GREMLIN Database
MTNN - 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
UniProt: P0AF12 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11090
Length: 232 (217)
Sequences: 5222 (3824)
Seq/√Len: 259.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_N37_Q3.4191.00
146_V168_A3.1521.00
77_A195_I3.0151.00
52_K149_D2.7971.00
122_D188_P2.6551.00
4_G62_L2.6091.00
93_D142_R2.4221.00
175_A191_V2.3701.00
130_E142_R2.3081.00
98_H148_G2.2451.00
63_L187_V2.2321.00
5_I16_L2.2141.00
157_G160_K2.2141.00
160_K164_N2.2131.00
94_E120_K2.1311.00
94_E118_G2.1291.00
90_V170_A2.1151.00
7_G13_V2.1081.00
24_Q35_T2.0561.00
94_E144_L2.0511.00
127_A131_A2.0181.00
37_Q42_E1.9751.00
61_L64_E1.9201.00
172_E175_A1.8961.00
70_V188_P1.8781.00
60_T185_F1.8211.00
81_A169_I1.8191.00
60_T64_E1.8011.00
159_A163_H1.7921.00
77_A170_A1.7741.00
69_D187_V1.7341.00
126_I142_R1.7171.00
129_A190_V1.6921.00
170_A195_I1.6901.00
143_G169_I1.6551.00
64_E185_F1.6481.00
154_G157_G1.6141.00
123_D127_A1.5901.00
52_K147_S1.5781.00
55_A178_I1.5731.00
52_K177_A1.5621.00
10_E47_K1.5571.00
84_L141_V1.5111.00
27_S32_E1.5011.00
141_V169_I1.4891.00
8_A73_N1.4491.00
26_I66_C1.4411.00
71_I182_C1.4281.00
90_V169_I1.4221.00
59_A71_I1.4101.00
25_T32_E1.4031.00
79_G195_I1.4021.00
97_Y180_H1.3971.00
46_L58_G1.3911.00
92_S121_A1.3881.00
63_L71_I1.3701.00
159_A162_R1.3701.00
10_E14_T1.3571.00
97_Y176_T1.3331.00
63_L68_P1.3171.00
126_I190_V1.2961.00
92_S145_I1.2941.00
80_L171_V1.2921.00
95_A191_V1.2861.00
146_V161_I1.2791.00
24_Q42_E1.2611.00
130_E134_A1.2611.00
95_A179_A1.2591.00
21_E37_Q1.2591.00
26_I35_T1.2541.00
79_G198_V1.2521.00
20_I36_G1.2481.00
90_V195_I1.2421.00
59_A181_V1.2411.00
97_Y100_A1.2291.00
206_S209_E1.2271.00
17_R34_Y1.2231.00
57_L181_V1.2231.00
73_N178_I1.2201.00
127_A130_E1.2171.00
91_V126_I1.2171.00
83_T141_V1.2141.00
96_R146_V1.2091.00
101_D105_F1.2031.00
145_I170_A1.1931.00
205_L208_D1.1871.00
158_L162_R1.1851.00
145_I193_R1.1831.00
28_L65_H1.1611.00
85_K88_D1.1561.00
89_I194_A1.1431.00
52_K99_D1.1371.00
78_G199_A1.1341.00
59_A178_I1.1331.00
102_V105_F1.1291.00
102_V107_Y1.1171.00
14_T18_D1.1171.00
156_V159_A1.1141.00
109_Y164_N1.1101.00
207_F211_L1.1101.00
182_C189_F1.1091.00
179_A189_F1.1071.00
33_I44_A1.0951.00
79_G84_L1.0921.00
96_R118_G1.0631.00
31_C47_K1.0631.00
104_A107_Y1.0531.00
93_D133_I1.0501.00
33_I66_C1.0431.00
220_L224_S1.0421.00
20_I23_R1.0361.00
13_V34_Y1.0281.00
80_L168_A1.0231.00
17_R23_R1.0131.00
194_A210_F1.0051.00
77_A90_V1.0041.00
127_A134_A0.9931.00
214_A218_S0.9921.00
93_D144_L0.9921.00
37_Q40_G0.9871.00
91_V218_S0.9871.00
155_S159_A0.9871.00
46_L62_L0.9821.00
104_A108_E0.9781.00
133_I140_A0.9681.00
57_L60_T0.9671.00
98_H150_A0.9551.00
125_L129_A0.9511.00
20_I45_L0.9451.00
216_K220_L0.9441.00
104_A110_G0.9441.00
80_L199_A0.9431.00
200_D203_S0.9401.00
103_T106_G0.9381.00
78_G171_V0.9361.00
101_D108_E0.9361.00
165_F168_A0.9311.00
55_A177_A0.9301.00
80_L162_R0.9291.00
124_K128_A0.9281.00
211_L216_K0.9281.00
213_V217_Q0.9231.00
91_V140_A0.9221.00
150_A157_G0.9171.00
53_V149_D0.9151.00
91_V130_E0.9131.00
77_A193_R0.9101.00
135_E224_S0.9091.00
215_A219_S0.9081.00
13_V45_L0.9071.00
210_F214_A0.9071.00
38_L223_E0.9041.00
212_A216_K0.9031.00
100_A105_F0.8861.00
213_V216_K0.8821.00
102_V106_G0.8811.00
106_G110_G0.8741.00
81_A84_L0.8711.00
147_S175_A0.8681.00
95_A175_A0.8681.00
63_L185_F0.8661.00
53_V57_L0.8631.00
26_I46_L0.8581.00
126_I130_E0.8571.00
152_I171_V0.8561.00
177_A181_V0.8541.00
171_V197_D0.8520.99
16_L19_K0.8520.99
11_E209_E0.8470.99
85_K198_V0.8430.99
44_A66_C0.8370.99
19_K223_E0.8360.99
131_A135_E0.8340.99
105_F108_E0.8310.99
76_S211_L0.8260.99
219_S223_E0.8250.99
119_F180_H0.8250.99
151_F173_M0.8240.99
156_V160_K0.8170.99
17_R45_L0.8130.99
207_F210_F0.8030.99
29_G65_H0.8020.99
144_L168_A0.7990.99
76_S197_D0.7960.99
49_G126_I0.7810.99
36_G43_V0.7780.99
101_D104_A0.7750.99
198_V201_Q0.7740.99
131_A134_A0.7710.99
99_D149_D0.7700.99
56_A177_A0.7690.99
91_V190_V0.7610.99
71_I187_V0.7550.99
72_I219_S0.7490.99
33_I61_L0.7470.99
92_S190_V0.7440.99
110_G165_F0.7420.99
51_G173_M0.7410.99
122_D125_L0.7400.99
148_G152_I0.7370.99
32_E47_K0.7340.98
102_V108_E0.7340.98
80_L158_L0.7330.98
89_I214_A0.7270.98
128_A131_A0.7260.98
104_A109_Y0.7220.98
56_A60_T0.7130.98
23_R34_Y0.7100.98
76_S207_F0.7090.98
120_K185_F0.7080.98
29_G33_I0.7040.98
218_S221_M0.6960.98
47_K133_I0.6880.98
70_V124_K0.6870.98
101_D151_F0.6870.98
89_I218_S0.6860.98
132_C135_E0.6850.98
10_E17_R0.6850.98
118_G144_L0.6840.98
148_G161_I0.6810.98
103_T107_Y0.6800.98
70_V125_L0.6780.97
199_A203_S0.6750.97
103_T150_A0.6720.97
161_I165_F0.6610.97
99_D102_V0.6580.97
158_L161_I0.6560.97
128_A132_C0.6560.97
14_T17_R0.6500.97
29_G61_L0.6460.97
121_A126_I0.6450.97
4_G71_I0.6410.96
120_K123_D0.6410.96
103_T110_G0.6400.96
92_S95_A0.6390.96
50_I196_S0.6390.96
173_M203_S0.6380.96
115_C119_F0.6370.96
15_L219_S0.6360.96
100_A107_Y0.6310.96
152_I157_G0.6280.96
95_A189_F0.6270.96
208_D212_A0.6250.96
30_G61_L0.6240.96
220_L223_E0.6240.96
99_D150_A0.6240.96
101_D106_G0.6220.96
218_S222_V0.6180.96
172_E191_V0.6180.96
161_I164_N0.6170.96
105_F109_Y0.6170.96
35_T66_C0.6160.96
205_L209_E0.6140.96
62_L68_P0.6120.95
160_K163_H0.6100.95
101_D107_Y0.6070.95
13_V17_R0.6060.95
124_K127_A0.6050.95
217_Q220_L0.6000.95
126_I129_A0.5990.95
102_V109_Y0.5990.95
55_A59_A0.5980.95
56_A181_V0.5980.95
153_N204_H0.5940.95
15_L18_D0.5930.95
85_K203_S0.5930.95
146_V171_V0.5920.95
52_K97_Y0.5890.94
89_I138_L0.5880.94
151_F203_S0.5880.94
116_P183_H0.5870.94
32_E127_A0.5860.94
196_S205_L0.5790.94
57_L61_L0.5770.94
7_G15_L0.5770.94
116_P119_F0.5760.94
84_L195_I0.5710.93
221_M224_S0.5700.93
21_E36_G0.5690.93
145_I172_E0.5670.93
158_L201_Q0.5650.93
129_A132_C0.5640.93
79_G86_V0.5630.93
8_A173_M0.5590.93
154_G184_N0.5580.93
90_V145_I0.5580.93
173_M205_L0.5560.93
8_A12_E0.5560.93
4_G44_A0.5540.92
124_K188_P0.5540.92
107_Y110_G0.5500.92
35_T42_E0.5470.92
39_N223_E0.5460.92
84_L90_V0.5450.92
85_K201_Q0.5440.92
6_I178_I0.5430.92
98_H101_D0.5430.92
59_A63_L0.5430.92
21_E24_Q0.5430.92
6_I73_N0.5410.91
15_L216_K0.5400.91
98_H171_V0.5380.91
211_L215_A0.5380.91
171_V199_A0.5380.91
9_M50_I0.5360.91
121_A179_A0.5350.91
108_E114_G0.5320.91
25_T34_Y0.5290.91
211_L219_S0.5270.90
81_A141_V0.5260.90
80_L148_G0.5260.90
125_L190_V0.5230.90
180_H184_N0.5220.90
198_V203_S0.5210.90
175_A193_R0.5210.90
29_G185_F0.5180.90
120_K144_L0.5140.89
28_L64_E0.5130.89
208_D211_L0.5110.89
103_T108_E0.5080.89
99_D148_G0.5080.89
91_V142_R0.5080.89
31_C58_G0.5060.89
211_L217_Q0.5040.88
99_D106_G0.5030.88
107_Y114_G0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qezB 2 0.9784 100 0.207 Contact Map
1zosA 2 0.9914 100 0.21 Contact Map
3bl6A 2 0.9871 100 0.217 Contact Map
3dp9A 2 0.9871 100 0.224 Contact Map
3eeiA 2 0.9871 100 0.23 Contact Map
4josA 2 0.9784 100 0.23 Contact Map
4l0mA 2 0.9784 100 0.233 Contact Map
4f1wA 2 1 100 0.235 Contact Map
4oy3A 2 0.9828 100 0.237 Contact Map
4g41A 2 0.9957 100 0.238 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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