GREMLIN Database
MRP - Protein mrp
UniProt: P0AF08 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10611
Length: 369 (337)
Sequences: 3047 (1751)
Seq/√Len: 95.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
283_C286_C5.7091.00
125_A220_V4.8151.00
299_E303_E4.7241.00
32_N35_T4.7011.00
285_N288_H3.9051.00
125_A141_I3.8001.00
311_G345_L3.7251.00
135_E347_D3.6291.00
281_H290_E3.1671.00
179_A214_P3.0671.00
308_Q352_Q3.0421.00
180_T185_Y2.9761.00
280_V289_H2.9691.00
19_G22_A2.8561.00
247_T298_A2.8251.00
309_L312_Q2.8041.00
155_L180_T2.7951.00
124_T342_Y2.6741.00
137_A218_Y2.6171.00
299_E312_Q2.5891.00
67_K71_S2.5651.00
135_E343_R2.5611.00
126_V155_L2.5531.00
140_G216_L2.4701.00
281_H284_S2.4371.00
112_V220_V2.4351.00
40_H54_V2.3951.00
154_M252_I2.2011.00
22_A32_N2.1811.00
152_P184_G2.1531.00
44_W49_L2.1281.00
157_A180_T2.0871.00
291_P295_T2.0571.00
49_L80_A2.0511.00
286_C290_E2.0281.00
48_T82_A2.0141.00
33_L39_L1.9931.00
108_N241_T1.9691.00
41_H52_E1.9351.00
126_V151_I1.9341.00
300_K303_E1.9341.00
192_A262_V1.9131.00
52_E86_K1.9091.00
65_E69_Q1.8691.00
275_V345_L1.8641.00
171_A212_L1.8281.00
299_E309_L1.8261.00
134_A343_R1.8201.00
283_C290_E1.8141.00
336_S339_T1.8091.00
174_M179_A1.7801.00
318_S321_E1.7401.00
200_A230_I1.7341.00
64_E67_K1.7181.00
47_D81_K1.6781.00
285_N290_E1.6361.00
155_L178_L1.6321.00
51_V70_C1.6231.00
71_S75_L1.6081.00
18_A42_V1.6041.00
15_A19_G1.5991.00
48_T84_D1.5961.00
18_A34_T1.5821.00
165_P171_A1.5801.00
147_Y228_G1.5271.00
308_Q348_R1.5151.00
16_M19_G1.5081.00
344_Q348_R1.5001.00
153_T255_I1.4571.00
284_S290_E1.4501.00
282_I289_H1.4381.00
126_V154_M1.4381.00
205_M209_Q1.4100.99
298_A309_L1.4060.99
53_L70_C1.3860.99
159_N173_I1.3840.99
22_A34_T1.3830.99
313_M345_L1.3800.99
188_T191_N1.3750.99
42_V51_V1.3670.99
130_L178_L1.3640.99
320_R324_D1.3520.99
68_E72_A1.3470.99
262_V265_E1.3410.99
176_H327_T1.3300.99
17_V42_V1.3290.99
333_R336_S1.3230.99
45_M48_T1.3200.99
181_N211_T1.3190.99
113_S245_V1.3060.99
50_H84_D1.3010.99
221_L234_L1.2940.99
133_A178_L1.2940.99
25_Q30_K1.2880.99
274_I307_T1.2860.99
157_A173_I1.2840.99
279_S312_Q1.2820.99
157_A185_Y1.2810.99
124_T246_V1.2730.99
132_L218_Y1.2680.99
258_K304_K1.2670.99
280_V291_P1.2570.99
128_L349_V1.2500.99
241_T353_L1.2490.99
131_A346_A1.2470.99
21_L34_T1.2470.99
113_S260_G1.2370.99
292_I315_L1.2360.99
206_Q210_E1.2320.99
298_A302_A1.2200.98
17_V44_W1.2200.98
300_K304_K1.2170.98
242_G270_P1.2140.98
20_T77_I1.2130.98
20_T74_L1.2120.98
73_E76_R1.2100.98
43_A50_H1.2080.98
124_T313_M1.2000.98
318_S333_R1.1740.98
31_H35_T1.1710.98
24_F70_C1.1680.98
137_A350_A1.1650.98
242_G272_L1.1640.98
64_E68_E1.1600.98
201_S233_T1.1580.98
26_H36_L1.1560.98
51_V74_L1.1550.98
110_I272_L1.1470.98
132_L220_V1.1440.98
283_C288_H1.1400.98
261_I305_Y1.1350.98
316_H338_F1.1340.97
56_P60_H1.1300.97
345_L349_V1.1240.97
26_H30_K1.1240.97
321_E325_K1.1180.97
127_N328_P1.1170.97
348_R351_A1.1150.97
301_L305_Y1.1110.97
41_H50_H1.1090.97
77_I80_A1.1010.97
187_V193_M1.1000.97
23_N73_E1.0950.97
334_P339_T1.0950.97
329_T336_S1.0920.97
340_A343_R1.0660.96
93_T96_R1.0650.96
74_L77_I1.0610.96
223_M260_G1.0610.96
141_I180_T1.0600.96
46_D81_K1.0590.96
54_V88_S1.0530.96
195_W203_A1.0500.96
330_V339_T1.0480.96
17_V74_L1.0470.96
201_S230_I1.0440.96
38_A61_S1.0390.96
252_I323_L1.0310.96
216_L219_L1.0300.96
18_A22_A1.0300.96
280_V312_Q1.0190.95
153_T189_D1.0170.95
17_V49_L1.0120.95
29_L36_L1.0120.95
23_N32_N1.0100.95
235_A269_V0.9970.95
48_T81_K0.9960.95
340_A344_Q0.9960.95
31_H36_L0.9940.95
201_S237_N0.9930.95
141_I151_I0.9900.95
220_V349_V0.9880.94
24_F69_Q0.9830.94
349_V353_L0.9750.94
28_T36_L0.9750.94
112_V128_L0.9740.94
283_C287_G0.9730.94
140_G219_L0.9710.94
69_Q72_A0.9700.94
151_I180_T0.9610.94
296_G299_E0.9610.94
337_E340_A0.9570.93
74_L83_I0.9570.93
66_L70_C0.9380.93
153_T158_E0.9370.93
337_E341_I0.9360.93
244_V345_L0.9310.92
20_T24_F0.9230.92
301_L304_K0.9170.92
28_T38_A0.9140.92
344_Q347_D0.9080.92
341_I344_Q0.9070.91
165_P212_L0.9040.91
113_S223_M0.9020.91
164_S167_G0.8920.91
28_T62_A0.8890.91
122_S151_I0.8800.90
194_V232_L0.8730.90
207_M211_T0.8680.90
174_M177_G0.8640.89
132_L350_A0.8630.89
24_F73_E0.8610.89
108_N218_Y0.8590.89
38_A62_A0.8580.89
71_S82_A0.8570.89
26_H29_L0.8540.89
191_N266_K0.8530.89
80_A83_I0.8530.89
20_T73_E0.8470.88
49_L74_L0.8410.88
34_T38_A0.8390.88
103_I106_V0.8370.88
110_I244_V0.8360.88
69_Q73_E0.8350.88
25_Q31_H0.8350.88
26_H57_F0.8260.87
181_N185_Y0.8250.87
235_A267_V0.8230.87
335_E340_A0.8220.87
60_H63_F0.8210.87
130_L134_A0.8210.87
261_I271_V0.8180.87
112_V244_V0.8160.87
327_T332_S0.8150.86
170_M181_N0.8100.86
131_A330_V0.8090.86
200_A207_M0.8050.86
282_I337_E0.8040.86
55_M60_H0.8030.86
47_D80_A0.8020.86
317_I321_E0.8010.86
38_A56_P0.8000.85
281_H292_I0.7990.85
323_L329_T0.7910.85
110_I218_Y0.7900.85
63_F67_K0.7860.84
275_V349_V0.7820.84
221_L238_I0.7820.84
24_F37_K0.7800.84
22_A31_H0.7760.84
135_E350_A0.7710.83
55_M59_W0.7710.83
40_H52_E0.7690.83
233_T237_N0.7680.83
231_Q264_F0.7620.83
121_K225_P0.7580.82
25_Q28_T0.7580.82
124_T128_L0.7550.82
149_P256_D0.7550.82
192_A345_L0.7520.82
130_L331_I0.7510.82
313_M341_I0.7500.82
203_A210_E0.7500.82
199_M202_K0.7480.81
141_I155_L0.7460.81
261_I265_E0.7460.81
73_E77_I0.7450.81
192_A261_I0.7450.81
322_D327_T0.7420.81
149_P242_G0.7410.81
32_N37_K0.7400.81
345_L348_R0.7380.81
68_E82_A0.7380.81
39_L53_L0.7380.81
322_D332_S0.7360.80
36_L66_L0.7330.80
130_L330_V0.7300.80
20_T23_N0.7280.80
147_Y231_Q0.7280.80
257_A315_L0.7220.79
190_D267_V0.7200.79
285_N289_H0.7200.79
33_L38_A0.7190.79
187_V232_L0.7170.79
281_H288_H0.7160.78
26_H37_K0.7140.78
252_I255_I0.7130.78
289_H312_Q0.7110.78
58_V350_A0.7030.77
231_Q260_G0.7020.77
34_T39_L0.7020.77
144_A221_L0.6990.77
142_L219_L0.6980.77
39_L42_V0.6970.77
337_E344_Q0.6960.77
16_M77_I0.6950.76
229_D248_T0.6950.76
55_M61_S0.6940.76
256_D264_F0.6930.76
204_L230_I0.6910.76
56_P61_S0.6910.76
322_D329_T0.6890.76
57_F60_H0.6890.76
52_E88_S0.6840.75
333_R339_T0.6830.75
261_I301_L0.6820.75
72_A76_R0.6820.75
243_A264_F0.6810.75
127_N130_L0.6790.75
257_A261_I0.6790.75
152_P182_S0.6790.75
105_G214_P0.6780.75
28_T56_P0.6760.74
313_M338_F0.6760.74
24_F33_L0.6750.74
228_G231_Q0.6750.74
205_M237_N0.6740.74
245_V261_I0.6740.74
61_S66_L0.6720.74
56_P59_W0.6720.74
32_N36_L0.6710.74
29_L38_A0.6710.74
141_I220_V0.6700.74
191_N262_V0.6690.74
154_M323_L0.6690.74
329_T334_P0.6670.73
150_S267_V0.6600.73
126_V180_T0.6590.73
243_A256_D0.6590.73
19_G43_A0.6550.72
67_K75_L0.6540.72
25_Q69_Q0.6530.72
150_S256_D0.6520.72
170_M211_T0.6510.72
245_V257_A0.6510.72
170_M210_E0.6500.72
33_L53_L0.6480.71
147_Y260_G0.6470.71
248_T278_M0.6460.71
201_S205_M0.6430.71
108_N137_A0.6420.71
165_P168_T0.6420.71
122_S150_S0.6420.71
68_E347_D0.6400.70
122_S257_A0.6400.70
179_A216_L0.6390.70
32_N39_L0.6370.70
51_V54_V0.6360.70
150_S230_I0.6320.69
329_T332_S0.6290.69
38_A60_H0.6280.69
138_K215_D0.6280.69
19_G23_N0.6260.69
145_D225_P0.6260.69
218_Y350_A0.6250.69
151_I157_A0.6250.69
120_G277_N0.6230.68
279_S289_H0.6230.68
251_D254_L0.6230.68
45_M50_H0.6220.68
290_E317_I0.6220.68
150_S257_A0.6220.68
343_R347_D0.6210.68
288_H291_P0.6190.68
324_D328_P0.6180.68
226_G249_P0.6170.68
31_H56_P0.6170.68
252_I256_D0.6170.68
284_S317_I0.6150.67
41_H51_V0.6140.67
261_I274_I0.6120.67
144_A204_L0.6110.67
42_V49_L0.6110.67
204_L234_L0.6090.67
38_A63_F0.6090.67
200_A211_T0.6080.66
342_Y345_L0.6070.66
148_G227_T0.6070.66
197_G229_D0.6040.66
156_G175_S0.6040.66
91_I137_A0.6040.66
75_L83_I0.6030.66
163_T166_D0.6010.66
22_A33_L0.5980.65
16_M20_T0.5980.65
55_M58_V0.5980.65
71_S86_K0.5970.65
158_E189_D0.5960.65
111_A240_V0.5960.65
103_I109_I0.5950.65
330_V343_R0.5930.64
125_A135_E0.5930.64
182_S229_D0.5920.64
257_A307_T0.5910.64
150_S252_I0.5890.64
253_A297_G0.5880.64
196_R226_G0.5860.64
148_G182_S0.5860.64
25_Q29_L0.5830.63
49_L83_I0.5830.63
156_G176_H0.5830.63
303_E306_H0.5830.63
25_Q33_L0.5810.63
56_P62_A0.5810.63
144_A223_M0.5800.63
218_Y247_T0.5790.63
54_V90_N0.5780.63
91_I94_L0.5780.63
59_W63_F0.5750.62
164_S168_T0.5750.62
226_G248_T0.5710.62
16_M22_A0.5700.61
26_H61_S0.5700.61
193_M200_A0.5690.61
187_V199_M0.5680.61
162_P173_I0.5670.61
141_I157_A0.5670.61
229_D249_P0.5650.61
24_F61_S0.5650.61
271_V353_L0.5630.61
29_L32_N0.5620.60
22_A43_A0.5610.60
91_I350_A0.5600.60
36_L61_S0.5590.60
154_M324_D0.5590.60
26_H60_H0.5580.60
34_T37_K0.5570.60
276_E279_S0.5570.60
57_F62_A0.5560.60
319_L333_R0.5560.60
125_A151_I0.5550.59
16_M23_N0.5550.59
339_T342_Y0.5550.59
294_G320_R0.5540.59
190_D301_L0.5530.59
58_V137_A0.5530.59
279_S297_G0.5500.59
196_R278_M0.5500.59
196_R249_P0.5490.59
137_A351_A0.5480.58
163_T171_A0.5480.58
199_M203_A0.5470.58
227_T248_T0.5470.58
203_A207_M0.5450.58
29_L57_F0.5450.58
32_N38_A0.5450.58
187_V201_S0.5440.58
55_M63_F0.5440.58
28_T60_H0.5430.58
251_D317_I0.5430.58
47_D82_A0.5420.58
206_Q324_D0.5410.58
232_L266_K0.5410.58
225_P273_G0.5390.57
194_V263_M0.5380.57
33_L37_K0.5370.57
231_Q243_A0.5370.57
278_M315_L0.5350.57
152_P183_I0.5340.57
142_L207_M0.5330.56
282_I290_E0.5330.56
148_G278_M0.5330.56
329_T333_R0.5320.56
16_M42_V0.5320.56
274_I298_A0.5310.56
265_E306_H0.5280.56
296_G309_L0.5270.56
251_D258_K0.5260.55
50_H86_K0.5260.55
347_D351_A0.5260.55
111_A231_Q0.5240.55
62_A69_Q0.5240.55
190_D262_V0.5240.55
243_A260_G0.5230.55
111_A223_M0.5230.55
121_K145_D0.5220.55
38_A55_M0.5210.55
162_P168_T0.5200.55
279_S282_I0.5200.55
247_T312_Q0.5190.54
283_C317_I0.5190.54
240_V269_V0.5190.54
195_W273_G0.5180.54
202_K205_M0.5180.54
281_H317_I0.5180.54
27_P38_A0.5170.54
284_S291_P0.5170.54
295_T312_Q0.5170.54
43_A47_D0.5170.54
226_G229_D0.5160.54
114_S226_G0.5150.54
15_A18_A0.5140.54
113_S204_L0.5140.54
197_G249_P0.5140.54
146_I213_W0.5140.54
40_H88_S0.5130.54
196_R229_D0.5120.53
235_A243_A0.5120.53
107_K138_K0.5120.53
43_A86_K0.5110.53
201_S211_T0.5080.53
26_H31_H0.5080.53
26_H33_L0.5060.53
179_A215_D0.5050.52
319_L342_Y0.5050.52
23_N42_V0.5050.52
254_L297_G0.5040.52
23_N34_T0.5040.52
291_P312_Q0.5030.52
265_E268_E0.5030.52
36_L60_H0.5020.52
23_N76_R0.5010.52
36_L53_L0.5010.52
208_L238_I0.5010.52
28_T33_L0.5000.52
338_F341_I0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g3qA 1 0.6206 100 0.532 Contact Map
1hyqA 1 0.607 100 0.532 Contact Map
4pfsA 1 0.6233 100 0.532 Contact Map
3pg5A 2 0.5854 100 0.533 Contact Map
5aunB 2 0.6504 100 0.537 Contact Map
4rz3A 2 0.6287 100 0.538 Contact Map
2ph1A 2 0.6612 100 0.54 Contact Map
3ea0A 2 0.6125 100 0.544 Contact Map
1wcv1 2 0.6206 100 0.555 Contact Map
4v03A 2 0.6125 100 0.557 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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