GREMLIN Database
MLTD - Membrane-bound lytic murein transglycosylase D
UniProt: P0AEZ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10246
Length: 452 (374)
Sequences: 1320 (931)
Seq/√Len: 48.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
402_Y417_H7.4881.00
343_Y349_D6.3701.00
343_Y358_L6.0921.00
402_Y408_D5.2081.00
154_L172_A3.8781.00
108_Q111_K3.8081.00
345_V380_Q3.7651.00
112_R174_L3.3441.00
109_V174_L3.1671.00
427_W443_F3.1431.00
149_G156_Q3.1391.00
112_R175_N3.1371.00
419_V427_W3.1071.00
409_S412_S2.7851.00
366_Q374_S2.7621.00
345_V378_P2.7391.00
112_R178_Q2.6481.00
217_D220_S2.6231.00
105_I128_F2.6061.00
152_Y179_R2.5711.00
62_F110_K2.5601.00
137_N145_I2.5581.00
364_D368_W2.4241.00
109_V118_L2.3811.00
114_M118_L2.3121.00
108_Q171_T2.2811.00
81_K239_D2.2641.00
133_T164_R2.1631.00
424_V442_L2.1211.00
197_S201_R2.0581.00
149_G154_L2.0581.00
108_Q174_L2.0261.00
180_L194_A2.0130.99
110_K116_M1.9890.99
361_S364_D1.9680.99
181_N191_T1.9560.99
183_M199_E1.9180.99
271_M274_V1.8920.99
136_A145_I1.8500.99
365_L384_I1.8470.99
421_I424_V1.8420.99
350_T353_S1.8050.99
344_T381_S1.8040.99
114_M178_Q1.7950.99
179_R183_M1.7910.99
425_M432_A1.7750.99
360_V368_W1.7650.99
403_R439_K1.7620.99
402_Y413_I1.7570.99
410_L430_D1.7540.99
96_L99_E1.7530.99
184_F203_M1.7510.99
340_S385_G1.7230.98
133_T139_A1.7080.98
340_S383_T1.7070.98
151_N199_E1.7060.98
411_S415_K1.6710.98
352_S362_T1.6640.98
342_V381_S1.6590.98
404_V440_L1.6450.98
360_V365_L1.6320.98
366_Q373_G1.6120.98
183_M203_M1.5930.97
368_W385_G1.5840.97
281_S284_K1.5830.97
404_V413_I1.5800.97
197_S224_P1.5750.97
260_L306_M1.5610.97
80_Q233_K1.5570.97
179_R199_E1.5530.97
171_T175_N1.5470.97
174_L178_Q1.5390.97
66_E116_M1.5140.96
240_I249_V1.5130.96
315_L318_S1.5090.96
260_L288_F1.4940.96
197_S223_L1.4860.96
420_N423_D1.4750.96
280_I311_H1.4710.96
192_V218_F1.4550.95
170_T174_L1.4390.95
202_V224_P1.4310.95
373_G376_L1.4140.95
401_T439_K1.4130.95
144_I176_M1.3930.94
159_N294_G1.3910.94
193_A232_P1.3770.94
298_G303_Q1.3760.94
399_S441_T1.3620.93
175_N178_Q1.3610.93
102_M119_V1.3570.93
262_R304_Y1.3530.93
106_A119_V1.3480.93
227_T231_V1.3420.93
104_W166_V1.3300.93
206_I216_T1.3290.93
199_E203_M1.3280.93
139_A164_R1.3260.93
90_Y94_V1.3130.92
286_K295_S1.3070.92
349_D378_P1.2990.92
422_K425_M1.2910.91
193_A231_V1.2870.91
292_V303_Q1.2850.91
411_S414_A1.2840.91
274_V278_A1.2840.91
307_V312_A1.2780.91
93_D127_A1.2780.91
201_R204_K1.2760.91
102_M128_F1.2720.91
209_N214_K1.2590.90
112_R171_T1.2570.90
279_G311_H1.2540.90
362_T366_Q1.2520.90
275_A280_I1.2480.90
218_F232_P1.2470.90
360_V364_D1.2290.89
177_M180_L1.2240.89
199_E204_K1.2200.89
100_P260_L1.2160.89
121_L177_M1.2150.89
162_A291_G1.2100.89
320_A323_E1.2070.88
345_V354_I1.2050.88
192_V234_M1.2000.88
341_R365_L1.1920.88
197_S202_V1.1900.88
148_T176_M1.1880.88
410_L425_M1.1860.88
193_A219_W1.1810.87
209_N216_T1.1710.87
61_A65_D1.1710.87
362_T365_L1.1690.87
76_R218_F1.1670.87
411_S434_L1.1620.86
177_M191_T1.1550.86
425_M433_N1.1510.86
193_A227_T1.1510.86
360_V385_G1.1500.86
430_D438_D1.1500.86
351_L382_L1.1490.86
307_V315_L1.1460.86
180_L199_E1.1460.86
397_S415_K1.1460.86
319_L323_E1.1440.86
85_L244_S1.1440.86
150_R156_Q1.1430.86
226_E232_P1.1270.85
402_Y405_R1.1250.85
343_Y354_I1.1190.84
108_Q112_R1.0990.83
209_N215_S1.0970.83
104_W171_T1.0950.83
354_I382_L1.0890.83
193_A218_F1.0870.83
91_L94_V1.0820.82
354_I365_L1.0760.82
285_L305_V1.0700.82
219_W232_P1.0690.81
159_N299_A1.0610.81
159_N297_L1.0580.81
124_V237_L1.0540.81
109_V116_M1.0460.80
158_R294_G1.0450.80
106_A116_M1.0420.80
268_P299_A1.0400.80
121_L234_M1.0390.80
419_V423_D1.0380.80
209_N222_P1.0360.79
149_G204_K1.0320.79
173_A177_M1.0260.79
89_S93_D1.0260.79
425_M430_D1.0240.79
341_R358_L1.0230.79
243_N247_Y1.0200.78
105_I141_I1.0110.78
133_T137_N1.0100.78
396_N401_T1.0100.78
78_R82_Q1.0060.77
187_D190_L1.0050.77
119_V128_F1.0030.77
209_N217_D0.9940.77
202_V280_I0.9930.76
114_M174_L0.9930.76
343_Y346_R0.9920.76
201_R224_P0.9920.76
430_D440_L0.9880.76
227_T232_P0.9860.76
423_D426_R0.9840.76
322_G337_P0.9830.76
63_I106_A0.9770.75
408_D417_H0.9760.75
435_Q438_D0.9730.75
401_T406_K0.9730.75
154_L226_E0.9730.75
122_P174_L0.9720.75
410_L424_V0.9720.75
244_S247_Y0.9700.75
269_V274_V0.9600.74
104_W108_Q0.9520.73
337_P340_S0.9470.73
109_V112_R0.9470.73
168_A171_T0.9450.73
404_V407_G0.9440.73
399_S430_D0.9410.72
180_L184_F0.9410.72
371_L380_Q0.9380.72
74_N219_W0.9320.72
69_M189_L0.9320.72
311_H314_Q0.9250.71
241_L251_L0.9240.71
80_Q83_K0.9210.71
209_N220_S0.9110.70
215_S220_S0.9070.70
345_V377_K0.9050.69
353_S357_R0.9040.69
144_I154_L0.9000.69
134_S138_A0.8990.69
120_L241_L0.8990.69
169_S248_G0.8960.69
274_V315_L0.8960.69
352_S376_L0.8910.68
189_L219_W0.8900.68
101_Y260_L0.8890.68
134_S173_A0.8890.68
91_L249_V0.8800.67
263_V315_L0.8800.67
278_A315_L0.8790.67
181_N188_W0.8790.67
218_F228_K0.8780.67
131_H286_K0.8780.67
377_K380_Q0.8740.67
136_A201_R0.8730.67
400_I424_V0.8680.66
371_L374_S0.8680.66
424_V430_D0.8680.66
421_I425_M0.8680.66
58_D62_F0.8670.66
243_N246_R0.8660.66
176_M184_F0.8640.66
109_V114_M0.8620.66
377_K413_I0.8580.65
271_M285_L0.8560.65
353_S376_L0.8550.65
63_I67_L0.8520.65
62_F66_E0.8500.65
349_D353_S0.8490.64
235_L238_S0.8480.64
418_G429_S0.8480.64
412_S415_K0.8420.64
434_L438_D0.8300.63
270_E295_S0.8300.63
142_W173_A0.8300.63
419_V442_L0.8140.61
413_I429_S0.8130.61
351_L362_T0.8110.61
62_F107_G0.8110.61
59_L69_M0.8090.61
151_N365_L0.8090.61
78_R81_K0.8070.61
145_I176_M0.8030.60
219_W297_L0.7960.59
315_L319_L0.7940.59
414_A421_I0.7930.59
351_L365_L0.7900.59
158_R295_S0.7900.59
102_M106_A0.7860.59
203_M207_K0.7850.58
270_E297_L0.7850.58
105_I119_V0.7850.58
101_Y259_A0.7840.58
189_L235_L0.7840.58
192_V231_V0.7820.58
423_D427_W0.7820.58
349_D354_I0.7800.58
102_M109_V0.7780.58
368_W384_I0.7750.57
97_R105_I0.7740.57
147_S176_M0.7700.57
151_N179_R0.7690.57
105_I174_L0.7690.57
92_H252_P0.7680.57
219_W351_L0.7660.57
351_L366_Q0.7610.56
120_L214_K0.7600.56
399_S442_L0.7580.56
254_T258_R0.7580.56
197_S228_K0.7580.56
90_Y97_R0.7560.56
125_E143_Q0.7510.55
155_K298_G0.7490.55
187_D232_P0.7470.55
429_S441_T0.7450.54
208_T222_P0.7440.54
345_V381_S0.7440.54
277_M288_F0.7440.54
399_S443_F0.7440.54
149_G152_Y0.7410.54
271_M282_V0.7410.54
376_L380_Q0.7370.54
224_P231_V0.7370.54
360_V384_I0.7330.53
138_A226_E0.7320.53
242_K279_G0.7320.53
295_S305_V0.7300.53
423_D429_S0.7290.53
402_Y436_P0.7290.53
99_E149_G0.7280.53
51_T55_P0.7250.52
348_G351_L0.7230.52
186_G206_I0.7210.52
119_V234_M0.7200.52
270_E273_K0.7180.52
400_I419_V0.7170.52
193_A226_E0.7160.52
406_K424_V0.7140.51
160_Y291_G0.7090.51
402_Y407_G0.7080.51
142_W188_W0.7080.51
270_E278_A0.7060.51
164_R293_K0.7050.50
157_T423_D0.7030.50
241_L249_V0.7030.50
274_V282_V0.7020.50
80_Q229_Q0.7010.50
56_D65_D0.6980.50
169_S433_N0.6980.50
406_K436_P0.6960.50
157_T298_G0.6960.50
131_H164_R0.6950.49
102_M237_L0.6950.49
279_G283_S0.6950.49
434_L440_L0.6930.49
81_K247_Y0.6910.49
158_R296_T0.6900.49
55_P58_D0.6870.49
144_I152_Y0.6870.49
76_R80_Q0.6870.49
346_R372_R0.6860.49
362_T377_K0.6850.48
134_S196_N0.6820.48
77_I384_I0.6800.48
280_I285_L0.6790.48
403_R441_T0.6780.48
388_S395_N0.6760.48
427_W441_T0.6760.48
201_R223_L0.6760.48
141_I263_V0.6740.47
348_G354_I0.6730.47
239_D285_L0.6730.47
81_K201_R0.6720.47
122_P128_F0.6720.47
94_V117_E0.6710.47
284_K287_T0.6700.47
138_A144_I0.6680.47
224_P227_T0.6670.47
160_Y298_G0.6660.47
354_I358_L0.6660.47
106_A120_L0.6650.46
401_T441_T0.6590.46
146_P260_L0.6590.46
80_Q84_Y0.6570.46
264_H302_P0.6570.46
206_I217_D0.6560.46
58_D253_T0.6560.46
274_V277_M0.6560.46
342_V383_T0.6540.45
235_L291_G0.6530.45
80_Q90_Y0.6530.45
387_G442_L0.6530.45
147_S151_N0.6520.45
134_S144_I0.6520.45
340_S368_W0.6520.45
229_Q233_K0.6520.45
400_I418_G0.6500.45
239_D244_S0.6490.45
219_W223_L0.6440.44
396_N422_K0.6420.44
417_H436_P0.6410.44
335_N376_L0.6400.44
274_V305_V0.6390.44
239_D247_Y0.6370.44
197_S226_E0.6320.43
193_A230_Y0.6320.43
122_P293_K0.6300.43
84_Y127_A0.6300.43
184_F194_A0.6290.43
88_K92_H0.6290.43
123_I237_L0.6270.43
346_R357_R0.6270.43
162_A168_A0.6240.42
182_K250_R0.6230.42
406_K411_S0.6210.42
425_M431_T0.6190.42
377_K409_S0.6190.42
430_D441_T0.6170.42
52_S55_P0.6170.42
350_T378_P0.6150.41
118_L189_L0.6150.41
129_D132_A0.6140.41
380_Q386_A0.6130.41
118_L193_A0.6120.41
411_S430_D0.6120.41
410_L432_A0.6120.41
343_Y382_L0.6110.41
150_R366_Q0.6090.41
60_W117_E0.6080.41
420_N431_T0.6070.41
312_A315_L0.6070.41
209_N221_L0.6060.41
100_P284_K0.6050.40
153_G354_I0.6040.40
278_A282_V0.6020.40
352_S411_S0.6010.40
201_R208_T0.6010.40
61_A64_G0.6000.40
192_V237_L0.6000.40
396_N400_I0.5990.40
428_N437_G0.5980.40
362_T416_R0.5980.40
94_V123_I0.5980.40
413_I434_L0.5980.40
272_A276_D0.5970.40
202_V232_P0.5970.40
409_S421_I0.5960.40
397_S433_N0.5960.40
416_R442_L0.5950.40
349_D377_K0.5950.40
429_S439_K0.5950.40
397_S403_R0.5940.39
147_S152_Y0.5940.39
355_A361_S0.5930.39
184_F199_E0.5920.39
148_T190_L0.5910.39
323_E335_N0.5910.39
78_R266_S0.5910.39
128_F197_S0.5900.39
264_H304_Y0.5890.39
194_A199_E0.5870.39
349_D352_S0.5870.39
54_A57_G0.5870.39
395_N418_G0.5820.38
94_V127_A0.5770.38
415_K418_G0.5770.38
84_Y233_K0.5760.38
104_W168_A0.5760.38
166_V169_S0.5750.38
58_D64_G0.5750.38
282_V286_K0.5750.38
410_L440_L0.5740.38
190_L263_V0.5740.38
180_L195_Y0.5720.37
71_I74_N0.5710.37
74_N77_I0.5710.37
108_Q122_P0.5710.37
414_A417_H0.5690.37
109_V178_Q0.5690.37
78_R248_G0.5680.37
268_P303_Q0.5670.37
314_Q318_S0.5660.37
291_G303_Q0.5650.37
221_L228_K0.5640.37
158_R340_S0.5640.37
63_I116_M0.5630.36
202_V230_Y0.5630.36
193_A223_L0.5630.36
246_R341_R0.5620.36
126_S143_Q0.5590.36
200_G230_Y0.5590.36
221_L243_N0.5590.36
84_Y128_F0.5580.36
353_S373_G0.5580.36
399_S403_R0.5580.36
376_L438_D0.5570.36
377_K419_V0.5540.36
138_A195_Y0.5540.36
401_T420_N0.5540.36
94_V129_D0.5540.36
423_D435_Q0.5530.36
202_V223_L0.5530.36
206_I225_Q0.5520.35
275_A278_A0.5520.35
104_W122_P0.5520.35
366_Q376_L0.5520.35
283_S356_S0.5510.35
310_K315_L0.5510.35
268_P297_L0.5500.35
271_M292_V0.5500.35
366_Q382_L0.5490.35
218_F230_Y0.5480.35
122_P141_I0.5460.35
149_G187_D0.5440.35
101_Y130_P0.5420.35
135_G360_V0.5420.35
233_K240_I0.5420.35
60_W120_L0.5400.34
422_K432_A0.5380.34
69_M166_V0.5380.34
67_L75_D0.5370.34
193_A224_P0.5370.34
430_D434_L0.5360.34
238_S242_K0.5360.34
129_D179_R0.5360.34
350_T385_G0.5360.34
419_V426_R0.5350.34
176_M179_R0.5340.34
117_E205_A0.5340.34
305_V400_I0.5320.34
122_P241_L0.5320.34
127_A225_Q0.5320.34
347_S406_K0.5310.34
63_I241_L0.5290.33
346_R398_D0.5290.33
180_L193_A0.5280.33
364_D367_Q0.5270.33
255_D358_L0.5270.33
416_R422_K0.5270.33
279_G314_Q0.5270.33
347_S372_R0.5270.33
426_R439_K0.5260.33
271_M275_A0.5250.33
408_D435_Q0.5250.33
81_K85_L0.5250.33
168_A202_V0.5230.33
336_T371_L0.5210.33
109_V234_M0.5200.33
323_E337_P0.5200.33
69_M213_G0.5190.33
100_P160_Y0.5180.32
53_I56_D0.5180.32
357_R361_S0.5150.32
162_A299_A0.5150.32
397_S409_S0.5140.32
402_Y412_S0.5140.32
419_V424_V0.5140.32
74_N81_K0.5120.32
75_D344_T0.5110.32
236_A240_I0.5100.32
157_T253_T0.5100.32
89_S92_H0.5100.32
66_E71_I0.5100.32
184_F206_I0.5090.32
159_N223_L0.5090.32
85_L371_L0.5080.32
226_E231_V0.5080.32
112_R258_R0.5080.32
117_E234_M0.5070.31
397_S439_K0.5060.31
376_L420_N0.5060.31
118_L286_K0.5050.31
196_N407_G0.5040.31
214_K220_S0.5040.31
145_I200_G0.5040.31
51_T54_A0.5020.31
136_A240_I0.5020.31
398_D402_Y0.5020.31
285_L292_V0.5010.31
344_T357_R0.5010.31
95_T98_A0.5010.31
358_L362_T0.5000.31
119_V260_L0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cfpA 1 0.5221 100 0.744 Contact Map
4hjzA 1 0.3496 100 0.769 Contact Map
4p0gA 1 0.531 100 0.776 Contact Map
1qsaA 1 0.5553 100 0.781 Contact Map
4b8vA 2 0.4093 100 0.792 Contact Map
4ebyA 1 0.3982 100 0.794 Contact Map
1gbsA 1 0.3695 99.9 0.813 Contact Map
4g9sA 1 0.3761 99.9 0.815 Contact Map
3gxrA 1 0.3739 99.9 0.816 Contact Map
3w6bA 1 0.3363 99.9 0.816 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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