GREMLIN Database
MURJ - Lipid II flippase MurJ
UniProt: P0AF16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13880
Length: 511 (454)
Sequences: 16690 (14269)
Seq/√Len: 669.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
299_N302_E4.9191.00
227_M231_K3.4181.00
156_R159_I3.2381.00
105_A108_W3.2211.00
443_A447_R3.1761.00
379_D382_T3.0351.00
351_Q355_I2.9571.00
42_F266_Y2.8931.00
326_G355_I2.7671.00
155_N293_K2.7291.00
381_K385_K2.6951.00
379_D432_Q2.6241.00
264_W349_M2.3601.00
329_S351_Q2.3561.00
330_G334_V2.3241.00
356_A408_A2.2911.00
458_V491_A2.2791.00
390_T421_N2.2421.00
250_N265_M2.2301.00
363_G419_C2.2171.00
250_N398_N2.2091.00
185_P188_A2.2031.00
103_M132_K2.1991.00
68_L153_T2.1871.00
353_A407_H2.1631.00
329_S355_I2.1581.00
397_M413_S2.1341.00
294_S302_E2.1311.00
455_M459_L2.1311.00
293_K297_S2.0901.00
238_L384_V2.0691.00
128_S132_K2.0591.00
258_A261_S2.0301.00
402_I410_L2.0021.00
253_F402_I1.9661.00
305_R309_W1.9631.00
66_P70_E1.9561.00
223_D227_M1.9561.00
33_G36_M1.9491.00
9_A158_S1.9401.00
386_I424_L1.9301.00
67_I232_Q1.9231.00
455_M488_G1.9201.00
82_V222_H1.9181.00
405_L412_L1.9131.00
328_L331_P1.8981.00
300_H304_N1.8911.00
323_V456_S1.8801.00
324_A328_L1.8631.00
444_F447_R1.8531.00
356_A415_G1.8301.00
107_P128_S1.8251.00
102_G135_F1.8041.00
459_L488_G1.7931.00
318_A365_I1.7921.00
79_A82_V1.7791.00
331_P334_V1.7731.00
324_A485_V1.7621.00
319_L452_V1.7281.00
307_M373_G1.7141.00
106_A132_K1.7131.00
393_L420_L1.7101.00
250_N414_I1.7101.00
409_G413_S1.6911.00
352_R408_A1.6871.00
253_F398_N1.6811.00
30_R338_Q1.6711.00
353_A411_S1.6511.00
295_F377_R1.6481.00
401_F413_S1.6481.00
150_I154_W1.6371.00
398_N402_I1.6351.00
401_F405_L1.6201.00
322_A362_I1.6091.00
356_A412_L1.6051.00
330_G351_Q1.5851.00
260_G264_W1.5851.00
242_V388_I1.5851.00
70_E378_Q1.5791.00
356_A411_S1.5561.00
423_S427_W1.5551.00
352_R355_I1.5491.00
413_S417_A1.5421.00
155_N290_S1.5401.00
406_K409_G1.5331.00
41_F45_F1.5251.00
333_T350_T1.5241.00
34_A346_D1.5231.00
188_A192_A1.5131.00
261_S407_H1.4991.00
81_R85_S1.4931.00
302_E305_R1.4921.00
330_G355_I1.4841.00
360_G415_G1.4821.00
43_V255_S1.4801.00
338_Q347_A1.4801.00
158_S162_F1.4741.00
254_A410_L1.4681.00
171_M196_G1.4661.00
333_T354_L1.4631.00
304_N308_D1.4591.00
456_S460_L1.4591.00
84_V150_I1.4551.00
156_R211_I1.4441.00
325_L358_S1.4421.00
400_A403_G1.4411.00
253_F399_L1.4221.00
385_K389_V1.4211.00
291_L303_Y1.4191.00
302_E306_L1.4181.00
72_K80_T1.4161.00
328_L332_L1.4131.00
345_F348_L1.4111.00
396_L400_A1.4101.00
461_G464_H1.4051.00
44_A134_T1.4011.00
363_G422_A1.3981.00
29_A267_Y1.3921.00
272_M357_Y1.3891.00
64_F87_V1.3711.00
294_S306_L1.3701.00
39_D260_G1.3631.00
349_M352_R1.3591.00
249_I395_Q1.3451.00
394_T398_N1.3431.00
15_M19_V1.3401.00
254_A262_V1.3341.00
170_S199_L1.3221.00
287_L310_G1.3151.00
130_L190_A1.3141.00
303_Y373_G1.3121.00
427_W431_K1.3111.00
401_F404_P1.3071.00
308_D312_R1.3071.00
16_F165_T1.3021.00
235_P384_V1.3021.00
222_H225_G1.3021.00
177_F181_Y1.3001.00
176_L180_P1.2891.00
268_A353_A1.2851.00
359_V415_G1.2831.00
400_A404_P1.2671.00
174_F192_A1.2641.00
301_D305_R1.2581.00
386_I428_Q1.2561.00
22_F26_A1.2541.00
25_D270_R1.2511.00
26_A30_R1.2391.00
268_A350_T1.2261.00
86_Y226_A1.2221.00
295_F303_Y1.2181.00
34_A264_W1.2121.00
87_V229_V1.2121.00
394_T414_I1.2071.00
82_V86_Y1.2011.00
324_A455_M1.2001.00
173_G177_F1.1961.00
248_I251_T1.1961.00
139_L142_S1.1901.00
393_L397_M1.1831.00
461_G465_I1.1791.00
463_L484_V1.1791.00
106_A128_S1.1741.00
254_A407_H1.1701.00
408_A411_S1.1641.00
386_I425_L1.1611.00
184_P188_A1.1591.00
24_R172_I1.1581.00
234_G238_L1.1581.00
405_L409_G1.1571.00
205_L209_K1.1521.00
17_S168_N1.1511.00
235_P381_K1.1511.00
71_Y79_A1.1491.00
136_P139_L1.1481.00
67_I228_R1.1461.00
333_T351_Q1.1451.00
325_L354_L1.1431.00
288_L292_S1.1411.00
107_P132_K1.1391.00
291_L376_S1.1361.00
373_G429_L1.1321.00
264_W350_T1.1321.00
69_A153_T1.1301.00
398_N414_I1.1291.00
353_A408_A1.1251.00
187_L190_A1.1251.00
398_N401_F1.1191.00
315_F319_L1.1181.00
107_P111_M1.1161.00
13_M161_A1.1121.00
115_P126_L1.1121.00
331_P463_L1.1101.00
19_V23_A1.1091.00
140_L198_V1.1041.00
307_M370_L1.1041.00
482_M486_L1.1041.00
41_F189_L1.1011.00
388_I392_I1.1011.00
333_T337_F1.0991.00
136_P194_T1.0991.00
460_L464_H1.0971.00
163_A203_Y1.0951.00
108_W112_V1.0941.00
360_G363_G1.0911.00
99_T103_M1.0901.00
63_A232_Q1.0851.00
157_F286_I1.0811.00
68_L80_T1.0771.00
294_S299_N1.0731.00
250_N394_T1.0711.00
228_R378_Q1.0701.00
93_L97_V1.0661.00
242_V384_V1.0651.00
245_I391_L1.0651.00
65_V149_A1.0631.00
374_F428_Q1.0591.00
360_G411_S1.0561.00
34_A263_S1.0561.00
232_Q380_I1.0561.00
202_V206_P1.0531.00
36_M40_A1.0531.00
110_I127_T1.0501.00
300_H377_R1.0501.00
452_V456_S1.0501.00
328_L484_V1.0461.00
397_M401_F1.0461.00
301_D304_N1.0431.00
332_L336_L1.0331.00
101_A105_A1.0331.00
394_T417_A1.0331.00
366_V422_A1.0301.00
385_K388_I1.0291.00
99_T102_G1.0271.00
370_L426_Y1.0261.00
140_L201_L1.0241.00
242_V391_L1.0221.00
39_D263_S1.0201.00
70_E228_R1.0181.00
254_A265_M1.0181.00
90_L226_A1.0181.00
89_G93_L1.0171.00
322_A326_G1.0171.00
43_V262_V1.0161.00
427_W430_R1.0161.00
263_S266_Y1.0151.00
42_F263_S1.0141.00
404_P408_A1.0121.00
67_I70_E1.0091.00
327_I456_S1.0081.00
451_A455_M1.0051.00
163_A204_Q1.0031.00
239_G383_P1.0021.00
147_V205_L1.0001.00
25_D337_F0.9991.00
424_L427_W0.9991.00
326_G329_S0.9991.00
79_A225_G0.9991.00
40_A259_S0.9981.00
375_Y383_P0.9961.00
485_V489_I0.9961.00
462_M487_A0.9941.00
370_L425_L0.9931.00
412_L416_L0.9861.00
106_A110_I0.9861.00
88_S147_V0.9811.00
7_L283_L0.9801.00
31_I180_P0.9781.00
104_L107_P0.9771.00
246_S394_T0.9741.00
80_T154_W0.9741.00
126_L129_Q0.9731.00
66_P378_Q0.9701.00
159_I207_H0.9681.00
191_W195_V0.9681.00
7_L286_I0.9681.00
382_T428_Q0.9681.00
258_A262_V0.9671.00
63_A233_M0.9671.00
10_V286_I0.9651.00
29_A337_F0.9631.00
110_I128_S0.9621.00
132_K136_P0.9591.00
415_G418_A0.9581.00
335_S481_L0.9561.00
225_G228_R0.9501.00
355_I359_V0.9481.00
268_A357_Y0.9481.00
103_M107_P0.9471.00
267_Y337_F0.9451.00
191_W194_T0.9441.00
442_M446_L0.9411.00
129_Q132_K0.9381.00
303_Y377_R0.9381.00
348_L352_R0.9371.00
224_A227_M0.9341.00
68_L154_W0.9331.00
56_A61_S0.9331.00
177_F180_P0.9311.00
174_F178_A0.9301.00
392_I396_L0.9301.00
85_S89_G0.9291.00
348_L351_Q0.9281.00
83_F87_V0.9261.00
10_V161_A0.9261.00
263_S267_Y0.9251.00
192_A196_G0.9231.00
329_S354_L0.9231.00
446_L450_V0.9201.00
430_R433_K0.9181.00
420_L424_L0.9151.00
27_I31_I0.9131.00
460_L463_L0.9121.00
20_L172_I0.9091.00
63_A229_V0.9091.00
11_S282_A0.9071.00
323_V452_V0.9051.00
26_A337_F0.9041.00
115_P125_A0.9031.00
135_F139_L0.8971.00
357_Y411_S0.8941.00
251_T262_V0.8921.00
320_P492_Y0.8901.00
480_R484_V0.8881.00
33_G346_D0.8871.00
326_G359_V0.8861.00
63_A67_I0.8851.00
104_L108_W0.8851.00
444_F448_L0.8831.00
193_V197_G0.8831.00
397_M416_L0.8821.00
253_F257_L0.8801.00
129_Q187_L0.8801.00
230_V233_M0.8761.00
44_A130_L0.8751.00
290_S293_K0.8731.00
14_T18_R0.8701.00
175_A192_A0.8701.00
93_L96_A0.8701.00
457_G461_G0.8681.00
230_V234_G0.8671.00
350_T353_A0.8601.00
174_F195_V0.8601.00
464_H467_P0.8591.00
28_V189_L0.8581.00
96_A100_V0.8561.00
399_L403_G0.8561.00
77_E81_R0.8541.00
97_V101_A0.8541.00
464_H468_E0.8531.00
312_R316_L0.8531.00
6_S155_N0.8481.00
484_V488_G0.8461.00
272_M361_L0.8401.00
262_V266_Y0.8391.00
412_L415_G0.8391.00
309_W312_R0.8391.00
37_A42_F0.8341.00
382_T385_K0.8331.00
99_T139_L0.8321.00
326_G330_G0.8321.00
95_L142_S0.8311.00
106_A135_F0.8311.00
428_Q431_K0.8291.00
100_V104_L0.8261.00
26_A29_A0.8221.00
108_W111_M0.8181.00
194_T197_G0.8181.00
60_F87_V0.8181.00
408_A412_L0.8141.00
78_D82_V0.8131.00
426_Y430_R0.8101.00
320_P452_V0.8091.00
171_M175_A0.8091.00
360_G414_I0.8061.00
46_K251_T0.8041.00
268_A354_L0.8041.00
203_Y207_H0.8031.00
58_G233_M0.8021.00
452_V455_M0.8001.00
148_G152_N0.7991.00
206_P210_K0.7991.00
374_F383_P0.7981.00
403_G410_L0.7981.00
178_A184_P0.7971.00
292_S296_A0.7951.00
34_A260_G0.7941.00
140_L194_T0.7941.00
430_R434_I0.7931.00
324_A489_I0.7921.00
265_M357_Y0.7881.00
335_S478_L0.7881.00
331_P484_V0.7881.00
236_A380_I0.7851.00
242_V387_A0.7841.00
261_S264_W0.7831.00
383_P387_A0.7831.00
359_V363_G0.7811.00
196_G200_Q0.7811.00
334_V348_L0.7791.00
45_F49_N0.7771.00
257_L402_I0.7771.00
397_M400_A0.7711.00
41_F186_V0.7711.00
441_W444_F0.7671.00
270_R274_F0.7671.00
389_V424_L0.7661.00
359_V362_I0.7651.00
424_L428_Q0.7631.00
290_S294_S0.7601.00
314_C365_I0.7581.00
31_I179_A0.7571.00
133_I194_T0.7561.00
294_S297_S0.7551.00
334_V338_Q0.7551.00
189_L193_V0.7551.00
95_L99_T0.7531.00
137_Y197_G0.7531.00
7_L11_S0.7521.00
90_L94_A0.7511.00
92_T96_A0.7491.00
20_L24_R0.7481.00
372_P375_Y0.7461.00
9_A13_M0.7461.00
398_N410_L0.7461.00
64_F83_F0.7451.00
324_A488_G0.7451.00
231_K235_P0.7451.00
49_N53_R0.7441.00
269_D273_E0.7431.00
306_L310_G0.7391.00
267_Y270_R0.7361.00
235_P380_I0.7341.00
241_S245_I0.7301.00
8_A12_S0.7301.00
151_L208_L0.7301.00
428_Q432_Q0.7271.00
266_Y270_R0.7271.00
320_P323_V0.7251.00
441_W448_L0.7251.00
459_L463_L0.7241.00
448_L452_V0.7241.00
419_C423_S0.7211.00
64_F68_L0.7211.00
338_Q346_D0.7201.00
288_L372_P0.7171.00
125_A129_Q0.7161.00
386_I390_T0.7141.00
485_V488_G0.7141.00
26_A336_L0.7121.00
72_K154_W0.7121.00
280_G284_G0.7101.00
310_G369_V0.7091.00
169_I173_G0.7041.00
443_A446_L0.7041.00
167_L171_M0.7011.00
393_L396_L0.7011.00
172_I176_L0.7011.00
174_F177_F0.7001.00
5_K158_S0.7001.00
77_E80_T0.6981.00
34_A347_A0.6971.00
25_D29_A0.6951.00
429_L432_Q0.6951.00
326_G358_S0.6931.00
321_S324_A0.6921.00
28_V175_A0.6921.00
316_L320_P0.6921.00
252_I256_F0.6881.00
231_K234_G0.6871.00
372_P376_S0.6861.00
35_G259_S0.6861.00
449_V452_V0.6861.00
306_L309_W0.6841.00
323_V327_I0.6831.00
231_K381_K0.6831.00
131_L135_F0.6821.00
395_Q399_L0.6801.00
384_V388_I0.6801.00
250_N269_D0.6791.00
459_L484_V0.6791.00
12_S16_F0.6791.00
288_L376_S0.6781.00
244_Q248_I0.6771.00
286_I289_P0.6771.00
32_F186_V0.6761.00
65_V153_T0.6711.00
248_I252_I0.6671.00
481_L485_V0.6661.00
49_N52_R0.6651.00
314_C369_V0.6621.00
43_V46_K0.6611.00
224_A228_R0.6531.00
82_V225_G0.6521.00
56_A91_L0.6501.00
207_H211_I0.6481.00
204_Q208_L0.6441.00
66_P380_I0.6431.00
97_V100_V0.6421.00
320_P455_M0.6411.00
4_L8_A0.6401.00
106_A131_L0.6401.00
66_P376_S0.6391.00
267_Y347_A0.6391.00
331_P480_R0.6381.00
272_M275_P0.6371.00
453_L457_G0.6371.00
152_N160_P0.6361.00
463_L480_R0.6351.00
354_L358_S0.6331.00
327_I459_L0.6331.00
226_A230_V0.6321.00
178_A181_Y0.6321.00
78_D81_R0.6321.00
246_S391_L0.6321.00
370_L422_A0.6321.00
323_V326_G0.6311.00
167_L200_Q0.6291.00
374_F429_L0.6281.00
83_F225_G0.6211.00
144_A201_L0.6181.00
6_S286_I0.6181.00
61_S149_A0.6171.00
159_I162_F0.6151.00
270_R273_E0.6151.00
65_V69_A0.6101.00
270_R337_F0.6101.00
271_L337_F0.6101.00
13_M165_T0.6081.00
414_I417_A0.6081.00
239_G387_A0.6061.00
11_S15_M0.6061.00
106_A109_V0.6061.00
48_P52_R0.6041.00
402_I409_G0.6031.00
132_K135_F0.6021.00
389_V392_I0.6011.00
370_L429_L0.6001.00
462_M465_I0.5991.00
380_I383_P0.5981.00
229_V233_M0.5981.00
68_L84_V0.5971.00
398_N413_S0.5961.00
360_G418_A0.5951.00
99_T135_F0.5951.00
151_L159_I0.5951.00
329_S358_S0.5941.00
265_M269_D0.5941.00
35_G40_A0.5931.00
10_V157_F0.5931.00
50_L244_Q0.5931.00
133_I191_W0.5921.00
255_S262_V0.5911.00
85_S219_I0.5891.00
48_P138_I0.5871.00
21_G25_D0.5861.00
163_A200_Q0.5851.00
33_G347_A0.5831.00
27_I176_L0.5821.00
193_V196_G0.5821.00
320_P324_A0.5821.00
16_F20_L0.5811.00
394_T413_S0.5801.00
261_S265_M0.5801.00
41_F190_A0.5801.00
125_A128_S0.5791.00
465_I468_E0.5781.00
141_I197_G0.5781.00
16_F169_I0.5771.00
25_D37_A0.5771.00
393_L417_A0.5761.00
37_A267_Y0.5761.00
32_F36_M0.5741.00
129_Q133_I0.5741.00
367_V422_A0.5731.00
163_A167_L0.5731.00
463_L467_P0.5721.00
267_Y350_T0.5711.00
89_G92_T0.5701.00
415_G419_C0.5701.00
451_A492_Y0.5691.00
388_I391_L0.5691.00
431_K434_I0.5681.00
232_Q236_A0.5681.00
162_F166_L0.5681.00
334_V351_Q0.5681.00
171_M192_A0.5671.00
283_L287_L0.5671.00
43_V251_T0.5661.00
330_G348_L0.5641.00
170_S173_G0.5631.00
107_P110_I0.5631.00
181_Y184_P0.5591.00
294_S303_Y0.5581.00
187_L191_W0.5581.00
185_P192_A0.5571.00
149_A153_T0.5561.00
454_V457_G0.5551.00
10_V14_T0.5531.00
347_A350_T0.5511.00
481_L484_V0.5501.00
312_R444_F0.5491.00
236_A375_Y0.5481.00
290_S306_L0.5481.00
168_N172_I0.5471.00
334_V337_F0.5471.00
27_I180_P0.5471.00
478_L482_M0.5461.00
105_A109_V0.5461.00
188_A191_W0.5461.00
154_W211_I0.5451.00
102_G131_L0.5441.00
249_I253_F0.5441.00
148_G164_P0.5431.00
321_S325_L0.5431.00
166_L203_Y0.5431.00
401_F409_G0.5421.00
88_S91_L0.5411.00
384_V387_A0.5401.00
71_Y80_T0.5391.00
175_A179_A0.5381.00
456_S459_L0.5381.00
486_L490_A0.5371.00
168_N171_M0.5351.00
480_R483_A0.5341.00
86_Y225_G0.5341.00
72_K155_N0.5331.00
35_G260_G0.5331.00
432_Q436_T0.5331.00
448_L451_A0.5331.00
228_R232_Q0.5301.00
135_F138_I0.5301.00
70_E296_A0.5301.00
89_G217_P0.5291.00
5_K9_A0.5291.00
462_M484_V0.5291.00
203_Y206_P0.5291.00
239_G242_V0.5281.00
346_D349_M0.5281.00
454_V458_V0.5271.00
170_S196_G0.5271.00
457_G460_L0.5260.99
251_T269_D0.5260.99
86_Y223_D0.5260.99
194_T198_V0.5260.99
85_S88_S0.5260.99
322_A358_S0.5240.99
103_M106_A0.5230.99
455_M458_V0.5230.99
364_L418_A0.5220.99
71_Y83_F0.5220.99
483_A486_L0.5210.99
282_A285_T0.5200.99
363_G415_G0.5200.99
383_P425_L0.5200.99
455_M491_A0.5190.99
280_G368_K0.5190.99
71_Y225_G0.5190.99
458_V487_A0.5170.99
47_L51_L0.5170.99
382_T386_I0.5160.99
394_T397_M0.5160.99
218_R221_F0.5150.99
96_A99_T0.5140.99
28_V32_F0.5120.99
82_V85_S0.5110.99
200_Q204_Q0.5100.99
414_I418_A0.5100.99
52_R56_A0.5100.99
67_I71_Y0.5090.99
248_I273_E0.5090.99
209_K213_M0.5060.99
390_T417_A0.5050.99
14_T282_A0.5050.99
86_Y90_L0.5040.99
110_I131_L0.5040.99
314_C318_A0.5030.99
200_Q203_Y0.5030.99
328_L488_G0.5020.99
462_M466_M0.5010.99
275_P280_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.8356 100 0.348 Contact Map
4humA 1 0.8493 100 0.366 Contact Map
3w4tA 1 0.8258 100 0.367 Contact Map
3mktA 1 0.8454 100 0.375 Contact Map
3wdoA 1 0.7613 50.7 0.942 Contact Map
2cfqA 1 0.7652 35.2 0.948 Contact Map
1pw4A 1 0.3933 16.2 0.955 Contact Map
4tphA 2 0.3757 15.4 0.956 Contact Map
4w6vA 1 0.3875 13 0.957 Contact Map
3o7qA 1 0.3875 9.3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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