T45_S0.7281.00
146_N151_P0.7281.00
227_R236_L0.7251.00
192_S195_H0.7241.00
10_F50_I0.7231.00
294_Y299_C0.7211.00
202_E206_G0.7201.00
4_L44_R0.7201.00
349_L359_N0.7181.00
162_N166_I0.7181.00
143_H149_R0.7161.00
128_L131_E0.7151.00
213_F217_L0.7141.00
107_M110_G0.7131.00
129_H133_P0.7131.00
189_I192_S0.7121.00
142_T145_P0.7051.00
207_F210_G0.7041.00
227_R230_G0.7021.00
316_G320_L0.6951.00
62_G83_M0.6951.00
206_G209_A0.6931.00
351_T354_A0.6891.00
283_E290_K0.6871.00
272_T277_P0.6861.00
143_H148_V0.6851.00
212_T216_H0.6851.00
269_C273_D0.6831.00
215_T222_P0.6831.00
209_A213_F0.6821.00
201_K204_K0.6801.00
144_N152_D0.6801.00
227_R233_G0.6791.00
320_L324_C0.6791.00
56_I343_I0.6761.00
300_V303_N0.6761.00
166_I171_L0.6741.00
316_G319_N0.6701.00
350_G359_N0.6681.00
168_K172_A0.6681.00
191_V195_H0.6661.00
330_E338_Y0.6661.00
202_E205_A0.6651.00
230_G236_L0.6631.00
311_L314_I0.6631.00
230_G239_A0.6611.00
181_I185_A0.6601.00
145_P152_D0.6561.00
314_I318_R0.6551.00
229_P233_G0.6531.00
12_G351_T0.6531.00
287_F342_A0.6531.00
216_H219_N0.6511.00
245_I248_D0.6491.00
305_T310_S0.6481.00
19_H32_C0.6471.00
22_V35_A0.6471.00
215_T221_M0.6451.00
218_Y221_M0.6431.00
173_P177_P0.6431.00
144_N149_R0.6431.00
337_L346_E0.6421.00
86_A89_K0.6421.00
37_L40_E0.6401.00
225_T228_E0.6381.00
169_V174_E0.6361.00
8_R15_F0.6351.00
230_G235_I0.6341.00
231_L238_E0.6341.00
314_I317_V0.6321.00
86_A90_S0.6301.00
232_A235_I0.6291.00
144_N150_K0.6291.00
161_E164_D0.6291.00
85_K89_K0.6291.00
295_R299_C0.6271.00
243_C246_I0.6261.00
167_T173_P0.6251.00
258_R261_K0.6241.00
146_N153_A0.6191.00
278_A282_I0.6191.00
62_G84_Q0.6191.00
14_E329_D0.6151.00
132_G136_N0.6141.00
118_L121_H0.6141.00
269_C272_T0.6141.00
147_F152_D0.6111.00
336_T339_P0.6111.00
278_A281_N0.6111.00
321_V328_L0.6101.00
66_V82_I0.6091.00
331_V335_A0.6081.00
160_C163_A0.6061.00
184_L189_I0.6061.00
313_M320_L0.6041.00
128_L133_P0.6041.00
203_A207_F0.6031.00
270_L277_P0.6011.00
283_E286_I0.6011.00
221_M224_I0.6011.00
155_L161_E0.6001.00
271_V275_T0.5991.00
117_Y120_K0.5961.00
94_N349_L0.5951.00
184_L191_V0.5951.00
340_A350_G0.5921.00
133_P138_V0.5921.00
240_D342_A0.5911.00
260_A263_L0.5911.00
172_A177_P0.5901.00
185_A188_G0.5891.00
312_T335_A0.5881.00
264_K267_K0.5881.00
125_A131_E0.5871.00
169_V173_P0.5871.00
58_V287_F0.5861.00
144_N151_P0.5821.00
228_E233_G0.5821.00
185_A212_T0.5811.00
46_L49_A0.5791.00
182_S185_A0.5771.00
248_D251_H0.5761.00
188_G191_V0.5761.00
141_G144_N0.5741.00
315_E318_R0.5731.00
347_K357_V0.5681.00
8_R365_P0.5661.00
248_D253_D0.5641.00
6_Q46_L0.5621.00
320_L326_I0.5601.00
193_A196_S0.5601.00
60_L87_N0.5591.00
268_L272_T0.5591.00
58_V96_L0.5581.00
110_G117_Y0.5581.00
317_V335_A0.5571.00
149_R153_A0.5561.00
222_P225_T0.5551.00
189_I193_A0.5521.00
166_I174_E0.5491.00
140_K148_V0.5481.00
207_F212_T0.5481.00
221_M225_T0.5471.00
249_G252_V0.5461.00
314_I369_I0.5451.00
142_T146_N0.5451.00
203_A206_G0.5441.00
313_M335_A0.5441.00
229_P236_L0.5421.00
266_D277_P0.5411.00
270_L276_A0.5411.00
132_G138_V0.5401.00
46_L371_K0.5401.00
199_T203_A0.5391.00
23_I29_K0.5391.00
231_L237_D0.5381.00
3_A40_E0.5381.00
215_T219_N0.5371.00
228_E231_L0.5371.00
82_I86_A0.5341.00
15_F18_D0.5341.00
245_I250_L0.5331.00
285_F290_K0.5321.00
210_G214_A0.5321.00
223_Y227_R0.5311.00
115_R118_L0.5311.00
154_A159_L0.5311.00
285_F289_G0.5291.00
268_L271_V0.5291.00
141_G146_N0.5280.99
77_V81_E0.5260.99
242_Y245_I0.5260.99
283_E289_G0.5260.99
265_G268_L0.5260.99
14_E17_D0.5260.99
78_E83_M0.5240.99
317_V331_V0.5240.99
270_L275_T0.5230.99
275_T279_G0.5230.99
287_F291_T0.5220.99
141_G148_V0.5200.99
64_G68_F0.5190.99
108_K114_M0.5190.99
124_Q375_N0.5170.99
133_P137_L0.5160.99
266_D274_A0.5160.99
326_I330_E0.5150.99
105_E111_V0.5140.99
105_E110_G0.5140.99
224_I227_R0.5130.99
81_E121_H0.5120.99
276_A279_G0.5110.99
254_Y257_I0.5100.99
285_F288_A0.5100.99
279_G282_I0.5090.99
186_N189_I0.5080.99
143_H151_P0.5060.99
246_I250_L0.5050.99
252_V315_E0.5030.99
127_G131_E0.5030.99
154_A160_C0.5020.99
93_T359_N0.5020.99
208_R212_T0.5010.99
175_M206_G0.5010.99
11_T14_E0.5000.99
131_E137_L0.5000.99
317_V322_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yrrA 3 0.9948 100 0.198 Contact Map
3iv8A 2 0.9895 100 0.225 Contact Map
2vhlA 1 0.9895 100 0.249 Contact Map
1o12A 2 0.9398 100 0.315 Contact Map
2ftwA 3 0.9817 100 0.353 Contact Map
3dc8A 3 0.9529 100 0.366 Contact Map
4lcqA 3 0.9791 100 0.375 Contact Map
2vm8A 3 0.9791 100 0.387 Contact Map
3be7A 5 0.9346 100 0.389 Contact Map
3sfwA 3 0.9555 100 0.389 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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