MRP - ECOLI - GREMLIN Contacts

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MRP - Protein mrp

UniProt:	P0AF08	Sequences: MNEQSQAKSPEALRAMVAGTLANFQHPTLKHNLTTLKALHHVAWMDDTLHVELVMPFVWHSAFEELKEQCSAELLRITGAKAIDWKLSHNIATLKRVKNQPGINGVKNIIAVSSGKGGVGKSSTAVNLALALAAEGAKVGILDADIYGPSIPTMLGAENQRPTSPDGTHMAPIMSHGLATNSIGYLVTDDNAMVWRGPMASKALMQMLQETLWPDLDYLVLDMPPGTGDIQLTLAQNIPVTGAVVVTTPQDIALIDAKKGIVMFEKVEVPVLGIVENMSVHICSNCGHHEPIFGTGGAEKLAEKYHTQLLGQMPLHISLREDLDKGTPTVISRPESEFTAIYRQLADRVAAQLYWQGEVIPGEISFRAV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10611
Length:	369 (337)
Sequences:	3047 (1751)
Seq/√Len:	95.4

ECOLI - MRP
BACSU - SALA
HALSA - Q9HQJ7 Q9HHZ7 Q9HQY5 Q9HNF1 Q9HHU2
SULSO - Q97ZW4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
283_C	286_C	5.709	1.00
125_A	220_V	4.815	1.00
299_E	303_E	4.724	1.00
32_N	35_T	4.701	1.00
285_N	288_H	3.905	1.00
125_A	141_I	3.800	1.00
311_G	345_L	3.725	1.00
135_E	347_D	3.629	1.00
281_H	290_E	3.167	1.00
179_A	214_P	3.067	1.00
308_Q	352_Q	3.042	1.00
180_T	185_Y	2.976	1.00
280_V	289_H	2.969	1.00
19_G	22_A	2.856	1.00
247_T	298_A	2.825	1.00
309_L	312_Q	2.804	1.00
155_L	180_T	2.795	1.00
124_T	342_Y	2.674	1.00
137_A	218_Y	2.617	1.00
299_E	312_Q	2.589	1.00
67_K	71_S	2.565	1.00
135_E	343_R	2.561	1.00
126_V	155_L	2.553	1.00
140_G	216_L	2.470	1.00
281_H	284_S	2.437	1.00
112_V	220_V	2.435	1.00
40_H	54_V	2.395	1.00
154_M	252_I	2.201	1.00
22_A	32_N	2.181	1.00
152_P	184_G	2.153	1.00
44_W	49_L	2.128	1.00
157_A	180_T	2.087	1.00
291_P	295_T	2.057	1.00
49_L	80_A	2.051	1.00
286_C	290_E	2.028	1.00
48_T	82_A	2.014	1.00
33_L	39_L	1.993	1.00
108_N	241_T	1.969	1.00
41_H	52_E	1.935	1.00
126_V	151_I	1.934	1.00
300_K	303_E	1.934	1.00
192_A	262_V	1.913	1.00
52_E	86_K	1.909	1.00
65_E	69_Q	1.869	1.00
275_V	345_L	1.864	1.00
171_A	212_L	1.828	1.00
299_E	309_L	1.826	1.00
134_A	343_R	1.820	1.00
283_C	290_E	1.814	1.00
336_S	339_T	1.809	1.00
174_M	179_A	1.780	1.00
318_S	321_E	1.740	1.00
200_A	230_I	1.734	1.00
64_E	67_K	1.718	1.00
47_D	81_K	1.678	1.00
285_N	290_E	1.636	1.00
155_L	178_L	1.632	1.00
51_V	70_C	1.623	1.00
71_S	75_L	1.608	1.00
18_A	42_V	1.604	1.00
15_A	19_G	1.599	1.00
48_T	84_D	1.596	1.00
18_A	34_T	1.582	1.00
165_P	171_A	1.580	1.00
147_Y	228_G	1.527	1.00
308_Q	348_R	1.515	1.00
16_M	19_G	1.508	1.00
344_Q	348_R	1.500	1.00
153_T	255_I	1.457	1.00
284_S	290_E	1.450	1.00
282_I	289_H	1.438	1.00
126_V	154_M	1.438	1.00
205_M	209_Q	1.410	0.99
298_A	309_L	1.406	0.99
53_L	70_C	1.386	0.99
159_N	173_I	1.384	0.99
22_A	34_T	1.383	0.99
313_M	345_L	1.380	0.99
188_T	191_N	1.375	0.99
42_V	51_V	1.367	0.99
130_L	178_L	1.364	0.99
320_R	324_D	1.352	0.99
68_E	72_A	1.347	0.99
262_V	265_E	1.341	0.99
176_H	327_T	1.330	0.99
17_V	42_V	1.329	0.99
333_R	336_S	1.323	0.99
45_M	48_T	1.320	0.99
181_N	211_T	1.319	0.99
113_S	245_V	1.306	0.99
50_H	84_D	1.301	0.99
221_L	234_L	1.294	0.99
133_A	178_L	1.294	0.99
25_Q	30_K	1.288	0.99
274_I	307_T	1.286	0.99
157_A	173_I	1.284	0.99
279_S	312_Q	1.282	0.99
157_A	185_Y	1.281	0.99
124_T	246_V	1.273	0.99
132_L	218_Y	1.268	0.99
258_K	304_K	1.267	0.99
280_V	291_P	1.257	0.99
128_L	349_V	1.250	0.99
241_T	353_L	1.249	0.99
131_A	346_A	1.247	0.99
21_L	34_T	1.247	0.99
113_S	260_G	1.237	0.99
292_I	315_L	1.236	0.99
206_Q	210_E	1.232	0.99
298_A	302_A	1.220	0.98
17_V	44_W	1.220	0.98
300_K	304_K	1.217	0.98
242_G	270_P	1.214	0.98
20_T	77_I	1.213	0.98
20_T	74_L	1.212	0.98
73_E	76_R	1.210	0.98
43_A	50_H	1.208	0.98
124_T	313_M	1.200	0.98
318_S	333_R	1.174	0.98
31_H	35_T	1.171	0.98
24_F	70_C	1.168	0.98
137_A	350_A	1.165	0.98
242_G	272_L	1.164	0.98
64_E	68_E	1.160	0.98
201_S	233_T	1.158	0.98
26_H	36_L	1.156	0.98
51_V	74_L	1.155	0.98
110_I	272_L	1.147	0.98
132_L	220_V	1.144	0.98
283_C	288_H	1.140	0.98
261_I	305_Y	1.135	0.98
316_H	338_F	1.134	0.97
56_P	60_H	1.130	0.97
345_L	349_V	1.124	0.97
26_H	30_K	1.124	0.97
321_E	325_K	1.118	0.97
127_N	328_P	1.117	0.97
348_R	351_A	1.115	0.97
301_L	305_Y	1.111	0.97
41_H	50_H	1.109	0.97
77_I	80_A	1.101	0.97
187_V	193_M	1.100	0.97
23_N	73_E	1.095	0.97
334_P	339_T	1.095	0.97
329_T	336_S	1.092	0.97
340_A	343_R	1.066	0.96
93_T	96_R	1.065	0.96
74_L	77_I	1.061	0.96
223_M	260_G	1.061	0.96
141_I	180_T	1.060	0.96
46_D	81_K	1.059	0.96
54_V	88_S	1.053	0.96
195_W	203_A	1.050	0.96
330_V	339_T	1.048	0.96
17_V	74_L	1.047	0.96
201_S	230_I	1.044	0.96
38_A	61_S	1.039	0.96
252_I	323_L	1.031	0.96
216_L	219_L	1.030	0.96
18_A	22_A	1.030	0.96
280_V	312_Q	1.019	0.95
153_T	189_D	1.017	0.95
17_V	49_L	1.012	0.95
29_L	36_L	1.012	0.95
23_N	32_N	1.010	0.95
235_A	269_V	0.997	0.95
48_T	81_K	0.996	0.95
340_A	344_Q	0.996	0.95
31_H	36_L	0.994	0.95
201_S	237_N	0.993	0.95
141_I	151_I	0.990	0.95
220_V	349_V	0.988	0.94
24_F	69_Q	0.983	0.94
349_V	353_L	0.975	0.94
28_T	36_L	0.975	0.94
112_V	128_L	0.974	0.94
283_C	287_G	0.973	0.94
140_G	219_L	0.971	0.94
69_Q	72_A	0.970	0.94
151_I	180_T	0.961	0.94
296_G	299_E	0.961	0.94
337_E	340_A	0.957	0.93
74_L	83_I	0.957	0.93
66_L	70_C	0.938	0.93
153_T	158_E	0.937	0.93
337_E	341_I	0.936	0.93
244_V	345_L	0.931	0.92
20_T	24_F	0.923	0.92
301_L	304_K	0.917	0.92
28_T	38_A	0.914	0.92
344_Q	347_D	0.908	0.92
341_I	344_Q	0.907	0.91
165_P	212_L	0.904	0.91
113_S	223_M	0.902	0.91
164_S	167_G	0.892	0.91
28_T	62_A	0.889	0.91
122_S	151_I	0.880	0.90
194_V	232_L	0.873	0.90
207_M	211_T	0.868	0.90
174_M	177_G	0.864	0.89
132_L	350_A	0.863	0.89
24_F	73_E	0.861	0.89
108_N	218_Y	0.859	0.89
38_A	62_A	0.858	0.89
71_S	82_A	0.857	0.89
26_H	29_L	0.854	0.89
191_N	266_K	0.853	0.89
80_A	83_I	0.853	0.89
20_T	73_E	0.847	0.88
49_L	74_L	0.841	0.88
34_T	38_A	0.839	0.88
103_I	106_V	0.837	0.88
110_I	244_V	0.836	0.88
69_Q	73_E	0.835	0.88
25_Q	31_H	0.835	0.88
26_H	57_F	0.826	0.87
181_N	185_Y	0.825	0.87
235_A	267_V	0.823	0.87
335_E	340_A	0.822	0.87
60_H	63_F	0.821	0.87
130_L	134_A	0.821	0.87
261_I	271_V	0.818	0.87
112_V	244_V	0.816	0.87
327_T	332_S	0.815	0.86
170_M	181_N	0.810	0.86
131_A	330_V	0.809	0.86
200_A	207_M	0.805	0.86
282_I	337_E	0.804	0.86
55_M	60_H	0.803	0.86
47_D	80_A	0.802	0.86
317_I	321_E	0.801	0.86
38_A	56_P	0.800	0.85
281_H	292_I	0.799	0.85
323_L	329_T	0.791	0.85
110_I	218_Y	0.790	0.85
63_F	67_K	0.786	0.84
275_V	349_V	0.782	0.84
221_L	238_I	0.782	0.84
24_F	37_K	0.780	0.84
22_A	31_H	0.776	0.84
135_E	350_A	0.771	0.83
55_M	59_W	0.771	0.83
40_H	52_E	0.769	0.83
233_T	237_N	0.768	0.83
231_Q	264_F	0.762	0.83
121_K	225_P	0.758	0.82
25_Q	28_T	0.758	0.82
124_T	128_L	0.755	0.82
149_P	256_D	0.755	0.82
192_A	345_L	0.752	0.82
130_L	331_I	0.751	0.82
313_M	341_I	0.750	0.82
203_A	210_E	0.750	0.82
199_M	202_K	0.748	0.81
141_I	155_L	0.746	0.81
261_I	265_E	0.746	0.81
73_E	77_I	0.745	0.81
192_A	261_I	0.745	0.81
322_D	327_T	0.742	0.81
149_P	242_G	0.741	0.81
32_N	37_K	0.740	0.81
345_L	348_R	0.738	0.81
68_E	82_A	0.738	0.81
39_L	53_L	0.738	0.81
322_D	332_S	0.736	0.80
36_L	66_L	0.733	0.80
130_L	330_V	0.730	0.80
20_T	23_N	0.728	0.80
147_Y	231_Q	0.728	0.80
257_A	315_L	0.722	0.79
190_D	267_V	0.720	0.79
285_N	289_H	0.720	0.79
33_L	38_A	0.719	0.79
187_V	232_L	0.717	0.79
281_H	288_H	0.716	0.78
26_H	37_K	0.714	0.78
252_I	255_I	0.713	0.78
289_H	312_Q	0.711	0.78
58_V	350_A	0.703	0.77
231_Q	260_G	0.702	0.77
34_T	39_L	0.702	0.77
144_A	221_L	0.699	0.77
142_L	219_L	0.698	0.77
39_L	42_V	0.697	0.77
337_E	344_Q	0.696	0.77
16_M	77_I	0.695	0.76
229_D	248_T	0.695	0.76
55_M	61_S	0.694	0.76
256_D	264_F	0.693	0.76
204_L	230_I	0.691	0.76
56_P	61_S	0.691	0.76
322_D	329_T	0.689	0.76
57_F	60_H	0.689	0.76
52_E	88_S	0.684	0.75
333_R	339_T	0.683	0.75
261_I	301_L	0.682	0.75
72_A	76_R	0.682	0.75
243_A	264_F	0.681	0.75
127_N	130_L	0.679	0.75
257_A	261_I	0.679	0.75
152_P	182_S	0.679	0.75
105_G	214_P	0.678	0.75
28_T	56_P	0.676	0.74
313_M	338_F	0.676	0.74
24_F	33_L	0.675	0.74
228_G	231_Q	0.675	0.74
205_M	237_N	0.674	0.74
245_V	261_I	0.674	0.74
61_S	66_L	0.672	0.74
56_P	59_W	0.672	0.74
32_N	36_L	0.671	0.74
29_L	38_A	0.671	0.74
141_I	220_V	0.670	0.74
191_N	262_V	0.669	0.74
154_M	323_L	0.669	0.74
329_T	334_P	0.667	0.73
150_S	267_V	0.660	0.73
126_V	180_T	0.659	0.73
243_A	256_D	0.659	0.73
19_G	43_A	0.655	0.72
67_K	75_L	0.654	0.72
25_Q	69_Q	0.653	0.72
150_S	256_D	0.652	0.72
170_M	211_T	0.651	0.72
245_V	257_A	0.651	0.72
170_M	210_E	0.650	0.72
33_L	53_L	0.648	0.71
147_Y	260_G	0.647	0.71
248_T	278_M	0.646	0.71
201_S	205_M	0.643	0.71
108_N	137_A	0.642	0.71
165_P	168_T	0.642	0.71
122_S	150_S	0.642	0.71
68_E	347_D	0.640	0.70
122_S	257_A	0.640	0.70
179_A	216_L	0.639	0.70
32_N	39_L	0.637	0.70
51_V	54_V	0.636	0.70
150_S	230_I	0.632	0.69
329_T	332_S	0.629	0.69
38_A	60_H	0.628	0.69
138_K	215_D	0.628	0.69
19_G	23_N	0.626	0.69
145_D	225_P	0.626	0.69
218_Y	350_A	0.625	0.69
151_I	157_A	0.625	0.69
120_G	277_N	0.623	0.68
279_S	289_H	0.623	0.68
251_D	254_L	0.623	0.68
45_M	50_H	0.622	0.68
290_E	317_I	0.622	0.68
150_S	257_A	0.622	0.68
343_R	347_D	0.621	0.68
288_H	291_P	0.619	0.68
324_D	328_P	0.618	0.68
226_G	249_P	0.617	0.68
31_H	56_P	0.617	0.68
252_I	256_D	0.617	0.68
284_S	317_I	0.615	0.67
41_H	51_V	0.614	0.67
261_I	274_I	0.612	0.67
144_A	204_L	0.611	0.67
42_V	49_L	0.611	0.67
204_L	234_L	0.609	0.67
38_A	63_F	0.609	0.67
200_A	211_T	0.608	0.66
342_Y	345_L	0.607	0.66
148_G	227_T	0.607	0.66
197_G	229_D	0.604	0.66
156_G	175_S	0.604	0.66
91_I	137_A	0.604	0.66
75_L	83_I	0.603	0.66
163_T	166_D	0.601	0.66
22_A	33_L	0.598	0.65
16_M	20_T	0.598	0.65
55_M	58_V	0.598	0.65
71_S	86_K	0.597	0.65
158_E	189_D	0.596	0.65
111_A	240_V	0.596	0.65
103_I	109_I	0.595	0.65
330_V	343_R	0.593	0.64
125_A	135_E	0.593	0.64
182_S	229_D	0.592	0.64
257_A	307_T	0.591	0.64
150_S	252_I	0.589	0.64
253_A	297_G	0.588	0.64
196_R	226_G	0.586	0.64
148_G	182_S	0.586	0.64
25_Q	29_L	0.583	0.63
49_L	83_I	0.583	0.63
156_G	176_H	0.583	0.63
303_E	306_H	0.583	0.63
25_Q	33_L	0.581	0.63
56_P	62_A	0.581	0.63
144_A	223_M	0.580	0.63
218_Y	247_T	0.579	0.63
54_V	90_N	0.578	0.63
91_I	94_L	0.578	0.63
59_W	63_F	0.575	0.62
164_S	168_T	0.575	0.62
226_G	248_T	0.571	0.62
16_M	22_A	0.570	0.61
26_H	61_S	0.570	0.61
193_M	200_A	0.569	0.61
187_V	199_M	0.568	0.61
162_P	173_I	0.567	0.61
141_I	157_A	0.567	0.61
229_D	249_P	0.565	0.61
24_F	61_S	0.565	0.61
271_V	353_L	0.563	0.61
29_L	32_N	0.562	0.60
22_A	43_A	0.561	0.60
91_I	350_A	0.560	0.60
36_L	61_S	0.559	0.60
154_M	324_D	0.559	0.60
26_H	60_H	0.558	0.60
34_T	37_K	0.557	0.60
276_E	279_S	0.557	0.60
57_F	62_A	0.556	0.60
319_L	333_R	0.556	0.60
125_A	151_I	0.555	0.59
16_M	23_N	0.555	0.59
339_T	342_Y	0.555	0.59
294_G	320_R	0.554	0.59
190_D	301_L	0.553	0.59
58_V	137_A	0.553	0.59
279_S	297_G	0.550	0.59
196_R	278_M	0.550	0.59
196_R	249_P	0.549	0.59
137_A	351_A	0.548	0.58
163_T	171_A	0.548	0.58
199_M	203_A	0.547	0.58
227_T	248_T	0.547	0.58
203_A	207_M	0.545	0.58
29_L	57_F	0.545	0.58
32_N	38_A	0.545	0.58
187_V	201_S	0.544	0.58
55_M	63_F	0.544	0.58
28_T	60_H	0.543	0.58
251_D	317_I	0.543	0.58
47_D	82_A	0.542	0.58
206_Q	324_D	0.541	0.58
232_L	266_K	0.541	0.58
225_P	273_G	0.539	0.57
194_V	263_M	0.538	0.57
33_L	37_K	0.537	0.57
231_Q	243_A	0.537	0.57
278_M	315_L	0.535	0.57
152_P	183_I	0.534	0.57
142_L	207_M	0.533	0.56
282_I	290_E	0.533	0.56
148_G	278_M	0.533	0.56
329_T	333_R	0.532	0.56
16_M	42_V	0.532	0.56
274_I	298_A	0.531	0.56
265_E	306_H	0.528	0.56
296_G	309_L	0.527	0.56
251_D	258_K	0.526	0.55
50_H	86_K	0.526	0.55
347_D	351_A	0.526	0.55
111_A	231_Q	0.524	0.55
62_A	69_Q	0.524	0.55
190_D	262_V	0.524	0.55
243_A	260_G	0.523	0.55
111_A	223_M	0.523	0.55
121_K	145_D	0.522	0.55
38_A	55_M	0.521	0.55
162_P	168_T	0.520	0.55
279_S	282_I	0.520	0.55
247_T	312_Q	0.519	0.54
283_C	317_I	0.519	0.54
240_V	269_V	0.519	0.54
195_W	273_G	0.518	0.54
202_K	205_M	0.518	0.54
281_H	317_I	0.518	0.54
27_P	38_A	0.517	0.54
284_S	291_P	0.517	0.54
295_T	312_Q	0.517	0.54
43_A	47_D	0.517	0.54
226_G	229_D	0.516	0.54
114_S	226_G	0.515	0.54
15_A	18_A	0.514	0.54
113_S	204_L	0.514	0.54
197_G	249_P	0.514	0.54
146_I	213_W	0.514	0.54
40_H	88_S	0.513	0.54
196_R	229_D	0.512	0.53
235_A	243_A	0.512	0.53
107_K	138_K	0.512	0.53
43_A	86_K	0.511	0.53
201_S	211_T	0.508	0.53
26_H	31_H	0.508	0.53
26_H	33_L	0.506	0.53
179_A	215_D	0.505	0.52
319_L	342_Y	0.505	0.52
23_N	42_V	0.505	0.52
254_L	297_G	0.504	0.52
23_N	34_T	0.504	0.52
291_P	312_Q	0.503	0.52
265_E	268_E	0.503	0.52
36_L	60_H	0.502	0.52
23_N	76_R	0.501	0.52
36_L	53_L	0.501	0.52
208_L	238_I	0.501	0.52
28_T	33_L	0.500	0.52
338_F	341_I	0.500	0.52

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1g3qA	1	0.6206	100	0.532	Contact Map
1hyqA	1	0.607	100	0.532	Contact Map
4pfsA	1	0.6233	100	0.532	Contact Map
3pg5A	2	0.5854	100	0.533	Contact Map
5aunB	2	0.6504	100	0.537	Contact Map
4rz3A	2	0.6287	100	0.538	Contact Map
2ph1A	2	0.6612	100	0.54	Contact Map
3ea0A	2	0.6125	100	0.544	Contact Map
1wcv1	2	0.6206	100	0.555	Contact Map
4v03A	2	0.6125	100	0.557	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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