GREMLIN Database
MIND - Septum site-determining protein MinD
UniProt: P0AEZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10597
Length: 270 (235)
Sequences: 16940 (11007)
Seq/√Len: 718.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_P238_A3.9131.00
20_S118_V3.6581.00
84_Y114_F3.6241.00
30_K244_E3.1341.00
32_K116_F2.8991.00
19_S239_Y2.8361.00
27_L116_F2.8351.00
6_V136_A2.7621.00
226_P229_L2.7151.00
3_R138_E2.6761.00
35_V114_F2.6731.00
36_V46_L2.5551.00
144_N182_R2.4251.00
180_L183_Y2.4051.00
21_A46_L2.3921.00
182_R213_E2.3561.00
24_A36_V2.2031.00
49_I148_S2.1911.00
76_K84_Y2.0721.00
216_S219_R2.0571.00
7_V23_I2.0131.00
184_N213_E2.0031.00
26_G243_V1.9721.00
20_S36_V1.9621.00
29_Q240_A1.9611.00
26_G228_I1.9211.00
197_E201_E1.9001.00
209_G245_R1.8271.00
27_L118_V1.8031.00
33_K115_E1.7721.00
19_S179_L1.7581.00
48_L151_R1.7441.00
21_A49_I1.7281.00
30_K240_A1.7101.00
69_T72_Q1.7091.00
39_F132_A1.6911.00
32_K247_L1.6551.00
6_V121_S1.6531.00
4_I119_C1.6051.00
24_A118_V1.5941.00
209_G242_T1.5861.00
214_D235_A1.5811.00
32_K115_E1.5301.00
7_V140_I1.5181.00
138_E176_E1.5181.00
180_L196_M1.5041.00
197_E210_V1.4781.00
179_L242_T1.4341.00
196_M200_L1.4311.00
45_N152_D1.4261.00
182_R185_P1.4221.00
23_I246_L1.4081.00
215_Q219_R1.4081.00
59_D62_N1.3961.00
71_N113_D1.3951.00
178_L187_R1.3921.00
139_A160_L1.3891.00
39_F119_C1.3781.00
3_R137_D1.3741.00
198_D202_I1.3591.00
21_A50_M1.3521.00
24_A46_L1.3481.00
39_F60_F1.3471.00
61_V65_Q1.3181.00
8_T156_I1.3091.00
23_I243_V1.3071.00
145_P180_L1.3001.00
28_A83_L1.2811.00
7_V20_S1.2711.00
77_D80_T1.2591.00
30_K247_L1.2561.00
177_H208_V1.2521.00
217_V235_A1.2521.00
35_V117_I1.2361.00
219_R223_Q1.2311.00
138_E177_H1.2291.00
146_E149_S1.2231.00
199_V203_L1.2231.00
100_E103_A1.2101.00
216_S230_D1.2081.00
169_N172_E1.1961.00
68_A72_Q1.1891.00
183_Y210_V1.1831.00
102_V105_V1.1831.00
15_G181_T1.1791.00
140_I179_L1.1721.00
8_T121_S1.1721.00
27_L34_T1.1611.00
237_K240_A1.1521.00
50_M83_L1.1501.00
194_L197_E1.1431.00
233_A236_G1.1101.00
238_A241_D1.1001.00
207_L210_V1.0871.00
17_T49_I1.0811.00
225_E229_L1.0761.00
211_I235_A1.0751.00
146_E218_L1.0741.00
25_T29_Q1.0691.00
116_F247_L1.0661.00
73_A76_K1.0651.00
22_A25_T1.0641.00
90_Q155_R1.0641.00
45_N148_S1.0591.00
214_D233_A1.0511.00
80_T229_L1.0451.00
19_S23_I1.0361.00
148_S221_S1.0351.00
241_D245_R1.0351.00
69_T74_L1.0291.00
240_A244_E1.0281.00
19_S181_T1.0261.00
100_E104_K1.0251.00
95_D98_T1.0251.00
58_Y62_N1.0241.00
80_T83_L1.0221.00
17_T46_L1.0171.00
72_Q75_I1.0061.00
195_S198_D1.0061.00
37_I119_C1.0051.00
198_D201_E1.0031.00
27_L243_V1.0031.00
241_D244_E0.9991.00
101_G105_V0.9941.00
60_F63_V0.9921.00
105_V108_D0.9821.00
244_E248_G0.9801.00
26_G30_K0.9791.00
22_A228_I0.9781.00
104_K108_D0.9771.00
88_A91_T0.9741.00
33_K113_D0.9731.00
84_Y87_P0.9601.00
41_I128_G0.9571.00
28_A82_N0.9481.00
4_I117_I0.9411.00
37_I117_I0.9401.00
26_G240_A0.9391.00
121_S132_A0.9331.00
214_D234_D0.9191.00
63_V66_G0.9191.00
61_V64_I0.9181.00
143_T196_M0.9161.00
70_L86_L0.9151.00
5_I246_L0.9141.00
7_V19_S0.9101.00
242_T246_L0.9081.00
228_I240_A0.9051.00
43_L47_D0.9051.00
18_T221_S0.9031.00
8_T129_A0.9021.00
174_I177_H0.8991.00
154_D202_I0.8981.00
178_L181_T0.8951.00
103_A107_D0.8941.00
194_L198_D0.8931.00
235_A238_A0.8931.00
141_I153_S0.8881.00
195_S200_L0.8871.00
211_I238_A0.8851.00
25_T228_I0.8841.00
18_T217_V0.8811.00
5_I116_F0.8741.00
7_V118_V0.8711.00
158_G161_A0.8701.00
234_D237_K0.8641.00
44_R47_D0.8611.00
68_A71_N0.8601.00
29_Q229_L0.8521.00
192_D195_S0.8471.00
231_I236_G0.8471.00
96_A126_E0.8461.00
43_L123_A0.8411.00
4_I110_K0.8361.00
73_A86_L0.8331.00
74_L77_D0.8331.00
24_A83_L0.8301.00
234_D238_A0.8271.00
181_T239_Y0.8231.00
67_D74_L0.8191.00
44_R88_A0.8111.00
4_I137_D0.8061.00
164_S173_P0.8051.00
71_N75_I0.8051.00
68_A73_A0.8021.00
71_N76_K0.8021.00
114_F117_I0.7981.00
34_T116_F0.7961.00
197_E200_L0.7891.00
145_P183_Y0.7881.00
230_D233_A0.7861.00
137_D171_E0.7821.00
236_G240_A0.7801.00
144_N149_S0.7801.00
11_K148_S0.7791.00
71_N74_L0.7781.00
141_I157_L0.7681.00
14_V149_S0.7681.00
25_T229_L0.7561.00
5_I138_E0.7501.00
22_A226_P0.7501.00
110_K137_D0.7481.00
67_D71_N0.7471.00
80_T84_Y0.7451.00
212_P234_D0.7451.00
94_K98_T0.7401.00
39_F128_G0.7401.00
121_S129_A0.7391.00
26_G29_Q0.7391.00
47_D83_L0.7381.00
99_R131_M0.7351.00
102_V106_L0.7351.00
193_M197_E0.7311.00
177_H186_G0.7301.00
227_V236_G0.7301.00
188_V193_M0.7301.00
62_N65_Q0.7281.00
26_G239_Y0.7261.00
58_Y68_A0.7251.00
19_S142_T0.7241.00
63_V73_A0.7231.00
20_S46_L0.7221.00
92_R96_A0.7191.00
87_P90_Q0.7191.00
16_K123_A0.7171.00
187_R215_Q0.7141.00
10_G159_I0.7141.00
67_D75_I0.7111.00
72_Q77_D0.7101.00
232_N237_K0.7091.00
11_K14_V0.6981.00
45_N151_R0.6961.00
130_L159_I0.6941.00
206_K245_R0.6901.00
208_V245_R0.6891.00
91_T94_K0.6881.00
105_V109_L0.6871.00
35_V74_L0.6811.00
180_L199_V0.6811.00
140_I246_L0.6791.00
48_L147_V0.6751.00
22_A239_Y0.6741.00
228_I236_G0.6741.00
142_T181_T0.6731.00
9_S14_V0.6691.00
29_Q228_I0.6661.00
199_V202_I0.6651.00
34_T118_V0.6641.00
126_E129_A0.6641.00
182_R187_R0.6611.00
69_T75_I0.6601.00
179_L186_G0.6581.00
237_K241_D0.6571.00
36_V50_M0.6551.00
3_R32_K0.6501.00
19_S211_I0.6491.00
176_E208_V0.6461.00
132_A136_A0.6421.00
63_V105_V0.6411.00
157_L161_A0.6411.00
22_A227_V0.6361.00
138_E173_P0.6341.00
69_T73_A0.6331.00
200_L210_V0.6311.00
158_G162_S0.6301.00
239_Y242_T0.6241.00
200_L203_L0.6211.00
245_R248_G0.6191.00
145_P192_D0.6181.00
4_I135_F0.6171.00
69_T76_K0.6161.00
70_L77_D0.6131.00
23_I242_T0.6111.00
11_K16_K0.6081.00
220_A227_V0.6031.00
141_I156_I0.6001.00
86_L90_Q0.5991.00
147_V151_R0.5991.00
154_D158_G0.5981.00
31_G82_N0.5971.00
133_L139_A0.5961.00
94_K97_L0.5961.00
34_T83_L0.5941.00
3_R176_E0.5931.00
44_R89_S0.5901.00
243_V247_L0.5891.00
39_F102_V0.5891.00
119_C132_A0.5891.00
25_T226_P0.5851.00
45_N48_L0.5851.00
37_I106_L0.5851.00
69_T108_D0.5821.00
99_R102_V0.5801.00
216_S233_A0.5801.00
192_D200_L0.5781.00
147_V222_N0.5771.00
187_R192_D0.5761.00
62_N66_G0.5751.00
8_T133_L0.5741.00
227_V235_A0.5741.00
215_Q218_L0.5721.00
107_D110_K0.5711.00
211_I242_T0.5681.00
34_T115_E0.5681.00
17_T45_N0.5661.00
118_V246_L0.5651.00
155_R158_G0.5621.00
77_D81_E0.5601.00
161_A164_S0.5591.00
4_I106_L0.5561.00
217_V221_S0.5561.00
98_T128_G0.5551.00
220_A226_P0.5531.00
61_V98_T0.5521.00
25_T28_A0.5521.00
21_A36_V0.5511.00
220_A225_E0.5511.00
195_S203_L0.5511.00
26_G236_G0.5451.00
150_V154_D0.5441.00
181_T187_R0.5421.00
183_Y188_V0.5421.00
47_D87_P0.5421.00
218_L221_S0.5411.00
183_Y187_R0.5391.00
127_T130_L0.5381.00
77_D85_I0.5371.00
131_M134_Y0.5371.00
106_L135_F0.5361.00
30_K243_V0.5351.00
123_A152_D0.5341.00
10_G124_G0.5331.00
218_L222_N0.5331.00
184_N215_Q0.5291.00
28_A34_T0.5281.00
201_E204_R0.5241.00
100_E134_Y0.5231.00
70_L74_L0.5231.00
48_L148_S0.5231.00
74_L84_Y0.5221.00
92_R98_T0.5201.00
92_R95_D0.5191.00
91_T158_G0.5131.00
15_G19_S0.5101.00
192_D202_I0.5091.00
196_M210_V0.5091.00
33_K114_F0.5070.99
193_M200_L0.5070.99
177_H206_K0.5070.99
83_L87_P0.5050.99
188_V222_N0.5000.99
77_D84_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pfsA 1 0.8778 100 0.286 Contact Map
1hyqA 1 0.8519 100 0.289 Contact Map
4rz3A 2 0.8741 100 0.295 Contact Map
3q9lA 2 0.9481 100 0.301 Contact Map
4v03A 2 0.8741 100 0.309 Contact Map
3pg5A 2 0.8259 100 0.312 Contact Map
1g3qA 1 0.8704 100 0.313 Contact Map
1wcv1 2 0.8778 100 0.324 Contact Map
3ez9A 2 0.7852 100 0.331 Contact Map
3ez2A 2 0.9222 100 0.333 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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