GREMLIN Database
MAZG - Nucleoside triphosphate pyrophosphohydrolase
UniProt: P0AEY3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10572
Length: 263 (252)
Sequences: 2362 (1655)
Seq/√Len: 104.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
250_E254_Q4.5671.00
170_Y177_M3.6431.00
71_Q74_Q3.1981.00
10_I89_S2.8821.00
234_V244_V2.8731.00
179_E189_K2.8711.00
146_Q212_A2.8671.00
191_E218_K2.8061.00
30_A50_E2.7291.00
43_V55_L2.6261.00
94_R118_I2.5691.00
233_I236_A2.5391.00
229_E256_V2.4761.00
148_I220_N2.4751.00
8_L81_F2.4381.00
141_A213_E2.3371.00
239_L248_T2.2931.00
4_I81_F2.2651.00
224_E228_R2.1831.00
107_N110_E2.1711.00
16_D19_N2.1501.00
176_V194_M2.1481.00
168_K171_E2.1201.00
11_M68_F2.1081.00
26_E108_S2.0871.00
144_R224_E2.0771.00
29_F69_Y2.0391.00
52_F78_R1.9561.00
244_V249_M1.9491.00
169_V200_A1.9471.00
245_D248_T1.9361.00
45_D49_R1.8861.00
233_I255_Q1.8791.00
229_E233_I1.8391.00
43_V62_L1.8021.00
161_T164_P1.7801.00
54_D57_G1.7781.00
108_S111_V1.7711.00
234_V241_M1.7501.00
141_A216_L1.7351.00
237_R252_V1.7101.00
194_M201_T1.7021.00
86_A90_D1.6921.00
12_Q71_Q1.6831.00
191_E214_I1.6541.00
237_R255_Q1.6501.00
194_M205_A1.6471.00
19_N25_K1.6351.00
80_D83_D1.6331.00
192_E222_K1.6281.00
70_A84_I1.6151.00
160_T164_P1.6041.00
165_V204_L1.6041.00
130_S228_R1.6001.00
240_E243_G1.5761.00
142_L202_V1.5701.00
234_V249_M1.5591.00
170_Y174_D1.5491.00
56_R87_A1.5401.00
189_K192_E1.5371.00
16_D20_G1.5351.00
103_S114_R1.5281.00
40_T44_L1.5091.00
4_I85_C1.5031.00
188_A218_K1.5011.00
74_Q80_D1.4901.00
229_E255_Q1.4801.00
241_M244_V1.4651.00
210_T215_A1.4491.00
105_A111_V1.4461.00
51_D54_D1.4371.00
123_R151_R1.4131.00
229_E259_Q1.4071.00
176_V190_L1.4071.00
7_L88_I1.3791.00
81_F85_C1.3791.00
49_R54_D1.3631.00
234_V252_V1.3611.00
90_D94_R1.3580.99
105_A114_R1.3540.99
32_I72_M1.3460.99
15_R75_E1.3330.99
33_A48_A1.3300.99
111_V114_R1.3180.99
130_S232_R1.3030.99
28_T31_T1.2840.99
67_V88_I1.2820.99
16_D25_K1.2450.99
133_D228_R1.2430.99
36_T69_Y1.2160.99
136_P139_L1.2030.99
186_D189_K1.1750.99
230_V244_V1.1630.98
29_F72_M1.1590.98
13_R16_D1.1540.98
35_Y92_L1.1350.98
36_T40_T1.1310.98
239_L244_V1.1230.98
192_E219_A1.1150.98
56_R73_A1.1140.98
105_A110_E1.1110.98
169_V197_L1.1030.98
3_Q86_A1.0990.98
166_V177_M1.0990.98
52_F76_E1.0790.97
241_M249_M1.0780.97
164_P167_D1.0770.97
94_R122_E1.0700.97
190_L210_T1.0620.97
63_L85_C1.0560.97
33_A44_L1.0560.97
233_I252_V1.0560.97
29_F36_T1.0550.97
239_L243_G1.0520.97
194_M210_T1.0460.97
230_V252_V1.0290.97
192_E218_K1.0110.96
174_D177_M1.0080.96
56_R83_D1.0060.96
230_V241_M1.0050.96
176_V201_T1.0040.96
169_V201_T1.0000.96
36_T44_L0.9930.96
106_E110_E0.9920.96
5_D9_T0.9900.96
176_V197_L0.9880.96
32_I35_Y0.9870.96
8_L82_N0.9770.95
71_Q75_E0.9710.95
11_M92_L0.9580.95
57_G87_A0.9580.95
149_Q202_V0.9540.95
174_D178_Y0.9480.95
7_L67_V0.9460.95
13_R20_G0.9390.94
108_S112_L0.9380.94
165_V207_H0.9320.94
114_R118_I0.9280.94
12_Q74_Q0.9260.94
6_R90_D0.9220.94
36_T62_L0.9150.93
172_E175_E0.9130.93
232_R236_A0.9110.93
244_V252_V0.9070.93
64_F69_Y0.8980.93
234_V237_R0.8970.93
148_I224_E0.8960.93
194_M208_L0.8930.93
13_R19_N0.8920.93
198_L216_L0.8920.93
173_I197_L0.8920.93
230_V249_M0.8910.93
118_I121_E0.8870.92
29_F73_A0.8790.92
175_E193_E0.8790.92
22_P111_V0.8780.92
29_F76_E0.8780.92
149_Q203_N0.8760.92
152_C223_F0.8740.92
29_F52_F0.8680.92
180_A190_L0.8630.91
149_Q158_D0.8630.91
11_M67_V0.8600.91
198_L201_T0.8600.91
48_A217_Q0.8600.91
43_V47_I0.8580.91
179_E185_V0.8580.91
211_K214_I0.8540.91
163_G181_R0.8540.91
32_I36_T0.8490.91
244_V248_T0.8460.91
110_E114_R0.8420.90
22_P99_V0.8420.90
53_D56_R0.8380.90
157_F227_F0.8350.90
197_L201_T0.8340.90
203_N206_R0.8320.90
233_I259_Q0.8100.89
247_E250_E0.8030.88
191_E215_A0.8000.88
193_E196_D0.7990.88
117_Q120_T0.7990.88
35_Y65_Q0.7980.88
159_W165_V0.7940.88
111_V118_I0.7930.87
146_Q202_V0.7920.87
175_E196_D0.7880.87
136_P147_K0.7850.87
29_F78_R0.7840.87
70_A81_F0.7830.87
237_R244_V0.7790.87
144_R217_Q0.7790.87
134_D151_R0.7770.86
8_L67_V0.7730.86
252_V256_V0.7690.86
3_Q82_N0.7690.86
3_Q85_C0.7690.86
147_K150_K0.7670.86
25_K28_T0.7660.86
22_P26_E0.7630.85
7_L92_L0.7620.85
230_V234_V0.7600.85
144_R221_E0.7490.84
167_D170_Y0.7480.84
130_S133_D0.7450.84
146_Q211_K0.7440.84
64_F88_I0.7420.84
172_E193_E0.7410.84
49_R137_R0.7370.83
232_R235_A0.7350.83
29_F55_L0.7340.83
6_R10_I0.7300.83
146_Q150_K0.7260.82
193_E226_R0.7240.82
169_V204_L0.7230.82
246_L250_E0.7220.82
187_Q209_G0.7220.82
93_E99_V0.7200.82
135_I148_I0.7190.82
149_Q207_H0.7190.82
176_V208_L0.7180.82
114_R117_Q0.7180.82
6_R89_S0.7180.82
162_L165_V0.7170.82
251_E254_Q0.7150.81
165_V200_A0.7150.81
128_Q133_D0.7090.81
176_V210_T0.7080.81
255_Q259_Q0.7070.81
3_Q6_R0.7050.81
40_T62_L0.7040.80
188_A191_E0.6980.80
63_L66_V0.6970.80
159_W172_E0.6960.80
148_I152_C0.6890.79
159_W175_E0.6880.79
229_E232_R0.6880.79
47_I55_L0.6870.79
184_V189_K0.6870.79
163_G177_M0.6850.79
45_D54_D0.6850.79
172_E196_D0.6830.78
221_E225_R0.6830.78
185_V190_L0.6770.78
68_F89_S0.6770.78
72_M75_E0.6770.78
176_V205_A0.6730.77
8_L74_Q0.6700.77
132_L231_E0.6670.77
89_S93_E0.6670.77
6_R9_T0.6670.77
162_L207_H0.6660.77
113_A117_Q0.6520.75
44_L48_A0.6490.75
159_W168_K0.6480.75
246_L249_M0.6470.75
9_T13_R0.6470.75
69_Y73_A0.6470.75
128_Q134_D0.6470.75
85_C89_S0.6430.74
107_N111_V0.6390.74
6_R85_C0.6390.74
162_L204_L0.6370.73
109_S113_A0.6370.73
172_E226_R0.6350.73
131_A134_D0.6350.73
247_E254_Q0.6340.73
179_E190_L0.6300.73
55_L73_A0.6210.72
149_Q199_F0.6210.72
228_R232_R0.6200.71
34_P65_Q0.6190.71
30_A47_I0.6160.71
159_W193_E0.6150.71
251_E255_Q0.6130.71
158_D206_R0.6130.71
159_W171_E0.6100.70
6_R86_A0.6070.70
107_N114_R0.6060.70
55_L69_Y0.6030.69
196_D226_R0.6030.69
59_L66_V0.6010.69
199_F219_A0.6000.69
168_K175_E0.5990.69
157_F196_D0.5960.68
36_T43_V0.5960.68
88_I92_L0.5950.68
13_R100_F0.5950.68
6_R13_R0.5950.68
33_A214_I0.5930.68
20_G27_Q0.5860.67
33_A92_L0.5860.67
24_D96_H0.5850.67
101_A105_A0.5850.67
167_D177_M0.5840.67
43_V59_L0.5840.67
54_D154_N0.5840.67
234_V239_L0.5830.67
139_L147_K0.5800.66
252_V255_Q0.5780.66
164_P207_H0.5760.66
170_Y173_I0.5740.66
9_T12_Q0.5730.65
11_M62_L0.5720.65
110_E113_A0.5690.65
4_I8_L0.5690.65
233_I237_R0.5680.65
169_V176_V0.5670.65
255_Q258_R0.5670.65
158_D207_H0.5660.64
177_M180_A0.5660.64
187_Q190_L0.5640.64
10_I32_I0.5630.64
62_L66_V0.5610.64
158_D203_N0.5600.64
180_A208_L0.5580.63
11_M35_Y0.5570.63
92_L154_N0.5570.63
186_D190_L0.5560.63
168_K172_E0.5560.63
64_F92_L0.5550.63
173_I177_M0.5550.63
10_I93_E0.5550.63
240_E244_V0.5540.63
30_A48_A0.5530.63
41_Y138_S0.5530.63
11_M64_F0.5520.63
16_D71_Q0.5480.62
205_A211_K0.5470.62
221_E224_E0.5470.62
200_A246_L0.5470.62
82_N85_C0.5470.62
133_D224_E0.5460.62
199_F223_F0.5450.62
64_F72_M0.5430.61
166_V173_I0.5430.61
26_E112_L0.5420.61
175_E226_R0.5420.61
132_L135_I0.5390.61
185_V189_K0.5380.61
235_A240_E0.5380.61
164_P230_V0.5350.60
24_D27_Q0.5350.60
25_K72_M0.5340.60
73_A83_D0.5330.60
32_I144_R0.5320.60
187_Q191_E0.5320.60
31_T34_P0.5310.60
159_W196_D0.5300.59
65_Q69_Y0.5300.59
83_D86_A0.5280.59
240_E245_D0.5270.59
222_K226_R0.5260.59
168_K193_E0.5240.59
97_P118_I0.5240.59
143_M211_K0.5220.58
68_F92_L0.5220.58
46_A54_D0.5210.58
33_A69_Y0.5190.58
175_E222_K0.5190.58
106_E114_R0.5160.57
239_L242_T0.5140.57
160_T165_V0.5130.57
157_F172_E0.5130.57
37_L143_M0.5110.57
201_T204_L0.5110.57
202_V206_R0.5100.57
180_A185_V0.5090.56
103_S106_E0.5070.56
136_P151_R0.5060.56
205_A212_A0.5050.56
29_F32_I0.5050.56
225_R229_E0.5040.56
142_L213_E0.5040.56
94_R121_E0.5020.55
230_V233_I0.5010.55
70_A83_D0.5000.55
157_F175_E0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3craA 2 0.9202 100 0.077 Contact Map
2yxhA 2 0.4373 100 0.68 Contact Map
2a3qA 3 0.3688 99.9 0.791 Contact Map
2oieA 3 0.3536 99.8 0.808 Contact Map
4qgpA 4 0.346 99.7 0.82 Contact Map
2q5zA 4 0.3308 99.7 0.831 Contact Map
2gtaA 4 0.365 99.6 0.832 Contact Map
2q73A 4 0.3194 99.6 0.84 Contact Map
1vmgA 4 0.3042 99.6 0.842 Contact Map
1yxbA 4 0.3042 97.2 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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