GREMLIN Database
MDAB - Modulator of drug activity B
UniProt: P0AEY5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12656
Length: 193 (167)
Sequences: 3714 (2635)
Seq/√Len: 203.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_R59_W4.0971.00
3_N38_D2.8641.00
9_G77_T2.5121.00
80_K84_D2.5061.00
74_A151_F2.2781.00
8_N25_T2.1811.00
40_R56_N2.1761.00
54_V92_T2.0941.00
118_K161_E2.0541.00
27_V185_R2.0531.00
69_G123_L2.0221.00
55_Q59_W1.9811.00
21_N124_T1.9681.00
173_K176_D1.9391.00
119_Y155_N1.9311.00
62_V118_K1.9271.00
58_L92_T1.9151.00
174_M178_P1.9001.00
52_A56_N1.8941.00
55_Q58_L1.8681.00
3_N59_W1.8471.00
4_I62_V1.8471.00
51_K55_Q1.8071.00
79_K83_D1.7401.00
27_V30_G1.7061.00
63_V160_M1.6991.00
5_L56_N1.6891.00
42_V56_N1.6551.00
26_E30_G1.6521.00
76_W80_K1.6241.00
53_E81_Y1.5991.00
20_L124_T1.5901.00
54_V93_L1.5851.00
182_E185_R1.5521.00
122_S184_Y1.5171.00
30_G185_R1.5101.00
20_L177_V1.4571.00
21_N66_Q1.4431.00
66_Q184_Y1.4291.00
29_D33_R1.4191.00
4_I37_H1.4151.00
82_I86_F1.3971.00
6_I29_D1.3891.00
176_D179_R1.3731.00
31_T185_R1.3541.00
27_V31_T1.3531.00
25_T41_I1.3221.00
35_L60_A1.3051.00
5_L60_A1.3051.00
119_Y160_M1.3021.00
50_V54_V1.2951.00
180_Y183_E1.2921.00
30_G34_D1.2901.00
96_S110_S1.2801.00
52_A55_Q1.2741.00
166_F183_E1.2741.00
115_Q159_G1.2581.00
178_P182_E1.2561.00
172_I177_V1.2501.00
66_Q122_S1.2211.00
28_A184_Y1.2181.00
28_A188_L1.2001.00
144_V167_I1.2001.00
182_E186_K1.1681.00
27_V182_E1.1631.00
179_R183_E1.1631.00
29_D41_I1.1531.00
155_N160_M1.1521.00
49_D52_A1.1491.00
8_N22_D1.1481.00
146_G149_L1.1401.00
27_V181_T1.1321.00
9_G78_V1.1271.00
122_S166_F1.1071.00
26_E29_D1.0991.00
112_G115_Q1.0891.00
129_M133_T1.0851.00
60_A63_V1.0801.00
37_H56_N1.0801.00
46_S80_K1.0741.00
95_A113_L1.0641.00
86_F158_L1.0591.00
129_M169_N1.0571.00
114_V160_M1.0541.00
168_A180_Y1.0451.00
22_D26_E1.0431.00
61_D117_K1.0411.00
184_Y188_L1.0381.00
24_L124_T1.0261.00
74_A78_V1.0211.00
153_K156_Q1.0141.00
31_T35_L1.0121.00
11_K70_W0.9951.00
142_V146_G0.9941.00
20_L171_V0.9931.00
64_I120_M0.9921.00
95_A111_G0.9851.00
125_W169_N0.9821.00
23_T27_V0.9791.00
116_G161_E0.9771.00
51_K54_V0.9751.00
42_V53_E0.9661.00
56_N59_W0.9610.99
19_Q174_M0.9490.99
58_L113_L0.9420.99
30_G33_R0.9400.99
40_R77_T0.9390.99
168_A172_I0.9380.99
67_M121_L0.9380.99
69_G144_V0.9270.99
37_H42_V0.9150.99
149_L152_H0.9090.99
23_T181_T0.9070.99
25_T29_D0.8940.99
54_V87_T0.8920.99
57_F63_V0.8890.99
107_K110_S0.8890.99
123_L148_Y0.8750.99
82_I154_A0.8700.99
72_M153_K0.8630.99
24_L180_Y0.8620.99
38_D41_I0.8620.99
24_L122_S0.8590.99
118_K163_L0.8590.99
12_K18_G0.8540.99
71_W83_D0.8480.99
177_V181_T0.8410.99
142_V149_L0.8340.99
41_I44_A0.8280.98
3_N40_R0.8260.98
147_V150_P0.8200.98
155_N162_P0.8180.98
6_I28_A0.8050.98
9_G39_V0.7990.98
31_T34_D0.7970.98
120_M187_H0.7860.98
128_P131_A0.7820.98
33_R38_D0.7820.98
122_S168_A0.7790.98
164_P187_H0.7750.98
123_L167_I0.7720.98
88_E96_S0.7700.98
76_W84_D0.7690.98
34_D185_R0.7590.97
24_L28_A0.7590.97
3_N61_D0.7460.97
33_R39_V0.7400.97
8_N21_N0.7400.97
57_F81_Y0.7370.97
173_K177_V0.7360.97
6_I64_I0.7350.97
69_G147_V0.7330.97
121_L151_F0.7310.97
120_M166_F0.7290.97
62_V120_M0.7290.97
69_G132_F0.7240.96
184_Y187_H0.7240.96
7_I81_Y0.7220.96
125_W167_I0.7210.96
57_F65_W0.7150.96
36_G39_V0.7100.96
9_G40_R0.7080.96
77_T81_Y0.7070.96
177_V180_Y0.7060.96
88_E94_Y0.7030.96
131_A139_F0.7030.96
179_R182_E0.6950.96
49_D53_E0.6940.95
172_I180_Y0.6910.95
28_A31_T0.6900.95
72_M157_F0.6900.95
38_D59_W0.6890.95
147_V153_K0.6890.95
74_A150_P0.6870.95
25_T36_G0.6870.95
71_W94_Y0.6850.95
6_I25_T0.6800.95
7_I65_W0.6780.95
142_V147_V0.6720.95
65_W155_N0.6700.95
29_D39_V0.6700.95
43_R48_Y0.6640.94
46_S87_T0.6640.94
54_V85_V0.6600.94
8_N13_F0.6580.94
18_G26_E0.6570.94
42_V81_Y0.6550.94
54_V88_E0.6530.94
67_M123_L0.6520.94
39_V44_A0.6510.94
24_L184_Y0.6460.93
127_A140_H0.6410.93
111_G115_Q0.6320.93
53_E56_N0.6290.92
93_L114_V0.6270.92
119_Y162_P0.6270.92
44_A48_Y0.6250.92
20_L168_A0.6240.92
74_A82_I0.6230.92
125_W132_F0.6220.92
112_G159_G0.6220.92
67_M78_V0.6180.92
132_F136_D0.6100.91
145_D148_Y0.6090.91
174_M177_V0.6070.91
154_A158_L0.6040.91
67_M75_P0.6010.91
67_M148_Y0.6000.91
125_W144_V0.5980.90
166_F184_Y0.5980.90
44_A47_D0.5950.90
23_T26_E0.5900.90
37_H62_V0.5830.89
183_E186_K0.5780.89
47_D80_K0.5760.89
67_M151_F0.5730.89
18_G22_D0.5690.88
4_I32_L0.5690.88
23_T177_V0.5680.88
51_K87_T0.5670.88
67_M74_A0.5610.88
51_K179_R0.5600.87
56_N60_A0.5590.87
123_L165_T0.5580.87
144_V148_Y0.5570.87
7_I37_H0.5560.87
57_F86_F0.5550.87
55_Q178_P0.5530.87
20_L24_L0.5530.87
33_R36_G0.5530.87
36_G44_A0.5450.86
84_D87_T0.5450.86
118_K159_G0.5420.86
96_S158_L0.5380.85
44_A84_D0.5360.85
78_V82_I0.5350.85
44_A78_V0.5340.85
145_D152_H0.5330.85
22_D43_R0.5300.84
82_I151_F0.5250.84
48_Y52_A0.5240.84
181_T184_Y0.5220.84
89_G95_A0.5210.83
139_F157_F0.5140.83
23_T178_P0.5110.82
75_P83_D0.5070.82
140_H156_Q0.5050.81
20_L181_T0.5020.81
47_D84_D0.5000.81
125_W171_V0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2amjA 2 0.9378 100 0.36 Contact Map
3rpeA 2 0.9896 100 0.39 Contact Map
1d4aA 2 0.9067 100 0.393 Contact Map
4gi5A 2 0.9482 100 0.407 Contact Map
4fglA 2 0.9067 100 0.454 Contact Map
3ha2A 2 0.8549 100 0.478 Contact Map
3l9wA 2 0.8601 100 0.493 Contact Map
3lcmA 2 0.8705 100 0.494 Contact Map
4r81A 4 0.8808 100 0.495 Contact Map
3f2vA 2 0.8549 100 0.497 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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