MURJ - ECOLI - GREMLIN Contacts

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MURJ - Lipid II flippase MurJ

UniProt:	P0AF16	Sequences: MNLLKSLAAVSSMTMFSRVLGFARDAIVARIFGAGMATDAFFVAFKLPNLLRRIFAEGAFSQAFVPILAEYKSKQGEDATRVFVSYVSGLLTLALAVVTVAGMLAAPWVIMVTAPGFADTADKFALTSQLLKITFPYILLISLASLVGAILNTWNRFSIPAFAPTLLNISMIGFALFAAPYFNPPVLALAWAVTVGGVLQLVYQLPHLKKIGMLVLPRINFHDAGAMRVVKQMGPAILGVSVSQISLIINTIFASFLASGSVSWMYYADRLMEFPSGVLGVALGTILLPSLSKSFASGNHDEYNRLMDWGLRLCFLLALPSAVALGILSGPLTVSLFQYGKFTAFDALMTQRALIAYSVGLIGLIVVKVLAPGFYSRQDIKTPVKIAIVTLILTQLMNLAFIGPLKHAGLSLSIGLAACLNASLLYWQLRKQKIFTPQPGWMAFLLRLVVAVLVMSGVLLGMLHIMPEWSLGTMPWRLLRLMAVVLAGIAAYFAALAVLGFKVKEFARRTV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13880
Length:	511 (454)
Sequences:	16690 (14269)
Seq/√Len:	669.7

ECOLI - MURJ WZXC WZXE RFBX YGHQ MDTK DINF YEEO
BACSU - EPSK YTGP SP5B YABM TUAB YKVU YOEA YPNP NORM
HALSA - Q9HRT3 Q9HSW2 Q9HQQ5 Q9HRF2 Q9HN79 Q9HMS7 Q9HRF7
SULSO - Q97XG2 Q97XT3 Q7LXE2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
299_N	302_E	4.919	1.00
227_M	231_K	3.418	1.00
156_R	159_I	3.238	1.00
105_A	108_W	3.221	1.00
443_A	447_R	3.176	1.00
379_D	382_T	3.035	1.00
351_Q	355_I	2.957	1.00
42_F	266_Y	2.893	1.00
326_G	355_I	2.767	1.00
155_N	293_K	2.729	1.00
381_K	385_K	2.695	1.00
379_D	432_Q	2.624	1.00
264_W	349_M	2.360	1.00
329_S	351_Q	2.356	1.00
330_G	334_V	2.324	1.00
356_A	408_A	2.291	1.00
458_V	491_A	2.279	1.00
390_T	421_N	2.242	1.00
250_N	265_M	2.230	1.00
363_G	419_C	2.217	1.00
250_N	398_N	2.209	1.00
185_P	188_A	2.203	1.00
103_M	132_K	2.199	1.00
68_L	153_T	2.187	1.00
353_A	407_H	2.163	1.00
329_S	355_I	2.158	1.00
397_M	413_S	2.134	1.00
294_S	302_E	2.131	1.00
455_M	459_L	2.131	1.00
293_K	297_S	2.090	1.00
238_L	384_V	2.069	1.00
128_S	132_K	2.059	1.00
258_A	261_S	2.030	1.00
402_I	410_L	2.002	1.00
253_F	402_I	1.966	1.00
305_R	309_W	1.963	1.00
66_P	70_E	1.956	1.00
223_D	227_M	1.956	1.00
33_G	36_M	1.949	1.00
9_A	158_S	1.940	1.00
386_I	424_L	1.930	1.00
67_I	232_Q	1.923	1.00
455_M	488_G	1.920	1.00
82_V	222_H	1.918	1.00
405_L	412_L	1.913	1.00
328_L	331_P	1.898	1.00
300_H	304_N	1.891	1.00
323_V	456_S	1.880	1.00
324_A	328_L	1.863	1.00
444_F	447_R	1.853	1.00
356_A	415_G	1.830	1.00
107_P	128_S	1.825	1.00
102_G	135_F	1.804	1.00
459_L	488_G	1.793	1.00
318_A	365_I	1.792	1.00
79_A	82_V	1.779	1.00
331_P	334_V	1.773	1.00
324_A	485_V	1.762	1.00
319_L	452_V	1.728	1.00
307_M	373_G	1.714	1.00
106_A	132_K	1.713	1.00
393_L	420_L	1.710	1.00
250_N	414_I	1.710	1.00
409_G	413_S	1.691	1.00
352_R	408_A	1.687	1.00
253_F	398_N	1.681	1.00
30_R	338_Q	1.671	1.00
353_A	411_S	1.651	1.00
295_F	377_R	1.648	1.00
401_F	413_S	1.648	1.00
150_I	154_W	1.637	1.00
398_N	402_I	1.635	1.00
401_F	405_L	1.620	1.00
322_A	362_I	1.609	1.00
356_A	412_L	1.605	1.00
330_G	351_Q	1.585	1.00
260_G	264_W	1.585	1.00
242_V	388_I	1.585	1.00
70_E	378_Q	1.579	1.00
356_A	411_S	1.556	1.00
423_S	427_W	1.555	1.00
352_R	355_I	1.549	1.00
413_S	417_A	1.542	1.00
155_N	290_S	1.540	1.00
406_K	409_G	1.533	1.00
41_F	45_F	1.525	1.00
333_T	350_T	1.524	1.00
34_A	346_D	1.523	1.00
188_A	192_A	1.513	1.00
261_S	407_H	1.499	1.00
81_R	85_S	1.493	1.00
302_E	305_R	1.492	1.00
330_G	355_I	1.484	1.00
360_G	415_G	1.482	1.00
43_V	255_S	1.480	1.00
338_Q	347_A	1.480	1.00
158_S	162_F	1.474	1.00
254_A	410_L	1.468	1.00
171_M	196_G	1.466	1.00
333_T	354_L	1.463	1.00
304_N	308_D	1.459	1.00
456_S	460_L	1.459	1.00
84_V	150_I	1.455	1.00
156_R	211_I	1.444	1.00
325_L	358_S	1.442	1.00
400_A	403_G	1.441	1.00
253_F	399_L	1.422	1.00
385_K	389_V	1.421	1.00
291_L	303_Y	1.419	1.00
302_E	306_L	1.418	1.00
72_K	80_T	1.416	1.00
328_L	332_L	1.413	1.00
345_F	348_L	1.411	1.00
396_L	400_A	1.410	1.00
461_G	464_H	1.405	1.00
44_A	134_T	1.401	1.00
363_G	422_A	1.398	1.00
29_A	267_Y	1.392	1.00
272_M	357_Y	1.389	1.00
64_F	87_V	1.371	1.00
294_S	306_L	1.370	1.00
39_D	260_G	1.363	1.00
349_M	352_R	1.359	1.00
249_I	395_Q	1.345	1.00
394_T	398_N	1.343	1.00
15_M	19_V	1.340	1.00
254_A	262_V	1.334	1.00
170_S	199_L	1.322	1.00
287_L	310_G	1.315	1.00
130_L	190_A	1.314	1.00
303_Y	373_G	1.312	1.00
427_W	431_K	1.311	1.00
401_F	404_P	1.307	1.00
308_D	312_R	1.307	1.00
16_F	165_T	1.302	1.00
235_P	384_V	1.302	1.00
222_H	225_G	1.302	1.00
177_F	181_Y	1.300	1.00
176_L	180_P	1.289	1.00
268_A	353_A	1.285	1.00
359_V	415_G	1.283	1.00
400_A	404_P	1.267	1.00
174_F	192_A	1.264	1.00
301_D	305_R	1.258	1.00
386_I	428_Q	1.256	1.00
22_F	26_A	1.254	1.00
25_D	270_R	1.251	1.00
26_A	30_R	1.239	1.00
268_A	350_T	1.226	1.00
86_Y	226_A	1.222	1.00
295_F	303_Y	1.218	1.00
34_A	264_W	1.212	1.00
87_V	229_V	1.212	1.00
394_T	414_I	1.207	1.00
82_V	86_Y	1.201	1.00
324_A	455_M	1.200	1.00
173_G	177_F	1.196	1.00
248_I	251_T	1.196	1.00
139_L	142_S	1.190	1.00
393_L	397_M	1.183	1.00
461_G	465_I	1.179	1.00
463_L	484_V	1.179	1.00
106_A	128_S	1.174	1.00
254_A	407_H	1.170	1.00
408_A	411_S	1.164	1.00
386_I	425_L	1.161	1.00
184_P	188_A	1.159	1.00
24_R	172_I	1.158	1.00
234_G	238_L	1.158	1.00
405_L	409_G	1.157	1.00
205_L	209_K	1.152	1.00
17_S	168_N	1.151	1.00
235_P	381_K	1.151	1.00
71_Y	79_A	1.149	1.00
136_P	139_L	1.148	1.00
67_I	228_R	1.146	1.00
333_T	351_Q	1.145	1.00
325_L	354_L	1.143	1.00
288_L	292_S	1.141	1.00
107_P	132_K	1.139	1.00
291_L	376_S	1.136	1.00
373_G	429_L	1.132	1.00
264_W	350_T	1.132	1.00
69_A	153_T	1.130	1.00
398_N	414_I	1.129	1.00
353_A	408_A	1.125	1.00
187_L	190_A	1.125	1.00
398_N	401_F	1.119	1.00
315_F	319_L	1.118	1.00
107_P	111_M	1.116	1.00
13_M	161_A	1.112	1.00
115_P	126_L	1.112	1.00
331_P	463_L	1.110	1.00
19_V	23_A	1.109	1.00
140_L	198_V	1.104	1.00
307_M	370_L	1.104	1.00
482_M	486_L	1.104	1.00
41_F	189_L	1.101	1.00
388_I	392_I	1.101	1.00
333_T	337_F	1.099	1.00
136_P	194_T	1.099	1.00
460_L	464_H	1.097	1.00
163_A	203_Y	1.095	1.00
108_W	112_V	1.094	1.00
360_G	363_G	1.091	1.00
99_T	103_M	1.090	1.00
63_A	232_Q	1.085	1.00
157_F	286_I	1.081	1.00
68_L	80_T	1.077	1.00
294_S	299_N	1.073	1.00
250_N	394_T	1.071	1.00
228_R	378_Q	1.070	1.00
93_L	97_V	1.066	1.00
242_V	384_V	1.065	1.00
245_I	391_L	1.065	1.00
65_V	149_A	1.063	1.00
374_F	428_Q	1.059	1.00
360_G	411_S	1.056	1.00
34_A	263_S	1.056	1.00
232_Q	380_I	1.056	1.00
202_V	206_P	1.053	1.00
36_M	40_A	1.053	1.00
110_I	127_T	1.050	1.00
300_H	377_R	1.050	1.00
452_V	456_S	1.050	1.00
328_L	484_V	1.046	1.00
397_M	401_F	1.046	1.00
301_D	304_N	1.043	1.00
332_L	336_L	1.033	1.00
101_A	105_A	1.033	1.00
394_T	417_A	1.033	1.00
366_V	422_A	1.030	1.00
385_K	388_I	1.029	1.00
99_T	102_G	1.027	1.00
370_L	426_Y	1.026	1.00
140_L	201_L	1.024	1.00
242_V	391_L	1.022	1.00
39_D	263_S	1.020	1.00
70_E	228_R	1.018	1.00
254_A	265_M	1.018	1.00
90_L	226_A	1.018	1.00
89_G	93_L	1.017	1.00
322_A	326_G	1.017	1.00
43_V	262_V	1.016	1.00
427_W	430_R	1.016	1.00
263_S	266_Y	1.015	1.00
42_F	263_S	1.014	1.00
404_P	408_A	1.012	1.00
67_I	70_E	1.009	1.00
327_I	456_S	1.008	1.00
451_A	455_M	1.005	1.00
163_A	204_Q	1.003	1.00
239_G	383_P	1.002	1.00
147_V	205_L	1.000	1.00
25_D	337_F	0.999	1.00
424_L	427_W	0.999	1.00
326_G	329_S	0.999	1.00
79_A	225_G	0.999	1.00
40_A	259_S	0.998	1.00
375_Y	383_P	0.996	1.00
485_V	489_I	0.996	1.00
462_M	487_A	0.994	1.00
370_L	425_L	0.993	1.00
412_L	416_L	0.986	1.00
106_A	110_I	0.986	1.00
88_S	147_V	0.981	1.00
7_L	283_L	0.980	1.00
31_I	180_P	0.978	1.00
104_L	107_P	0.977	1.00
246_S	394_T	0.974	1.00
80_T	154_W	0.974	1.00
126_L	129_Q	0.973	1.00
66_P	378_Q	0.970	1.00
159_I	207_H	0.968	1.00
191_W	195_V	0.968	1.00
7_L	286_I	0.968	1.00
382_T	428_Q	0.968	1.00
258_A	262_V	0.967	1.00
63_A	233_M	0.967	1.00
10_V	286_I	0.965	1.00
29_A	337_F	0.963	1.00
110_I	128_S	0.962	1.00
132_K	136_P	0.959	1.00
415_G	418_A	0.958	1.00
335_S	481_L	0.956	1.00
225_G	228_R	0.950	1.00
355_I	359_V	0.948	1.00
268_A	357_Y	0.948	1.00
103_M	107_P	0.947	1.00
267_Y	337_F	0.945	1.00
191_W	194_T	0.944	1.00
442_M	446_L	0.941	1.00
129_Q	132_K	0.938	1.00
303_Y	377_R	0.938	1.00
348_L	352_R	0.937	1.00
224_A	227_M	0.934	1.00
68_L	154_W	0.933	1.00
56_A	61_S	0.933	1.00
177_F	180_P	0.931	1.00
174_F	178_A	0.930	1.00
392_I	396_L	0.930	1.00
85_S	89_G	0.929	1.00
348_L	351_Q	0.928	1.00
83_F	87_V	0.926	1.00
10_V	161_A	0.926	1.00
263_S	267_Y	0.925	1.00
192_A	196_G	0.923	1.00
329_S	354_L	0.923	1.00
446_L	450_V	0.920	1.00
430_R	433_K	0.918	1.00
420_L	424_L	0.915	1.00
27_I	31_I	0.913	1.00
460_L	463_L	0.912	1.00
20_L	172_I	0.909	1.00
63_A	229_V	0.909	1.00
11_S	282_A	0.907	1.00
323_V	452_V	0.905	1.00
26_A	337_F	0.904	1.00
115_P	125_A	0.903	1.00
135_F	139_L	0.897	1.00
357_Y	411_S	0.894	1.00
251_T	262_V	0.892	1.00
320_P	492_Y	0.890	1.00
480_R	484_V	0.888	1.00
33_G	346_D	0.887	1.00
326_G	359_V	0.886	1.00
63_A	67_I	0.885	1.00
104_L	108_W	0.885	1.00
444_F	448_L	0.883	1.00
193_V	197_G	0.883	1.00
397_M	416_L	0.882	1.00
253_F	257_L	0.880	1.00
129_Q	187_L	0.880	1.00
230_V	233_M	0.876	1.00
44_A	130_L	0.875	1.00
290_S	293_K	0.873	1.00
14_T	18_R	0.870	1.00
175_A	192_A	0.870	1.00
93_L	96_A	0.870	1.00
457_G	461_G	0.868	1.00
230_V	234_G	0.867	1.00
350_T	353_A	0.860	1.00
174_F	195_V	0.860	1.00
464_H	467_P	0.859	1.00
28_V	189_L	0.858	1.00
96_A	100_V	0.856	1.00
399_L	403_G	0.856	1.00
77_E	81_R	0.854	1.00
97_V	101_A	0.854	1.00
464_H	468_E	0.853	1.00
312_R	316_L	0.853	1.00
6_S	155_N	0.848	1.00
484_V	488_G	0.846	1.00
272_M	361_L	0.840	1.00
262_V	266_Y	0.839	1.00
412_L	415_G	0.839	1.00
309_W	312_R	0.839	1.00
37_A	42_F	0.834	1.00
382_T	385_K	0.833	1.00
99_T	139_L	0.832	1.00
326_G	330_G	0.832	1.00
95_L	142_S	0.831	1.00
106_A	135_F	0.831	1.00
428_Q	431_K	0.829	1.00
100_V	104_L	0.826	1.00
26_A	29_A	0.822	1.00
108_W	111_M	0.818	1.00
194_T	197_G	0.818	1.00
60_F	87_V	0.818	1.00
408_A	412_L	0.814	1.00
78_D	82_V	0.813	1.00
426_Y	430_R	0.810	1.00
320_P	452_V	0.809	1.00
171_M	175_A	0.809	1.00
360_G	414_I	0.806	1.00
46_K	251_T	0.804	1.00
268_A	354_L	0.804	1.00
203_Y	207_H	0.803	1.00
58_G	233_M	0.802	1.00
452_V	455_M	0.800	1.00
148_G	152_N	0.799	1.00
206_P	210_K	0.799	1.00
374_F	383_P	0.798	1.00
403_G	410_L	0.798	1.00
178_A	184_P	0.797	1.00
292_S	296_A	0.795	1.00
34_A	260_G	0.794	1.00
140_L	194_T	0.794	1.00
430_R	434_I	0.793	1.00
324_A	489_I	0.792	1.00
265_M	357_Y	0.788	1.00
335_S	478_L	0.788	1.00
331_P	484_V	0.788	1.00
236_A	380_I	0.785	1.00
242_V	387_A	0.784	1.00
261_S	264_W	0.783	1.00
383_P	387_A	0.783	1.00
359_V	363_G	0.781	1.00
196_G	200_Q	0.781	1.00
334_V	348_L	0.779	1.00
45_F	49_N	0.777	1.00
257_L	402_I	0.777	1.00
397_M	400_A	0.771	1.00
41_F	186_V	0.771	1.00
441_W	444_F	0.767	1.00
270_R	274_F	0.767	1.00
389_V	424_L	0.766	1.00
359_V	362_I	0.765	1.00
424_L	428_Q	0.763	1.00
290_S	294_S	0.760	1.00
314_C	365_I	0.758	1.00
31_I	179_A	0.757	1.00
133_I	194_T	0.756	1.00
294_S	297_S	0.755	1.00
334_V	338_Q	0.755	1.00
189_L	193_V	0.755	1.00
95_L	99_T	0.753	1.00
137_Y	197_G	0.753	1.00
7_L	11_S	0.752	1.00
90_L	94_A	0.751	1.00
92_T	96_A	0.749	1.00
20_L	24_R	0.748	1.00
372_P	375_Y	0.746	1.00
9_A	13_M	0.746	1.00
398_N	410_L	0.746	1.00
64_F	83_F	0.745	1.00
324_A	488_G	0.745	1.00
231_K	235_P	0.745	1.00
49_N	53_R	0.744	1.00
269_D	273_E	0.743	1.00
306_L	310_G	0.739	1.00
267_Y	270_R	0.736	1.00
235_P	380_I	0.734	1.00
241_S	245_I	0.730	1.00
8_A	12_S	0.730	1.00
151_L	208_L	0.730	1.00
428_Q	432_Q	0.727	1.00
266_Y	270_R	0.727	1.00
320_P	323_V	0.725	1.00
441_W	448_L	0.725	1.00
459_L	463_L	0.724	1.00
448_L	452_V	0.724	1.00
419_C	423_S	0.721	1.00
64_F	68_L	0.721	1.00
338_Q	346_D	0.720	1.00
288_L	372_P	0.717	1.00
125_A	129_Q	0.716	1.00
386_I	390_T	0.714	1.00
485_V	488_G	0.714	1.00
26_A	336_L	0.712	1.00
72_K	154_W	0.712	1.00
280_G	284_G	0.710	1.00
310_G	369_V	0.709	1.00
169_I	173_G	0.704	1.00
443_A	446_L	0.704	1.00
167_L	171_M	0.701	1.00
393_L	396_L	0.701	1.00
172_I	176_L	0.701	1.00
174_F	177_F	0.700	1.00
5_K	158_S	0.700	1.00
77_E	80_T	0.698	1.00
34_A	347_A	0.697	1.00
25_D	29_A	0.695	1.00
429_L	432_Q	0.695	1.00
326_G	358_S	0.693	1.00
321_S	324_A	0.692	1.00
28_V	175_A	0.692	1.00
316_L	320_P	0.692	1.00
252_I	256_F	0.688	1.00
231_K	234_G	0.687	1.00
372_P	376_S	0.686	1.00
35_G	259_S	0.686	1.00
449_V	452_V	0.686	1.00
306_L	309_W	0.684	1.00
323_V	327_I	0.683	1.00
231_K	381_K	0.683	1.00
131_L	135_F	0.682	1.00
395_Q	399_L	0.680	1.00
384_V	388_I	0.680	1.00
250_N	269_D	0.679	1.00
459_L	484_V	0.679	1.00
12_S	16_F	0.679	1.00
288_L	376_S	0.678	1.00
244_Q	248_I	0.677	1.00
286_I	289_P	0.677	1.00
32_F	186_V	0.676	1.00
65_V	153_T	0.671	1.00
248_I	252_I	0.667	1.00
481_L	485_V	0.666	1.00
49_N	52_R	0.665	1.00
314_C	369_V	0.662	1.00
43_V	46_K	0.661	1.00
224_A	228_R	0.653	1.00
82_V	225_G	0.652	1.00
56_A	91_L	0.650	1.00
207_H	211_I	0.648	1.00
204_Q	208_L	0.644	1.00
66_P	380_I	0.643	1.00
97_V	100_V	0.642	1.00
320_P	455_M	0.641	1.00
4_L	8_A	0.640	1.00
106_A	131_L	0.640	1.00
66_P	376_S	0.639	1.00
267_Y	347_A	0.639	1.00
331_P	480_R	0.638	1.00
272_M	275_P	0.637	1.00
453_L	457_G	0.637	1.00
152_N	160_P	0.636	1.00
463_L	480_R	0.635	1.00
354_L	358_S	0.633	1.00
327_I	459_L	0.633	1.00
226_A	230_V	0.632	1.00
178_A	181_Y	0.632	1.00
78_D	81_R	0.632	1.00
246_S	391_L	0.632	1.00
370_L	422_A	0.632	1.00
323_V	326_G	0.631	1.00
167_L	200_Q	0.629	1.00
374_F	429_L	0.628	1.00
83_F	225_G	0.621	1.00
144_A	201_L	0.618	1.00
6_S	286_I	0.618	1.00
61_S	149_A	0.617	1.00
159_I	162_F	0.615	1.00
270_R	273_E	0.615	1.00
65_V	69_A	0.610	1.00
270_R	337_F	0.610	1.00
271_L	337_F	0.610	1.00
13_M	165_T	0.608	1.00
414_I	417_A	0.608	1.00
239_G	387_A	0.606	1.00
11_S	15_M	0.606	1.00
106_A	109_V	0.606	1.00
48_P	52_R	0.604	1.00
402_I	409_G	0.603	1.00
132_K	135_F	0.602	1.00
389_V	392_I	0.601	1.00
370_L	429_L	0.600	1.00
462_M	465_I	0.599	1.00
380_I	383_P	0.598	1.00
229_V	233_M	0.598	1.00
68_L	84_V	0.597	1.00
398_N	413_S	0.596	1.00
360_G	418_A	0.595	1.00
99_T	135_F	0.595	1.00
151_L	159_I	0.595	1.00
329_S	358_S	0.594	1.00
265_M	269_D	0.594	1.00
35_G	40_A	0.593	1.00
10_V	157_F	0.593	1.00
50_L	244_Q	0.593	1.00
133_I	191_W	0.592	1.00
255_S	262_V	0.591	1.00
85_S	219_I	0.589	1.00
48_P	138_I	0.587	1.00
21_G	25_D	0.586	1.00
163_A	200_Q	0.585	1.00
33_G	347_A	0.583	1.00
27_I	176_L	0.582	1.00
193_V	196_G	0.582	1.00
320_P	324_A	0.582	1.00
16_F	20_L	0.581	1.00
394_T	413_S	0.580	1.00
261_S	265_M	0.580	1.00
41_F	190_A	0.580	1.00
125_A	128_S	0.579	1.00
465_I	468_E	0.578	1.00
141_I	197_G	0.578	1.00
16_F	169_I	0.577	1.00
25_D	37_A	0.577	1.00
393_L	417_A	0.576	1.00
37_A	267_Y	0.576	1.00
32_F	36_M	0.574	1.00
129_Q	133_I	0.574	1.00
367_V	422_A	0.573	1.00
163_A	167_L	0.573	1.00
463_L	467_P	0.572	1.00
267_Y	350_T	0.571	1.00
89_G	92_T	0.570	1.00
415_G	419_C	0.570	1.00
451_A	492_Y	0.569	1.00
388_I	391_L	0.569	1.00
431_K	434_I	0.568	1.00
232_Q	236_A	0.568	1.00
162_F	166_L	0.568	1.00
334_V	351_Q	0.568	1.00
171_M	192_A	0.567	1.00
283_L	287_L	0.567	1.00
43_V	251_T	0.566	1.00
330_G	348_L	0.564	1.00
170_S	173_G	0.563	1.00
107_P	110_I	0.563	1.00
181_Y	184_P	0.559	1.00
294_S	303_Y	0.558	1.00
187_L	191_W	0.558	1.00
185_P	192_A	0.557	1.00
149_A	153_T	0.556	1.00
454_V	457_G	0.555	1.00
10_V	14_T	0.553	1.00
347_A	350_T	0.551	1.00
481_L	484_V	0.550	1.00
312_R	444_F	0.549	1.00
236_A	375_Y	0.548	1.00
290_S	306_L	0.548	1.00
168_N	172_I	0.547	1.00
334_V	337_F	0.547	1.00
27_I	180_P	0.547	1.00
478_L	482_M	0.546	1.00
105_A	109_V	0.546	1.00
188_A	191_W	0.546	1.00
154_W	211_I	0.545	1.00
102_G	131_L	0.544	1.00
249_I	253_F	0.544	1.00
148_G	164_P	0.543	1.00
321_S	325_L	0.543	1.00
166_L	203_Y	0.543	1.00
401_F	409_G	0.542	1.00
88_S	91_L	0.541	1.00
384_V	387_A	0.540	1.00
71_Y	80_T	0.539	1.00
175_A	179_A	0.538	1.00
456_S	459_L	0.538	1.00
486_L	490_A	0.537	1.00
168_N	171_M	0.535	1.00
480_R	483_A	0.534	1.00
86_Y	225_G	0.534	1.00
72_K	155_N	0.533	1.00
35_G	260_G	0.533	1.00
432_Q	436_T	0.533	1.00
448_L	451_A	0.533	1.00
228_R	232_Q	0.530	1.00
135_F	138_I	0.530	1.00
70_E	296_A	0.530	1.00
89_G	217_P	0.529	1.00
5_K	9_A	0.529	1.00
462_M	484_V	0.529	1.00
203_Y	206_P	0.529	1.00
239_G	242_V	0.528	1.00
346_D	349_M	0.528	1.00
454_V	458_V	0.527	1.00
170_S	196_G	0.527	1.00
457_G	460_L	0.526	0.99
251_T	269_D	0.526	0.99
86_Y	223_D	0.526	0.99
194_T	198_V	0.526	0.99
85_S	88_S	0.526	0.99
322_A	358_S	0.524	0.99
103_M	106_A	0.523	0.99
455_M	458_V	0.523	0.99
364_L	418_A	0.522	0.99
71_Y	83_F	0.522	0.99
483_A	486_L	0.521	0.99
282_A	285_T	0.520	0.99
363_G	415_G	0.520	0.99
383_P	425_L	0.520	0.99
455_M	491_A	0.519	0.99
280_G	368_K	0.519	0.99
71_Y	225_G	0.519	0.99
458_V	487_A	0.517	0.99
47_L	51_L	0.517	0.99
382_T	386_I	0.516	0.99
394_T	397_M	0.516	0.99
218_R	221_F	0.515	0.99
96_A	99_T	0.514	0.99
28_V	32_F	0.512	0.99
82_V	85_S	0.511	0.99
200_Q	204_Q	0.510	0.99
414_I	418_A	0.510	0.99
52_R	56_A	0.510	0.99
67_I	71_Y	0.509	0.99
248_I	273_E	0.509	0.99
209_K	213_M	0.506	0.99
390_T	417_A	0.505	0.99
14_T	282_A	0.505	0.99
86_Y	90_L	0.504	0.99
110_I	131_L	0.504	0.99
314_C	318_A	0.503	0.99
200_Q	203_Y	0.503	0.99
328_L	488_G	0.502	0.99
462_M	466_M	0.501	0.99
275_P	280_G	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4lz6A	1	0.8356	100	0.348	Contact Map
4humA	1	0.8493	100	0.366	Contact Map
3w4tA	1	0.8258	100	0.367	Contact Map
3mktA	1	0.8454	100	0.375	Contact Map
3wdoA	1	0.7613	50.7	0.942	Contact Map
2cfqA	1	0.7652	35.2	0.948	Contact Map
1pw4A	1	0.3933	16.2	0.955	Contact Map
4tphA	2	0.3757	15.4	0.956	Contact Map
4w6vA	1	0.3875	13	0.957	Contact Map
3o7qA	1	0.3875	9.3	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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