GREMLIN Database
MODB - Molybdenum transport system permease protein ModB
UniProt: P0AF01 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10002
Length: 229 (201)
Sequences: 67620 (39410)
Seq/√Len: 2779.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_R139_T3.8711.00
12_L16_K3.1441.00
112_R116_E2.9091.00
127_R136_V2.9051.00
123_E141_T2.5341.00
114_A148_G2.5231.00
38_R123_E2.4991.00
126_A136_V2.4701.00
9_Q12_L2.4241.00
20_L96_V2.3801.00
132_G135_R2.3621.00
10_A184_A2.2921.00
24_F100_A2.2911.00
22_V153_T2.2841.00
179_R187_T2.2821.00
133_R136_V2.2471.00
8_W12_L2.2061.00
111_I149_I2.1611.00
194_G197_G2.1451.00
134_W138_F2.1241.00
41_F44_K2.1101.00
131_A135_R2.0241.00
107_M152_G1.9391.00
135_R138_F1.9341.00
115_L145_T1.9231.00
30_I137_F1.9131.00
37_V116_E1.8821.00
16_K92_W1.8351.00
48_D112_R1.8231.00
122_L144_L1.7781.00
214_L218_W1.7681.00
126_A131_A1.7371.00
18_S157_F1.7231.00
123_E136_V1.6981.00
26_L153_T1.6941.00
127_R133_R1.6851.00
30_I145_T1.6821.00
184_A188_L1.6761.00
9_Q13_L1.6511.00
123_E127_R1.6051.00
21_A160_S1.5921.00
36_L108_V1.5821.00
29_G107_M1.5581.00
16_K20_L1.5511.00
30_I111_I1.5331.00
107_M156_A1.5111.00
32_F108_V1.5001.00
27_P31_F1.4681.00
120_V123_E1.4591.00
43_G46_L1.4091.00
33_A111_I1.3881.00
40_T44_K1.3831.00
179_R184_A1.3761.00
142_L149_I1.3421.00
151_V155_L1.3411.00
164_F168_I1.3401.00
111_I152_G1.3361.00
37_V112_R1.2881.00
98_A170_F1.2711.00
38_R120_V1.2651.00
25_S156_A1.2641.00
166_A170_F1.2581.00
6_P9_Q1.2511.00
115_L141_T1.2501.00
30_I149_I1.2201.00
92_W178_T1.2181.00
34_W115_L1.2041.00
120_V124_Q1.1921.00
121_K124_Q1.1921.00
216_S219_L1.1831.00
188_L194_G1.1811.00
126_A140_I1.1751.00
13_L16_K1.1711.00
70_M94_G1.1711.00
188_L192_P1.1701.00
180_T183_S1.1511.00
146_L150_I1.1361.00
91_S178_T1.1331.00
46_L49_S1.1311.00
14_S181_I1.1291.00
23_L27_P1.1211.00
118_V144_L1.1131.00
132_G136_V1.1101.00
20_L23_L1.1071.00
104_F108_V1.0901.00
90_F93_R1.0841.00
37_V115_L1.0831.00
215_I218_W1.0751.00
187_T191_T1.0631.00
173_N177_E1.0581.00
26_L149_I1.0351.00
24_F96_V1.0291.00
46_L50_V1.0181.00
171_V178_T1.0161.00
184_A187_T1.0061.00
179_R183_S1.0011.00
144_L147_P0.9961.00
164_F186_Y0.9891.00
20_L24_F0.9861.00
131_A136_V0.9851.00
17_V180_T0.9761.00
31_F35_L0.9761.00
95_A167_T0.9721.00
68_V72_R0.9721.00
163_E167_T0.9701.00
21_A25_S0.9701.00
123_E133_R0.9681.00
111_I148_G0.9671.00
89_A93_R0.9651.00
186_Y190_Q0.9611.00
184_A201_L0.9591.00
34_W137_F0.9581.00
96_V100_A0.9561.00
136_V139_T0.9531.00
11_V181_I0.9511.00
44_K116_E0.9491.00
163_E166_A0.9491.00
21_A99_A0.9311.00
110_A152_G0.9251.00
15_L19_S0.9241.00
93_R97_L0.9231.00
167_T180_T0.9221.00
131_A139_T0.9191.00
23_L153_T0.9161.00
92_W96_V0.9011.00
34_W133_R0.8951.00
13_L92_W0.8941.00
99_A160_S0.8891.00
33_A37_V0.8881.00
98_A166_A0.8881.00
88_F93_R0.8811.00
19_S23_L0.8771.00
189_I198_A0.8731.00
66_L170_F0.8711.00
16_K93_R0.8681.00
66_L98_A0.8671.00
111_I145_T0.8581.00
59_P102_M0.8561.00
11_V15_L0.8531.00
145_T148_G0.8491.00
136_V141_T0.8461.00
16_K19_S0.8461.00
42_P45_A0.8441.00
29_G108_V0.8371.00
195_E198_A0.8371.00
146_L149_I0.8331.00
45_A48_D0.8321.00
188_L197_G0.8311.00
209_A213_L0.8311.00
138_F142_L0.8291.00
33_A115_L0.8261.00
7_E201_L0.8261.00
17_V92_W0.8251.00
89_A92_W0.8181.00
67_L71_G0.8141.00
21_A96_V0.8131.00
35_L41_F0.8081.00
197_G201_L0.8081.00
137_F142_L0.8031.00
173_N178_T0.7961.00
114_A145_T0.7951.00
52_H109_R0.7951.00
156_A160_S0.7951.00
176_G179_R0.7911.00
24_F27_P0.7821.00
217_E220_A0.7811.00
107_M111_I0.7801.00
215_I219_L0.7781.00
25_S29_G0.7721.00
168_I183_S0.7681.00
90_F173_N0.7671.00
63_G165_G0.7671.00
195_E199_A0.7611.00
33_A108_V0.7601.00
18_S22_V0.7581.00
12_L15_L0.7561.00
25_S103_S0.7551.00
17_V99_A0.7551.00
133_R137_F0.7441.00
52_H55_L0.7431.00
173_N176_G0.7401.00
71_G89_A0.7381.00
125_A129_L0.7351.00
177_E182_P0.7331.00
32_F104_F0.7261.00
36_L48_D0.7251.00
26_L111_I0.7251.00
62_V101_V0.7221.00
20_L100_A0.7211.00
36_L47_L0.7131.00
10_A13_L0.7131.00
36_L112_R0.7121.00
35_L39_C0.7101.00
163_E180_T0.7091.00
91_S94_G0.7021.00
183_S187_T0.7001.00
188_L201_L0.7001.00
94_G98_A0.6981.00
199_A203_I0.6981.00
137_F141_T0.6971.00
29_G111_I0.6961.00
122_L140_I0.6881.00
103_S156_A0.6881.00
63_G169_T0.6871.00
93_R96_V0.6861.00
120_V127_R0.6851.00
125_A128_T0.6741.00
22_V157_F0.6711.00
111_I115_L0.6701.00
59_P165_G0.6681.00
178_T182_P0.6651.00
196_S199_A0.6631.00
149_I152_G0.6561.00
41_F47_L0.6531.00
118_V145_T0.6521.00
25_S107_M0.6511.00
5_D8_W0.6501.00
28_F100_A0.6491.00
205_S209_A0.6491.00
67_L89_A0.6461.00
103_S159_R0.6441.00
95_A171_V0.6421.00
8_W11_V0.6381.00
48_D109_R0.6361.00
90_F94_G0.6331.00
199_A202_C0.6301.00
22_V26_L0.6251.00
68_V71_G0.6221.00
10_A181_I0.6211.00
25_S160_S0.6181.00
148_G152_G0.6141.00
32_F51_L0.6111.00
25_S100_A0.6111.00
216_S220_A0.6101.00
14_S161_L0.6091.00
183_S186_Y0.6081.00
40_T45_A0.6061.00
5_D9_Q0.5991.00
17_V95_A0.5981.00
6_P179_R0.5971.00
141_T144_L0.5971.00
213_L217_E0.5931.00
95_A99_A0.5921.00
194_G198_A0.5921.00
211_I215_I0.5911.00
55_L105_P0.5881.00
149_I153_T0.5881.00
14_S182_P0.5861.00
167_T183_S0.5801.00
138_F141_T0.5791.00
94_G170_F0.5761.00
60_V169_T0.5741.00
39_C133_R0.5741.00
171_V179_R0.5741.00
197_G200_R0.5731.00
28_F104_F0.5711.00
165_G168_I0.5691.00
22_V160_S0.5691.00
188_L191_T0.5691.00
50_V54_P0.5681.00
66_L69_S0.5661.00
9_Q16_K0.5631.00
214_L217_E0.5631.00
182_P188_L0.5561.00
34_W141_T0.5521.00
43_G47_L0.5521.00
150_I153_T0.5481.00
132_G138_F0.5481.00
33_A112_R0.5461.00
17_V21_A0.5441.00
182_P205_S0.5441.00
26_L30_I0.5431.00
159_R162_G0.5421.00
141_T145_T0.5421.00
49_S53_L0.5381.00
185_M201_L0.5361.00
136_V140_I0.5361.00
45_A49_S0.5341.00
153_T156_A0.5321.00
42_P46_L0.5321.00
30_I115_L0.5311.00
179_R188_L0.5301.00
158_A162_G0.5241.00
208_L211_I0.5231.00
17_V96_V0.5221.00
55_L106_L0.5221.00
119_D122_L0.5211.00
63_G67_L0.5211.00
110_A148_G0.5201.00
99_A167_T0.5171.00
182_P186_Y0.5161.00
59_P63_G0.5141.00
160_S163_E0.5131.00
47_L51_L0.5121.00
182_P185_M0.5101.00
28_F31_F0.5091.00
179_R182_P0.5071.00
18_S161_L0.5051.00
48_D116_E0.5031.00
57_L61_V0.5021.00
202_C205_S0.5001.00
13_L178_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.9258 100 0.233 Contact Map
3d31C 2 0.917 100 0.233 Contact Map
3rlfF 1 0.9345 100 0.269 Contact Map
4tquM 1 0.9782 100 0.273 Contact Map
3rlfG 1 0.9607 100 0.338 Contact Map
4tquN 1 0.8821 100 0.368 Contact Map
4ymuD 2 0.9039 100 0.375 Contact Map
3tuiA 2 0.8996 99.9 0.411 Contact Map
4mt1A 3 0.7948 17.6 0.933 Contact Map
2m20A 2 0.1703 13.1 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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