MTNN - ECOLI - GREMLIN Contacts

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MTNN - 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

UniProt:	P0AF12	Sequences: MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11090
Length:	232 (217)
Sequences:	5222 (3824)
Seq/√Len:	259.6

ECOLI - MTNN DEOD UDP
BACSU - MTNN DEOD
HALSA - Q9HP14 Q9HR25
SULSO - PNPH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
22_N	37_Q	3.419	1.00
146_V	168_A	3.152	1.00
77_A	195_I	3.015	1.00
52_K	149_D	2.797	1.00
122_D	188_P	2.655	1.00
4_G	62_L	2.609	1.00
93_D	142_R	2.422	1.00
175_A	191_V	2.370	1.00
130_E	142_R	2.308	1.00
98_H	148_G	2.245	1.00
63_L	187_V	2.232	1.00
5_I	16_L	2.214	1.00
157_G	160_K	2.214	1.00
160_K	164_N	2.213	1.00
94_E	120_K	2.131	1.00
94_E	118_G	2.129	1.00
90_V	170_A	2.115	1.00
7_G	13_V	2.108	1.00
24_Q	35_T	2.056	1.00
94_E	144_L	2.051	1.00
127_A	131_A	2.018	1.00
37_Q	42_E	1.975	1.00
61_L	64_E	1.920	1.00
172_E	175_A	1.896	1.00
70_V	188_P	1.878	1.00
60_T	185_F	1.821	1.00
81_A	169_I	1.819	1.00
60_T	64_E	1.801	1.00
159_A	163_H	1.792	1.00
77_A	170_A	1.774	1.00
69_D	187_V	1.734	1.00
126_I	142_R	1.717	1.00
129_A	190_V	1.692	1.00
170_A	195_I	1.690	1.00
143_G	169_I	1.655	1.00
64_E	185_F	1.648	1.00
154_G	157_G	1.614	1.00
123_D	127_A	1.590	1.00
52_K	147_S	1.578	1.00
55_A	178_I	1.573	1.00
52_K	177_A	1.562	1.00
10_E	47_K	1.557	1.00
84_L	141_V	1.511	1.00
27_S	32_E	1.501	1.00
141_V	169_I	1.489	1.00
8_A	73_N	1.449	1.00
26_I	66_C	1.441	1.00
71_I	182_C	1.428	1.00
90_V	169_I	1.422	1.00
59_A	71_I	1.410	1.00
25_T	32_E	1.403	1.00
79_G	195_I	1.402	1.00
97_Y	180_H	1.397	1.00
46_L	58_G	1.391	1.00
92_S	121_A	1.388	1.00
63_L	71_I	1.370	1.00
159_A	162_R	1.370	1.00
10_E	14_T	1.357	1.00
97_Y	176_T	1.333	1.00
63_L	68_P	1.317	1.00
126_I	190_V	1.296	1.00
92_S	145_I	1.294	1.00
80_L	171_V	1.292	1.00
95_A	191_V	1.286	1.00
146_V	161_I	1.279	1.00
24_Q	42_E	1.261	1.00
130_E	134_A	1.261	1.00
95_A	179_A	1.259	1.00
21_E	37_Q	1.259	1.00
26_I	35_T	1.254	1.00
79_G	198_V	1.252	1.00
20_I	36_G	1.248	1.00
90_V	195_I	1.242	1.00
59_A	181_V	1.241	1.00
97_Y	100_A	1.229	1.00
206_S	209_E	1.227	1.00
17_R	34_Y	1.223	1.00
57_L	181_V	1.223	1.00
73_N	178_I	1.220	1.00
127_A	130_E	1.217	1.00
91_V	126_I	1.217	1.00
83_T	141_V	1.214	1.00
96_R	146_V	1.209	1.00
101_D	105_F	1.203	1.00
145_I	170_A	1.193	1.00
205_L	208_D	1.187	1.00
158_L	162_R	1.185	1.00
145_I	193_R	1.183	1.00
28_L	65_H	1.161	1.00
85_K	88_D	1.156	1.00
89_I	194_A	1.143	1.00
52_K	99_D	1.137	1.00
78_G	199_A	1.134	1.00
59_A	178_I	1.133	1.00
102_V	105_F	1.129	1.00
102_V	107_Y	1.117	1.00
14_T	18_D	1.117	1.00
156_V	159_A	1.114	1.00
109_Y	164_N	1.110	1.00
207_F	211_L	1.110	1.00
182_C	189_F	1.109	1.00
179_A	189_F	1.107	1.00
33_I	44_A	1.095	1.00
79_G	84_L	1.092	1.00
96_R	118_G	1.063	1.00
31_C	47_K	1.063	1.00
104_A	107_Y	1.053	1.00
93_D	133_I	1.050	1.00
33_I	66_C	1.043	1.00
220_L	224_S	1.042	1.00
20_I	23_R	1.036	1.00
13_V	34_Y	1.028	1.00
80_L	168_A	1.023	1.00
17_R	23_R	1.013	1.00
194_A	210_F	1.005	1.00
77_A	90_V	1.004	1.00
127_A	134_A	0.993	1.00
214_A	218_S	0.992	1.00
93_D	144_L	0.992	1.00
37_Q	40_G	0.987	1.00
91_V	218_S	0.987	1.00
155_S	159_A	0.987	1.00
46_L	62_L	0.982	1.00
104_A	108_E	0.978	1.00
133_I	140_A	0.968	1.00
57_L	60_T	0.967	1.00
98_H	150_A	0.955	1.00
125_L	129_A	0.951	1.00
20_I	45_L	0.945	1.00
216_K	220_L	0.944	1.00
104_A	110_G	0.944	1.00
80_L	199_A	0.943	1.00
200_D	203_S	0.940	1.00
103_T	106_G	0.938	1.00
78_G	171_V	0.936	1.00
101_D	108_E	0.936	1.00
165_F	168_A	0.931	1.00
55_A	177_A	0.930	1.00
80_L	162_R	0.929	1.00
124_K	128_A	0.928	1.00
211_L	216_K	0.928	1.00
213_V	217_Q	0.923	1.00
91_V	140_A	0.922	1.00
150_A	157_G	0.917	1.00
53_V	149_D	0.915	1.00
91_V	130_E	0.913	1.00
77_A	193_R	0.910	1.00
135_E	224_S	0.909	1.00
215_A	219_S	0.908	1.00
13_V	45_L	0.907	1.00
210_F	214_A	0.907	1.00
38_L	223_E	0.904	1.00
212_A	216_K	0.903	1.00
100_A	105_F	0.886	1.00
213_V	216_K	0.882	1.00
102_V	106_G	0.881	1.00
106_G	110_G	0.874	1.00
81_A	84_L	0.871	1.00
147_S	175_A	0.868	1.00
95_A	175_A	0.868	1.00
63_L	185_F	0.866	1.00
53_V	57_L	0.863	1.00
26_I	46_L	0.858	1.00
126_I	130_E	0.857	1.00
152_I	171_V	0.856	1.00
177_A	181_V	0.854	1.00
171_V	197_D	0.852	0.99
16_L	19_K	0.852	0.99
11_E	209_E	0.847	0.99
85_K	198_V	0.843	0.99
44_A	66_C	0.837	0.99
19_K	223_E	0.836	0.99
131_A	135_E	0.834	0.99
105_F	108_E	0.831	0.99
76_S	211_L	0.826	0.99
219_S	223_E	0.825	0.99
119_F	180_H	0.825	0.99
151_F	173_M	0.824	0.99
156_V	160_K	0.817	0.99
17_R	45_L	0.813	0.99
207_F	210_F	0.803	0.99
29_G	65_H	0.802	0.99
144_L	168_A	0.799	0.99
76_S	197_D	0.796	0.99
49_G	126_I	0.781	0.99
36_G	43_V	0.778	0.99
101_D	104_A	0.775	0.99
198_V	201_Q	0.774	0.99
131_A	134_A	0.771	0.99
99_D	149_D	0.770	0.99
56_A	177_A	0.769	0.99
91_V	190_V	0.761	0.99
71_I	187_V	0.755	0.99
72_I	219_S	0.749	0.99
33_I	61_L	0.747	0.99
92_S	190_V	0.744	0.99
110_G	165_F	0.742	0.99
51_G	173_M	0.741	0.99
122_D	125_L	0.740	0.99
148_G	152_I	0.737	0.99
32_E	47_K	0.734	0.98
102_V	108_E	0.734	0.98
80_L	158_L	0.733	0.98
89_I	214_A	0.727	0.98
128_A	131_A	0.726	0.98
104_A	109_Y	0.722	0.98
56_A	60_T	0.713	0.98
23_R	34_Y	0.710	0.98
76_S	207_F	0.709	0.98
120_K	185_F	0.708	0.98
29_G	33_I	0.704	0.98
218_S	221_M	0.696	0.98
47_K	133_I	0.688	0.98
70_V	124_K	0.687	0.98
101_D	151_F	0.687	0.98
89_I	218_S	0.686	0.98
132_C	135_E	0.685	0.98
10_E	17_R	0.685	0.98
118_G	144_L	0.684	0.98
148_G	161_I	0.681	0.98
103_T	107_Y	0.680	0.98
70_V	125_L	0.678	0.97
199_A	203_S	0.675	0.97
103_T	150_A	0.672	0.97
161_I	165_F	0.661	0.97
99_D	102_V	0.658	0.97
158_L	161_I	0.656	0.97
128_A	132_C	0.656	0.97
14_T	17_R	0.650	0.97
29_G	61_L	0.646	0.97
121_A	126_I	0.645	0.97
4_G	71_I	0.641	0.96
120_K	123_D	0.641	0.96
103_T	110_G	0.640	0.96
92_S	95_A	0.639	0.96
50_I	196_S	0.639	0.96
173_M	203_S	0.638	0.96
115_C	119_F	0.637	0.96
15_L	219_S	0.636	0.96
100_A	107_Y	0.631	0.96
152_I	157_G	0.628	0.96
95_A	189_F	0.627	0.96
208_D	212_A	0.625	0.96
30_G	61_L	0.624	0.96
220_L	223_E	0.624	0.96
99_D	150_A	0.624	0.96
101_D	106_G	0.622	0.96
218_S	222_V	0.618	0.96
172_E	191_V	0.618	0.96
161_I	164_N	0.617	0.96
105_F	109_Y	0.617	0.96
35_T	66_C	0.616	0.96
205_L	209_E	0.614	0.96
62_L	68_P	0.612	0.95
160_K	163_H	0.610	0.95
101_D	107_Y	0.607	0.95
13_V	17_R	0.606	0.95
124_K	127_A	0.605	0.95
217_Q	220_L	0.600	0.95
126_I	129_A	0.599	0.95
102_V	109_Y	0.599	0.95
55_A	59_A	0.598	0.95
56_A	181_V	0.598	0.95
153_N	204_H	0.594	0.95
15_L	18_D	0.593	0.95
85_K	203_S	0.593	0.95
146_V	171_V	0.592	0.95
52_K	97_Y	0.589	0.94
89_I	138_L	0.588	0.94
151_F	203_S	0.588	0.94
116_P	183_H	0.587	0.94
32_E	127_A	0.586	0.94
196_S	205_L	0.579	0.94
57_L	61_L	0.577	0.94
7_G	15_L	0.577	0.94
116_P	119_F	0.576	0.94
84_L	195_I	0.571	0.93
221_M	224_S	0.570	0.93
21_E	36_G	0.569	0.93
145_I	172_E	0.567	0.93
158_L	201_Q	0.565	0.93
129_A	132_C	0.564	0.93
79_G	86_V	0.563	0.93
8_A	173_M	0.559	0.93
154_G	184_N	0.558	0.93
90_V	145_I	0.558	0.93
173_M	205_L	0.556	0.93
8_A	12_E	0.556	0.93
4_G	44_A	0.554	0.92
124_K	188_P	0.554	0.92
107_Y	110_G	0.550	0.92
35_T	42_E	0.547	0.92
39_N	223_E	0.546	0.92
84_L	90_V	0.545	0.92
85_K	201_Q	0.544	0.92
6_I	178_I	0.543	0.92
98_H	101_D	0.543	0.92
59_A	63_L	0.543	0.92
21_E	24_Q	0.543	0.92
6_I	73_N	0.541	0.91
15_L	216_K	0.540	0.91
98_H	171_V	0.538	0.91
211_L	215_A	0.538	0.91
171_V	199_A	0.538	0.91
9_M	50_I	0.536	0.91
121_A	179_A	0.535	0.91
108_E	114_G	0.532	0.91
25_T	34_Y	0.529	0.91
211_L	219_S	0.527	0.90
81_A	141_V	0.526	0.90
80_L	148_G	0.526	0.90
125_L	190_V	0.523	0.90
180_H	184_N	0.522	0.90
198_V	203_S	0.521	0.90
175_A	193_R	0.521	0.90
29_G	185_F	0.518	0.90
120_K	144_L	0.514	0.89
28_L	64_E	0.513	0.89
208_D	211_L	0.511	0.89
103_T	108_E	0.508	0.89
99_D	148_G	0.508	0.89
91_V	142_R	0.508	0.89
31_C	58_G	0.506	0.89
211_L	217_Q	0.504	0.88
99_D	106_G	0.503	0.88
107_Y	114_G	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qezB	2	0.9784	100	0.207	Contact Map
1zosA	2	0.9914	100	0.21	Contact Map
3bl6A	2	0.9871	100	0.217	Contact Map
3dp9A	2	0.9871	100	0.224	Contact Map
3eeiA	2	0.9871	100	0.23	Contact Map
4josA	2	0.9784	100	0.23	Contact Map
4l0mA	2	0.9784	100	0.233	Contact Map
4f1wA	2	1	100	0.235	Contact Map
4oy3A	2	0.9828	100	0.237	Contact Map
4g41A	2	0.9957	100	0.238	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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