GREMLIN Database
MTLR - Mannitol operon repressor
UniProt: P0AF10 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11965
Length: 195 (166)
Sequences: 121 (63)
Seq/√Len: 4.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_I138_F3.2700.77
32_V172_V2.9280.68
78_P95_L2.8560.66
73_K136_G2.8080.64
75_A96_I2.7270.62
37_N127_Y2.6750.60
60_L94_K2.4860.54
123_D127_Y2.3750.51
68_D78_P2.3270.49
80_L95_L2.2240.46
41_T190_K2.1260.43
93_L120_L2.0810.41
67_K94_K2.0390.40
68_D80_L2.0270.40
103_N112_L2.0220.40
95_L170_Q2.0190.40
70_Y74_Y1.9860.39
43_R126_E1.9730.38
37_N131_D1.9310.37
57_V153_F1.9270.37
93_L141_L1.9000.36
88_D135_L1.8900.36
138_F172_V1.8020.33
68_D76_V1.7920.33
88_D128_A1.7730.32
29_E34_E1.7610.32
47_I117_R1.7450.32
49_A144_V1.7240.31
45_F120_L1.6290.28
68_D95_L1.6200.28
57_V181_T1.5750.27
105_Q180_L1.5730.27
157_D174_S1.5520.26
129_F178_L1.5390.26
103_N149_P1.5240.26
72_V92_R1.5060.25
63_Q191_K1.4650.24
32_V96_I1.4590.24
102_I186_K1.4410.24
53_L183_L1.4360.24
106_E190_K1.4280.23
44_S187_I1.4140.23
114_M172_V1.3980.23
32_V110_A1.3910.23
121_N126_E1.3800.22
98_G117_R1.3790.22
40_K44_S1.3710.22
72_V131_D1.3680.22
136_G144_V1.3600.22
66_R73_K1.3450.22
91_V122_H1.3400.21
31_R173_R1.3170.21
75_A98_G1.2940.20
173_R190_K1.2790.20
173_R182_E1.2580.20
55_E151_P1.2560.20
166_Q182_E1.2500.20
91_V130_T1.2430.19
83_D134_I1.2340.19
42_V130_T1.2300.19
75_A132_D1.2230.19
73_K134_I1.2020.19
39_G98_G1.1830.18
102_I118_E1.1610.18
47_I126_E1.1550.18
68_D107_Y1.1540.18
69_D73_K1.1540.18
62_L107_Y1.1340.17
124_G150_P1.1330.17
46_L125_N1.1300.17
177_V181_T1.1290.17
157_D160_L1.1200.17
76_V118_E1.1140.17
51_E124_G1.1070.17
45_F191_K1.0600.16
78_P107_Y1.0530.16
46_L117_R1.0480.16
113_L166_Q1.0410.16
45_F89_L1.0400.16
102_I112_L1.0400.16
115_A190_K1.0370.16
70_Y75_A1.0220.15
155_P160_L1.0060.15
40_K125_N1.0030.15
30_N137_P0.9870.15
74_Y132_D0.9840.15
120_L127_Y0.9790.15
40_K122_H0.9770.15
113_L137_P0.9740.15
123_D141_L0.9710.15
57_V112_L0.9640.14
60_L67_K0.9560.14
95_L107_Y0.9500.14
69_D108_E0.9440.14
117_R165_I0.9360.14
115_A152_Q0.9290.14
92_R174_S0.9270.14
76_V173_R0.9220.14
66_R93_L0.9150.14
115_A136_G0.9130.14
167_R178_L0.9110.14
81_D87_G0.9070.14
91_V128_A0.9070.14
120_L157_D0.9070.14
60_L89_L0.9010.13
49_A108_E0.8980.13
104_R108_E0.8900.13
118_E143_C0.8820.13
134_I142_H0.8810.13
46_L49_A0.8800.13
130_T170_Q0.8770.13
133_E136_G0.8760.13
164_Q174_S0.8720.13
143_C179_S0.8710.13
163_M174_S0.8700.13
40_K172_V0.8600.13
27_A83_D0.8590.13
32_V138_F0.8580.13
163_M175_T0.8560.13
38_A105_Q0.8550.13
31_R48_T0.8530.13
102_I181_T0.8460.13
35_R78_P0.8460.13
33_L95_L0.8420.13
37_N66_R0.8370.13
45_F52_L0.8350.13
67_K92_R0.8330.12
74_Y98_G0.8290.12
35_R42_V0.8260.12
120_L142_H0.8060.12
60_L70_Y0.7970.12
54_T106_E0.7920.12
34_E72_V0.7900.12
42_V91_V0.7880.12
64_V96_I0.7840.12
77_E186_K0.7790.12
52_L183_L0.7720.12
63_Q161_Y0.7690.12
42_V56_A0.7620.12
73_K77_E0.7580.11
153_F172_V0.7540.11
52_L187_I0.7520.11
33_L117_R0.7410.11
65_F94_K0.7380.11
46_L91_V0.7320.11
97_Y107_Y0.7320.11
45_F164_Q0.7300.11
50_V157_D0.7220.11
88_D118_E0.7150.11
44_S191_K0.7130.11
162_A183_L0.7080.11
45_F93_L0.7070.11
63_Q141_L0.7060.11
96_I180_L0.7050.11
70_Y94_K0.7030.11
170_Q175_T0.7030.11
28_F31_R0.7010.11
166_Q169_Q0.6880.11
29_E49_A0.6870.11
161_Y191_K0.6850.11
71_A135_L0.6830.11
110_A138_F0.6820.11
113_L151_P0.6740.10
124_G128_A0.6680.10
152_Q186_K0.6640.10
38_A97_Y0.6630.10
61_V163_M0.6620.10
47_I98_G0.6590.10
79_L84_G0.6590.10
85_P100_G0.6590.10
85_P109_D0.6590.10
86_L100_G0.6590.10
86_L109_D0.6590.10
100_G109_D0.6590.10
84_G100_G0.6590.10
84_G109_D0.6590.10
79_L109_D0.6590.10
79_L100_G0.6590.10
79_L86_L0.6590.10
79_L85_P0.6590.10
44_S58_N0.6580.10
148_P160_L0.6570.10
111_E116_L0.6570.10
110_A179_S0.6510.10
46_L83_D0.6500.10
152_Q163_M0.6490.10
49_A104_R0.6450.10
32_V128_A0.6430.10
49_A176_M0.6410.10
57_V118_E0.6340.10
47_I121_N0.6340.10
36_L45_F0.6270.10
28_F137_P0.6260.10
154_E183_L0.6200.10
122_H172_V0.6170.10
57_V154_E0.6140.10
146_A172_V0.6130.10
78_P159_S0.6110.10
56_A66_R0.6100.10
112_L181_T0.6100.10
170_Q174_S0.6100.10
108_E136_G0.6100.10
35_R120_L0.6070.10
112_L165_I0.6070.10
83_D119_E0.6060.10
48_T54_T0.6050.10
63_Q152_Q0.6030.10
36_L65_F0.6020.10
91_V163_M0.6000.10
64_V94_K0.5990.10
80_L189_L0.5990.10
58_N187_I0.5940.09
42_V123_D0.5940.09
41_T121_N0.5890.09
163_M177_V0.5820.09
146_A151_P0.5780.09
38_A106_E0.5780.09
80_L177_V0.5770.09
138_F153_F0.5730.09
46_L150_P0.5660.09
80_L107_Y0.5620.09
55_E121_N0.5610.09
154_E157_D0.5610.09
74_Y191_K0.5570.09
39_G54_T0.5560.09
53_L96_I0.5540.09
45_F63_Q0.5540.09
61_V180_L0.5460.09
61_V78_P0.5420.09
37_N126_E0.5410.09
28_F54_T0.5400.09
43_R121_N0.5380.09
57_V103_N0.5350.09
33_L91_V0.5350.09
52_L112_L0.5320.09
66_R71_A0.5260.09
83_D150_P0.5250.09
67_K75_A0.5230.09
31_R190_K0.5210.09
172_V175_T0.5200.09
152_Q165_I0.5140.09
179_S186_K0.5120.09
41_T126_E0.5110.09
57_V125_N0.5070.09
99_L180_L0.5050.09
42_V94_K0.5030.09
37_N123_D0.5020.09
46_L102_I0.5020.09
48_T182_E0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3brjA 2 0.841 100 0.268 Contact Map
3c8gA 2 0.8205 100 0.296 Contact Map
4nqiA 2 0.4974 12.5 0.964 Contact Map
1t0fC 1 0.2205 4.5 0.971 Contact Map
1ylmA 2 0.641 4.5 0.971 Contact Map
4eukB 1 0.5179 3.5 0.972 Contact Map
4a56A 2 0.4256 3.5 0.972 Contact Map
4fvgA 2 0.3077 3.4 0.973 Contact Map
3solA 1 0.4154 3.3 0.973 Contact Map
2qgqA 1 0.8462 3 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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