GREMLIN Database
MOAB - Molybdenum cofactor biosynthesis protein B
UniProt: P0AEZ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11596
Length: 170 (142)
Sequences: 7931 (5205)
Seq/√Len: 436.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_A70_V3.7191.00
37_A42_H3.2341.00
36_S148_E2.2921.00
92_L98_E2.2901.00
54_R93_P2.2221.00
109_L112_E2.1681.00
54_R58_R2.1471.00
91_L135_A2.1371.00
45_V70_V2.0151.00
32_Y144_R2.0051.00
51_K56_A1.9031.00
13_I37_A1.8921.00
20_N84_G1.8851.00
58_R62_S1.8791.00
104_E107_R1.8621.00
12_R43_H1.8411.00
53_N56_A1.8371.00
134_F151_I1.8311.00
48_A60_Q1.7991.00
34_R38_Q1.7831.00
60_Q63_A1.7551.00
15_I34_R1.7391.00
40_A147_W1.7001.00
16_L64_W1.6731.00
14_A64_W1.6431.00
147_W151_I1.5541.00
40_A152_A1.5361.00
152_A156_D1.5051.00
50_V60_Q1.4801.00
102_F121_S1.4721.00
33_L147_W1.4541.00
12_R45_V1.4461.00
58_R98_E1.4361.00
10_P43_H1.4091.00
111_F150_I1.3951.00
81_L99_V1.3941.00
72_V155_L1.3791.00
29_S76_T1.3451.00
34_R47_K1.3331.00
91_L95_F1.3251.00
58_R93_P1.3051.00
134_F154_Q1.2991.00
28_T140_T1.2821.00
65_I131_T1.2741.00
60_Q64_W1.2581.00
103_G107_R1.2361.00
118_T135_A1.2351.00
73_V131_T1.2221.00
17_T76_T1.2211.00
36_S147_W1.2181.00
18_V50_V1.1961.00
37_A44_V1.1721.00
141_K145_T1.1711.00
156_D161_P1.1651.00
18_V57_I1.1621.00
37_A147_W1.1351.00
21_R25_E1.1281.00
56_A60_Q1.1271.00
56_A59_A1.1261.00
55_Y59_A1.1191.00
32_Y140_T1.1131.00
63_A69_D1.1081.00
75_I133_I1.1051.00
55_Y58_R1.0991.00
16_L60_Q1.0871.00
48_A63_A1.0771.00
32_Y36_S1.0701.00
59_A63_A1.0591.00
27_D30_G1.0591.00
148_E152_A1.0441.00
105_V119_L1.0401.00
54_R86_Q1.0361.00
31_H35_D1.0321.00
35_D39_E1.0271.00
14_A47_K1.0241.00
74_L151_I1.0211.00
36_S40_A1.0171.00
74_L136_M1.0151.00
136_M146_A1.0061.00
104_E121_S1.0031.00
109_L150_I0.9971.00
20_N51_K0.9881.00
66_A69_D0.9881.00
111_F146_A0.9751.00
95_F133_I0.9691.00
11_T42_H0.9661.00
72_V134_F0.9651.00
32_Y143_C0.9621.00
115_G142_A0.9581.00
122_R129_N0.9581.00
95_F98_E0.9491.00
16_L50_V0.9461.00
17_T30_G0.9461.00
15_I44_V0.9411.00
106_F146_A0.9341.00
54_R57_I0.9321.00
103_G106_F0.9281.00
30_G46_D0.9231.00
32_Y35_D0.9221.00
47_K64_W0.9071.00
47_K70_V0.9031.00
95_F101_G0.8981.00
27_D31_H0.8911.00
16_L48_A0.8881.00
23_G26_D0.8851.00
33_L76_T0.8721.00
17_T49_I0.8701.00
117_S146_A0.8651.00
101_G122_R0.8581.00
66_A129_N0.8571.00
53_N57_I0.8401.00
8_F159_T0.8351.00
54_R94_L0.8291.00
102_F106_F0.8281.00
31_H47_K0.8281.00
96_D129_N0.8211.00
64_W70_V0.8031.00
117_S150_I0.8021.00
57_I86_Q0.8011.00
119_L134_F0.7971.00
144_R148_E0.7921.00
12_R70_V0.7891.00
9_I71_Q0.7791.00
121_S130_K0.7771.00
12_R71_Q0.7751.00
92_L95_F0.7721.00
146_A150_I0.7721.00
156_D159_T0.7661.00
17_T27_D0.7651.00
15_I37_A0.7621.00
47_K69_D0.7591.00
13_I42_H0.7581.00
75_I135_A0.7581.00
147_W152_A0.7581.00
122_R132_L0.7561.00
119_L132_L0.7541.00
101_G120_Q0.7531.00
34_R44_V0.7491.00
121_S132_L0.7471.00
18_V21_R0.7431.00
34_R46_D0.7331.00
13_I72_V0.7271.00
27_D49_I0.7251.00
14_A46_D0.7201.00
65_I73_V0.7121.00
92_L96_D0.7051.00
41_G44_V0.7041.00
137_P142_A0.6961.00
62_S129_N0.6941.00
75_I79_T0.6901.00
36_S144_R0.6801.00
62_S66_A0.6771.00
63_A66_A0.6751.00
136_M143_C0.6701.00
121_S129_N0.6671.00
15_I30_G0.6661.00
109_L149_N0.6591.00
61_V75_I0.6561.00
106_F118_T0.6540.99
61_V73_V0.6430.99
15_I33_L0.6420.99
45_V69_D0.6370.99
132_L158_R0.6280.99
91_L133_I0.6230.99
18_V75_I0.6210.99
50_V56_A0.6210.99
72_V132_L0.6190.99
52_E138_G0.6100.99
105_V109_L0.6030.99
154_Q158_R0.6030.99
38_Q43_H0.5990.99
53_N86_Q0.5990.99
98_E103_G0.5980.99
33_L136_M0.5960.99
79_T118_T0.5960.99
28_T31_H0.5930.99
72_V158_R0.5910.99
58_R94_L0.5900.99
17_T29_S0.5890.99
79_T135_A0.5860.99
17_T48_A0.5860.99
24_E47_K0.5860.99
33_L143_C0.5850.99
70_V73_V0.5800.99
99_V103_G0.5780.99
115_G119_L0.5740.99
38_Q44_V0.5700.99
30_G47_K0.5660.99
37_A74_L0.5640.99
21_R24_E0.5630.99
73_V133_I0.5600.98
62_S65_I0.5590.98
105_V111_F0.5580.98
101_G104_E0.5560.98
42_H155_L0.5560.98
57_I61_V0.5520.98
102_F105_V0.5490.98
132_L154_Q0.5450.98
137_P146_A0.5390.98
91_L94_L0.5380.98
80_G116_T0.5370.98
110_S114_I0.5330.98
65_I129_N0.5290.98
66_A70_V0.5290.98
64_W73_V0.5270.98
35_D38_Q0.5240.98
140_T144_R0.5210.98
54_R98_E0.5180.97
99_V102_F0.5020.97
38_Q41_G0.5020.97
65_I133_I0.5000.97
79_T84_G0.5000.97
103_G118_T0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd0A 2 0.9471 100 0.223 Contact Map
1g8lA 2 0.9118 100 0.239 Contact Map
1uz5A 1 0.8824 100 0.246 Contact Map
1y5eA 4 0.9294 100 0.261 Contact Map
1wu2A 2 0.8235 100 0.263 Contact Map
3rfqA 5 0.9059 100 0.264 Contact Map
1mkzA 2 0.9941 100 0.27 Contact Map
1jljA 3 0.9235 100 0.282 Contact Map
4lhbA 4 0.9059 100 0.287 Contact Map
3iwtA 4 0.9118 100 0.292 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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