MOAB - ECOLI - GREMLIN Contacts

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MOAB - Molybdenum cofactor biosynthesis protein B

UniProt:	P0AEZ9	Sequences: MSQVSTEFIPTRIAILTVSNRRGEEDDTSGHYLRDSAQEAGHHVVDKAIVKENRYAIRAQVSAWIASDDVQVVLITGGTGLTEGDQAPEALLPLFDREVEGFGEVFRMLSFEEIGTSTLQSRAVAGVANKTLIFAMPGSTKACRTAWENIIAPQLDARTRPCNFHPHLKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11596
Length:	170 (142)
Sequences:	7931 (5205)
Seq/√Len:	436.8

ECOLI - MOAB MOG MOEA
BACSU - MOAB MOEA
HALSA - Q9HP37 Q9HST2 Q9HST3
SULSO - Q981C6 Q97W71 Q7LXN4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_A	70_V	3.719	1.00
37_A	42_H	3.234	1.00
36_S	148_E	2.292	1.00
92_L	98_E	2.290	1.00
54_R	93_P	2.222	1.00
109_L	112_E	2.168	1.00
54_R	58_R	2.147	1.00
91_L	135_A	2.137	1.00
45_V	70_V	2.015	1.00
32_Y	144_R	2.005	1.00
51_K	56_A	1.903	1.00
13_I	37_A	1.892	1.00
20_N	84_G	1.885	1.00
58_R	62_S	1.879	1.00
104_E	107_R	1.862	1.00
12_R	43_H	1.841	1.00
53_N	56_A	1.837	1.00
134_F	151_I	1.831	1.00
48_A	60_Q	1.799	1.00
34_R	38_Q	1.783	1.00
60_Q	63_A	1.755	1.00
15_I	34_R	1.739	1.00
40_A	147_W	1.700	1.00
16_L	64_W	1.673	1.00
14_A	64_W	1.643	1.00
147_W	151_I	1.554	1.00
40_A	152_A	1.536	1.00
152_A	156_D	1.505	1.00
50_V	60_Q	1.480	1.00
102_F	121_S	1.472	1.00
33_L	147_W	1.454	1.00
12_R	45_V	1.446	1.00
58_R	98_E	1.436	1.00
10_P	43_H	1.409	1.00
111_F	150_I	1.395	1.00
81_L	99_V	1.394	1.00
72_V	155_L	1.379	1.00
29_S	76_T	1.345	1.00
34_R	47_K	1.333	1.00
91_L	95_F	1.325	1.00
58_R	93_P	1.305	1.00
134_F	154_Q	1.299	1.00
28_T	140_T	1.282	1.00
65_I	131_T	1.274	1.00
60_Q	64_W	1.258	1.00
103_G	107_R	1.236	1.00
118_T	135_A	1.235	1.00
73_V	131_T	1.222	1.00
17_T	76_T	1.221	1.00
36_S	147_W	1.218	1.00
18_V	50_V	1.196	1.00
37_A	44_V	1.172	1.00
141_K	145_T	1.171	1.00
156_D	161_P	1.165	1.00
18_V	57_I	1.162	1.00
37_A	147_W	1.135	1.00
21_R	25_E	1.128	1.00
56_A	60_Q	1.127	1.00
56_A	59_A	1.126	1.00
55_Y	59_A	1.119	1.00
32_Y	140_T	1.113	1.00
63_A	69_D	1.108	1.00
75_I	133_I	1.105	1.00
55_Y	58_R	1.099	1.00
16_L	60_Q	1.087	1.00
48_A	63_A	1.077	1.00
32_Y	36_S	1.070	1.00
59_A	63_A	1.059	1.00
27_D	30_G	1.059	1.00
148_E	152_A	1.044	1.00
105_V	119_L	1.040	1.00
54_R	86_Q	1.036	1.00
31_H	35_D	1.032	1.00
35_D	39_E	1.027	1.00
14_A	47_K	1.024	1.00
74_L	151_I	1.021	1.00
36_S	40_A	1.017	1.00
74_L	136_M	1.015	1.00
136_M	146_A	1.006	1.00
104_E	121_S	1.003	1.00
109_L	150_I	0.997	1.00
20_N	51_K	0.988	1.00
66_A	69_D	0.988	1.00
111_F	146_A	0.975	1.00
95_F	133_I	0.969	1.00
11_T	42_H	0.966	1.00
72_V	134_F	0.965	1.00
32_Y	143_C	0.962	1.00
115_G	142_A	0.958	1.00
122_R	129_N	0.958	1.00
95_F	98_E	0.949	1.00
16_L	50_V	0.946	1.00
17_T	30_G	0.946	1.00
15_I	44_V	0.941	1.00
106_F	146_A	0.934	1.00
54_R	57_I	0.932	1.00
103_G	106_F	0.928	1.00
30_G	46_D	0.923	1.00
32_Y	35_D	0.922	1.00
47_K	64_W	0.907	1.00
47_K	70_V	0.903	1.00
95_F	101_G	0.898	1.00
27_D	31_H	0.891	1.00
16_L	48_A	0.888	1.00
23_G	26_D	0.885	1.00
33_L	76_T	0.872	1.00
17_T	49_I	0.870	1.00
117_S	146_A	0.865	1.00
101_G	122_R	0.858	1.00
66_A	129_N	0.857	1.00
53_N	57_I	0.840	1.00
8_F	159_T	0.835	1.00
54_R	94_L	0.829	1.00
102_F	106_F	0.828	1.00
31_H	47_K	0.828	1.00
96_D	129_N	0.821	1.00
64_W	70_V	0.803	1.00
117_S	150_I	0.802	1.00
57_I	86_Q	0.801	1.00
119_L	134_F	0.797	1.00
144_R	148_E	0.792	1.00
12_R	70_V	0.789	1.00
9_I	71_Q	0.779	1.00
121_S	130_K	0.777	1.00
12_R	71_Q	0.775	1.00
92_L	95_F	0.772	1.00
146_A	150_I	0.772	1.00
156_D	159_T	0.766	1.00
17_T	27_D	0.765	1.00
15_I	37_A	0.762	1.00
47_K	69_D	0.759	1.00
13_I	42_H	0.758	1.00
75_I	135_A	0.758	1.00
147_W	152_A	0.758	1.00
122_R	132_L	0.756	1.00
119_L	132_L	0.754	1.00
101_G	120_Q	0.753	1.00
34_R	44_V	0.749	1.00
121_S	132_L	0.747	1.00
18_V	21_R	0.743	1.00
34_R	46_D	0.733	1.00
13_I	72_V	0.727	1.00
27_D	49_I	0.725	1.00
14_A	46_D	0.720	1.00
65_I	73_V	0.712	1.00
92_L	96_D	0.705	1.00
41_G	44_V	0.704	1.00
137_P	142_A	0.696	1.00
62_S	129_N	0.694	1.00
75_I	79_T	0.690	1.00
36_S	144_R	0.680	1.00
62_S	66_A	0.677	1.00
63_A	66_A	0.675	1.00
136_M	143_C	0.670	1.00
121_S	129_N	0.667	1.00
15_I	30_G	0.666	1.00
109_L	149_N	0.659	1.00
61_V	75_I	0.656	1.00
106_F	118_T	0.654	0.99
61_V	73_V	0.643	0.99
15_I	33_L	0.642	0.99
45_V	69_D	0.637	0.99
132_L	158_R	0.628	0.99
91_L	133_I	0.623	0.99
18_V	75_I	0.621	0.99
50_V	56_A	0.621	0.99
72_V	132_L	0.619	0.99
52_E	138_G	0.610	0.99
105_V	109_L	0.603	0.99
154_Q	158_R	0.603	0.99
38_Q	43_H	0.599	0.99
53_N	86_Q	0.599	0.99
98_E	103_G	0.598	0.99
33_L	136_M	0.596	0.99
79_T	118_T	0.596	0.99
28_T	31_H	0.593	0.99
72_V	158_R	0.591	0.99
58_R	94_L	0.590	0.99
17_T	29_S	0.589	0.99
79_T	135_A	0.586	0.99
17_T	48_A	0.586	0.99
24_E	47_K	0.586	0.99
33_L	143_C	0.585	0.99
70_V	73_V	0.580	0.99
99_V	103_G	0.578	0.99
115_G	119_L	0.574	0.99
38_Q	44_V	0.570	0.99
30_G	47_K	0.566	0.99
37_A	74_L	0.564	0.99
21_R	24_E	0.563	0.99
73_V	133_I	0.560	0.98
62_S	65_I	0.559	0.98
105_V	111_F	0.558	0.98
101_G	104_E	0.556	0.98
42_H	155_L	0.556	0.98
57_I	61_V	0.552	0.98
102_F	105_V	0.549	0.98
132_L	154_Q	0.545	0.98
137_P	146_A	0.539	0.98
91_L	94_L	0.538	0.98
80_G	116_T	0.537	0.98
110_S	114_I	0.533	0.98
65_I	129_N	0.529	0.98
66_A	70_V	0.529	0.98
64_W	73_V	0.527	0.98
35_D	38_Q	0.524	0.98
140_T	144_R	0.521	0.98
54_R	98_E	0.518	0.97
99_V	102_F	0.502	0.97
38_Q	41_G	0.502	0.97
65_I	133_I	0.500	0.97
79_T	84_G	0.500	0.97
103_G	118_T	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pd0A	2	0.9471	100	0.223	Contact Map
1g8lA	2	0.9118	100	0.239	Contact Map
1uz5A	1	0.8824	100	0.246	Contact Map
1y5eA	4	0.9294	100	0.261	Contact Map
1wu2A	2	0.8235	100	0.263	Contact Map
3rfqA	5	0.9059	100	0.264	Contact Map
1mkzA	2	0.9941	100	0.27	Contact Map
1jljA	3	0.9235	100	0.282	Contact Map
4lhbA	4	0.9059	100	0.287	Contact Map
3iwtA	4	0.9118	100	0.292	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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